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PL
Określono wpływ protaminy na wewnątrzcząsteczkową (pH 2,5) i autokatalityczną (pH 3,5) aktywację pepsynogenu oraz na aktywność pepsyny. Wykazano, że protamina hamuje jedynie nieznacznie aktywację pepsynogenu i aktywność pepsyny.
EN
Protamine only slightly inhibits pepsinogen activation and pepsin activity. This effect is observed both at pH 2.5 when those proteins do not form insoluble complexes and at pH 3.5, when they do form the insoluble complexes.
PL
Określono wpływy produktów trypsynowej degradacji protaminy na tworzenie kompleksów z pepsyną i na aktywność proteolityczną tego enzymu. Postępująca w czasie degradacja protaminy powoduje stopniowe obniżenie jej zdolności do tworzenia kompleksów z pepsyną i hamowania aktywności pepsyny.
EN
Trypsin degrades protamine to arginine and peptides of low molecular weight. These products do not form complexes with pepsin and they do not inhibit its activity.
PL
Nasiona niektórych roślin spożywanych przez człowieka hamują aktywność proteolityczną preparatu Kreon, Neo-Pancreatinum i Panzytrat.
EN
Extracts from the seeds of broad bean, pumpkin, bean, pea, buckwheat, barley, corn, poppy, almond, peanut, hazel nut, common walnut, oat, millet, wheat, rice, sunflower, soya and rye contain proteolytic activity inhibitors for of Kreon, Nco-Pancreatinum, and Panzytrat preparations.
PL
Nasiona niektórych roślin spożywanych przez człowieka zawierają inhibitory pepsyny, a wszystkie gatunki roślin zawierają inhibitory trypsyny i chymotrypsyny. Ogrzewanie obniża aktywność tych inhibitorów.
EN
Pepsin inhibitors occur in extracts of the seeds of pumpkin, peanut, common walnut, oat, wheat, sunflower, lentil, soya and rye. Trypsin and chymotrypsin inhibitors arc contained in the extracts of the seeds of broad bean, pumpkin, bean, pea, buckwheat, barley, corn, poppy, almond, peanut, hazel nut, common walnut, oat, millet, wheat, rice, sunflower, lentil, soya, and rye. Heating the examined extracts at 100°C for 1 hour decreases the activity of these inhibitors in the degree dependent on the species and a given inhibitor specificity.
EN
Objective: To evaluate the efficacy, satisfaction, safety and tolerability of sildenafil taken as prescribed prior to anticipated sexual activity in male outpatients with erectile dysfunction (ED). Materials and methods: Two hundred and three adult male with ED participated in a 2-week, no treatment, run-in period followed by a 6-week open treatment period. In the present trial, they received 50 mg of Viagra. The primary efficacy variable was the change from baseline in response to item 3 and 4 of the International Index of Erectile Function (IIEF). The secondary efficacy variables were as follows: response to the other questions of the IIEF, the IIEF domain scores, response to the Global Efficacy Assessment Question (GAQ), the Event Logs of Erectile Function and Erectile Dysfunction Inventory of Treatment Satisfaction Questionnaire. Results: A total of 203 subjects were screened and 175 subjects received the study drug. A total of 168 subjects completed the study. The percent of improved erection based on the (GAQ) was 84.5%. The mean rate of successful intercourse was 0.6. Almost thirty-seven percent of patients were satisfied with the effect of treatment in their erections at week 2. The treatment satisfaction increased to 83.3 % at the end of the study, after 62.6 % of patients increased dose to 100 mg of Viagra. A total of 7 (4%) subject discontinued the study prior to the final visit. The reasons of discontinuation were: adverse events - 1.1%, lost to follow-up - 1.1%, subject no longer willing to participate - 3. Of the 175 subjects who received Viagra, 34 subjects experienced at least one adverse event. Conclusions: The results of the analyses of the responses to the primary variable were highly statistically significantly in favour of sildenafil, as well as the results of the analyses of all the secondary efficacy variables. These findings support effectiveness of sildenafil. The adverse event profile of sildenafil in this study was consistent with the labeled adverse events for this product.
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