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Ekspozycja na dym tytoniowy a poziom 1-hydroksypirenu u osob palacych i niepalacych

100%

Konieczna L. , Plenis A.

Bromatologia i Chemia Toksykologiczna

2009

tom 42

nr 3

553-557

Simultaneous determination of six quinolone antibiotics in poultry and porcine samples by capillary electrophoresis

100%

Kowalski P. , Plenis A.

Bulletin of the Veterinary Institute in Puławy

2008

tom 52

nr 1

A capillary electrophoresis (CE) method for the simultaneous determination of residues of six quinolones (enrofloxacin, ciprofloxacin, ofloxacin, lomefloxacin, norfloxacin, cinoxacin) in chicken, hen, and swine tissue samples were developed and validated. The sample preparation consisted of a solid phase extraction on C-18 cartridges prior to the analysis by CE with UV detection. The method was validated in terms of selectivity, linearity, precision, accuracy, recovery, and stability. The calibration curves were linear to at least 10-1 000 ng/g for all quinolones with r² > 0.999. The values of decision limits (CCα) and detection capabilities (CCβ) for the analysed substances were between 3.2-16.9 and 3.5-20.3 ng/g, respectively. The CE method was robust and specific, allowing reliable quantification of quinolone residues in animal tissues and should also be useful for clinical and biomedical investigations.

Wykrywanie i oznaczanie pozostalosci florfenikolu i tiamfenikolu w tkankach jadalnych zwierzat metoda elektroforezy kapilarnej

80%

Kowalski P. , Plenis A. , Oledzka I.

Bromatologia i Chemia Toksykologiczna

2009

tom 42

nr 3

569-573

Elektroforetyczne oznaczanie kationów: sodu, potasu, wapnia i magnezu w butelkowanych wodach mineralnych

80%

Kowalski P. , Oledzka I. , Plenis A. , Baczek T.

Bromatologia i Chemia Toksykologiczna

2011

tom 44

nr 3

Quantitative determination of pentoxifylline in human plasma

80%

Chmielewska A. , Konieczna L. , Plenis A. , Lamparczyk H.

Acta Chromatographica

2006

tom No. 16

70-79

A rapid, optimized, and sensitive reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for deter-mination of pentoxifylline in human plasma. The analyte was extracted from the plasma with dichloromethane after addition of 0.2 mL 1 M NaOH. HPLC separation was performed on a C18 analytical column (250 mm × 4 mm i.d.) with acetonitrile–water, 45:55 (v/v), as mobile phase. Spectro-photometric detection was performed at 275 nm. Calibration graphs were linear from 25 to 1000 ng mL-1 pentoxifylline. Recovery of the drug from human plasma was 92.1%, and the detection limit was 20 ng mL-1.

Rapid analysis of loratadine in human serum by high-performance liquid chromatography with fluorescence detection

80%

Plenis A. , Konieczna L. , Olędzka I. , Kowalski P.

Acta Chromatographica

2010

tom Vol. 22, no. 1

69--79

A simple and rapid high-performance liquid chromatographic method with fluorescence detection for analysis of loratadine (LOR) in small volumes of human serum has been developed and validated. After solid-phase extraction (SPE), with thioridazine hydrochloride as internal standard, chromatographic separation was performed on a C 18 analytical column with 70:30 ( v / v ) acetonitrile-water, adjusted to pH 2.7 with orthophosphoric acid as mobile phase at a flow-rate of 1 min mL -1. The column was maintained at 28°C. Fluorescence detection was performed at excitation and emission wavelengths of 265 of 454 nm, respectively. The method was validated for accuracy, precision, selectivity, linearity, recovery, and stability. Absolute recovery of LOR was >93.0%. The limits of detection (LOD) and quantification (LOQ) were 0.07 and 0.2 ng mL -1,respectively. Linearity was confirmed in the range 0.2–30 ng mL -1 (correlation coefficient >0.9998). This HPLC method is selective, robust, and specific and would enable efficient analysis of large numbers of serum samples in support of pharmacokinetic, bioavailability, or bioequivalence studies after therapeutic doses of LOR.