Wyniki wyszukiwania - Biblioteka Nauki

1

Therapeutic advantages of omega-3 fatty acid supplementation in patients with schizophrenia – a systematic review

100%

Vityala S. , Priya Kanteti K. , Vityala Y. , Tagaev T. , Damineni U.

European Journal of Clinical and Experimental Medicine

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2024

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tom 22

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nr 1

172-178

EN

Introduction and aim. In patients with schizophrenia, omega-3 (n-3) polyunsaturated fatty acids (PUFAs) treatment was found to ameliorate the cardiovascular, metabolic, and inflammatory problems caused by antipsychotic medication and even reduce the need for medication by 20%. In this study, we evaluated the potential therapeutic effects of n-3 PUFA supplementation in patients with schizophrenia. Material and methods. The PRISMA guidelines were followed in conducting this systematic review. The Embase, MEDLINE, Web of Science, and Google Scholar databases were searched electronically. The first search yielded 50 papers in total. Subsequently, 43 publications that did not meet our eligibility requirements were removed, and seven articles were selected. Analysis of the literature. The analysis showed that n-3 PUFA supplementation and the placebo group both decreased their psychotic (PANSS and GAF scales) and Calgary Depression Scale symptomatology and boosted their functional ability (GAF) when used as an adjuvant to antipsychotic medication. When administered as a monotherapy with a metabolic antioxidant, n-3 PUFA supplementation proved beneficial for treating schizophrenia. In patients with schizophrenia, n-3 PUFAs have therapeutic benefits as adjuvant treatments to medications, although not for different variables or patient groups. Conclusion. In many studies, patients with chronic schizophrenia who received n-3 PUFA supplementation showed no improvement in their clinical condition.

2

Deficiency of long-chain polyunsaturated fatty acids in phenylketonuria: a cross-sectional study

86%

Drzymała-Czyż S. , Kałużny Ł. , Krzyżanowska-Jankowska P. , Walkowiak D. , Mozrzymas R. , Walkowiak J.

Acta Biochimica Polonica

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2018

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tom 65

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nr 2

303-308

EN

The etiology of altered blood fatty acid (FA) profile in phenylketonuria (PKU) is understood only partially. We aimed to determine whether FAs deficiency is dependent on the diet or metabolic disturbances. The study comprised 40 PKU patients (20 female, 20 male; aged 11 to 35 years; 12 children and 28 adults) and 40 healthy subjects (HS; 20 female, 20 male, aged 18 to 33 years). We assessed the profile of FAs (gas chromatography/mass spectrometry) and analyzed the 72-hour dietary recalls. The amount of C14:0, C16:0 and C16:1n-7, C18:1n-9 did not differ between the analyzed groups. The percentage of C18:0 was higher, while C20:3n-9, C18:2n-6, C20:2n-6, C20:4n-6, C22:4n-6, C22:5n-6 and C22:6n-3 was lower in PKU than in HS. However, C18:3n-6, C18:3n-3 and n-6/n-3 ratio were higher in PKU patients. The C20:4n-6/C20:3n-6 ratio (reaction catalyzed by Δ5-desaturase), the C22:5n-6/C22:4n-6 and the C22:6n-3/C22:5n-3 ratio (both reactions catalyzed by Δ6 desaturase) were significantly lower in PKU patients. Therefore, the deficiency of long-chain polyunsaturated fatty acids in PKU patients may result not only from inadequate supply but also from metabolic disturbances.

3

Acute anti-fibrillating and defibrillating potential of atorvastatin, melatonin, eicosapentaenoic acid and docosahexaenoic acid demonstrated in isolated heart model

86%

Benova T. , Knezl V. , Viczenczova C. , Bacova B. S. , Radosinska J. , Tribulova N.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 1

4

Seasonal proximate and fatty acid variations of some seaweeds from the northeastern Mediterranean coast

86%

Polat S. , Ozogul Y.

Oceanologia

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2013

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tom No. 55 (2)

375-391

EN

The seasonal nutritional value of red (Jania rubens, Laurencia papillosa, Spyridia filamentosa and Dasya rigidula) and brown macroalgae (Padina pavonia and Stypopodium schimperi) was evaluated as a dietary supplement for human and animal nutrition based on proximate and fatty acid profiles. The protein content varied from 0.80% (L. papillosa) to 3.41% (J. rubens) of wet weight with the highest values in winter. The highest lipid levels were recorded in S. schimperi (2.03% in spring, 2.16% in summer), the lowest in S. filamentosa (0.08% in spring). The ash content of J. rubens (46.11-51.63%) was significantly higher than that of the other species (2.28-16.57%). Analysis of the fatty acid composition showed that these seaweed species are very rich in n-3 fatty acids.

5

Discrepancy between clinical and histological effects of DHA supplementation in a rat model of pouchitis

72%

Drzymala-Czyz S. , Banasiewicz T. , Tubacka M. , Tarasiuk-Rusek A. , Majewski P. , Drews M. , Walkowiak J.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 1

6

Docosahexaenoic acid inhibits ethanol/palmitoleic acid-induced necroptosis in AR42J cells

72%

Ku L. , Lee J. , Lim J. W. , Jin L. , Seo J. T. , Kim H.

Journal of Physiology and Pharmacology

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2020

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tom 71

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nr 3

7

Peroxisome proliferator-activated receptor alpha activation inducesunfavourable changes in fatty acid composition of myocardial phospholipids

72%

Baranowski M. , Blachnio-Zabielska A. , Gorski J.

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tom 60

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nr 2

13-20

EN

Peroxisome proliferator-activated receptor alpha (PPAR) plays a crucial role in the transcriptional regulation of myocardial lipid metabolism. In vitro studies on isolated cardiomyocytes showed that PPAR activation induces expression of numerous genes involved in virtually all steps of fatty acid catabolism. However, there is very few data on the effect of PPAR activation on the content and composition of myocardial lipids in vivo. Therefore, our main aim was to examine effects of selective PPAR agonist WY-14643 on the content and fatty acid composition of major lipid classes in the heart of rats fed a standard chow (STD) or a high-fat diet (HFD). In STD rats WY-14643 paradoxically decreased palmitate oxidation rate in the heart, however, in HFD animals such effect was not observed. WY-14643 markedly reduced myocardial free fatty acid and diacylglycerol content in STD rats, whereas in HFD group the opposite effect was observed. These changes reflected alterations in plasma lipid concentration which suggests that effects of WY-14643 on the heart were indirect and secondary to changes in plasma lipid availability induced by the drug. Basal myocardial glucose uptake was not affected by PPAR agonist in either group, however, glycogen content in the heart was markedly increased. WY-14643 exerted profound influence on the fatty acid composition of myocardial phospholipids in both diet groups. These changes included increased percentage of monounsaturated fatty acids and replacement of n-3 polyunsaturated fatty acids (PUFA) by those from the n-6 family. This action of WY-14643 might be detrimental to the heart since n-3 PUFA possess cardioprotective and antiarrhythmic properties.

8

Wzbogacanie żywności w długołańcuchowe kwasy omega-3

58%

Jochym K. , Kapuśniak J.

Chemistry, Environment, Biotechnology

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2010

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tom Vol. 14

121-138

PL

Nowoczesna żywność ma nie tylko dostarczać energii, ale również poprawiać lub podtrzymywać dobry stan zdrowia. Przykładem może być żywność wzbogacona długołańcuchowymi wielonienasyconymi kwasami tłuszczowymi (LC PUFA) z rodziny omega-3, szczególnie kwasem dokozaheksaenowym (DHA) oraz eikozapentaenowym (EPA). Kwasy te bardzo korzystnie oddziałują na układ krążenia oraz nerwowy. Niestety ich wytwarzanie w organizmie zachodzi z niewielką wydajnością. Dlatego głównym źródłem LC PUFA powinna być spożywana żywność. Najbogatsze w te dobroczynne kwasy są ryby i inne organizmy morskie, które niestety w większości krajów z tzw. zachodnim typem diety, w tym w Polsce, nie są spożywane w dostatecznej ilości. Dla uzupełnienia niedoborów można stosować suplementy diety oraz żywność wzbogaconą w omega-3. Wytwarzanie żywności z dodatkiem oleju rybiego wymaga pokonania wielu trudności technologicznych, przede wszystkim związanych z występowaniem "rybiego" posmaku i zapachu, a także z ochroną wielonienasyconych kwasów przed utlenianiem. Możliwym sposobem rozwiązania tych problemów jest dodawanie do żywności oleju rybiego w formie mikrokapsułek. Do enkapsulacji olejów bogatych w omega-3 LC PUFA stosuje sie takie metody, jak: suszenie rozpyłowe, ekstruzję i koacerwację. Dla osiągnięcia jak najlepszej stabilności oksydatywnej LC PUFA istotny jest również odpowiedni dobór materiałów osłonkowych do mikrokapsułkowania. Zastosowanie substancji odpornych na trawienie w górnym odcinku przewodu pokarmowego stwarza nadzieje na kontrolowane dostarczanie kwasów omega-3 do jelita grubego.

EN

Modern food is intended not only to produce energy, but also to improve or maintain good health. Food enriched with long-chain omega-3 polyunsaturated fatty acids (LC PUFAs), particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) can be an example. These acids favorably affect cardiovascular and nervous systems. Unfortunately, their production in the body occurs at low efficiency. Therefore, the main source of LC PUFAs should be ingested food. Fish and other marine organisms are the richest source of these beneficial fatty acids. Unfortunately, in most countries with the so-called western type diet, including Poland, they are not consumed in sufficient quantity. Food supplements and food enriched with omega-3 fatty acids may be used to complete their deficiency. Manufacture of food with fish oil addition requires overcoming many technological difficulties, primarily associated with the occurrence of "fish" taste and smell, as well as the protection of polyunsaturated acids against oxidation. The addition of microencapsulated fish oil to food is a possible way to solve these problems. For the encapsulation of oil rich in omega-3 LC PUFAs such methods as spray-drying, extrusion and coacervation were used. To achieve the best oxidative stability of LC PUFAs, an appropriate choice of wall material is also crucial. The use of substances resistant to digestion in the upper part of gastrointestinal tract creates hope for the controlled delivery of omega-3 to the large intestine.

9

The effects of fish oil microcapsules on quality of potato dish

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Domiszewski Z. , Bienkiewicz G. , Tarnowiecka-Kuca A. , Zywicki S. , Tokarczyk G. , Krawczynska W. , Hrebien-Filisinska A. , Rogalewska M. , Synowiec E. , Laskowska A.

Electronic Journal of Polish Agricultural Universities. Series Food Science and Technology

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2013

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tom 16

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nr 2

10

The effects of docosahexaenoic acid on glial derived neurotrophic factor and neurturin in bilateral rat model of Parkinson's disease

58%

Tanriover G. , Seval-Celik Y. , Ozsoy O. , Akkoyunlu G. , Savcioglu F. , Hacioglu G. , Demir N. , Agar A.

Folia Histochemica et Cytobiologica

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2010

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tom 48

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nr 3

11

Seasonal proximate and fatty acid variations of some seaweeds from the Northeastern Mediterranean coast

58%

Polat S. , Ozogul Y.

Oceanologia

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2013

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tom 55

|

nr 2

12

Neuronal nitric oxide synthase phosphorylation induced by docosahexaenoic acid protects dopaminergic neurons in an experimental model of Parkinson’s disease

58%

Parlak H. , Ozkan A. , Dilmac S. , Tanriover G. , Ozsoy O. , Agar A.

Folia Histochemica et Cytobiologica

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2018

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tom 56

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nr 1

13

Mikrobiologiczne źródła DHA

58%

Gientka I. , Grela P. , Kot A. M. , Stasiak-Różańska L.

Przemysł Spożywczy

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2016

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tom T. 70, nr 11

25--27

PL

Głównymi źródłami kwasu dokozaheksaenowego (DHA) w diecie człowieka jest mięso ryb. W artykule omówiono możliwości otrzymywania kwasu dokozaheksaenowego z komórek drobnoustrojów. Zdolność do syntezy DHA wykazują wszystkie mikroorganizmy. Najlepszymi producentami DHA są mikroalgi i to one znajdują zastosowanie w przemysłowej produkcji olejów bogatych w DHA. Wśród nich można wymienić heterotroficzny protist Crypthecodinium cohnii oraz szczepy mikroalg Schizochytrium. Zastosowanie oleju z mikroalg dopuszczono m.in. do produktów mlekopodobnych, tłuszczów do smarowania oraz suplementów diety. Należy przypuszczać, iż asortyment produktów spożywczych wzbogaconych w kwas dokozaheksaenowy pochodzenia mikrobiologicznego będzie coraz większy.

EN

The main source of docosahexaenoic acid (DHA) in the human diet is fish meat. The article discusses the possibility of production of docosahexaenoic acid by the microbial cells. The ability to synthesize DHA is indicated by all microorganisms. Microalgae are the best producers of DHA. These include heterotrophic protist Crypthecodinium cohnii and the strains of microalgae Schizochytrium. They are employed in the industrial production of oils rich in DHA. The use of oil from microalgae was admitted to milk-like products, spreadable fats and food supplements. It should be expected that the assortment of food products enriched with microbial docosahexaenoic acid will be increasing.

14

Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease

58%

Hacioglu G. , Seval-Celik Y. , Tanriover G. , Ozsoy O. , Saka-Topcuoglu E. , Balkan S. , Agar A.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 2

15

Sklad kwasow tluszczowych mleka kobiecego

51%

Karwowska W. , Duda G. , Obiedzinski M. , Kroc M.

Bromatologia i Chemia Toksykologiczna

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2005

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tom 38

|

nr Supl.

105-109

EN

The dietary components used by 102 breast-feeding women included in the study were reflected in the content of fatty acids in their breast-milk. Fatty acid profile in the milk was changing during lactation. Higher correlation ratios were found between the proportion of fatty acids in the analysed samples of human colostrum and the supply of fatty acids in the diet of women during pregnancy, when compared to mature milk. An inhibitory effect of trans fatty acids upon the synthesis of long-chain unsaturated fatty acids from their precursors, the linoleic acid and alpha-linoleic acid was observed.

16

Stopien oddzialywania produktow utleniania tluszczu na zmiany ilosciowe dostepnej lizyny i metioniny w ukladach modelowych o zroznicowanym odczynie srodowiska

36%

Hes M. , Korczak J. , Gorecka D. , Gramza A. , Jedrusek-Golinska A.

Bromatologia i Chemia Toksykologiczna

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2005

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tom 38

|

nr Supl.

455-460

PL

W pracy określano podatność aminokwasów występujących w postaci jonu obojnaczego i postaci kationu na reakcje z produktami utleniania tłuszczu. Prowadzono badania modelowe w emulsjach estrów metylowych kwasów tłuszczowych: dokozaheksaenowego, linolowego, oleinowego i stearynowego.

EN

For understanding factors which can determined quantitative changes of lysine and methionine, the model studies in emulsions methyl esters of acid fatty (docosahcxaenoic, linoleic, oleic and stearic) were led. Both amino acids were estimated in isoelectric point and at pH lower than isoelectric point. In emulsified systems the lipid oxidation products significant influenced the available lysine and methionine content. TBARS were characterized as more reactive with amino acids than hydroperoxides. The highest decrease of amino acids contents in emulsions of methyl esters of docosahcxaenoic acid were found. The losses of amino acids in others emulsions were lower when less unsaturated of fatty acid was. Influence of lipid oxidation products on available lysine and methionine content was dependent on pH. The highest losses of amino acids in emulsions of methyl docosahexaenoate in pH equal isoelectric point and in emulsions of methyl stearate in pH low than isoelectric point was observed.