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Characterization of biomaterials with reference to biocompatibility dedicated for patient-specific finger implants

Byrski Adam, Kopernik Magdalena, Major Lukasz, Kasperkiewicz Katarzyna, Dyner Marcin, Lackner Juergen M., Lumenta David B., Major Roman

Acta of Bioengineering and Biomechanics

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2023

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Vol. 25, no. 1

3--17

EN

The research was focused on determining basic mechanical properties, surface, and phase structure taking into consideration basic cytotoxicity analysis towards human cells. Methods: Biological tests were performed on human C-12302 fibroblasts cells using 3D-printed Ti6Al4V alloy (Ti64), produced by laser-based powder bed fusion (LB-PBF) and Alumina Toughened Zirconia 20 (ATZ20), produced by lithography-based ceramic manufacturing (LCM). Surface modifications included electropolishing and hydroxyapatite or hydroxyapatite/zinc coating. Structure analysis was carried out using a variety of techniques such as X-Ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM), followed by mechanical properties evaluation using nanoindentation testing. Results: Samples subjected to surface modifications showed diversity among surface and phase structure and mechanical properties. However, the cytotoxicity towards tested cells was not significantly higher than the control. Though, a trend was noted among the materials analysed, indicating that HAp/Zn coating on Ti64 and ATZ20 resulted in the best biological performance increasing cell survivability by more than 10%. Conclusions: Hydroxyapatite coating on Ti64 and ATZ20 resulted in the best biological properties. Tested materials are suitable for in vivo toxicity testing.

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Microstructure and antibacterial properties of a ZnO coating on a biomaterial surface

Basiaga Marcin, Paszenda Zbigniew, Lisoń Julia, Taratuta Anna, Kazek-Kęsik Alicja, Krok-Borkowicz Małgorzata, Nuckowski Paweł, Szindler Magdalena, Staszuk Marcin, Major Łukasz, Major Roman, Barabaszová Karla Čech, Dyner Marcin

Archives of Civil and Mechanical Engineering

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2022

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Vol. 22, no. 2

art. no. e93, 1--18

EN

A promising strategy for fighting the bacterial biofilm on the surface of biomaterials involves modification of their surface with the use of bactericidal and bacteriostatic coatings. Ongoing studies concentrate on the development of material that can limit bacterial colonisation and is safe for the human organism. Therefore, the current research focuses on the conditions related to implant coating to limit biofilm formation. However, previous outcomes in this area have not been satisfactory. Accordingly, the main goal of the carried out tests was to study the impact of the physicochemical properties of the surface layers on the course of processes taking place on the surface of implants made of metallic biomaterials used in the bone system. The surface of the analysed biomaterial -316LVM steel - was modified using such processes as grinding, electrochemical polishing, sandblasting, application of a ZnO layer using low-temperature Atomic Layer Deposition (ALD), and medical sterilisation. Initial assessments involved the chemical composition, phase composition, and the microstructure of the surface layer. The last stage involved microbiological studies, including an assessment of the adhesion of Gram-positive and Gram-negative bacteria to the modified surface, proliferation of MG-63 osteoblast-like cells and cytotoxicity tests. The analysis of adhesion of S. aureus and E. coli colonies confirmed that the ZnO coating is effective in reducing bacterial adhesion to the 316LVM steel substrate, regardless of the number of cycles, process temperature and surface treatment method.

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A study on the physicochemical properties of surface modified Ti13Nb13Zr alloy for skeletal implants

Lisoń Julia, Taratuta Anna, Paszenda Zbigniew, Dyner Marcin, Basiaga Marcin

Acta of Bioengineering and Biomechanics

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2022

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Vol. 24, no. 1

39--47

EN

As it is widely stated in the literature, biofilms are responsible for most chronic infections, which have grown exponentially over the past three decades. The use of so-called alloys, as a new generation of materials, enables us to find the golden mean in the arena widely known as implantology. The use of the surface layer, using the chosen Atomic Layer Deposition method, is to be the basis for minimizing the risk of an organism reactions. Therefore, the primary objective of this study was to observe the impact of physicochemical properties of the surface layers (bactericidal) on the processes that occur on the implants surface made of titanium biomaterials used in bone structures. The study also attempted to evaluate the physicochemical properties of the ZnO coatings, deposited on the substrate of one of the new generation Ti13Nb13Zr alloys, using the ALD method. Included in the assessment of the physicochemical properties of the surface layers formed in this manner, we perform pitting corrosion resistance tests, scratch tests, tribological tests and surface wettability tests. Based on the obtained data, the differing physicochemical properties of the alloy with ZnO coatings are found to be dependent on the applied surface modification. For the conducted tests, differences are determined for the tests on the corrosion resistance, surface wettability and the abrasion resistance for samples with and without the ZnO coating. In addition, tests show that the coating applied to the alloy, which is previously subjected to the sand-blasted process, is characterized by improved adhesion.

4

New design of patient-specific, antimicrobial bioactive finger implants for durable functional reconstruction after amputation

Dyner Marcin, Byrski Adam, Major Roman, Gawlikowski Maciej, Kasperkiewicz Katarzyna, Lackner Juergen M., Dyner Aneta, Major Bogusław

Engineering of Biomaterials

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2021

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Vol. 24, no. 161

8--14

EN

The absence of even a single finger results in a major impairment in the hand function (precise grasping, grip power), therefore significantly affecting the social and professional life of victims who are frequently young people. Finger amputation is a surgical treatment for ~69.000 patients in the EU after traumatic injury, in which replantation microsurgery fails due to the severity of tissue damage. The surgical reconstruction is currently possible only via autograft transplantation, e.g. a toe-to-hand transfer, thus leading to foot impairment. Some motion functional restoration is also possible using a bone-anchored silicone prosthesis but without the sense revalidation. Our current research focuses on alternatives for surgical reconstruction by means of novel patient- -specific, durable, biomimetic, bioactive and antibacterial implants for reconstructing lost bone and joints. The implant design – and the improved micro(neuro) surgery (beyond the project) – will consist in the fast successful rehabilitation, including the soft-tissue related mobility, the implantation of state-of-the-art nerve conduits as well as the aesthetic appearance. Key issues for the long-term functionality of the biomaterial-based reconstruction of hard tissue are based on surgical demands, such as: (1) perfect integration of a bone-substituting metal with the surrounding bone tissue (a) with no signs of loosening due to stress shielding at the interface and (b) enhanced with protective activity against bacterial inflammation (antimicrobial properties and formation of vascularized bone tissue (ossification)) even months to years after the injury; (2) biomimetic finger joints based on non-wearing materials without ossification meant to prevent the loss of the motion function.

5

Sheet metal forming using environmentally benign lubricant

Więckowski Wojciech, Adamus Janina, Dyner Marcin

Archives of Civil and Mechanical Engineering

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2020

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Vol. 20, no. 2

307--319

EN

Sheet metal forming belongs to one of the most important technologies enabling the production durable but quite lightweight metal parts. The quality of the drawn parts depends on the deformed sheet metal, applied forming technology and process parameters, such as contact pressure, relative velocity, temperature or lubrication. The forming of steel (1.4021) parts using benign lubricant is analysed. The paper proposes replacing conventional mineral/synthetic lubricants with ones based on vegetable oils and boric acid. The effectiveness of the lubricants was assessed in laboratory strip drawing and cupping tests, and in production. An oil-based lubricant with an additive of boric acid is very effective in reducing frictional resistance and protecting the forming tools against galling.

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Numerical simulation of forming titanium thin-wall panels with stiffeners

Adamus Janina, Winowiecka Julita, Dyner Marcin, Lacki Piotr

Advances in Science and Technology. Research Journal

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2018

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Vol. 12, no 1

54--62

EN

Due to the increase in the application of titanium components made of thin titanium sheets, in the work titanium panels made of 4 mm thick sheets are analysed. To increase the rigidity of the panels, some cross-shaped stiffeners were made. Such panels enable a reduction in weight while maintaining the existing strength of the drawn parts. Three kinds of commercially pure titanium are considered: Grade 1, 2 and 3. Numerical calculations were performed with PamStamp 2G based on the finite element method. The basic mechanical and technological properties of the analysed sheets, which are necessary for numerical modelling, were determined by static tensile testing. The friction coefficient was assumed based on the literature. On the basis of the performed numerical analyses, it was stated that the proper forming of panels with stiffeners depends not only on the drawability of the sheets but also on the technological parameters such as blank holder force and frictional conditions.