Wyniki wyszukiwania - Biblioteka Nauki

1

Influence of the zearalenone on the activity of chosen liver enzymes in a rat

100%

Stadnik A. , Borzecki A.

Annals of Agricultural and Environmental Medicine

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2009

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tom 16

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nr 1

31-35

2

Effect of 28-day exposure to fenpropathrin on the activities of serum alanine transaminase and liver antioxidant enzymes in mice

100%

Nieradko-Iwanicka B. , Borzecki A.

Bulletin of the Veterinary Institute in Puławy

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2015

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tom 59

|

nr 1

EN

Fenpropathrin (FEN) was administered intraperitoneally in doses of 2.38 mg/kg, 5.9 5mg/kg, or 11.9 mg/kg b.w. to mice for 28 consecutive days. FEN did not significantly affect the activity of alanine transaminase (ALT) in the sera. Superoxide dismutase and glutathione peroxidase activities were significantly elevated in the liver after a 28-d exposure to moderate or highest doses of the pesticide. These results demonstrate that the 28-day exposure to FEN leads to an up-regulation of expression of antioxidant enzymes in response to an oxidative stress in mouse liver without causing a significant increase in ALT activity.

3

How deltamethrin produces oxidative stress in liver and kidney

100%

Nieradko-Iwanicka B. , Borzecki A.

Polish Journal of Environmental Studies

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2016

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tom 25

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nr 3

EN

Deltamethrin (DEL) is a synthetic pyrethroid widely used as an insecticide. The aim of our study was to determine the effect of a single exposure of female albino Swiss mice to DEL (at doses of 8.3 mg/kg, 20.75 mg/kg, or 41.5 mg/kg) on parameters of liver and kidney function and activities of antioxidant enzymes in these organs. The activity of alanine transaminase (ALT) in the blood sera of the experimental animals was not significantly elevated after exposure to DEL. Asparagine transaminase (AST) activity was signifi cantly higher in the groups exposed to the moderate and the highest dose of DEL. The levels of creatinine in the blood sera of the experimental animals did not significantly differ among the groups. The activities of superoxide dismuthase (SOD) and glutathione peroxidase (GPx) were significantly reduced in the livers of mice exposed to the highest dose of DEL in comparison with controls. In the kidneys, however, the SOD and GPx activities were significantly elevated after exposure to the highest dose of DEL. In conclusion, DEL produces oxidative stress in the livers and, to a lesser degree, the kidneys of exposed animals.

4

Effect of lambda-cyhalothrin on memory and movement in mice after transient incomplete cerebral Ischemia

100%

Nieradko- Iwanicka B. , Borzecki A.

Annals of Agricultural and Environmental Medicine

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2011

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tom 18

|

nr 1

5

Effect of bifenthrin on memory processes, movement activity, and coordination in mice exposed to transient cerebral oligaemia

100%

Nieradko-Iwanicka B. , Borzecki A.

Bulletin of the Veterinary Institute in Puławy

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2008

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tom 52

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nr 2

EN

The purpose of the present study was to examine whether the effects of exposure to 0.1LD₅₀ of bifenthrin on memory processes, movement activity, and coordination could be exacerbated by transient reduction of cerebral oxygen supply. The transient occlusion of both common carotid arteries (BCCA) in adult mice was performed under anaesthesia. Intraperitoneal LD₅₀ for bifethrin was estimated to be 16.1mg/kg b.w. The memory retention was evaluated in a step-through passive avoidance task (PA), working spatial memory in a Y-maze, movement coordination on a rota-rod, and movement activity in an automated device. Long-term memory impairment caused by bifenthrin was exacerbated by BCCA. Movement co-ordination was significantly altered in animals treated with the compound. Movement activity was slightly decreased in animals after BCCA and pesticide injection. These results indicate that cerebral oligaemic hypoxia potentiates long-term memory impairing effect of bifenthrin.

6

Influence of subtoxic doses of fenitrothion on memory processes, movement activity, and movement coordination in mice exposed to transient oligaemic brain hypoxia

100%

Nieradko-Iwanicka B. , Borzecki A.

Bulletin of the Veterinary Institute in Puławy

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2008

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tom 52

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nr 2

EN

The aim of the study was to find out if subtoxic doses of fenitrothion (0.1 LD₅₀, LD₅₀ =166.6 mg/kg) administered to mice exposed to transient oligaemic brain hypoxia induced by bilateral clamping of the carotid arteries (BCCA) influence memory processes, movement activity, and coordination. The BCCA was carried out under ketamine + xylazine anaesthesia. Common carotid arteries were clamped for 30 min. Twenty-four hours later; the animals were injected intraperitoneally with 0.1 LD₅₀ of fenitrothion. Controls and sham-operated animals (with carotids separated but not clamped) were injected with respective volumes of bidistilled water. All the animals were trained in passive avoidance (PA) task. The examination of memory retention in PA was done 24 h later followed by testing of fresh spatial memory in a Y- maze, movement co-ordination, and spontaneous movement activity in a 30-min period. Fenitrothion did not significantly alter memory processes in the examined mice. However, the movement coordination was significantly impaired in animals that underwent BCCA alone as well as being oligaemic and under the influence of fenitrothion vs control groups. The same groups demonstrated significantly impaired spontaneous movement activity vs controls.

7

The influence of poisoning with patulin on activity of acid phosphatase, cathepsin B and D in mice kidneys and livers

80%

Borzecki A. , Nieradko-Iwanicka B. , Mikocka J.

Journal of Pre-Clinical and Clinical Research

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2020

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tom 14

|

nr 3

8

Prolonged exposure to transdermal nicotine improves memory in male mice, but impairs biochemical parameters in male and female mice

80%

Nieradko-Iwanicka B. , Pietraszek D. , Posnik K. , Borzecki A.

Annals of Agricultural and Environmental Medicine

|

2019

|

tom 26

|

nr 1

9

Zawartość jonu fluorkowego w tkankach myszy otrzymujących w pożywieniu NaF o różnym stężeniu

80%

Boguszewska A. , Sztanke M. , Pasternak K. , Borzecki A.

Journal of Elementology

|

2004

|

tom 09

|

nr 3

10

Loss of heterozygosity for Rb locus and pRb immunostaining in laryngeal cancer: a clinicopathologic, molecular and immunohistochemical study

80%

Pietruszewska W. , Klatka J. , Borzecki A. , Rieske P.

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tom 46

|

nr 4

479-485

11

Magnesium and calcium concentrations in tissues of mice receiving manganese in food

80%

Boguszewska A. , Pasternak K. , Sztanke M. , Borzecki A.

Polish Journal of Environmental Studies

|

2004

|

tom 13

|

nr Suppl.2, Part 1

EN

Manganese is very important trace element whose mechanism of actions involves activity regulation of enzymes taking part in key metabolic processes in organisms. It is a structural element of skin and bones, it also prevents osteoporosis. Its very important role in reproduction processes and in central nervous system has been already stated. The magnesium ion is of great importance in physiology by its intervention in 300 enzymatic systems, its membrane role and its function in neuromuscular excitability. The first pool of magnesium in organism is skeleton. The principal site of magnesium excretion are kidneys, which show important magnesium regulation mechanisms. For intestinal absorption, renal metabolism, bone accretion and resorption, magnesium shows analogies with calcium. Calcium is important macroelement in enzyme activation and inhibition, muscle and nerve function, and intracellular metabolism of all organisms. It is the main component of bones, where it is stored in organism. The aim of our work was to estimate influence of manganese chloride administration on concentrations of magnesium and calcium in mice tissues. Significant changes in magnesium and calcium content in dependence on the doses of administered manganese as well as the duration of the exposure have been stated in our experiment.

12

Wpływ ochratoksyny a na stężenie magnezu w wybranych tkankach szczurzyc i ich potomstwa

80%

Pasternak K. , Bober E. , Borzecki A. , Ogrodnik W.

|

nr 4

623-628

PL

Celem pracy było określenie wpływu ochratoksyny A (OTA) na stężenie magnezu w tkankach szczurzyc i ich potomstwa. Ciężarnym szczurzycom podawano OTA w stężeniu 2,5 ug kg-1 oraz 25 ug • kg-1. Po urodzeniu młodych od szczurzyc i ich potomstwa pobierano wątrobę, nerki i mózg, a następnie w tych tkankach oznaczano stężenie magnezu. Wykazano, że podawanie OTA wpływa na obniżenie stężenia magnezu zarówno w tkankach szczurzyc, jak i ich potomstwa, a wielkość zmian stężenia magnezu zależy od stosowanego stężenia OTA, jak również od rodzaju badanej tkanki. Obniżenie stężenia magnezu było znaczniejsze w tkankach szczurzyc aniżeli w tkankach ich potomstwa.

EN

The aim of the work was to study the effect of ochratoxine A (OTA) treatment on magnesium concentration in tissues of female rats and their progeny. Pregnant female rats received OTA in concentrations of 2,5 ug kg-1 and 25 ug kg-1. After delivery, liver, kidney and brain samples were taken from female rats and their progeny for determination of magnesium concentrations. 1 OTA decreased magnesium concentrations in the tissues of female rats and their progeny. Changes in magnesium concentrations were dependent on the concentration of OTA and the type of tissue. Decrease in magnesium concentrations was larger in tissues of female rats than in tissues of their progeny.

13

Stężenie magnezu i wapnia w tkankach myszy otrzymujących fluor

80%

Boguszewska A. , Pasternak K. , Sztanke M. , Borzecki A.

Journal of Elementology

|

2004

|

tom 09

|

nr 3

14

Wplyw magnezu na aktywnosc enzymow przeciwytleniajacych w tkankach szczurow intoksykowanych ochratoksyna A

80%

Szpetnar M. , Pasternak K. , Kielczykowska M. , Borzecki A.

Bromatologia i Chemia Toksykologiczna

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2001

|

tom 34

|

nr 1

13-16

PL

Przeprowadzono badania wpływu magnezu na aktywność enzymów przeciwutleniających: dysmutazy ponadtlenkowej [EC 1.15.1.1], peroksydazy glutationowej [EC 1.11.1.9] i katalazy [EC 1.11.1.6] w mózgu, wątrobie i nerkach szczurów poddanych intoksykacji ochratoksyną А (ОТА). Podawanie przez 14 dni ochratoksyny A powodowało obniżenie aktywności badanych enzymów we wszystkich badanych tkankach w stosunku do grupy kontrolnej. Suplementacja magnezowa częściowo niwelowała negatywny wpływ trucizny.

EN

The effect of magnesium on the activity of antioxidant enzymes: superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) in brain, liver and kidneys of rats exposed to ochratoxin A (OTA) was investigated. Young male and female Wistar rats were used in the experiment. The animals (males and females separately) were divided into three groups: I (control) receiving pure drinking water, II group receiving intragastrically a daily dose of 1 mg/kg b.w. OTA; and III group receiving intragastrically a daily dose of 1 mg/kg b.w. OTA and, after ca. 20 minutes, 5 mg/kg b.w. magnesium in the form of magnesium chloride. After 14 days, the animals were killed by decapitation and their liver, kidneys and brain were collected for analysis. The collected tissues were homogenised in 0.1 M Tris-HCl buffer at pH 7.4. The resultant supematants were tested for SOD, GPx and CAT activities. Protein was determined according to Bradford. The OTA exposure caused a reduction in the activity of the studied enzymes in all studied organs vs. control. Our results show that OTA intoxication reduces the efficiency of the mechanisms which protect the cell from the toxic activity of free oxygen radicals. The lower activity of GPx, an important enzyme inactivating the lipid radicals, may cause irreversible damage in the organs. The magnesium supplementation prevented, to some extent, the detrimental effect of the toxin.

15

Influence of zearalenone on free radical reactions in rat liver cells

80%

Stadnik A. , Wojtowicz-Chomicz K. , Borzecki A.

|

2010

|

tom 54

|

nr 4

EN

The aim of the study was to examine the toxic effect of different doses of zearalenone on liver cells by estimating mycotoxin influence on antioxidant systems and on formation of free radicals in the liver. The research was carried out on male Wistar rats. The rats were divided into nine groups of 10 animals each. Group A was orally given 8% ethyl alcohol once a day for 10 d. Groups B, C, D, and E were given, orally once a day 50, 100, 200, and 500 µg/kg b.w. of zearalenone in alcohol solution for 10 days. The animals from groups X, Y. and Z received a single dose of 1, 2, and 3 mg/kg b.w of zearalenone, respectively, and group W (control) - a single dose of 8% ethyl alcohol. The liver was removed and homogenised. Glutathione peroxidase and superoxide dismutase activities, and concentration of L-ascorbic acid in the homogenate were determined. Received outcome and statistical analysis showed the essential fall of superoxide dismutase activity after 10 d of administering 200 and 500 µg/kg b.w of ZEA in comparison with the control group, and drop of glutathione peroxidase activity after 500 µg/kg b.w. dose. The results of the experiment showed that oxidative stress is one of the main toxic effects of zearalenone activity. Low doses of zearalenone applied for a long time do not have an influence on free radical reaction. Short-lasting zearalenone influence does not cause changes in the activity of antioxidant enzymes.

16

Benefits and dangers of hormone replacement therapy in the opinion of a female patient

80%

Barnas E. , Janowska J. , Borzecki A.

Polish Journal of Environmental Studies

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2004

|

tom 13

|

nr Suppl.2, Part 1

EN

The aim of this research was to determine to what degree women in the climacterium period know the benefits and dangers resulting from hormone replacement therapy (HRT). The most common benefits, resulting from HRT, are doing away with the fits of heat (34.2%), prevention of osteoporosis (33.3%), emotional stability (29.2%) and prolongation of the lifespan and general fitness (15.5%). Most of the women that used HRT are well-informed about the mechanism of the medicimes efficacy, they are also aware of short-term benefits resulting from the therapy. The most common fear that women using substitution hormonotherapy have is the fear of neoplasmatic disease.

17

The influence of manganese on silicon concentrations in mice tissues

80%

Boguszewska A. , Pasternak K. , Sztanke M. , Borzecki A.

Polish Journal of Environmental Studies

|

2004

|

tom 13

|

nr Suppl.2, Part 1

EN

Trace elements are important in appropriate organisms functioning. Among them manganese as well as silicon play essential roles. Manganese takes parts in composition of many enzymes, it is a cofactor of numerous enzymatic reactions, a structural element of skin and bones, it also prevents osteoporosis. Its very important role in reproduction processes and in central nervous system has been already stated. Silicon is a very important factor, which takes active part in vital processes, regenerating tissues and increasing general immunity of organism. It has basic meaning in metabolism of connective tissue, collagen formation and bone development and mineralization, cartilages, hair, nails, teeth in human and animals, and also in processes of convalescence and ageing of organism. The aim of our experiment was to estimate influence of manganese chloride on the concentration of silicone in mice tissues. It has been find out that doses of administered manganese as well as the duration of exposure have influence on silicon content in tissues.

18

Wpływ fluoru na stężenie krzemu w tkankach myszy

80%

Boguszewska A. , Pasternak K. , Sztanke M. , Borzecki A.

Journal of Elementology

|

2004

|

tom 09

|

nr 3

19

Wpływ podawania fluoru na stężenie kwasu askorbinowego w tkankach myszy

80%

Pasternak K. , Sztanke M. , Borzecki A.

Journal of Elementology

|

2004

|

tom 09

|

nr 4

20

Concentration of some amino acids in blood plasma and study results of lumbosacral bone system computer tomography

80%

Wojcik G. , Sokolowska B. , Borzecki A.

Health Problems of Civilization

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2015

|

tom 09

|

nr 3

EN

Introduction and objective: Back pain are the most common ailment within the human locomotor system. Because of their prevalence, they were classified as diseases of civilization. The aim of the study was to attempt to assess the concentration of selected amino acids in plasma and correlating the results of laboratory tests with the occurrence of backaches. Material and method: The study group included 188 patients presenting for CT scan administering as the cause of their symptoms low back pains. All of these patients gave the blood samples from which the concentration of free amino acids was estimated by ion exchange chromatography using an automated amino acid analyzer AAA 400 from INGOS Praha. The control group consisted of patients who underwent testing using computed tomography and there were no primary or secondary changes associated with degeneration in the lumbar spine. Results: Patients on the basis of research carried out by computed tomography were divided into five groups according to disease entity. Analyzing the average concentration of essential amino acids in the blood plasma of patients of each group, it was found that it is higher in the case of lysine for each considered disease entity. The average concentration of methionine in all disease entities does not deviate from the average values in the control group. Analysis of the average concentration of selected essential amino acids revealed that in the case presented disorders underwent their level of variation. Average concentrations of selected amino acids have proven to be very similar in both groups. Slightly higher values proved to be in the control group for proline and lysine. Conclusions: The concentration of amino acids varies with the severity of degenerative changes in the connections as well as in interbody joints. The highest increase in the concentrations of all tested amino acids are present in root bands. Decrease in the concentrations of all tested amino acids appears in cancer.