Wyniki wyszukiwania - Biblioteka Nauki

1

Nowe uzależnienia XXI wieku

100%

Filip M.

Wszechświat

|

2013

|

tom 114

|

nr 04-06

2

Psychologie osobních konstruktů po padesáti letech: Proč je teorie George Alexandra Kellyho dodnes inspirující?

100%

Filip M.

Československá psychologie (Czechoslovak Psychology)

|

2007

|

tom 51

|

nr 1

1-11

EN

The article remembers 50 years of G.A. Kelly's Personal Construct Psychology (PCP). It uses K. Lewins's distinction between 'Aristotelian' and 'Galileian' modes of thought by a presentation of the PCP. It discusses basic axioms and principles of the PCP (the fundamental postulate and the dichotomy corollary) and presents this theory as an example of the purely Galileian approach which is able to define various concepts used in particular classificatory Aristotelian areas (e.g. mental representation, unconsciousness) and to integrate different methodological approaches (e.g. psychometrical and hermeneutical) with the help of simple formal principles. The study discusses also problems of research in the field of the PCP.

3

Autobusy CNG w Rzeszowie

100%

Filip M.

Autobusy : technika, eksploatacja, systemy transportowe

|

2005

|

tom R. 6, nr 5

22-27

PL

W lutym 2005 roku minął pierwszy rok eksploatacji autobusów zasilanych sprężonym gazem ziemnym w MPK Rzeszów. Autobusy zasilane sprężonym gazem ziemnym (CNG) na dobre zadomowiły się w stolicy Podkarpacia. W artykule autor przedstawia doświadczenia i wnioski dotyczące eksploatacji autobusów gazowych.

4

Ścieżki restrukturyzacji i prywatyzacji Sektora Wielkiej Syntezy Chemicznej

75%

Filip M.

Chemik

|

2005

|

tom Vol.58, nr 11-12

566-569

5

Analiza i porównanie dokładności wybranych przyrostowych metod wytwarzania

63%

Dziubek T. , Filip M.

Mechanik

|

2015

|

tom R. 88, nr 12CD2

54--61

PL

Artykuł przedstawia problematykę związaną z dokładnością wybranych przyrostowych technik wytwarzania. Celem zdefiniowania dokładności wytwarzanej geometrii dla metod FDM, MEM oraz PolyJet wykonano wzorcowy model badawczy złożony z różnych cech geometrycznych. Na jego podstawie przeprowadzono pomiary optyczne, które umożliwiły określenie błędów geometrii i opracowanie analizy porównawczej dla analizowanych metod szybkiego prototypowania.

EN

The article presents the problems connected with the accuracy of selected incremental manufacturing techniques. To define the accuracy of generated geometry for FDM, PolyJet MEM and made reference research model consisting of various geometric features. On the basis of optical measurements were carried out, which enabled determination of fault geometry and a comparative analysis of the analyzed methods for Rapid Prototyping.

6

Therapeutic potential of 5-HT2C receptor ligands towards cocaine addiction

63%

Filip M. , Zaniewska M.

Acta Neurobiologiae Experimentalis

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2011

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tom 71

|

nr S

EN

Serotonin (5-HT) neurotransmission controls the brain physiology and contributes to the etiology of many neuropsychiatric disorders. One of the key modulators of 5-HT system is the 5-HT2C receptor which regulates feeding, satiety, mood and cognition as well as underlines the mechanisms of depression, schizophrenia and addiction (Filip and Bader 2009). Among abused drugs, cocaine addiction creates serious health and legal implications in developed world while no medication is approved for the treatment of cocaine addiction. Detailed preclinical pharmacological analyses with several selective 5-HT2C receptor ligands have provided consistent proofs that these receptors contribute to cocaine acute and repeated behaviors. In general, systemic pretreatment of 5-HT2C receptor agonists attenuates, while antagonists enhance cocaine-induced psychomotor activation, reward and reinforcement as well as subjective (discriminative stimulus) effects in laboratory animals (Filip et al. 2010). 5-HT2C receptors are also important neural mediators in the circuitry underlying cocaine-seeking and -taking behaviors since their stimulation attenuated conditioned hyperactivity to cocaine and the priming effect of acute cocaine, cue- or stresscontrolled cocaine-seeking. More importantly, the inhibitory action of 5-HT2C receptor agonists on the reinstatement of cocaine seeking, when extrapolated to abstinent human addicts, suggest therapeutic potential for these drugs as pro-abstinence and anti-relapse ones. The main shortcoming of 5-HT2C receptor agonists for cocaine addiction may be their inhibitory effects in motivated behaviors (including food consumption) as found in preclinical research (Neisewander and Acosta 2007) and recent clinical trials (Smith et al. 2009). This study was supported by the statutory activity of the Institute of Pharmacology Polish Academy of Sciences (Krakow)

7

Impact of serotonin (5-HT) receptor stimulation on the locomotor and discriminative effect of amphetamine and cocaine in rats

63%

Filip M. , Przegalinski E.

Acta Neurobiologiae Experimentalis

|

1997

|

tom 57

|

nr 5

8

An impact of enhanced endocannabinoid/endovanilloid neurotransmission on the behavioral effects of cocaine in rats

51%

Filip M. , Adamczyk P. , Bystrowska B. , Przegalinski E.

Acta Neurobiologiae Experimentalis

|

2011

|

tom 71

|

nr S

EN

The endocannabinoid system consists of cannabinoid (CB) receptors CB1 and CB2, several endogenous ligands (e.g., anandamide and 2-arachidonoylglycerol ; 2-AG), and many membrane-bound metabolizing enzymes. Endocannabinoids and mainly CB1 receptors are important for regulation of goal-maintained behaviors as well as for different pathologies affecting these processes. CB1 receptors modulate function on dopamine transmission through indirect mechanisms involving GABA or glutamate neurons while anandamide and certain eicosanoid-derived cannabinoids may also directly activate transient receptor potential vanilloid-1 (TRPV1) channels found in some dopaminergic pathways, thus allowing a direct regulation of dopamine function. Recent, preclinical reports indicate, that drugs affected endocannabinoid/endovanilloid system may play key role in drug addiction, especially in reinstatement of cocaine seeking behavior (Filip et al. 2006). Latest results coming from our laboratories indicate a role for CB1, CB2 or TRPV1 receptors to control food self-administration but not cocaine rewarding actions. We also report inhibitory effects of CB1, CB2 or TRPV1 receptor antagonists on drug-primed cocaine-seeking behavior. Only CB1 receptor antagonism attenuated cue-induced reinstatement of cocaine seeking. Ex vivo autoradiography (CB1 receptor binding measurements) and the LC/MS system (endocannabinoid/endovanilloid levels) revealed that chronic cocaine (either active or passive administration) evokes upregulation of rat brain CB1 receptors lasting until 10 days of cocaine withdrawal while self-administered cocaine (but not given passively in a “yoked” procedure) modulates the brain levels of anandamide and 2-AG. This study was supported by the grants by the Ministry of Science and Higher Education (Poland) to P.A. and B.B., as well as by the statutory activity of the Institute of Pharmacology Polish Academy.

9

Optimization of determination of reduced and oxidized glutathione in rat striatum by HPLC method with fluorescence detection and pre-column derivatization

51%

Gawlik M. , Krzyżanowska W. , Gawlik M. B. , Filip M.

Acta Chromatographica

|

2014

|

tom Vol. 26, no. 2

335--345

EN

A high-performance liquid chromatography (HPLC) method was used to assess the concentration of reduced and oxidized glutathione (GSH and GSSG) in rat striatum. Following decapitation, striatum was isolated from the male Wistar rat brain and immediately homogenized with double distilled water. GSH level was determined after pre-column derivatization with o-phthalaldehyde (OPA). The optimal incubation time with OPA was tested. The concentration of GSSG was determined after blockage the thiol groups of GSH by N-ethylmaleimide (NEM). The useful time for incubation with NEM was optimized. Next, disulfide bounds of GSSG were reduced by dithiothreitol (DTT), and released GSH is derivatized with OPA. The total glutathione, tGSH (sum of free and bound GSH, GSSG, and other low-molecular-mass aminothiols), was determined after reduction with DTT and then derivatization with OPA. The level of GSSG was calculated of the difference in concentrations of tGSH and GSH, but we showed that the calculated concentration of GSSG was within the range of standard deviation of the mean concentration of tGSH or GSH. Finally, the concentration of GSH was determined after 5-min incubation with OPA and the concentration of GSSG after 30-s incubation with NEM and 5-min incubation with DTT and OPA. The relative standard deviation (RSD) values obtained for the assay of GSH and GSSG were lower than 10%. The values obtained for accuracy for GSH (50–500 nM) and GSSG (0.5–5 nM) were within limits regarded as acceptable for analysis of biological samples (percent of recovery: 95–105%). Mean absolute recovery of GSH and GSSG was ranged from 97.1% to 99%. Limit of detection for GSH was 2.7 nM, and limit of quantification was 8.2 nM. Limit of detection (LOD) for GSSG is twice the value for GSH. Described method allows to determine GSH and GSSG levels in isolated rat brain structures with high level of reliability.

10

Bi-directional interaction between nicotine and serotonin (5-HT)2C receptors - behavioural and molecular aspects

51%

Zaniewska M. , Filip M. , Bader M.

Acta Neurobiologiae Experimentalis

|

2011

|

tom 71

|

nr S

EN

Recent data point to a role of serotonin (5-HT) and its receptors, mainly 5-HT2C receptor subtype, in the effects of nicotine - the key addictive component in cigarettes. Our series of studies performed on rats showed that pharmacological blockade of 5-HT2C receptors augmented the locomotor responses to acute nicotine, while activation of these receptors diminished nicotine-induced hyperactivity, the expression of behavioural sensitisation and conditioned locomotor activity as well as depression-like behaviour evoked by nicotine withdrawal. Our more recent studies demonstrated that nicotine challenge to nicotine-sensitised rats decreased [3H]mesulergine binding to 5-HT2C receptors in the prefrontal cortex, while nicotine withdrawal reduced receptor labelling in the ventral dentate gyrus and thalamic nuclei. To identify the mechanism associated with changes in radioligand binding, we analysed the pattern of 5-HT2C receptor mRNA editing (a posttranscriptional modification that may result in functionally different receptor isoforms) following repeated nicotine administration. Interestingly, our preliminary deep sequencing data showed significant decreases in 5-HT2C receptor mRNA editing in the hippocampus of nicotine-withdrawn animals. Such an alteration in editing may affect the availability of binding sites for 5-HT2C receptor radioligand and could partially explain changes in radioligand binding noted in this brain region. Taken together, our data support the existence of bi-directional interaction between 5-HT2C receptors and nicotine. Clear effects of 5-HT2C receptor agonists to ameliorate symptoms associated with nicotine dependence have been shown. On the other hand, the ability of nicotine to affect 5-HT2C receptor binding and editing has also been reported. Present data show a new direction in the search for efficient anti-nicotinic drugs and the possibility of using 5-HT2C receptor agonists as adjuncts to smoking cessation therapy.

11

An endogenous neuroprotective compound-lMeTTQ-prevents the cocaine addiction in self-administration model in rat:neurochemical correlates

51%

Antkiewicz-Michaluk L. , Romanska R. , Filip M. , Michaluk J.

Acta Neurobiologiae Experimentalis

|

2005

|

tom 65

|

nr 3

12

The use of unbiased conditioned place preference procedure as the predictive analysis of vulnerability to psychostimulant addiction in rats

51%

Niedzielska E. , Pomierny-Chamiolo L. , Filip M.

Acta Neurobiologiae Experimentalis

|

2014

|

tom 74

|

nr 3

EN

As in humans, also in laboratory animals, addiction phenotype including drug craving and relapses, develops only in about 20% subjects following initial drug abuse. The aim of our study was to verify if the conditioned place preference (CPP) paradigm can serve as a model for determination of the variable vulnerability to drug addiction. We used male Wistar rats (250–300 g) housed under standard laboratory conditions. Animals were exposed to either vehicle (n=20) or to the psychostimulant cocaine (15 mg/kg, ip; n=64) during 10 days with CPP. As a result, 15 animals (i.e., 23.4% of all experimental animals) that performed unbiased version of CPP, spent more time in cocaine-paired chamber in test in comparison to pretest (P<0.0005 vs. control); those rats were classified as addiction vulnerable. In conclusion, our results suggest that unbiased conditioned place preference procedure can serve as an animal model for predictive analysis of vulnerability to psychostimulant addiction in rats. Moreover, it also gives the opportunity to study the phenotype of animals (so called addiction-resistant) which did not develop drugassociated environment-linked craving.

13

Effects of direct and indirect dopamine receptor agonists on the cannabinoid CB1 receptor agonist CP 55,940-induced discrimination

51%

Frankowska M. , Filip M. , Przegalinski E.

Acta Neurobiologiae Experimentalis

|

2005

|

tom 65

|

nr 3

14

Elektrodializa odwracalna. Nowoczesne metody uzdatniania w zawracaniu strumieni wodnych

51%

Filip M. , Jasik K. , Latomski K.

Energetyka Cieplna i Zawodowa

|

2018

|

tom Nr 5

45--46, 48, 51

PL

Aktualne potrzeby rynkowe kreują powstawanie nowych technologii uzdatniania wody. Technologia EDR to niskociśnieniowa technologia membranowa o zaawansowanej konstrukcji. Zapewnia wyższy poziom odzysku, przy mniejszym zapotrzebowaniu energetycznym, w stosunku do metod konwencjonalnych. Takie rozwiązanie wpisuje się w aktualne trendy zamykania obiegów wodno-ściekowych (MLD2, ZLD3).

15

The role of corticosterone in behavioral sensitization to cocaine in rats

51%

Filip M. , Siwanowicz J. , Nowak E. , Przegalinski E.

Acta Neurobiologiae Experimentalis

|

1999

|

tom 59

|

nr 3

16

Opracowanie i ocena współczynników korekcji podwyższających dokładność modeli badawczych wykonanych w postaci prymitywów geometrycznych dla addytywnej metody wytwarzania PolyJet

51%

Dziubek T. , Sobolewski B. , Filip M.

|

2016

|

tom R. 89, nr 12

1914--1915

PL

Artykuł przedstawia problematykę podwyższenia dokładności wytwarzania prototypów metodą PolyJet. W tym celu wykonano modele badawcze w postaci prymitywów geometrycznych oraz poddano je pomiarom kontrolnym. W kolejnym kroku przeprowadzono korekty geometrii, ponownie wytworzono modele i wykonano pomiary w celu weryfikacji poprawności przyję- tych założeń.

EN

The article presents the problem of increasing the accuracy of prototyping by PolyJet. To this aim a test models in the form of geometric primitives, and subjected to measurement control. In the next stage, carried out the correction of geometry, re-produced models and measurements in order to verify the correctness of the assumptions

17

Maternal high-fat diet during pregnancy and lactation provokes depressive-like behavior and influences the irisin/brain-derived neurotrophic factor axis and inflammatory factors in male and female offspring in rats

51%

Gawlinska K. , Gawlinski D. , Przegalinski E. , Filip M.

|

tom 70

|

nr 3

18

GABA(B) receptor ligands as a pharmacotherapy for cocaine addiction-preclinical studies

51%

Filip M. , Frankowska M. , Przegalinski E.

Acta Neurobiologiae Experimentalis

|

2007

|

tom 67

|

nr 3

19

Economic and environmental aspects of using CNG in urban public transport – based on the experience of MPK Rzeszów

51%

Orzechowska M. , Filip M. , Szurlej A.

Logistyka

|

2014

|

tom nr 4

4756--4763, CD6

EN

The papers discusses selected economic and environmental aspects of using compressed natural gas (CNG) as an alternative fuel in the urban public transport, on the basis of MPK Rzeszów experience (the company is a national leader in the use of CNG). The progress made in the use of CNG as a fuel was shown at EU and global levels (countries with largest numbers of NGV vehicles were pointed out). Then, the paper presents key conditions for the extended use of CNG in Poland, compared with selected EU countries, paying particular attention to the use of this fuel in the urban public transport.

PL

W artykule przedstawiono wybrane aspekty ekonomiczne i ekologiczne w zakresie wykorzystania sprężonego gazu ziemnego (CNG) jako paliwa alternatywnego w komunikacji miejskiej na przykładzie MPK Rzeszów (przedsiębiorstwo to jest krajowym liderem w zakresie wykorzystania tego paliwa). Przedstawiono postęp w stosowaniu CNG jako paliwa zarówno w skali Unii Europejskiej, jak i świata (pokazano państwa, które w których jest najwięcej pojazdów na CNG). Przybliżono główne uwarunkowania rozwoju wykorzystania CNG w Polsce na tle wybranych krajów UE, zwracając szczególną uwagę na zastosowanie tego paliwa w komunikacji miejskiej.

20

Maternal high fat diet provokes depressive-like behavior in offspring rats and vulnerability to cocaine addiction

51%

Gawlinski D. , Frankowska M. , Kluska K. , Filip M.

Acta Neurobiologiae Experimentalis

|

2017

|

tom 77

|

nr Suppl.1

EN

INTRODUCTION: The epidemiological and animal studies underline that composition of maternal diet (e.g., high fat diet, HFD) is associated with an increased susceptibility to several health problems in the adult offspring, including risk of a cluster of behavioral disorders such as depression. AIM(S): The aim of this study was to investigate the effect of maternal HFD on the offspring phenotype assessed in locomotor activity study, forced swim test (FST) and cocaine self-administration. METHOD(S): Wistar rat dams were maintained ad libitum either on a special HFD (35% crude fat) or standard rodent chow during gestation and lactation (21 days). At postnatal day (PND) 27, the male and female litters were separated from their mother and were switched to a standard diet. Locomotor activity was recorded for 120 min at PND 28 and 63. At PND 34 the FST was performed. Moreover, at PND 63 male rats were introduced into two different cocaine self-administration protocols: 1) stable cocaine dose (0.5 mg/kg/inf.) with increasing schedule of reinforcement fixed ratio (FR) 1 to 5 or 2) increasing cocaine doses (0.25–1 mg/kg/inf.) and stable FR1. Following 10 extinction days, male rats were tested for the response reinstatement of drug-seeking behavior induced by cocaine-priming dose (10 mg/kg, i.p.) and cue (tone+light). RESULTS: HFD group exhibited depressive-like phenotype, characterized by increased immobility time and decreased climbing in both tested time points what was not affected by the changes in basal locomotor activity. The HFD rats displayed an attenuation of the cocaine-associated lever presses and cocaine intake during the acquisition/maintenance of cocaine self-administration and lower response to relapse behavior evoked by cocaine priming or the drug-associated conditioned stimulus. CONCLUSIONS: Our data suggest the influence of maternal HFD on the offspring’s behavior, however underlying molecular mechanism requires further investigations. FINANCIAL SUPPORT: Supported by research grant UMO-2016/21/B/N24/00203 from the NCN (Poland).