Wyniki wyszukiwania - Biblioteka Nauki

1

Investigation on the relationship between lymphocyte subsets, immunoglobulin levels and adenosine deaminase activities in immunosuppressive dove methylprednisolone treated dogs

100%

Altug N. , Agaoglu Z. T.

Bulletin of the Veterinary Institute in Puławy

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2007

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tom 51

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nr 1

EN

Seven healthy dogs were administered with methylprednisolone orally (2 mg/kg body weight/d) at the beginning of the study (between 0-10 d), then the dosing was decreased at 10 d intervals throughout 10 to 60 d in an alternate-day therapy programme. Drug administration to the dogs was stopped on the 60 d. Total leukocyte count; polymorphonuclear leukocytes, and neutrophil ratios increased and eosinophil, mononuclear leukocytes, lymphocyte, and monocyte ratios were decrease when these values were compared to changes between days. Furthermore, in lymphocyte subsets, B lymphocytes and CD 8 T lymphocytes ratios were found to decrease. In addition, CD 3 T lymphocyte ratios decreased on the 61 d and CD 4 T lymphocyte ratios increased on the 21, 41, 51 and 61 d. IgM and IgG levels decreased between the days. Serum total ADA and ADA 1 activities decreased during the application, but ADA 2 activity did not change significantly. As a result, after immunosuppressive dose of methylprednisolone application, reduction in the ADA and ADA 1 activity can be used as determinant of the suppression of immune system components.

2

Decreased serum adenosine deaminase activities in Van cats with feline retroviruses infections

80%

Altug N. , Yuksek N. , Agaoglu Z. T. , Ozkan C.

Medycyna Weterynaryjna

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2007

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tom 63

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nr 02

184-186

EN

This aim of the study was to determine the activity of ADA serum and isoenzyme in feline retroviral infections. The study involved 6 FeLV seropositive, 4 FIV seropositive and 10 healthy seronegative cats aged between 1-8 years. Haematological, serum enzyme acivity (AST; ALT; ALP; GGT) as well as ADA serum and isoenzyme activity were determined in all the cats. Haematological parameters were within the normal range except for the platelet count in FIV seropositive cats (p<0.05). Serum enzyme activity was unchanged except for the AST concentration in FeLV and FIV seropositive cats compared to the healthy subjects. ADA serum and ADA1 concentrations were lower in the seropositive group than in the seronegative group. However, the decrease in ADA serum and ADA1 concentrations in FIV seropositive cats (p<0.01) was more significant than that of FeLV seropositive cats (p<0.05). In conclusion, decreased ADA and ADA1 activity in feline retrovirus infections may be significant.

3

Adenosine deaminase in the diagnosis of white muscle diseases in lambs

71%

Altug N. , Agaoglu Z. T. , Yuksek N. , Kaya A. , Keles I.

Medycyna Weterynaryjna

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2006

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tom 62

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nr 09

1007-1010

EN

The aim of the study was to investigate the importance of ADA serum and its isoenzyme activity in diagnosing white muscle disease in lambs. The animal material used in the study was forty seven Akkaraman lambs - twenty seven of which had clinical signs of white muscle disease (white muscle disease group) and twenty healthy lambs (control group). Blood samples were taken and Se levels, CK, LDH, AST, ADA and ADA izoenzyme activity were determined. Following this, the animals in the white muscle disease group received 1 mg sodium selenit + 60 mg vitamin E intramuscularly as a single dose. Fourteen days following sodyum selenit + vitamin E application blood samples were again taken and the same analysis repeated. Apart from ADA2 activity, other enzyme activities were significantly high (p<0.001), and serum Se concentrations were significantly low (p<0.001) in animals of the white muscle disease group compared to the control group. When the parameters obtained from the white muscle disease group were compared before and after treatment it was indicated that all enzyme parameters decreased significantly (p<0.001) after treatment. On the other hand, serum Se concentration increased (p<0.01) after treatment in the diseased group. The results confirm that determining ADA serum and its isoenzymes, together with CK, LDH and AST values seems to be useful in diagnosing white muscle disease.

4

Rupture of the gastrocnemius muscle in a cow two months after twin birth

61%

Altug N. , Ozkan C. , Yuksek N. , Karasu A. , Keles I. , Agaoglu Z. T. , Ilhan F.

Bulletin of the Veterinary Institute in Puławy

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2007

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tom 51

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nr 4