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1
Manipulating inflammation and gliosis in neurological diseases-a clinical perspective
100%
Czlonkowska A.
Acta Neurobiologiae Experimentalis
|
2009
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tom 69
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nr 3
EN
In many neurological diseases, an infl ammatory reaction in the brain is observed. In some of them, as in multiple sclerosis, the brain infl ammation is a result of a systemic autoimmune response. In others, like the Parkinson’s disease, Alzheimer’s disease, brain injury and stroke, an infl ammation and glial proliferation in the brain are a secondary phenomenon to neural degeneration or injury. The role of these reactions in the pathogenesis of neurological diseases is unclear. From one side they can contribute to greater neurological defi cit. From the other side, infl ammatory cells may release trophic factors and contribute to neuroprotection and neuroregenaration. Experimental works provide some evidences that pharmacological inhibition of brain infl ammation and glial proliferation may be protective but also may be harmful. The infl uence of anti-infl ammatory therapies on the progression of neurological diseases depends on a dose and time of the treatment after injury. Therefore, a clinical use of drugs infl uencing infl ammation and glial proliferation is very diffi cult. Despite many anti-infl ammatory therapies used in neurological diseases at present, there is no clinical evidence of their benefi cial effects. Various immunomodulatory therapies have been tested in multiple sclerosis, but only some modest modifi cations of clinical course are observed. Similarly, in neurodegeneration like in the Parkinson’s disease, non-steroidal anti-infl ammatory drugs do not change disease progression.
2
Anti-inflammatory treatment diminish nigrostriatal degeneration in mice model of Parkinson's disease
100%
Czlonkowska A.
Acta Neurobiologiae Experimentalis
|
2001
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tom 61
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nr 3
3
Anti-inflammatory drugs in neurologic diseases
75%
Czlonkowska A.
Acta Neurobiologiae Experimentalis
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2007
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tom 67
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nr 3
4
Udary mozgu u starszych kobiet - czynniki ryzyka i rokowanie
63%
Czlonkowska A. , Kobayashi A.
Kosmos
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2003
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tom 52
|
nr 1
77-82
5
Magnetic resonance imaging findings correlated with clinical manifestations of Wilson's disease
51%
Gajda J. , Czlonkowska A. , Kryst-Widzgowska T.
Acta Neurobiologiae Experimentalis
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1992
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tom 52
|
nr 3
6
Gaba - 5-HT systems link in anxiety control in rats
51%
Nazar M. , Siemiatkowski M. , Czlonkowska A. , Plaznik A.
Acta Neurobiologiae Experimentalis
|
1997
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tom 57
|
nr 5
7
Neuropsychological impairment in Wilson's disease
51%
Seniow J. , Czlonkowska A. , Gajda J. , Jedryka-Goral A.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 5
8
Interaction between serotoninergic and gaba-ergic neurons in adaptive processes to fear evoking stimuli
51%
Siemiatkowski M. , Czlonkowska A. , Bidzinski A. , Plaznik A.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 5
9
Detection of oligoclonal bands in the cerebrospinal fluid by isoelectric focusing with the phast - system in neurological diseases
51%
Zaborski J. , Fiszer U. , Czlonkowska A.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 5
10
Anticardiolipin antibodies as a risk factor in patients with Multi Infarct Dementia
51%
Palasik W. , Jura E. , Bieganowska K. , Czlonkowska A.
Acta Neurobiologiae Experimentalis
|
1992
|
tom 52
|
nr 3
11
Immunolological alterations in the MPTP induced model of Parkinsons disease in mice
51%
Bieganowska K. , Czlonkowska A. , Mierzewska H. , Bidzinski A.
Acta Neurobiologiae Experimentalis
|
1992
|
tom 52
|
nr 3
12
Interleukin-6 secretion by glial cells in Parkinson's disease mouse model
51%
Kurkowska-Jastrzebska I. , Kohutnicka M. , Czlonkowski A. , Czlonkowska A.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 5
13
Cognitive functioning and life activity in patients with hepatic form of Wilson's disease
51%
Szutkowska-Hoser J. , Seniow J. , Czlonkowska A. , Laudanski K.
Polish Psychological Bulletin
|
2005
|
tom 36
|
nr 4
234-238
EN
The aim of our study was to investigate whether the changes of the cognitive functions and activities of daily life occur in the early stage of the hepatic form of Wilson's disease. The experimental group consisted of 17 patients with Wilson's disease as demonstrated by mild or slight liver dysfunction and matched group of healthy individuals on the basis of sex, age and education. Both groups performed several neuropsychological tasks such as The Block Design from The Wechsler Adult Intelligence Scale, The Rey Auditory Verbal Learning Test, The Trial Making Test, and specially designed clinical experiments. The patients did not do as well as the control group in accomplishing most of the neuropsychological tasks. Near statistical significance level was reached when the decline, in patient group, in accomplishing task involving arithmetical and visual-spatial functions. There was no difference between groups in the subjective assessment of the health-related quality of life. Our study shown that in the early stages of the hepatic form of the Wilson disease the cognitive changes are subtle. However we suggest that arithmetic skills and visual-motor functions maybe the first sign of the progressing Wilson's disease.
14
Content available Some behavioral effects of AMPA-kainate receptor agonist and antagonists
51%
Czlonkowska A. , Siemiatkowski M. , Plaznik A.
Journal of Physiology and Pharmacology
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1997
|
tom 48
|
nr 3
15
Reaction of microglial cells and lymphocytes after 1-methyl-4-phenyl-I ,2,3,6-tetrahydropiridine intoxication in mice
45%
Kurkowska-Jastrzebska I. , Kohutnicka M. , Wronska A. , Czlonkowska A. , Czlonkowski A.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 5
16
Gammadeltaplus T cells in Wilson's disease
45%
Fiszer U. , Korczak-Kowalska G. , Gajda J. , Gorski A. , Czlonkowska A.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 5
17
The APOE epsilon4, gender, and stroke severity and one-year outcome
45%
Gromadzka G. , Baranska-Gieruszczak M. , Sarzynska-Dlugosz I. , Ciesielska A. , Czlonkowska A.
Acta Neurobiologiae Experimentalis
|
2006
|
tom 66
|
nr 4
18
Simvastatin did not protect dopaminergic neurons from damage caused by MPTP
45%
Kurkowska-Jastrzebska I. , Joniec I. , Balkowiec-Iskra E. , Czlonkowski A. , Czlonkowska A.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 3
19
Post intoxicative therapeutic immunization with myelin oligodendrocyte glycoproteine [MOG 35-55] suppresses spontaneous regeneration of dopaminergic neurons injured with 1-methyl-4 phenyl-1,2,3,6-tetrahydropiridine [MPTP]
45%
Balkowiec-Iskra E. , Kurkowska-Jastrzebska I. , Joniec I. , Czlonkowska A. , Czlonkowski A.
Acta Neurobiologiae Experimentalis
|
2003
|
tom 63
|
nr 2
20
MHC class II positive microglia and lymhocytic infiltration are present in the substantia nigra and striatum in mouse model of Parkinson's disease
45%
Kurkowska-Jastrzebska I. , Wronska A. , Kohutnicka M. , Czlonkowski A. , Czlonkowska A.
Acta Neurobiologiae Experimentalis
|
1999
|
tom 59
|
nr 1
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