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2
Content available CARE : Creative Application to Remedy Epidemics
100%
EN
The paper focuses special attention on a project named CARE. The developers of the project is NosoiFighters team, which consists of students of the Cybernetics Faculty in Military University of Technology. The system is a very creative software solution that takes advantage of pioneering sociological theories, graph/networks theory and the last but not least most advanced technologies. It has a very practical purpose, in particular nowadays: countering infectious diseases, for instance HIV/AIDS, malaria, SARS, etc. The paper demonstrates how the system can help us to nail epidemics. CARE has enormous practical potential in regions such as Africa, where there are not enough medicines to treat all who are at risk.
EN
Chronically hemodialyzed (HD) patients are at a high risk of developing very severe forms of COVID-19 disease. In this article we describe three HD patients (all males, aged 70, 70 and 74 years) vaccinated intramuscularly with a two-dose mRNA BNT162b2 vaccine; BionTech/Pfizer Comirnaty, in whom subsequent breakthrough SARS-CoV-2 infections developed. All patients achieved post-vaccine seroconversion for anti-spike antibodies with IgG titers of 445, 227 and 92.5 AU/mL (cut-off, 13 AU/mL) case 1, 2 and 3 respectively. SARS-CoV-2 infection was diagnosed 44, 28 and 48 days after the second dose of BNT162b2 and confirmed with the polymerase-chain-reaction (PCR) test. Two asymptomatic patients underwent this test because of their direct contact with a person with confirmed COVID-19. The third patient reported only a non-significant drop in oxygen saturation, and was hospitalized (case 3). All these patients were characterized by a low post-vaccination neutralizing antibody titer and a high production of these antibodies after falling ill (795, 845 and 5770). Perhaps this production of antibodies is responsible for the mild course of the disease, and the likely reduction of mortality. These breakthrough cases in no way undermine the importance of the vaccinations, and on the contrary argue for their urgency.
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Obligatory protective vaccinations and the implementation of parental authority: a study of judicial decisions in the area of legal liability
6
Content available remote Vaccination policies and state-building in post-war Angola
100%
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nr 1
106-127
EN
The article explores how public health policies may be used by the state to (re)gain its legitimacy. The author examines this through the example of the use of vaccination policies in Angola, a Southern African country torn apart by thirty years of civil war. In particular, the author looks at how the Angolan government has managed to regain control of the country, understood as both a territory and a population, and focuses on the construction of the Angolan nation and the key role of women in this tactic. Vaccination policies have been used with four non-medical purposes: to reconquer the territory, to frame the nursing workforce, to shape motherhood, and, through the use of statistics, to reinforce and integrate the Angolan health system into the global one. Women as the primary carers of children and as health workers are instrumental to the Angolan state’s strategy for winning back the territory and the population.
EN
Introduction: Human papillomavirus (HPV) is the most common sexually transmitted virus worldwide. It’s associated with over 99% of cases of cervical cancer and also connected with other cancers like rectal, vaginal or penile. Aim: To evaluate the level of knowledge about cervical cancer and HPV vaccine among students attending medical and non-medical universities and to discuss problems connected with low interest in cancer prevention. Materials and methods: 427 students took part in the anonymous survey. Original questionnaire consisted of 19 questions and was prepared by the authors powered by review of valid references. Results: 93.2% of interviewees have heard about HPV vaccine and 20.6% of them have been vaccinated. There was a statistically significant difference in knowledge and attitude to vaccination and cancer prevention between medical and non-medical students. Discussion: Interviewees are aware of hazards involved in HPV infection, but they don’t know the exact scale of it. They cannot evaluate the risks connected with cervical cancer properly, what may influence their low interest in prevention. Knowledge about HPV vaccine’s existence is common, but there is a huge disinformation about its characteristics and side effects. Main source of knowledge are mass media, subject of vaccination is discussed at school or with general physician extremely rarely. The price of the vaccine is main reason for resignation, so regional government’s prevention programs play a very important role. Conclusions: The education of the society is a strong base for excellent prevention of cancers. Doctors should be included in more active operations for cervical cancer prevention
EN
The present review summarizes data on neurological adverse events following vaccination in the relation to intensity, time of onset, taking into account the immunological and non-immunological mechanisms. The authors described the physio-logical development of the immune system and the possible immune system responses following vaccination. Toxic property of thimerosal - a mercury-containing preservative used in some vaccines was presented. The neurological compli-cations after vaccination were described. The role of vaccination in the natural course of infectious diseases and the current immunizations schedule in Poland was discussed.
9
Content available remote Analysis of immunotherapy models in the context of cancer dynamics
100%
EN
A basic mathematical model of the immune response when cancer cells are recognized is proposed. The model consists of six ordinary differential equations. It is extended by taking into account two types of immunotherapy: active immunotherapy and adoptive immunotherapy. An analysis of the corresponding models is made to answer the question which of the presented methods of immunotherapy is better. The analysis is completed by numerical simulations which show that the method of adoptive immunotherapy seems better for the patient at least in some cases.
EN
The capacities of differentiation of Mycobacterium bovis BCG from other members of M. tuberculosis complex species using PCR-RFLP, multiplex PCR, and PCR-based genomic deletion analysis approaches were compared. In the study, mycobacteria isolated from patients suspected of adverse events following vaccination with BCG, primarily classified according presence of RD1 marker as virulent and avirulent mycobacteria, were used. The PCR-based genomic deletion analysis was found the best option for mycobacteria diagnostics improvement, as it was capable precisely differentiate virulent and avirulent mycobacteria or virulent species of M. tuberculosis complex. The routine confirmation of mycobacteria species in the cases of adverse events following BCG vaccination is highly expected, especially in clinical practice of patients with primary immunodeficiency.
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2024
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tom 12
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nr 1 (23)
13-35
EN
The pandemic of the new coronavirus and the introduction of coronavirus vaccines prompted the production of vaccines and vaccine discourses around the world. The same situation has been observable in Japan. The purpose of this study is to discuss what I call “the social phenomenon of vaccines” in Japan. The present article will describe the characteristics of the vaccine discourse and consider the relationship between the vaccine discourse and vaccine-induced sufferings, which refer to the experience of social damages and difficulties caused by vaccines. Firstly, I will review the research method of the previous studies of vaccination. It has been shown that both pro-vaccine and anti-vaccine existed from the beginning of the history of vaccination, and in that sense, the existence of both pro-vaccine and anti-vaccine can be considered as a part of “the social phenomenon of vaccines” from the beginning. Inspired by the Strong Program, I will explain a method which would enable me to describe both pro and anti-vaccine without a priori assumptions. One such method can be found in the repertoire analysis by Gilbert and Mulkey (1984), who analyzed controversies in scientific research. Following their method, I will explore how the vaccine discourse was developed in Japan. The vaccine discourse in Japan is found in three different types of literature, which discuss vaccine promotion, vaccine harms, and vaccine safety. Secondly, I will identify three kinds of repertoires: “componentist repertoire”, “manipulationist repertoire” and “psychologism repertoire”. I will then discuss the features of “the social phenomenon of vaccines” by examining the relationship among these repertoires and how these repertoires work. Finally, I will discuss how vaccine discourse is related to the discourse of vaccine-induced sufferings. In conclusion, vaccination, by its very nature, cannot be separated from the impossibility of direct experience of vaccination. Therefore, the more vaccine develops, the more vaccine discourse flourishes.
EN
Background During the COVID-19 era, it is crucial to determine the level of relevant infectious disease knowledge amongst medical students as they may influence public opinion by acting as informal medical advisors to their friends and family. We sought to assess the knowledge of students regarding COVID-19 at a single Polish medical university, to understand the level of knowledge and determine if dedicated COVID-19 education is necessary. Material and methods The survey was conducted in Google Forms and access was obtained through the university’s secure email. After exclusion, 1.001 students were enrolled. Results The most common mask used amongst students is a surgical mask. Regarding SARS-CoV-2 transmission, 79,1% chose droplet and 19,3% chose airborne transmission. Only 35% agreed that surgical masks protect them from coronavirus and 70% strongly agreed or agreed that all healthcare workers should wear an N95/FFP3 mask. Students with a healthcare worker in the family more likely agreed that all healthcare workers should wear N95/FFP3 (p = 0.001). The source of information used affected the route of transmission chosen (p = 0.006). Conclusions We recommend combatting contradicting information by healthcare students having dedicated education on SARS-CoV-2, PPE, filtering efficiency of masks, modes of transmission of viruses, and how to use evidence-based medicine for better public health dispersion.
EN
Although relatively easy to overcome for young and healthy individuals, seasonal influenza is a disease with considerable health, social, and economic consequences for society, especially for higher-risk groups. Even though vaccination against influenza is the most effective tool to prevent it, vaccination rates remain rather low. Together with the promotion of neoliberal individual responsibility over one’s health, vaccine hesitancy – a complex phenomenon indicating the lower uptake of vaccines compared to the accessibility of information and services – has risen among societies. In previous research, several barriers – for example, psychological, physical, contextual, and sociodemographic – have been identified as preventing influenza vaccine uptake among risk groups. We approach the topic by using the social constructionist theory regarding the meaning construction of illnesses on cultural, individual, and third-party level. The findings outline the importance of meaning construction on all these levels. It appears that culturally influenza has been seen as an inevitable infectious disease related to the northern climate. Due to that, influenza is not considered as a life-threatening disease that would need preventive actions, except some basic hygiene or usage of folk medicine tools (e.g., ginger and garlic). On an individual level, the meaning construction is based on individual experiences, both with the illness and the vaccine – in the case of negative experiences with vaccine, the perception of something useless or even harmful develops. In addition, it appears that people create their own strategies to rationalize rejection of vaccination for themselves. These involve considerations about belonging to the risk group or the possibility to manage daily activities in non-risky manner even when belonging to the risk group. On the third-party level, participants saw the potential of pharmacies to alleviate practical constraints (e.g., tight schedule, daily occupation, etc.). Different media channels are also important in mediating vaccination-related information, but the rationalization and selection of the channels vary widely. The context of the coronavirus changed the vaccination-related perception temporarily for a short term, indicating that fear-based special occasions do not entail a long-term shift in health behaviour as the development of health-related decisions and behaviour is also long-term.
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Content available Incidence of tuberculosis in the Tatras region
88%
EN
The authors point out that tuberculosis is the oldest infectious killer of humans and today it is such a serious threat to health that the World Health Organization (WHO) equates it to a time bomb. The most common source of infection by mycobacteria tuberculosis to a man is a sick person. Epidemiologically greatest danger is sick person with untreated decay pulmonary tuberculosis whose sputum may spread billions of tuberculosis bacilli every day. The overall situation in the incidence of tuberculosis (TB) in Slovakia is generally favorable, although in the eastern parts of Slovakia incidence is growing rapidly. Slovakia has compared with all Europe small to moderate incidence of this disease and its incidence has downward trend. East Slovakia so far has hot won combat this disease yet. It is therefore necessary to continue effective intervention and prevention to combat the spread of this disease.
19
Content available Szczepienia przeciwko grypie u personelu medycznego
75%
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tom 64
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nr 1
119-129
EN
Influenza is one of the most common respiratory diseases affecting people of all age groups all over the world. Seasonal influenza leads to substantial morbidity and mortality on a global scale. Vaccines are undeniably one of the most important health advances of the past century, however, managing influenza in working populations remains a difficult issue. Vaccination of health care workers (HCW) is an efficient way to reduce the risk of occupational infection and to prevent nosocomial transmission to vulnerable patients. Despite this, achieving high immunization rates among those professionals is a challenge. Knowledge and attitudes of healthcare providers have significant impact on the frequency with which vaccines are offered and accepted, but many HCWs are poorly equipped to make informed recommendations about vaccine merits and risks. Principal reasons for vaccination are the willing not to be infected and avoiding transmission to patients and the family. The main reasons for refusing is lack of time, a feeling of invulnerability to vaccination, conviction of not being at risk, of being too young or in good health. Misconceptions about influenza vaccine efficacy, like adverse effects, and fear of contracting illness from the vaccine are significantly associated with noncompliance with vaccination. Therefore, strategies to increase awareness of the importance of recommending influenza immunization among health professionals are required. Med Pr 2013;64(1):119–129
PL
Grypa jest jedną z częstszych infekcji dróg oddechowych, zachorowania na nią występują we wszystkich grupach wiekowych pacjentów na całym świecie. Liczba zachorowań na grypę sezonową i zgonów z powodu jej powikłań jest znaczna w skali globalnej. Szczepienia, również przeciwko grypie, są istotnym osiągnięciem medycyny ostatniego stulecia, jednak problemem pozostaje zwalczanie grypy za pomocą szczepień ochronnych wśród personelu medycznego. Szczepienie personelu medycznego jest procedurą o udowodnionym bezpieczeństwie i skuteczności, zapewnia zapobieganie zachorowaniom wśród pacjentów. Mimo licznych rekomendacji eksperckich stan zaszczepienia pracowników medycznych pozostaje niski. W celu zwiększenia liczby zaszczepionych pracowników medycznych konieczne jest prowadzenie kampanii edukacyjnych, które mają na celu polepszenie stanu wiedzy personelu na temat grypy, jej powikłań, szczepień przeciwko grypie, ze szczególnym uwzględnieniem ich bezpieczeństwa i skuteczności. Szczepieni pracownicy najczęściej decyzję o wykonaniu szczepienia motywują chęcią ochrony siebie oraz chęcią ochrony przed zakażeniem swoich pacjentów i ich rodzin. Z kolei wśród przyczyn nieszczepienia wymieniane są: brak czasu, błędne przekonania o nieskuteczności szczepienia, brak potrzeby szczepienia z powodu bagatelizowania choroby i jej powikłań, obawa przez niepożądanymi odczynami poszczepiennymi. Konieczne jest wdrożenie strategii mających na celu edukację personelu medycznego w zakresie stosowania szczepień przeciwko grypie w celu zwiększenia wyszczepialności przeciwko grypie w populacji pracowników medycznych. Med. Pr. 2013;64(1):119–129
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