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EN
Objectives: The roles of cardiorespiratory fitness (CF) in reducing cardiovascular disease (CVD) and allcause mortality risks are well established; however, little is known about the role of CF in reducing risk of metabolic syndrome (MetS), a cluster of CVD risk factors, particularly in Asian countries. This research examined associations between CF and MetS diagnosis and its five components in Indonesian middle-aged and older adults. Methods: This cross-sectional study included 161 participants (aged 63±8 years; 70% female). CF was assessed with a 6-minute walk test. MetS diagnosis and its components were assessed with the Adult Treatment Panel III. Logistic regression modelling was conducted to examine the relationships between CF and MetS diagnosis and its components, after adjustment for BMI and other confounders. BMI was categorized using cut-points for Asians. Results: In adjusted models, participants with low CF had a greater likelihood of being diagnosed with MetS than those with high CF (OR=4.79, 95%CI:2.17-10.62). They were also more likely to have low highdensity lipoprotein (OR=2.07, 95%CI:1.02-4.18) or hypertriglyceridemia (OR=2.37, 95%CI:1.15-4.86). There was also borderline significant findings that suggested that participants with low CF had greater likelihood of having abdominal obesity (OR=2.34, 95%CI:0.97-5.65, p=0.06) or hyperglycaemia (OR=2.07 95%CI:0.98-4.41, p=0.06). Conclusions: Low CF is associated with increased likelihood of being diagnosed with MetS. The adverse effects of low CF are mainly characterized by dyslipidaemia. Public health messages should emphasise the importance of improving CF for preventing MetS. Assessment of CF could be useful for targeting individuals most likely to benefit from intervention to prevent MetS.
EN
The present study aimed to determine the role of job components and individual parameters on the raised blood pressure among male workers of textile industry who were exposed to continuous high noise level. Information of all eligible subjects including demographic and individual characteristics, medical history and job characteristics were obtained by direct interview and referring to the medical records. All blood pressure measurements were done using mercury sphygmomanometer in the morning before work. The 8-hours equivalent A-weighted sound pressure level, the level of blood cholesterol and triglyceride, and noise annoyance was determined for each worker. As the result of weighted regression in path analysis (direct effect), only the work shift did not have a significant effect on blood pressure among the studiem variables. It can be seen that variables including the level of triglyceride, cholesterol, and noise exposure have the most direct effects on blood pressure. The results of total effects showed that variables, including using the hearing protection device, age, work experience and visibility of sound source, did not have a significant effect on blood pressure. The results of this study indicate that occupational noise exposure alone and combined with other job components and individual parameters is associated with raised blond pressure. However, noise exposure was probably a stronger stressor for increased blood pressure.
EN
Using Wistar rats the effect of exercise was studied on the level of lipid peroxides, superoxide dismutase activity in the serum and certain tissues, and the contents of triglycerides (TG), total cholesterol (TChol), cholesterol in high density lipoprotein fractions (HDL -chol and HDL3-chol) and alpha-tocopherol in the serum. Low-grade exercise decreased by about 10% the lipid peroxide level in the serum, the soleus muscle and myocardium. Greater exercise increased the lipid peroxide level in the studied tissues. In the liver the lipid peroxide level rose by 20% independently of the degree of exercise. Superoxide activity increased proportionally to the grade of exercise in the myocardium, the soleus muscle and the liver. The serum alphatocopherol level increased in the groups of animals subjected to exercise. In the group with higher grade of exercise a slight fall of TChol in the serum and a fall of HDL and HDL3, cholesterol.
PL
Na szczurach szczepu Wistar badano wpływ wysiłku fizycznego na zawartość nadtlenków lipidowych (NL), aktywność dysmutazy ponadtlenkowej (SOD) w surowicy krwi i wybranych tkankach, a także zawartość trójglicerydów (TG), cholesterolu całkowitego (TChol), cholesterolu lipoprotein o wysokiej gęstości (HDL-chol i HDL3-chol) oraz α-tokoferolu w surowicy. Stwierdzono, że mały wysiłek fizyczny wywołał około 10°/o zmniejszenie zawartości NL w surowicy, mięśniu płaszczkowatym i mięśniu sercowym. Zwiększony wysiłek fizyczny powodował wzrost NL w badanych tkankach. W wątrobie stwierdzono 20% wzrost NL niezależnie od stopnia wysiłku fizycznego. Aktywność SOD wzrastała proporcjonalnie do wysiłku fizycznego w mięśniu serca, mięśniu płaszczkowatym i wątrobie. Zawartość α-tokoferolu w surowicy wzrastała w grupach zwierząt trenujących. W grupie zwierząt o zwiększonym wysiłku fizycznym stwierdzono nieznaczny spadek TChol w surowicy oraz spadek cholesterolu w HDL i HDL2.
EN
The results of recent studies indicate that obesity is associated with an increase in peroxidation processes. The aim of the present study was to assess the degree of oxidative stress in obese women and to evaluate the relationship between selected markers of oxidative stress and body mass index. Study population consisted of 43 women aged 21 to 66. Subjects were divided into two groups according to their body mass index (BMI): Overweight group (BMI < 30 kg/m2) and Obese group (BMI > 30 kg/m2). Venous blood samples were taken from each subject after an overnight fast and following parameters were assessed: plasma total antioxidant status (TAS), plasma concentrations of thiobarbituric acid reactive substances (TBARS), serum levels of antibodies against oxidized low density lipoproteins (oLAB), serum lipid profiles, serum glucose and insulin concentrations. Additionally, serum low density lipoprotein (LDL) cholesterol and insulin resistance indices were calculated. Serum triglyceride concentrations, insulin levels and insulin resistance indices were significantly higher in obese women in comparison with overweight ones. No significant differences in TBARS concentrations, TAS and oLAB levels were found between the two study groups. However, oLAB titres in Obese group were above the upper limit of the reference range for healthy adults. In both study groups significant correlations (p <0.01) between BMI and levels of triglycerides, insulin concentrations and insulin resistance indices were observed. Additionally, positive correlations (p < 0.05) between BMI and LDL-cholesterol and diastolic blood pressure as well as negative correlations (p < 0.05) between HDL-cholesterol and diastolic blood pressure were found in Obese group. In the overweight women, there were positive correlations between oLAB levels and triglyceride and insulin concentrations, between oLAB titres and insulin resistance indices and between oLAB levels and systolic and diastolic blood pressure (p < 0.01 for all correlations). There was also a negative correlation between oLAB titres and TAS (p < 0.05). The results of the present study confirm that obesity is associated with oxidative stress. Oxidative stress may be the link between obesity and atherosclerosis.
EN
The level of glucose, total cholesterol and its HDL fraction, triglycerides, and free fatty acids were determined 4 weeks before delivery and 2 weeks postpartum in 45 cows. The estimation of ovary function was performed by measurements of progesterone in blood sampled every 3 or 4 days during a 60-day postpartum period. A positive correlation was found between disturbances in lipid metabolism and disorders in the fertility of cows. Moreover, an unfavourable effect of lipolysis on postpartum progesterone secretion was noted.
EN
This study was aimed at determining the effects of a radish-root-based mixed dried vegetable soup supplement as an adjunct to a balanced hypocaloric diet therapy in the management of obesity. Sixteen healthy obese middle aged women, divided into two equal groups, followed a hypocaloric (1000 Kcal/day) diet for four weeks. The first group consumed an additional portion of the soup twice daily, i.e. before lunch and before dinner. The second group served as control. Relevant anthropometric and biochemical parameters were measured before, after two and after four weeks. Both, the soup and control dieters lost 4.18% and 4.71% of their weights, respectively. The soup dieters showed a significant decrease in blood pressure and triglycerides. Total cholesterol levels showed slight variations in both groups. LDL-Cholesterol was significantly decreased in the control dieters, whereas superoxide dismutase (SOD) was significantly increased in the soup, but not in the control dieters. The negligible increase in the c-reactive protein (CRP) in the soup dieters contrasted with the highly significant rise of the control. Calcium was decreased to subnormal concentrations in both groups, while copper, zinc and magnesium showed variable but beneficial increases. We emphasize during and post-diet monitoring of serum TG, CRP and calcium for a more efficient obesity control. Regular consumption of the soup by virtue of its antioxidant and anti-inflammatory properties will help to blunt and/or delay weight cycling and other complications of obesity.
19
Content available remote Role of adiponectin in the regulation of carbohydrate and lipid metabolism
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EN
Adiponectin, an adipocyte-derived plasma protein, has been shown to play an important role in the regulation of fatty acid and glucose metabolism. Adiponectin enhances fatty acid oxidation both in skeletal and cardiac muscle as well as in the liver, thus reducing triglyceride content in these tissues. Moreover, it stimulates glucose uptake by skeletal and cardiac muscle, and inhibits glucose production by the liver; consequently decreasing blood glucose levels. This review focuses on the molecular mechanisms underlying adiponectin effects on carbohydrate and lipid metabolism in skeletal muscle, cardiac muscle and liver.
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