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Wpływ ksylazyny i wybranych antagonistów receptorów alfa2-adrenergicznych na kurczliwość aorty brzusznej świń oraz zmienionej tętniakowato aorty brzusznej człowieka w warunkach in vitro

100%

Niespielak P. , Czerski A. , Bujok J. , Zawadzki W. , Wincewicz E. , Hauzer W.

nr 06

The aim of the study was to demonstrate the effect of xylazine and selected antagonists of α2 -adrenergic receptors on the contractility of the human aneurysmal abdominal aorta compared with the contractility of the abdominal aorta of healthy pigs in vitro. The study was conducted on 34 aneurysmal human abdominal aorta sections and 28 unchanged porcine abdominal aorta sections. The pigs weighed between 50 and 70 kg. The influence of xylazine was investigated. The experiments also examined the impact of xylazine on sections preincubated with α2 -antagonists (BRL 44408, RX 821002, yohimbine). The application of xylazine in the incubation chamber evoked a similar relaxant response in human and porcine material. However, the increasing concentration of the α2 -agonist applied to sections preincubated with α2 -antagonists (BRL 44408, RX 821002) caused their contraction, and this reaction was much stronger in the porcine material. The results demonstrate that after the inhibition of α2 -receptors, xylazine induces contraction due to non-specific α1 -adrenergic receptor activation. The much weaker reaction in the human sections may indicate a reduced number of α1 -adrenergic receptors resulting from their decreased expression and/or the thinning of the smooth muscle layer. The application of yohimbine at a concentration of 10 µM and then of xylazine in the chamber with the porcine material induced a decrease in muscle tonus. This phenomenon is not entirely clear, but it appears that yohimbine at a high concentration behaves like a non-specific α1 -antagonist and causes a relaxant response.

Wystepowanie zakazen wywolanych przez Chlamydophila sp. a wskazniki biochemiczne u chorych operowanych z powodu tetniaka aorty brzusznej

100%

Niedziela P.

2003

tom 59

nr 06

525-528

Dieta a zawartosc kadmu w krwi, subkomorkowej scianie i skrzeplinie przysciennej tetniaka aorty brzusznej

60%

Socha K. , Borawska M. H. , Gacko M. , Guzowski A. , Markiewicz R.

tom 38

nr Supl.

51-55

W pracy dokonano oceny wpływu diety na zawartość kadmu w krwi, subkomórkowej ścianie i skrzeplinie przyściennej pacjentów z tętniakiem aorty brzusznej. Zawartość kadmu w badanych tkankach oznaczonego metodą atomowej spektrometrii absorpcyjnej z atomizacją w kuwecie grafitowej z korekcją tła Zeemana wynosiła odpowiednio: we krwi 3,22 ± 2,27 µg/l, w ścianie tętniaka 72,32± 32,69 ng/g, w skrzeplinie przyściennej 2,71± 2,30 ng/g. Wykazano istotny wpływ nawyków żywieniowych na zawartość kadmu u badanych pacjentów.

The aim of this study was to determine blood levels and the contents of cadmium in the arterial wall and parietal thrombus of patients with aortic abdominal aneurysm. The level of cadmium was determined by electrothermal atomic absorption spectrometry with Zeeman background correction (Hitachi, Japan). The level of cadmium was determined in deproteinatcd blood. Arterial wall and parietal thrombus samples were decomposed with concentrated nitric acid in microwave mineralizer BM-1 z instrument UniClever (Plazmatronika, Poland). The mean level of cadmium in blood of patients with aortic abdominal aneurysm was 3.22 ± 2.27 µg/L and we did not observe significant difference between the mean levels of cadmium in blood of healthy "people 2.60 ± 2.42 µg/L. The mean content of cadmium in arterial wall of examined group was 72.32 ± 32.69 ng/g and in parietal thrombus 2.71 ± 2.30 ng/g. We did not observe significant correlation n the content of cadmium between blood and arterial wall and parietal thrombus in examined patients. The consumption of pluck and coffee had influence on the concentration of cadmium in examined patients.