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Effects of subchronic exposure to atrazine on zebrafish (Danio rerio)

100%

Plhalova L. , Blahova J. , Mikulikova I. , Stepanova S. , Dolezelova P. , Praskova E. , Marsalek P. , Skoric M. , Pistekova V. , Bedanova I. , Svobodova Z.

Polish Journal of Veterinary Sciences

2012

tom 15

nr 3

The aim of this study was to investigate the effects of subchronic exposure to atrazine on fish growth and the development of histopathological changes in selected organs (gill, kidney, liver) in Danio rerio. Juvenile growth tests were performed on D. rerio according to OECD method No. 215. For 28 days, fish at an initial age of 30 days were exposed to the environmental atrazine concentration commonly detected in Czech rivers (0.3 μg/L) and a range of sublethal concentrations of atrazine (3.0, 30.0 and 90.0 μg/L). The results showed decreasing growth rates and morphological changes in the liver (dystrophic lesions of hepatocytes) at 90.0 μg/L of atrazine. The environmental concentration of atrazine in Czech rivers did not have any effect on fish growth and development of histopathological changes in D. rerio. The value of NOEC was 30.0 μg/L and the value of LOEC was 90.0 μg/L.

Efficacy of dietary sodium bentonite against subchronic exposure to dietary aflatoxin in broilers

80%

Eraslan G. , Essiz D. , Akdogan M. , Karaoz E. , Oncu M. , Ozyildiz Z.

Bulletin of the Veterinary Institute in Puławy

2006

tom 50

nr 1

Influence of subchronic exposure to fungicide tolylfluanid on humoral and cell-mediated immune parameters in sheep immunized with Coxiella vaccine

80%

Kovalkovicova N. , Pistl J. , Elias D. , Jackova A. , Novotny J. , Hlincikova S. , Legath J. , Revajova V. , Kovac G.

Bulletin of the Veterinary Institute in Puławy

2005

tom 49

nr 3

Methemoglobinemia oraz wybrane wskazniki biochemiczne funkcji watroby i nerek w subchronicznym narazeniu szczurow na rtec i azotyny

60%

Dudka J. , Dawidek-Pietryka K. , Szczepaniak S. , Leczynska D.

Bromatologia i Chemia Toksykologiczna

2000

tom 33

nr 2

151-154

Po 90-dniowym narażeniu szczurów per os w odstępach dobowych, na pojedyncze i łączne działanie HgCl2 (1,4 mg/kg m.c.) i NaNO2 (30 mg/kg m.c.) określono w pełnej krwi poziom methemoglobiny, a w osoczu aktywność aminotransferazy asparaginianowej (AspAT); [E.C.2.6.1.1.], aminotransferazy alaninowej (AlAT); [E.C.2.6.1.2 ], gammaglutamylotransferazy (GGTP-azy); [E.C.2.3.2.1.] oraz stężenie kreatyniny i mocznika.

The aim of this work was to check whether mercury and nitrites given to rats at doses causing methaemoglobinaemia disturb the normal function of liver and kidneys. Four groups of male Wistar rats received for 3 months: 1) distilled water (control), 2) sodium nitrite at 30 mg/kg b.w./day, 3) mercuric (II) chloride at 1.4 mg/kg b.w./day, 4) mercuric chloride and sodium nitrite in amounts as above. Methaemoglobin level was determined in the whole blood, while AspAT, AlAT and GGTP activities and creatinine and urea levels were determined in blood plasma. Our results indicate that both mercury and nitrite increase methaemoglobin level in the blood. With combined exposure to mercury and nitrite, the increase was less evident. Increased AspAT and AlAT activities were observed in the rats receiving mercury, suggesting a toxic effect on hepatocyte membranes. A similar effect was observed in the rats receiving, in combination, mercury and nitrite. Mercury increases serum urea level, indicating a toxic effect of mercury on the kidneys under conditions of subchronic exposure.