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Influence of active immunization against GnRH on VIP-and NPY-positive innervation of the porcine testis

100%

Wasowicz K. , Kaleczyc J. , Sienkiewicz W. , Czaja K. , Ziecik A. , Lakomy M.

nr 3

Prenatal exposure to antiandrogen flutamide affects androgen receptor (AR) expression in postnatal ovarian Development in Pig

84%

Durlej M. , Wieciech I. , Wegrzyn P. , Slomczynska M.

nr 1-2

Protective effects of L-carnitine on reproductive capacity in rats with diabetes

84%

Li X.-F. , Shi Z.-D. , Song H. , Wang Y.-L. , Li Q.-C. , Diao X.-H. , Pang Y.-W. , Zhou S.-H. , Liu H.-Y.

nr 1

The effect of feeding level of pre- and postpubertal heifers on their reproductive function and later milk production

84%

Bilik K. , Strzetelski J. , Osieglowski S. , Gogol P.

nr 2

Effect of IGF-I, leptin, ghrelin and MAPK-ERK on the nuclear maturation of bovine oocytes

84%

Popelkova M. , Sirotkin A. V. , Bezakova A. , Makarevic A. V. , Pivko J. , Kacmarik J. , Kovac G.

nr 2

Observations on the reproductive function of imported sheep of the Alpine breeds

84%

Kareta W. , Roborzynski M. , Cegla M.

nr 1

Regulation and molecular mechanisms of calcium transport genes: Do they play a role in calcium transport in the uterine endometrium?

67%

Choi K. C. , An B. S. , Yang H. , Jeung E. B.

2011

tom 62

nr 5

Modulatory effect of ghrelin in prepubertal porcine ovarian follicles

67%

Rak A. , Gregoraszczuk E. L.

nr 4

781-793

Ghrelin is a novel growth hormone-releasing peptide, originally identified in rat stomach as an endogenous ligand of the growth hormone secretagogue receptor. Ghrelin is an important regulator of growth hormone secretion, food intake, and reproductive function. This study investigates whether or not ghrelin can modulate prepubertal pig ovary function, which was measured as ovarian estradiol secretion, aromatase activity, cell proliferation, and apoptosis. To investigate this, ovarian cells were co-cultured with four different doses of ghrelin (100, 250, 500, and 1000 pg/ml) for 48 h. Culture media samples were collected, and estradiol levels were determined, while aromatase expression was measured in the cultured cells. Cell apoptosis was measured by determination of caspase-3 activity, DNA fragmentation and TUNEL assay. Ghrelin in 250 and 500 pg/ml doses stimulated estradiol secretion. At all doses ghrelin stimulated aromatase activity and protein expression. Moreover, ghrelin increased cell proliferation and decreased apoptosis. This study provides novel evidence that ghrelin has a modulatory effect in the ovary. We suggest two mechanisms that explain how ghrelin acts on estradiol secretion: 1) ghrelin directly influences aromatase activity and protein expression; 2) ghrelin stimulates cell proliferation and antiapoptotic actions.

Leptin as a nutritional signal regulating appetite and reproductive processes in seasonally-breeding ruminants

67%

Zieba D. A. , Szczesna M. , Klocek-Gorka B. , Williams G. L.

nr 9

7-18

Impairment of testicular endocrine and exocrine functions after dieldrin exposure in adult rats

67%

Hallegue D. , Rhouma K. B. , Tebourbi O. , Sakly M.

Polish Journal of Environmental Studies

2003

tom 12

nr 5

In this study we examined the mechanism of action of Dieldrin on the reproductive function in adult male rats. Experimental data suggest that exposure to pesticide at 3 and 6mg/kg/day for 10 consecutive days, induced a dose-dependant decrease of the number and the mobility of epididymal spermatozoa. Testicle histological analysis shows alteration of spermatogenesis with marked reduce of gametes production combined with reduction in the seminiferous tubule diameters in treated relative to control. Concentration of plasma testosterone dropped significantly in a dose-dependent manner after exposure to Dieldrin, while circulating levels of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) and weight of accessory sex glands were not affected significantly. Thus, it may be concluded that Dieldrin exposure can impair both testicle gametogenesis and steroidogenesis in adult rats.

Influence of heavy metals and 4-nonylphenol on reproductive function in fish

59%

Popek W. , Dietrich G. , Glogowski J. , Demska-Zakes K. , Drag-Kozak E. , Sionkowski J. , Luszczek-Trojan E. , Epler P. , Demianowicz W. , Sarosiek B. , Kowalski R. , Jankun M. , Zakes Z. , Krol J. , Czerniak S. , Szczepkowski M.

nr Suppl.1