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Niskocząsteczkowe inhibitory plazminy

100%

Midura-Nowaczek K.

Wiadomości Chemiczne

1998

tom [Z] 52, 11-12

871--887

Plasmin, serine protease with trypsin specifity, plays a key role in the process of fibrinolysis. Analogs of lysine like e-aminocaproic acid and trans-4-aminomethylclohexanecarboxylic acid are employed clinically as plasmin inhibitors and exhibit an inhibitory effect by blocking lysine binding sites of the enzyme. Their inhibitory activity on plasmin with the respect to fibrinogen and other proteins is much weaker than towards fibrin. Because of this reason investigations on the synthesis of an active centre directed inhibitors of plasmin were also undertaken. A great number of compounds was obtained including derivatives of w-aminoacids or lysine. Next important group were short peptides with C-terminal lysine or arginine derivatives such as aldehydes, chloromethylketones, fluoromethylketone, methylketones, amides or esters. This paper presents literature data on structure-activity relationship for low molecular inhibitors of plasmin with a structure of aminoacids or peptides derivatives.

Platelets in fibrinolytic system

100%

Korbut R. , Gryglewski R. J.

Journal of Physiology and Pharmacology

1995

tom 46

nr 4

Inhibition of fibrin formation and plasmin activity by formaldehyde: studies in vitro

100%

Jasielczuk J. , Dabrowski L.

Acta Toxicologica

2003

tom 11

nr 1

Wplyw inhibitora katepsyny D z lupin nasion wyki siewnej na aktywnosc enzymow proteolitycznych

75%

Roszkowska-Jakimiec W. , Krupkowska A. , Bielawska K. , Milewska E.

2008

tom 41

nr 3

262-264

Wplyw zwiazkow chemicznych wystepujacych w napojach alkoholowych na hemostaze. Cz.III. Wplyw na uklad fibrynolityczny osocza

75%

Jurkowski J. , Gacko M. , Worowski K.

Bromatologia i Chemia Toksykologiczna

1995

tom 28

nr 2

185-192

Określono wpływ 26 napojów alkoholowych, ich destylatów i pozostałości podestylacyjnych na aktywność fibrynolityczną i kazeinolityczną euglobulin osoczowych i plazminy.

The effect of strong drinks containing different amounts of alcohol (beer, wine, vodka, brandy) on fibrinolytic and caseinolytic activity of euglobulins and plasmin was assessed. Non-distilled drinks containing ethanol and the accompanying compounds, distillates of those drinks containing ethanol and accompanying volatile compounds, and the post-distillation residue with its accompanying compounds were analysed. Chemical compounds inhibiting fibrinolytic activity of euglobulins were found only in 6, and those decreasing fibrinolytic activity of plasmin in 2 of the 27 examined strong drinks. These compounds did not decrease caseinolytic activity of euglobulins or plasmin. They are found in non-distilled drinks and post-distillation residue. Ethanol slightly inhibits fibrinolytic and caseinolytic activity of euglobulins and plasmin in very high concentrations, which are beyond the concentration range of usual strong drinks.