Wyniki wyszukiwania - Biblioteka Nauki

1

Aldehyd malonowy w środowisku człowieka i w jego organiźmie

100%

Witas T.

Studia / Wyższa Szkoła Morska w Szczecinie

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1999

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tom nr 32

1-68

PL

Choć istnieje szereg zasadniczych różnic między drogami syntezy z udziałem malonylo-CoA a rozpadem kwasów tłuszczowych na fragmenty trójwęglowe - malonylowe, to współcześnie uwidaczniają się już coraz wyraźniej natężające się zakłócenia w tej koegzystancji, pomiędzy biogennością a abiogennością, jakie mają miejsce w organizmach żywych roślin, zwierząt i ludzi a zdewastowanym środowiskiem.

EN

Although there are a number of basic differences between ways of synthesis with the participation of malonyl-CoA and the decomposition of fatty acids into tricarbonic-malonyle fragments, disturbances in this coexistence are making themselves more and more visible at the present time, between biogenesis and abiogenesis, occuring in live organisms of plants, animals and humans, and the devastated environment.

2

Exhaled breath malondialdehyde, spirometric results and dust exposure assessment in ceramics production workers

70%

Sakhvidi M. J. , Biabani Ardekani J. , Firoozichahak A. , Zavarreza J. , Hajaghazade M. , Mostaghaci M. , Mehrparvar A. , Barkhordari A.

International Journal of Occupational Medicine and Environmental Health

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2015

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tom 28

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nr 1

81-89

EN

Introduction The study aimed at measuring exhaled breath malondialdehyde (EBC-MDA) in workers exposed to dust containing silica and at its comparison with the non-exposed control group. Material and methods The cross sectional, case-control study (N = 50) was performed in a tile and ceramics production factory in Yazd, Iran. EBC-MDA was quantified in exhaled breath of the participants by a lab made breath sampler. Exposure intensity was measured according to the NIOSH 0600 method in selected homogeneous exposure groups. Additionally, spirometry test was conducted to investigate a correlation between EBC-MDA and spirometric findings in the exposed workers. Results There was no difference in the observed exposure intensities of silica containing dust in different units. However, “coating preparation” was the unit with the highest concentration of dust. Although, the level of EBC-MDA in the cases was slightly higher than in the controls, the difference was not statistically significant (U = 252, p = 0.464). A significant and positive correlation was found between dust exposure intensity in working units and the measured EBC-MDA of workers (r = 0.467, N = 25, p = 0.027). There were also no statistically significant differences among job categories in the exposed group for the values of FEV1% (F(3, 44) = 0.656, p = 0.584), FVC% (F(3, 44) = 1.417, p = 0.172), and FEV1/FVC% (F(3, 44) = 1.929, p = 0.139). Conclusions The results showed a significant correlation between respirable dust exposure intensity and the level of EBC-MDA of the exposed subjects. However, our results did not show a significant correlation between lung function decreases and EBC-MDA.

3

Inference of oxidative stress in patients with hypothyroidism

70%

Rada F.

European Journal of Clinical and Experimental Medicine

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2024

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tom 22

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nr 2

270-274

EN

Introduction and aim. Oxidative stress is one of the complications that accompany defects in thyroid hormone levels. This study was designed to evaluate oxidative stress markers in patients with hypothyroidism. Material and methods. This case control study was comprised of forty-two hypothyroid patients aged 36–46 years and forty age matched (35–43 years) healthy control participants randomly selected from the Endocrine Clinic of Al-Yarmook Hospital in Iraq. Blood levels of thyroid hormones malondialdehyde, glutathione, and paraoxonase-1 were assessed. Body mass index was calculated for each patient and control participant. Results. Regarding the data of oxidative stress markers in hypothyroid patients compared to controls, a significant elevation was reported in blood levels of malondialdehyde and a significant reduction was found in blood levels of glutathione (p=0.031). On the other hand, the blood levels of paraoxonase-1 were significantly different in hypothyroid patients compared with the control. Conclusion. Elevated blood levels of malondialdehyde and declined blood levels of glutathione in hypothyroid patients are a signal of oxidative stress and consequently increase the risk of cardiovascular complications.

4

INFLUENCE OF SELENIUM ON OXIDATIVE STRESS IN ATHLETES. REVIEW ARTICLE

70%

Sieja K. , von Mach-Szczypińska J. , Kois N. , Ler P. , Piechanowska K. , Stolarska M.

Central European Journal of Sport Sciences and Medicine

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2016

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tom 14

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nr 2

87 - 92

EN

The aim of the study was to analyze the influence of selenium (Se) on the course of oxidative stress in trained athletes, on the basis of own former published studies and the reference of literature. In a number of references it was shown that the application of Se led to the diminishing of oxidative stress during the physical exercises in athletes. The application of Se to athletes − led to the increase of peroxidase glutathione the main selen − dependent enzyme. The fact of increased concentration of malondialdehyde (MDA) in blood serum, the main metabolite of lipid peroxidation can indirectly evidence about the intensity of physical endurance. This increase is significantly smaller in individuals taking exogenous antioxidative diet supplement containing Se. Moreover there is the evidence that oxidative muscles damage during physical effort could be diminished by compounds with antioxidative properties. Taking into consideration, the obtained results by many of authors empower to the conclusion that application of Se diminishes the degree of peroxidation of lipids in trained athletes.

5

Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction

70%

Omon E. A. , Ajay O. D.

European Journal of Clinical and Experimental Medicine

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2023

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nr 4

768-775

EN

Introduction and aim. Thyroid hormone abnormalities have been associated with oxidative changes in human beings. The aim of the study was to evaluate the oxidative stress marker and antioxidants status in individuals with thyroid hormone dysfunction in Ekiti State. Material and methods. A total of eighty samples were recruited in this study comprising forty subjects with thyroid hormones dysfunction and forty apparently healthy controls. Malondialdehyde (MDA), reduced glutathione (GSH) and catalase were determined spectrophotometerically. Results. MDA was non-significantly higher (p>0.05) in subjects (4.33±0.84 nmol/mL) compared with control (4.12±0.63 nmol/mL), catalase was non-significantly higher (p>0.05) in subjects (199.36±20.21 µm/mL) compared with control (181.55±16.61 µm/mL), while GSH was significantly lower (p<0.05) in subjects (79.31±10.12 µmol/mL) compared with control (127.21±7.29 µmol/mL). Conclusion. It can be concluded that the increase in the reactive oxygen species accompanied with impairment of the antioxidant system occurs in patients with thyroid hormone dysfunction. Hypothyroidism and hyperthyroidism induces disequilibrium of the oxidative/anti-oxidative balance that can lead to subsequent development of inflammation and associated diseases.

6

Physiological and Biochemical Responses of Fern Nephrolepis Biserrata (Sw.) Schott. to Coccus Hesperidum L. Infestation

60%

Golan K. , Rubinowska K. , Górska-Drabik E.

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tom 55

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nr 1

7

Influence of melatonin supplementation on serum antioxidative properties and impact of the quality of life in multiple sclerosis patients

60%

Adamczyk-Sowa M. , Pierzchala K. , Sowa P. , Polaniak R. , Kukla M. , Hartel M.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 4

8

Authors’ response (September 1, 2017) to the letter to the Editor concerning the paper “Impact of electromagnetic radiation emitted by monitors on changes in the cellular membrane structure and protective antioxidant effect of vitamin A – In vitro study”

60%

Lewicka M. , Henrykowska G. , Zawadzka M. , Rutkowski M. , Pacholski K. , Buczyński A.

International Journal of Occupational Medicine and Environmental Health

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2017

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tom 31

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nr 3

373-375

EN

-

9

Influence of electromagnetic field (1800 MHz) on lipid peroxidation in brain, blood, liver and kidney in rats

60%

Bodera P. , Stankiewicz W. , Antkowiak B. , Paluch M. , Kieliszek J. , Sobiech J. , Niemcewicz M.

International Journal of Occupational Medicine and Environmental Health

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2015

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tom 28

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nr 4

751-759

EN

Objectives The aim of this study is the evaluation of the influence of repeated (5 times for 15 min) exposure to electromagnetic field (EMF) of 1800 MHz frequency on tissue lipid peroxidation (LPO) both in normal and inflammatory state, combined with analgesic treatment. Material and Methods The concentration of malondialdehyde (MDA) as the end-product of the lipid peroxidation (LPO) was estimated in blood, liver, kidneys, and brain of Wistar rats, both healthy and those with complete Freund’s adjuvant (CFA)-induced persistent paw inflammation. Results The slightly elevated levels of the MDA in blood, kidney, and brain were observed among healthy rats in electromagnetic field (EMF)-exposed groups, treated with tramadol (TRAM/EMF and exposed to the EMF). The malondialdehyde remained at the same level in the liver in all investigated groups: the control group (CON), the exposed group (EMF), treated with tramadol (TRAM) as well as exposed to and treated with tramadol (TRAM/EMF). In the group of animals treated with the complete Freund’s adjuvant (CFA) we also observed slightly increased values of the MDA in the case of the control group (CON) and the exposed groups (EMF and TRAM/EMF). The MDA values concerning kidneys remained at the same levels in the control, exposed, and not-exposed group treated with tramadol. Results for healthy rats and animals with inflammation did not differ significantly. Conclusions The electromagnetic field exposure (EMF), applied in the repeated manner together with opioid drug tramadol (TRAM), slightly enhanced lipid peroxidation level in brain, blood, and kidneys.

10

Impact of electromagnetic radiation emitted by monitors on changes in the cellular membrane structure and protective antioxidant effect of vitamin A – In vitro study

60%

Lewicka M. , Henrykowska G. , Zawadzka M. , Rutkowski M. , Pacholski K. , Buczyński A.

International Journal of Occupational Medicine and Environmental Health

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2017

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tom 30

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nr 5

695-703

EN

Objectives The increasing number of devices emitting electromagnetic radiation (EMR) in people’s everyday life attracted the attention of researchers because of possible adverse effects of this factor on living organisms. One of the EMR effect may be peroxidation of lipid membranes formed as a result of free radical process. The article presents the results of in vitro studies aimed at identifying changes in malondialdehyde (MDA) concentration – a marker of lipid peroxidation and antioxidant role of vitamin A during the exposure of blood platelets to electromagnetic radiation generated by liquid-crystal-display (LCD) monitors. Material and Methods Electromagnetic radiation emitted by LCD monitors is characterized by parameters: 1 kHz frequency and 220 V/m intensity (15 cm from display screen). The time of exposure was 30 and 60 min. The study was conducted on porcine blood platelets. The samples were divided into 6 groups: unexposed to radiation, unexposed + vitamin A, exposed for 30 min, exposed for 30 min + vitamin A, exposed for 60 min, exposed for 60 min + vitamin A. Results The MDA concentration in blood platelets increases significantly as compared to control values after 60 min of exposure to EMR. A significant decrease in MDA concentration after the addition of vitamin A was noticed. In the blood samples exposed to EMR for 30 and 60 min the MDA concentration was significantly increased by addition of vitamin A. Conclusions The results show the possibly negative effect of electromagnetic radiation on the cellular membrane structure manifested by changes in malondialdehyde concentration and indicate a possible protective role of vitamin A in this process. Int J Occup Med Environ Health 2017;30(5):695–703

11

Glutathione and GSH-dependent enzymes in patients with liver cirrhosis and hepatocellular carcinoma

60%

Czeczot H. , Ścibior D. , Skrzycki M. , Podsiad M.

Acta Biochimica Polonica

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2006

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tom 53

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nr 1

237-242

EN

We investigated glutathione level, activities of selenium independent GSH peroxidase, selenium dependent GSH peroxidase, GSH S-transferase, GSH reductase and the rate of lipid peroxidation expressed as the level of malondialdehyde in liver tissues obtained from patients diagnosed with cirrhosis or hepatocellular carcinoma. GSH level was found to be lower in malignant tissues compared to adjacent normal tissues and it was higher in cancer than in cirrhotic tissue. Non-Se-GSH-Px activity was lower in cancer tissue compared with adjacent normal liver or cirrhotic tissue, while Se-GSH-Px activity in cancer was found to be similar to its activity in cirrhotic tissue and lower compared to control tissue. An increase in GST activity was observed in cirrhotic tissue compared with cancer tissue, whereas the GST activity in cancer was lower than in adjacent normal tissue. The activity of GSH-R was similar in cirrhotic and cancer tissues, but higher in cancer tissue compared to control liver tissue. An increased level of MDA was found in cancer tissue in comparison with control tissue, besides its level was higher in cancer tissue than in cirrhotic tissue. Our results show that the antioxidant system of cirrhosis and hepatocellular carcinoma is severely impaired. This is associated with changes of glutathione level and activities of GSH-dependent enzymes in liver tissue. GSH and enzymes cooperating with it are important factors in the process of liver diseases development.

12

Effect of extremely low frequency electromagnetic fields on cell proliferation, antioxidative enzyme activities and lipid peroxidation in 3T3-L1 preadipocytes - an in vitro study

60%

Zwirska-Korczala K. , Jochem J. , Adamczyk-Sowa M. , Sowa P. , Polaniak R. , Birkner E. , Latocha M. , Pilc K. , Suchanek R.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 6

101-108

EN

The exposure to extremely low frequency electromagnetic field (ELF-MF, frequencies less than 200-300 Hz) can alter the transcription and translation of genes, influence the cell proliferation rate and affect enzyme activities. Moreover, the hypothesis that ELF-MF increases free oxygen metabolites generation has been proposed. Since recent in vivo studies suggest that electric and magnetic fields are able to affect adipose cells metabolism. The aim of the study was to examine the effects of ELF-MF (frequency of basic impulse 180-195 Hz, induction 120 µT) on cell proliferation, antioxidative enzyme activities and malondialdehyde (MDA) concentration in 3T3-L1 preadipocyte cell culture. We found that ELF-MF application lasting 36 minutes daily failed to influence cell count after 24h and 48 h of incubation. After 24 h, in the ELF-MF treated group, manganese- and copper-zinc-containing superoxide dismutase (MnSOD and Cu/ZnSOD) isoenzymes media activities were decreased, catalase activity was increased, whereas there were no significant differences in glutathione peroxidase (GSH-Px) and glutathione reductase (GSSG-Rd) activities in comparison to the control. After 48 h of incubation, all enzyme activities were reduced, except for GSSG-Rd, in which no changes were noticed. MDA concentration at 24 h after incubation with the exposure to ELF-MF was significantly higher in comparison to the control, without ELF-MF. After 48 h of incubation, MDA levels were significantly lower in both groups with no differences between the groups without and with ELF-MF. We conclude that ELF-MF influences antioxidative enzyme activities and increases lipid peroxidation in 3T3-L1 preadipocyte cultures.

13

Ocena wpływu promieniowania elektromagnetycznego monitorów ekranowych LCD na krwinki płytkowe człowieka

60%

Lewicka M. , Henrykowska G. , Dziedziczak-Buczyńska M. , Buczyński A. , Pacholski K.

Przegląd Elektrotechniczny

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2013

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tom R. 89, nr 5

318-321

PL

Skutki negatywnego oddziaływania promieniowania elektromagnetycznego na organizm człowieka są w ostatnich latach przedmiotem wielu badań. W artykule przedstawiono wyniki badań in vitro mających na celu określenie wpływu promieniowania elektromagnetycznego generowanego przez monitory LCD na proces peroksydacji błon lipidowych krwinek płytkowych.

EN

Effect of negative electromagnetic radiation on human body is the aim a numerous of studies. The paper presents result in vitro studies of assessing the effect of electromagnetic radiation generated by a display screens on blood platelets lipid peroxidation.

14

Oxidative stress and cytotoxicity elicited lipid peroxidation in hemocytes of Bombyx mori larva infested with dipteran parasitoid, Exorista bombycis

60%

Pooja M. , Pradeep A. N. R. , Hungund S. P. , Sagar C. , Ponnuvel K. M. , Awasthi A. K. , Trivedy K.

Acta Parasitologica

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2017

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tom 62

|

nr 4

15

Occupational health surveillance: pulmonary function testing and oxidative stress among photocopying workers in Pakistan

60%

Javed H. , Ghani N. , Ghani N. , Fatima A.

Medycyna Pracy

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2019

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tom 70

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nr 4

403-410

EN

Background The photocopying occupation contributes to various health issues in workers. Elevated levels of oxidative stress have been found to be associated with respiratory problems in occupational workers. The intention of the current research is to evaluate the association between the pulmonary function parameters, a biomarker of oxidative stress, and the photocopying occupation in Lahore, Pakistan. Material and Methods The study was performed on a group of photocopying operators (N = 100) and a control group (N = 100). A structured questionnaire was developed to gather the demographic attributes. Lung function testing was done with the spirometer. The blood lipid peroxides level, as thiobarbituric acid reactive substances (TBARS), was assessed spectrophotometrically. Results A statistically significant reduction was found in the pulmonary function parameters as compared to the control group. In the study group, the prevalence of respiratory symptoms, including cough (31%), sneezing (18%), wheezing (9%) and breathing issues (19%), was high as compared to the control group. A significantly higher plasma TBARS concentration was observed in the photocopying workers. A negative correlation prevailed between FVC (−0.081), FVC% predicted (−0.038) and FEV1 (−0.043), and the duration of exposure. Conclusions The study showed that the occupational exposure could have a significant effect on the normal pulmonary function and the oxidative potential of well-being. The profound emissions in the vicinity of photocopying centers may be responsible for the variations in the pulmonary function parameters and oxidative stress. Med Pr. 2019;70(4):403–10

16

Changes in malondialdehyde level and catalase activity and effect of toltrazuril on these parameters in chicks infected with Eimeria tenella

60%

Eraslan G. , Cam Y. , Eren M. , Liman B. C.

Bulletin of the Veterinary Institute in Puławy

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2004

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tom 48

|

nr 3

17

The effect of nafamostat mesilate [FUT-175] and gabexate mesilate [FOY] on multiorgan oxidant-antioxidant balance in acute experimental pancreatitis

60%

Dabrowski A. , Gabryelewicz A.

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nr 3

18

Organophosphate insecticide chlorfenvinphos affects superoxide dismutase, catalase and malondialdehyde in rat liver

60%

Lukaszewicz-Hussain A.

Polish Journal of Environmental Studies

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2001

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tom 10

|

nr 4

EN

The aim of this paper was to study the activity of liver superoxide dismutase and catalase and the concentration of liver malondialdehyde in rats intoxicated with chlorfenvinphos, an organophosphate widely used as an insecticide. The study was carried out on male Wistar rats weighing 180-230 g. The rats were divided into two groups: examined - receiving oil solution of chlorfenvinphos in doses of 0.5 LD50, and 0.1 LD50, and control group - receiving oil. The activity of superoxide dismutase (SOD), catalase (CAT) and concentration of malondialdehyde (MDA) were determined after 1, 24 and 48 hours of intoxication. We observed an increase in the liver activity of SOD in further period of intoxication with chlorfenvinphos in both doses and a decrease of liver SOD activity in the rats intoxicated with the higher dose. The CAT activity in liver of the treated rats increased at the 1st hour of experiment with a dose of 0.5 LD50 and at the Ist hour and the 24th hour after intoxication with a dose 0.1 LD50. Hepatic concentration of MDA showed a decrease at the 24th hour of intoxication with chlorfenvinphos and an increase at the 48th hour of intoxication with the higher dose and returned to control value for the rats intoxicated with the lower dose. SOD and CAT play a major role in the maintaince of the physiological level of reactive form of oxygen. When reactive oxygen species generation exceeds capability of redox degrading systems, MDA levels increase. The results obtained suggest that reactive oxygen species in liver injury might be caused by chlorfenvinphos.

19

The role of reactive oxygen species in action of nitric oxide-donors on stress-induced gastric mucosal lesions

60%

Kwiecien S. , Brzozowski T. , Konturek P. C. , Konturek S. J.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 4,2

EN

The experimental model of acute gastritis such as water immersion restraint (WRS) stress-induced gastric injury is useful tool in examination of pathomechanism of acute gastritis. Nitric oxide (NO) plays an important role in the maintenance of gastric barrier, however, the interaction between reactive oxygen species (ROS) and NO on gastric mucosal integrity has been little studied. The purpose of our present study was to explain the participation of ROS in healing of WRS-induced gastric lesions accelerated by NO. Experiments were carrying out on 120 male Wistar rats. To assess gastric blood flow (GBF) laser Doppler flowmeter was used and the number of gastric lesions was counted in each stomach. The colorimetric assays were used to determine gastric tissue level of malondialdehyde (MDA) and 4- hydroxynonenal (4-HNE), the products of lipid peroxidation by ROS, as well as superoxide dismutase (SOD) activity, the enzyme scavanger of ROS. We demonstrated that 3.5 h of WRS resulted in appearance of acute gastric lesions accompanied by a significant decrease of GBF. Biological effects of ROS were estimated by measuring tissue levels of MDA and 4-HNE, as well as the SOD activity. It was demonstrated that 3.5 h of WRS led to significant increase of mucosal levels of MDA and 4-HNE, and it was accompanied by a decrease of SOD activity. Pretreatment with NO-donors (SIN-1, SNAP, nitroglycerin, NO-ASA) resulted in reduction in gastric lesion number, increment of GBF, decrease of MDA and 4-HNE tissue level and increase of SOD activity. Suppression of ROS plays an important role in the action of NO-donors on healing of acute gastric lesions induced by 3.5 h of WRS. NO-donors caused an attenuation of lipid peroxidation as documented by a decrease of MDA and 4-HNE levels and enhancement of antioxidative properties as evidenced by an increase of SOD activity.

20

Malondialdehyde as an indicator of the rancidity of fat used to enrich feed concentrates

60%

Zdunczyk Z. , Wroblewska M. , Juskiewicz J. , Brzuzan L. , Jankowski J.

Natural Sciences

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2000

|

tom 05