Wyniki wyszukiwania - Biblioteka Nauki

1

Efficiency of modified therapeutic protocol in the treatment of some varieties of canine cardiovascular dirofilariasis

100%

Stepanovic P. , Ilic T. , Krstic N. , Dimitrijevic S.

Bulletin of the Veterinary Institute in Puławy

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2015

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tom 59

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nr 4

EN

The paper presents clinical diagnostic approaches and therapeutic effects of a specific protocol for the treatment of dogs with cardiovascular dirofilariasis in the Belgrade City (Serbia) territory. The study involved 50 privately owned dogs of different breeds, gender, and age, all showing signs of cardio - respiratory disorders. In addition to a general physical examination, blood tests were done to detect microfilaria and adult forms, and X-ray, ECG, and echocardiography were performed as well. At the first examination, 34 out of 50 examined dogs were positive for microfilaria and adult forms. Because of a lack of drug used as „the golden standard" in dirofilariasis treatment, it involved a combination of doxycycline (10 mg/kg) and ivermectin (6 (µg/kg) supported with Advocate - Bayer spot-on. After six months, the first control was performed while continuing treatment with the aforesaid protocol, and the second control was performed after 12 months. Of the 34 treated dogs, all were negative for microfilaria, as early as after the first six months of the treatment (100%). One dog was positive for adult forms of the parasite after six and 12 months. In echocardiography and X-ray examination after 12 months, six dogs showed evident chronic changes. At controls conducted at sixth month and at one year, the implemented therapy was successful in 97.05% (33/34) of primarily infected dogs.

2

Ivermectin vs. lindane in the treatment of scabies

100%

Goldust M. , Rezaee E. , Raghifar R. , Naghavi-Behzad M.

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nr 1

EN

Scabies is commonly treated with acaricides but the treatment of choice is still controversial. This study aimed at comparing the efficacy of oral ivermectin vs. lindane lotion 1% for the treatment of scabies. Four hundred fourty patients with scabies were enrolled, and randomized into two groups: the first group received a single dose of oral ivermectin 200 μg/kg body weight, and the second group were treated with two applications of topical lindane lotion 1%, with a 1-week interval. Treatment was evaluated at intervals of 2 and 4 weeks, and if there was treatment failure at the 2-week follow-up, treatment was repeated. Single dose of oral ivermectin provided a cure rate of 63.6% at the 2-week follow-up, which increased to 81.8% at the 4-week follow-up after repeating the treatment. Treatment with two applications of lindane lotion 1%, with a 1-week interval between them, was effective in 45.4% of patients at the 2-week follow-up, which increased to 63.6% at the 4-week follow-up after this treatment was repeated. Single dose ivermectin was as effective as two applications of lindane lotion 1% at the 2-week follow-up. After repeating the treatment, ivermectin was superior to lindane lotion 1% at the 4-week follow up.

3

Application of ivermectin in microdoses for the treatment of bovine hypodermosis

100%

Ziomko I. , Cencek T.

Wiadomości Parazytologiczne

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1998

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tom 44

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nr 3

4

Seasonal dynamics of gastrointestinal nematode infections of goats and emergence of ivermectin resistance in Haemonchus contortus in Hubei Province, China

84%

Yuan W. , Lu K. , Li H. , Liu J. , He C. , Feng J. , Zhang X. , Mao Y. , Hong Y. , Zhou Y. , Lu J. , Jin Y. , Lin J.

Acta Parasitologica

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2019

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tom 64

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nr 3

5

Haemonchus contortus susceptibility and resistance to anthelmintics in naturally infected Egyptian sheep

84%

Aboelhadid S. M. , Arafa W. M. , El-Ashram S. , Noaman A. F. , Shokier K. A. , Darwish A. B. , Mahmoud M. M. , Gadelhaq S. M.

Acta Parasitologica

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2021

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tom 66

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nr 2

6

Opracowanie metody oznaczania iwermektyny w jadalnych tkankach zwierzat rzeznych

67%

Oledzka I. , Kowalski P.

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tom 38

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nr Supl.

387-390

PL

Opracowano metodą oznaczania iwermektyny w surowicy i tkankach jadalnych zwierząt z zastosowaniem elektroforezy kapilarnej, którą poddano ocenie statystycznej. Proces walidacji uwzględniał następujące elementy: liniowość w zakresie od 1 do 20 µg/kg, czułość, specyficzność, dokładność i precyzję metody. Odzysk analitu w procesie ekstrakcji wynosił 80,2%. Granicę wykrywalności ustalono na 0,3 µg/kg a oznaczalności ilościowej na 1 µg/kg.

EN

In this work the capillary clectrophoretic method, with liquid-liquid extraction, for the isolation and determination of the ivermectin in animal serum and tissues is presented. Ivermectin is a drug with a broad spectrum of activity against nematodes and arthropod parasites in food-producting animals such as sheep, cattle, pigs, horses. The method was statistically validated for its linearity, accurancy, precision and selectivity. A typical standard curve encompassing a range of 1 to 20 µg/kg ivermectin was linear (correlation coefficient r=0.9992). The lowest level validated in scrum and tissue by the method was 1 µg/kg and the limit of detection was 0.3 µg/kg. The average recovery from samples was 80.72%. The inter-assay precision was expressed as the mean SD and relative standard deviation (RSD). This characteristics make this method attractive when compared to classical isolation and determination procedures for ivermectin. The analytical method was successfully applied to determination for ivermectin residue in tissues and for pharmacokinetic studies.

7

Treatment of experimental Toxocara cati infection in mice with ivermectin and moxidectin

67%

Esatgil M. U.

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tom 51

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nr 3

EN

The aim of this study was to investigate the efficacy of two efficient macrocyclic lactone drugs, ivermectin, and moxidectin, on the numbers and distribution of Toxocara cati larvae in experimentally infected mice. Different post-infection periods (48 h and 7 d) and different administration methods (oral and subcutaneous) were compared. Ivermectin and moxidectin were tested (0.2 mg/kg with a single dose) for their larvicidal effects. Each mouse was infected with 1 000- embryonated eggs of T. cati. On the 10 d of the infection, the mice in each treatment group and the control group were sacrificed and the presence of T. cati larvae in various organs were determined and compared between groups. Statistically, the treatment regimens in all treatment groups were successful as compared with the controls. The worst results were achieved in the group in which ivermectin was given orally 7 d following egg inoculation. According to the decrease in total larvae recovery, oral administration of moxidectin 48 h following egg inoculation displayed the highest efficacy. The effect of ivermectin administered subcutaneously 7 d following infection was more effective than subcutaneous application of moxidectin after both 48 h and 7 d.

8

Efficacy of ivermectin against cattle warbles in Pakistan

67%

Khan M. Q. , Afzal M. , Khan M. I.

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tom 42

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nr 3

EN

Efficacy of ivermectin against cattle warbles was studied in an endemic area of Pakistan. A total of 229 cattle of three breeds and different ages were divided into two groups; treated and untreated control. Treated group was given ivermectin s/c at the rate of 200 µg/kg body weight during the 1st week of September. None of the treated animal developed warbles. Warbles were seen in 23,8% of untreated control animals. Statistically non-significant differences were seen amongst different breeds and age groups. The seasonality of warbles is discussed.

9

Wystepowanie nicieni pasozytniczych u zubrow hodowanych zagrodowo i ich zwalczanie z uzyciem iwermektyny

59%

Jasinski K. , Pacon J. , Zawadzki W.

Acta Scientiarum Polonorum. Medicina Veterinaria

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2007

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tom 06

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nr 3

11-16