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Manganese and iron accumulation in a eutrophic, submontane dam reservoir - the role of speciation

100%

Szarek-Gwiazda E.

Oceanological and Hydrobiological Studies

2005

tom 34

nr 3

Effect of selenium on Mg2plus, Fe3plus, Mn2plus, Cu2plus, Zn2plus accumulation in Zea mays L. treated by ABA

84%

Pazurkiewicz-Kocot K. , Kita A.

Acta Physiologiae Plantarum

2007

tom 29

nr 1 Suppl.

Stress-induced behaviour in adult and old rats: effects of neonatal asphyxia, body temperature and chelation of iron

67%

Rogalska J. , Caputa M. , Wentowska K. , Nowakowska A.

Journal of Physiology and Pharmacology. Supplement

2006

tom 57

nr 8

17-34

Perinatal asphyxia in mammals leads to iron accumulation in the brain, which results in delayed neurobehavioural disturbances, including impaired learning and abnormal alertness over their entire life span. The aim of this investigation was to verify our hypothesis that newborn rats, showing reduced normal body temperature, are protected against neurotoxicity of the asphyxia up to senescence. Alertness was studied in adult and old male Wistar rats after exposure to critical neonatal anoxia: (i) at physiological neonatal body temperature of 33°C, (ii) at body temperature elevated to 37°C, or (iii) at body temperature elevated to 39°C (the thermal conditions remained unchanged both during anoxia and for 2 h postanoxia). To elucidate the effect of iron-dependent postanoxic oxidative damage to the brain, half of the group (iii) was injected with deferoxamine, a chelator of iron. Postanoxic behavioural disturbances were recorded in open-field, elevated plus-maze, and sudden silence tests when the rats reached the age of 12 and 24 months. Open-field stress-induced motor activity was reduced in rats subjected to neonatal anoxia under hyperthermic conditions. In contrast, these rats were hyperactive in the plus-maze test. Both the plus-maze and sudden silence tests show reduced alertness of these rats to external stimuli signalling potential dangers. The behavioural disturbances were prevented by body temperature of 33°C and by administration of deferoxamine.

Dynamika kumulacji zelaza w skorze, miesniach i watrobie krolikow

51%

Maciejewska-Paszek I. , Grochowska-Niedworok E. , Pawlowska-Goral K. , Wardas M.

Bromatologia i Chemia Toksykologiczna

2005

tom 38

nr Supl.

269-274

Podawanie królikom codziennie domięśniowo farmakologicznego preparatu żelaza w ilości 6 mg/kg m.c./dobę doprowadziło po 90 dniach do jego kumulacji w wątrobie, skórze i mięśniach. Stwierdzono, iż wątroba i skóra najintensywniej kumulują żelazo między 3 a 10 dniem, zaś mięśnie w pierwszych trzech dniach eksperymentu.

The experiment was carried out on chinchilla rabbits. The rabbits were given (in the form of injection) "Jectofer" - an iron specimen; the amount of the injected specimen was 6 mg/kg of body mass per day for 3, 10 and 90 days. The amount of iron was determined in mineralised skin samples, in thigh muscle and liver by means of atomic absorption spectroscopy (AAS). It was observed that the time of exposition on iron ions influenced its amounts in the examined organs Conscquently, after 90 days of the experiment it was noted that the amount of iron grew 5 times in liver of the examined animals, 4 times in their skin and less than 2 times in their muscles. It was also noted that the muscles and liver accumulated iron the most intensively between the 3rd and the 10th day of the experiment, and that the skin accumulated iron the most intensively during the first three days. These results prove that excessive supply of iron leads to its accumulation in the organism with different intensity and dynamics for different organs.