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Tissue insulin sensitivity measurements in men. Quality factors and performance determinants for successful clamp experiments. Design and development of the TISS system and its clinical verifications

100%

Wójcicki J. M. , Ładyżyński P. , Foltyński P. , Mikulicz H. , Blachowicz J.

Biocybernetics and Biomedical Engineering

2002

tom Vol. 22, no. 2-3

129-144

Insulin sensitivity (IS) is one of the important diagnostic parameters used in treatments of diabetes, hypertension and other diseases as well as during evaluation of new drug therapies. Euglycaemic glucose clamp is the most accurate method of the IS measurement. Effectiveness of this procedure depends on accuracy of the tissue glucose utilization measurements (GU) and proper realization of the insulin infusion. Application of the accurate glucose control algorithm, sampling site, sampling frequency, duration of the procedure are also very important factors. Possible technical realization includes manual, semi-automatic and automatic modes. Recently the computerized semi-automatic system realizing this type of measurement has been designed and developed in the IBBE PAS. A developed system consist of control unit, infusion unit, glycaemia measurement unit and printer. Endogenous glucose secretion is suppressed by insulin infusion, which is determined according to individual patients parameters. The newest version of the measurement procedure allows to realize euglycaemic or normoglycaemic clamp studies. TISS system is inexpensive and easily operated by one person from middle medical staff. Till now GU measurements using TISS system were performed on over 200 patients in 4 Polish clinical centers. Developed and clinically tested TISS system seems to provide satisfying quality of the GU measurement in men.

The effect of cadmium intoxication on glucose utilization in skeletal muscle of the rats adapted to the exercise

75%

Kielan Z. , Ziolkowska B. , Falkus B. , Jethon Z.

Acta Biologica Silesiana

1990

tom 15

Leptin does not seem to influence glucose uptake by bovine mammary explants

75%

Accorsi P. A. , Gamberoni M. , Isani G. , Govoni N. , Viggiani R. , Monari M. , De Ambrogi M. , Munno A. , Tamanini C. , Seren E.

Journal of Physiology and Pharmacology

2005

tom 56

nr 4

Leptin, a protein produced and secreted by adipocytes, is know to regulate food intake and whole-body energy metabolism, but knowledge about its possible effect in bovine mammary gland is scarce. Leptin may be involved in the regulation of glucose transport even though this effect at the tissue level remains controversial. Once uptaken by the mammary gland, glucose is utilised in several ways but the majority, about 60-70%, is drained for lactose synthesis. This study was aimed at investigating the effect of leptin on glucose regulation in bovine mammary gland. We have examined the effects of leptin on the expression of GLUT1 mRNA, pyruvate kinase (PK) as well as glucose-6-phosphate dehydrogenase (G6PDH) activity. Treatment of mammary gland explants with recombinant leptin did not influence glucose assimilation, pathway transport (GLUT1 mRNA) and glucose metabolism (PK and G6PDH) in this tissue. The results from this study seem to exclude an involvement of leptin in glucose uptake and metabolism in bovine mammary gland.

Potentiation of adipogenesis and insulinomimetic effects of a novel vanadium complex (N′-[(E)-(5-bromo-2oxophenyl)methylidene]-4methoxybenzohydrazide)oxido(1,10phenanthroline)vanadium(IV) in 3T3-L1 cells

63%

Kazek G. , Głuch-Lutwin M. , Mordyl B. , Menaszek E. , Szklarzewicz J. , Gryboś R. , Papież M.

Science, Technology and Innovation

2019

tom Vol. 4, no. 1

55--62

Recent research on the action of vanadium compounds shows its important effect on adipogenesis processes and adipocyte function. On the basis of previous screening tests in cellular models, the novel vanadium complex (N′-[(E)-(5-bromo-2-oxophenyl)methylidene]4-methoxybenzohydrazide)oxido(1,10-phenanthroline)vanadium(IV) was selected for this study. This complex exhibits potent inhibition of tyrosine phosphatases, and differences in the degree of inhibition were observed particularly for phosphatases. A significant increase in intracellular lipid accumulation and proliferative effect on 3T3-L1 preadipocytes confirmed the ability of this complex to enhance adipogenesis. The insulinomimetic activity of the tested complex was also demonstrated in fully differentiated 3T3-L1 adipocytes, in which glucose utilization was potentiated. The obtained results support the hypothesis that vanadium complexes show promising possibilities for use as new therapeutic strategies for the treatment of type 2 diabetes.

Batch propionic acid fermentation using Propionibacterium sp. immobilized in different supports

51%

Czaczyk K. , Trojanowska K.

Biotechnologia

1998

nr 1

Carrageenan as a support material for immobilization of propionic acid bacteria

51%

Czaczyk K. , Trojanowska K.

Food Science and Technology. Scientific Papers of Agricultural University of Poznan

1998

tom 02