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Modulators of intracellular sodium concentration affect contractile vacuole activity in ciliate Blepharisma japonicum

100%

Fabczak H. , Fabczak S.

Acta Protozoologica

1989

tom 28

nr 3-4

Surface oscillations in Physarum polycephalum - computer simulation and comparison with the local influence of the respiratory inhibitors

100%

Mazur A. , Teplov V. A.

Acta Protozoologica

1991

tom 30

nr 2

The influence of nitric oxide on the contractile activity of the isolated porcine ovarian and uterine arteries

100%

Barszczewska B. , Jaroszewski J. J.

Polish Journal of Veterinary Sciences

2004

tom 07

nr 2

The influence of inflammatory process on prostaglandin F2alpha contractile activity in porcine uterus

100%

Kucharski J. , Jaroszewski J. , Jana B. , Gorska J. , Kozlowska A. , Markiewicz W.

Journal of Animal and Feed Sciences

2007

tom 16

nr 4

654-667

Regulation of endogenous contractile activity of Tenebrio molitor oviduct by biologically active compounds

84%

Chowanski S. , Lubawy J. , Rosinski G.

Acta Biologica Cracoviensia. Series Botanica. Supplement

2014

tom 56

nr 1

In vitro contractile activity of porcine myometrium during luteolysis and early pregnancy: effect of oxytocin and progesterone

84%

Kurowicka B. , Franczak A. , Oponowicz A. , Kotwica G.

Reproductive Biology

2005

tom 05

nr 2

The effect of sarcoplasmic reticulum Ca2+ leak on contractile activity of guinea pig heart myocytes depends on activity of sarcoplasmic reticulum Ca2+-ATPase and Na+/Ca2+ exchanger

84%

Mackiewicz U. , Lewartowski B.

Journal of Physiology and Pharmacology

2008

tom 59

nr 2

Decreased expression of sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA), overexpression of Na+/Ca2+ exchanger (NCX) and diastolic SR Ca2+ leak from the ryanodine receptors (RyRs) are believed to contribute to the decrease of myocyte contraction in failing heart. In this work we induced Ca2+ leak through RyRs in isolated myocytes of guinea pig hearts by 20µM FK-506. The SR Ca2+ leak resulted in (1) decreased amplitude of cell shortening and of Ca2+ transients, (2) decreased rate of Ca2+ transients decay (3) enhanced diastolic Ca2+ loss. The effect of FK-506 on amplitude of cell shortening was reversed and that on diastolic Ca2+ loss blocked by partial inhibition of NCX due to lowering Na+ concentration in superfusion solution from 144 mM to 100 mM. The amplitude of cell shortening and Ca2+ transients decreased by FK-506 was significantly increased by 10-7 M thapsigargin. In conclusion, the effect of SR Ca2+ leak induced by FK-506 on myocyte contraction is strictly dependent on activity of SERCA and NCX.