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Background. Diseases of the cardiovascular system (CVS) are among the most common diseases of humankind (WHO). Monitoring of blood pressure (BP) is an accessible method for evaluating global hemodynamic processes. The functional reserves of the circulatory system are traditionally determined by the use of functional loading trials and tests. Objectives. The aim of the study is to enhance the information collected during the blood pressure measurement process by studying the levels of adaptation of the CVS to physical activity with morphological, temporal, spectral and correlation analyses of arterial oscillography (AO). Material and methods. In 178 healthy individuals aged 18–20 years, arterial oscillograms were recorded during blood pressure measurement and correlations of the functional reserve of the cardiovascular system at various stages of adaptation to a Ruffier test were investigated. Results. The proposed methods of AO analysis significantly increase the informativeness of the procedure for blood pressure measurement, provide an opportunity to conduct a visual analysis of AOs and to assess the state of the cardiovascular system, its reserve capabilities and its ways of adapting to shoulder compression at rest, after physical load and in the process of recovery. Conclusions. Using the information technologies proposed by the authors of the morphological, temporal, spectral and correlation analysis of arterial oscillograms, their evaluation and clinical interpretation significantly increase the informativeness of the blood pressure measuring process. They can be used for early detection of pre-morbid conditions and functional blood circulation reserves, which will help the physician to more effectively plan a preventative, diagnostic and therapeutic process.
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Introduction The aim of the study was to analyze the changes in the indices of the autonomic nervous system and the adaptive capacity of Ukrainian Super League handball players prior to significant competitions. Material and methods This research involved 39 handball players from the Ukrainian Super League aged 18–22 years old. The study examined the overall tone of the autonomic nervous system (ANS ) measuring electrodermal activity of the athletes. Reactivity of the ANS of players was monitored by the method of R. Baevskyy, the efficiency of competitive activity in handball was analyzed by the integral index of technical and tactical handball skills. Results Before the competition, the reaction in the sympathoadrenal system was launched for vagotonics as the intended response to the upcoming games. The measured indicators marked mental stress and activation of the sympathoadrenal system for the sympathotonics group. The аtonics group provided the emotional ground due to the balanced influence of para- and sympathetic divisions of the autonomic nervous system. Conclusions The index of functional changes in all participants detected a satisfactory level of adaptation. The highest sympathetic activity was observed for аtonics, the lowest – for vagotonics. The best results were documented for athletes who did not have autonomic dysfunction and those who had a slight predominance of the sympathetic component of the autonomic regulation.
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Content available remote Angiotensin-(1-7): an active member of the renin-angiotensin system
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EN
Angiotensin-(1-7) [Ang-(1-7)] is an active member of renin-angiotensin system (RAS). It counterbalances vasoconstriction, mitogenic, arrhythmogenic and prothrombotic actions of Ang II. Inducing natiuresis and diuresis opposes also the water and sodium retention produced by Ang II. Till now the specific receptor side for Ang-(1-7) has been not cloned, but the current data strongly suggest that an interaction (cross- talk) between angiotensin receptors may play a role in the effects of Ang-(1-7).
EN
Objectives: To investigate the association between per capita pesticide consumption and infant mortality rates from CNS and CVS congenital malformations in microregions in the South and Southeast Region of Brazil. Material and Methods: An ecological study was conducted using data on pesticide expenditure in 1985 and 1996, and deaths caused by CNS and CVS malformations in infants under 1 year old in 1986-1990 and 1997-2001, respectively. Per capita pesticide consumption and infant mortality rates were calculated for each microregion. Microregions were grouped according to quintiles of pesticide consumption, taking the first quintile as reference. The association between pesticide consumption and infant mortality was examined by calculating Spearman correlation coefficients (r) and mortality rate ratios (RR), stratifying by gender and type of microregion (urban or rural). Results: Significant and positive correlations between per capita pesticide consumption and rates of mortality due to CNS and CVS defects were observed in rural but not urban microregions. In general, mortality RRs for the 2 types of malformations in rural microregions were significantly higher in each quintile of pesticide consumption compared to the lowest quintile in the 2 study periods, with elevations ranging between 10% and 30%. Likewise, mortality RRs in these microregions showed significant trends of increase across quintiles of pesticide consumption in both study periods. In urban areas, however, mortality RRs from both CNS and CVS malformations were weak and not statistically significant, and a trend of increase of mortality with increasing pesticide usage was not observed. Conclusions: The results show the relevance of pesticide exposure in rural areas with intense agricultural activity, suggesting that such prenatal exposures may be related with the occurrence of certain congenital defects.
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Evidence from research has not only excluded negative consequence of moderate wine consumption, but associated consumption of grapes and their components with a protective impact on health. Wine demonstrates anti-cancer, antioxidant and defensive results for the cardiovascular system. Not surprisingly, there is an interest in exploring a growing consumption of wine and turning it into innovative solutions with different approaches, making use of areas that have undergone significant transformations over last decades as a results of a global dynamical change which offer new consumption patterns seen now as driving forces for stagnating economies of the XXI century. This article builds on this perspective aiming to shed some light on wine consumption patterns, health attitudes and the perception and awareness of positive effect of a moderate consumption of wine on human health. The study was carried out between March and May 2013 as a self-administered questionnaire to visitors of liquor stores, wineries, wineries of the Lower Silesia region, Poland. Results demonstrate an interest in consumption of wine with opposite tendencies in opinions about the recommended about the recommended wine quantity of consumption. Some consciousness of health-related benefits and applications of wine show an increasing awareness in this matter.
PL
Krwotok podpajęczynówkowy (SAH), związany jest z wynaczynieniem się krwi do przestrzeni, która obejmuje obszar pomiędzy oponą pajęczą i miękką i wypełniona jest płynem mózgowo-rdzeniowym. Do krwotoku dochodzi najczęściej wskutek pęknięcia tętniaka, zlokalizowanego w obrębie koła tętniczego Willisa. U pacjentów po SAH rozwija się wiele patologicznych zmian, obejmujących zaburzenia śródczaszkowe oraz uogólnione zaburzenia układu sercowo-naczyniowego oraz płuc. W niniejszej pracy omówione zostały podstawowe mechanizmy prowadzące do wystąpienia SAH oraz towarzyszące im reakcje biochemiczne. Przedstawiono również najczęściej występujące w tej grupie pacjentów patologie układu sercowo-naczyniowego. Z punktu widzenia skuteczności leczenia istotne jest bowiem poznanie charakterystycznych zmian w układzie krążenia oraz mechanizmów ich powstawania.
EN
Subarachnoid haemorrhage (SAH) refers to extravasation of blood into the space between the pia and arachnoid membranes. Haemorrhage occurs mostly as a result of rupture of the aneurysm, located within the arterial circle of Willis. Among the patients with SAH a number of pathological changes are developed, including intracranial impairment and systemic disturbances, such as cardiovascular and pulmonary disorders. In this paper we present the basic mechanisms that lead to SAH occurrence and the biochemical reactions related to SAH. We also review the most common disturbances of cardiovascular system, occurred in this group of patients. For the effective treatment, it is important to know the characteristic changes in the cardiovascular system and the mechanisms involved in their appearance.
EN
Galanin is a 29 amino acid peptide acting as a neuromodulator in the central and peripheral nervous systems. It infl uences a variety of the central nervous system, functions, including food intake regulation, learning and memory, neuroendocrine control and pain transmission. In the present paper, we review the central and peripheral infl uences of galanin on the cardiovascular system. We discuss mechanisms involved in galanin action as well as interactions between galanin and other neuronal systems in the cardiovascular control. In conclusion, galanin, together with other neurotransmitters/neuromodulators, infl uences the central and peripheral przedzwocardiovascular regulation. Moreover, we suggest its involvement in the activation of compensatory mechanisms in the state of disturbed circulatory homeostasis.
PL
Galanina jest 29-aminokwasowym peptydem działającym jako neuromodulator w ośrodkowym i obwodowym układzie nerwowym. Wpływa na wiele czynności ośrodkowego układu nerwowego, włączając regulację ośrodka głodu i sytości, uczenie się i zapamiętywanie, regulację neuroendokrynną i przewodnictwo impulsów z nocyceptorów. W pracy dokonano przeglądu najnowszych doniesień dotyczących ośrodkowego i obwodowego wpływu galaniny na układ krążenia. Omówiono mechanizmy działania galaniny oraz interakcje między galaniną i innymi układami neuronalnymi w regulacji układu krążenia. Przedstawione informacje wskazują, że galanina wraz z innymi neuroprzekaźnikami/neuromodulatorami wpływa na ośrodkową i obwodową regulację układu krążenia. Najnowsze badania sugerują możliwy udział galaniny w aktywacji mechanizmów kompensacyjnych w stanie stresu, w tym podczas zaburzenia homeostazy krążeniowej.
EN
Impedance cardiography seems to be a very good, although underappreciated diagnostic method. What may distinguish it from among the many research methods is the fact that it enables non-invasive monitoring of cardiac output, stroke volume and systemic vascular resistance. Holter recording of the hemodynamic parameters makes it possible to study them not only in stationary (hospital, outpatient clinic) conditions, but also during household or professional activities, e.g., during road vehicle driving. Assessment of the trends of changes in the circulatory system of the employee at work makes it possible to judge whether the type of work performed by the worker is well tolerated – whether it is not too hard or too stressful. This is important, therefore, impedance cardiography can be extensively used in occupational medicine. Provision of preventive care to workers according to current standards requires, on the one hand, the use of the latest diagnostic methods while, on the other hand, the methods must be inexpensive, because otherwise the employer would not be able or willing to pay the associated costs. Impedance cardiography meets those criteria; however, few data is available in literature worldwide on the use of this method in the research on the impact of occupational work on cardiovascular responses of the employees. This work reports the use of impedance cardiography in studies on the various aspects of work environment.
EN
ObjectivesA method of continuous heart rate (HR) and blood pressure (BP) recording was used for the evaluation of the cardiovascular system parameters in participants of short-term (<1 month) high-latitude expeditions, in comparison with the parameters of residents of Central Russia and the Arctic region.Material and MethodsA dynamic examination of participants of Arctic expeditions (30 men, residents of middle-latitude regions, aged 46.7±1.7 years), workers permanently living in Central Russia (the Moscow region, 44 men, aged 46.7±1.0 years) and residents of the North (the Murmansk region, 35 men, aged 46.6±1.3 years) was performed. The authors used a spiroartheriocardiorythmograph allowing the parallel recording of HR, BP, spectral characteristics of HR variability (HRV) and the variability of systolic BP (sBP) and diastolic BP (dBP), cardiac performance parameters, and spontaneous baroreflex sensitivity (BRS). The parameters were recorded at rest, in a sitting position, over 2 min.ResultsThe basic clinical parameters (HR, BP and cardiac performance) did not differ in the workers living in different climatic zones. However, the residents of the North demonstrated a lower total power (TP) of the dBP variability spectrum and a lower relative power of the high-frequency (HF) range in both the sBP and dBP variability spectra. The participants of expeditions to the North had a lower TP of the HRV spectrum (in comparison with both control groups) that did not change during the expeditions; BRS was reduced, while the TP of the sBP spectrum was increased in comparison with the corresponding parameters obtained from the residents of circumpolar regions, and decreased during the expedition in parallel with a decrease in the sBP values. The TP of both the sBP and dBP variability spectra, as well as the power of the HF range in these spectra, were similar in the participants of expeditions to those obtained from the residents of Central Russia, and they considerably surpassed the corresponding parameters in the northerners surveyed.ConclusionsThe revealed peculiarities of the cardiovascular system in the participants of high-latitude expeditions can be considered as correlates of positive, and adequate in terms of the physiological value, adaptive shifts in the autonomous regulation of the cardiovascular system.
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The high performance liquid chromatography method for the determination of a newly synthesized amide derivatives of prolino- (2, 1 -f)-theophylline, with potential action on the cardiovascular system, was developed and validated. The method was specific for studied compounds and LOD were from 50 to 100 ng ml(-1) depending upon the compound. Recovery of extraction ranged from 68 to 96 % and coefficient of variation was below 15%. The developed method was applied forpharmacokinetic studies one of the synthesized cpmpound (AZ30) in rats after intravenous administration.
PL
Opracowano i przeprowadzono walidację metody wysokosprawnej chromatografii cieczowej oznaczania nowo zsyntetyzowanych połączeń amidowych prolino- (2, 1-f)-teofiliny o potencjalnym działaniu na układ sercowo - naczyniowy. Metoda jest specyficzna dla badanych związków a jej dolna granica oznaczalności wynosi od 50 do 100 ng ml"1 surowicy. Współczynnik zmienności dla opracowanej metody jest poniżej 15 %. Wydajność ekstrakcji w zależności od oznaczanego połączenia waha się od 68 do 96 %. Stosując opracowaną metodę przeprowadzono badania farmakokinetyczne związku AZ30 po jego dożylnym podaniu szczurom.
EN
In everyday life an important component of working efficiency is people’s physical capabilities and normal level of functioning of basic systems of the organism. One of the most popular means of physical culture among growing generation is health-improving fitness and its technologies. Aim of the article: research of influence of the health-improving fitness on level of physical activity and functional state of cardiovascular system of 11th form pupils. Methods of research: theoretical analysis and generalization of scientific and methodological literature and internet sources, pedagogical supervision, sociologic (questioning), pulsometry and Ruffier reaction, methods of mathematical statistics. Results of research. Research has shown that 70 % of pupils have mid-level degree cardiac insufficiency, 20 % got “good” marks and only 10 % of pupils have high indicators that correspond to mark “excellent”. The results of the questioning have shown that level of physical activity of 60 % youngsters is not sufficient in connection with low motivation for physical culture training. Research of pupils of the 11th form showed that among means of health-improving factors, the most popular among girls are classical and fitball-aerobics, yoga and pilates; amongs boys – athletics, gymnastycs, health-improving jogging, crossfit, riding a bicycle and health-improving swimming. Use of the means of health-improving fitness (basic aerobics) at physical training classes considerably influenced the increase of physical activity level, optimization of cardiovascular system of youngsters and increase of motivation to physical training classes. Conclusions. The research proves that at physical training classes the main issue that provokes 11th form pupils to take care about their own health is a possibility to choose among those means of physical education that entail fresh interest to classes. The use of health-improving element helped in optimization of work of cardiovascular system, increased level of physical activity and adolescent’s interest that proves its important place among other types of health-improving technologies. Perspectives of further researches lie within advanced learning of foreign experience of using health-improving fitness technologies.
EN
Thyroliberin (thyrotropin releasing hormone – TRH) is a tripeptide synthesized mainly in the paraventricular nucleus of the hypothalamus. It is a component of the hypothalamic–pituitary–thyroid axis, in which it intensifi es the synthesis and secretion of the thyroid stimulating hormone. It also regulates the release of other hormones (prolactin, vasopressin) and neurotransmitters in the central nervous system (noradrenaline and adrenaline). Acting as a neuromodulator, TRH aff ects many functions of the central nervous system. In the present review, we demonstrate interactions between the thyroliberinergic system and other neuronal systems, especially the role of TRH in the central cardiovascular regulation. The diff erences between TRH-induced eff ects in normotension, hypertension and hypotension have been presented.
PL
Tyreoliberyna (thyrotropin releasing hormone – TRH) to tripeptyd syntetyzowany głównie w jądrze przykomorowym podwzgórza. Jest składową osi podwzgórze–przysadka–tarczyca, w której nasila procesy syntezy i wydzielania hormonu tyreotropowego. Wpływa także na uwalnianie innych hormonów (prolaktyna, wazopresyna) i neuroprzekaźników w ośrodkowym układzie nerwowym (noradrenalina i adrenalina). Działając jako neuromodulator, TRH wpływa na wiele funkcji ośrodkowego układu nerwowego. W pracy przedstawiono współzależności między układem tyreoliberynergicznym a innymi układami neuronalnymi, ze szczególnym uwzględnieniem znaczenia THR w ośrodkowej regulacji układu krążenia. Zwrócono uwagę na różnice w działaniu TRH w stanach normotensji, hipertensji oraz hipotensji.
PL
Urządzenie ECP-100, opracowane przez ITAM Zabrze przy współpracy z 1B1B PAN Warszawa, umożliwia terapię pacjentów z chorobą niedokrwienną serca. Podczas zabiegu pacjent z zestawem mankietów pneumatycznych spoczywa na leżu zabiegowym. Zestaw składa się z trzech mankietów (podobnych do tych stosowanych przy pomiarze ciśnienia), które są owinięte dookoła łydek, ud i pośladków. Mankiety są napełniane sekwencyjnie na początku fazy rozkurczu serca i opróżniane przed fazą skurczu. Napełnianie i opróżnianie mankietów jest zsynchronizowane z przebiegiem EKG, tak by zoptymalizować korzyści terapeutyczne.
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Content available remote Classification of cardiovascular system according to the heart load
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EN
The aim of this paper was to show a possibility of determining energetic efficiency of the heart and to estimate the corresponding quality of the whole cardiovascular system of the man, with a simple non-invasive measurement only. For the examination we selected the probands whose cardiovascular systems demanded different energy. On the basis of clinical examinations we found the parameters A/i(/,, Kir They allowed us to measure the quality of the pumping ability and the efficiency of the cardiovascular system. These quantities made it possible to categorise the energy need of the heart and the compliance of the blood vessels.
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