Wyniki wyszukiwania - Biblioteka Nauki

1

Accidental pesticide exposures and non-Hodgkin's lymphoma

100%

Theriault G. , Pahwa P. , Choi N. W. , Robson D. , Spinelli J. , Skinnider L. F. , White D. , McDuffie H. H. , McLaughlin J. R. , Fincham S. , Dosman J. A.

Annals of Agricultural and Environmental Medicine

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1994

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tom 01

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nr 2

2

Complex mechanistic carcinogenicity modelling

100%

Kopp-Schneider A. , Edler L.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

|

nr 1

3

The cancer risk assessment as an optimal experimental design

100%

Kitsos C. P.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

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nr 1

4

Vegetables Enriched Diet and Oesophageal Cancer Risk. Systematic Review and Meta-Analysis of Case-Control Studies

75%

Smolińska K. , Dębińska I. , Paluszkiewicz P.

Polish Journal of Surgery

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2010

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tom 82

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nr 12

639-644

EN

Oesophagus is common primary localization of digestive system cancer. Recent analyses suggest the role of vegetarian food in reduction of cancer risk. The role of vegetables intake in oesophageal cancer prevention still needs to be proved.Objective. The estimation of the role of vegetables intake in oesophageal cancer risk based on published case-control studies using meta-analysis methods.Methods. The selected literature published till 2009 from MEDLINE, PubMed, Scopus, Embase, CancerLit, Google Scholar and Cochrane Library databases were included into meta-analysis. The following search terms, key words and text phrases were used: esophageal cancer, cancer risk, oesophageal cancer risk, oesophageal neoplasm; oesophageal neoplasm risk, diet, dietary habits, vegetables and life style. Articles investigating vegetables intake were reviewed and selected for further analysis.Results. Twelve studies have fulfilled the established criteria. The meta-analysis has confirmed the protective effect of vegetables against oesophageal cancer development. The vegetables intake, more frequent than once per week, reduce oesophageal cancer risk (relative risk 0.52; 95% CI 0.38-0.71). The declared intake more frequent than once daily was connected with reduction of cancer development about of 57% (relative risk 0.43; 95% CI 0.32-0.58). The dose-dependent manner of vegetables intake was observed against oesophageal cancer development.Conclusion. The vegetables intake is associated with reduced risk of developing an oesophageal cancer. The total reduction of oesophageal cancer risk is associated with frequency of vegetables intake in the diet.

5

Molecular bio-dosimetry for carcinogenic risk assessment in survivors of Bhopal gas tragedy

75%

Mishra P. K. , Raghuram G. V. , Bunkar N. , Bhargava A. , Khare N. K.

International Journal of Occupational Medicine and Environmental Health

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2015

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tom 28

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nr 6

921-939

EN

December 2014 marked the 30th year anniversary of Bhopal gas tragedy. This sudden and accidental leakage of deadly poisonous methyl isocyanate (MIC) gas instigated research efforts to understand the nature, severity of health damage and sufferings of 570 000 ailing survivors of this tragedy. In a decade-long period, our systematic laboratory investigations coupled with long-term molecular surveillance studies have comprehensively demonstrated that the risk of developing an environmental associated aberrant disease phenotype, including cancer, involves complex interplay of genomic and epigenetic reprogramming. These findings poised us to translate this knowledge into an investigative framework of “molecular biodosimetry” in a strictly selected cohort of MIC exposed individuals. A pragmatic cancer risk-assessment strategy pursued in concert with a large-scale epidemiological study might unfold molecular underpinnings of host-susceptibility and exposureresponse relationship. The challenges are enormous, but we postulate that the study will be necessary to establish a direct initiation-promotion paradigm of environmental carcinogenesis. Given that mitochondrial retrograde signaling-induced epigenetic reprogramming is apparently linked to neoplasticity, a cutting-edge tailored approach by an expert pool of biomedical researchers will be fundamental to drive these strategies from planning to execution. Validating the epigenomic signatures will hopefully result in the development of biomarkers to better protect human lives in an overburdened ecosystem, such as India, which is continuously challenged to meet population demands. Besides, delineating the mechanistic links between MIC exposure and cancer morbidity, our investigative strategy might help to formulate suitable regulatory policies and measures to reduce the overall burden of occupational and environmental carcinogenesis.

6

Authors’ response (December 8, 2017) to the letter to the Editor concerning the paper “Occupational exposure to radon for underground tourist routes in Poland: Doses to lung and the risk of developing lung cancer”

75%

Walczak K. , Olszewski J. , Politański P. , Zmyślony M.

International Journal of Occupational Medicine and Environmental Health

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2018

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tom 31

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nr 5

707-709

7

Potential Human Health Risk Assessment of Heavy Metals in Road Dusts Collected From Three Urban Roads of Enugu State, Nigeria

75%

Nnamani A. R. , Nduka J. K. , Ukamaka A. A.

World News of Natural Sciences

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2024

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tom 54

83-101

EN

Dust samples from roads classified based on traffic volumes (low, medium and high traffic) were collected from three different urban roads in Enugu South LGA, Enugu State, Nigeria followed by assessment of human health risks of each heavy metals. The concentrations of heavy metals in road dust were determined using computerized Agilent FS240AA Atomic Absorption Spectrophotometer. The heavy metal concentrations were dominated by Fe and Mn with mean concentration of 247.03 mg/kg and 26.43 mg/kg respectively. Other dominant elements were Cu and K with mean concentrations of 121.85 mg/kg and 73.39 mg/kg, respectively. The results revealed that the highest heavy metals in road are highest in industrial road site and commercial road while the dust from residential area has the lowest heavy metal concentration. Contrary to most metals detected, mercury (Hg) shows no detection. The health risk assessment through ingestion, dermal and inhalation contact was conducted according to the United States Environmental Protection Agency’s (USEPA) model for children and adults. The assessment of health risk indicated that there were mainly three exposure pathways for people: ingestion, dermal contact and inhalation. The main exposure pathway of heavy metals to both children and adults is ingestion. The values of HQ and HI are lower than the safe level (HI< 1), indicating no health risk exists in present condition. The cancer risk (CR) for children and adults from exposure to Pb, As, Ni, and Cr was found to be negligible (≤ 1 × 10−6). Meanwhile, the HI value for children is higher than that for adults, indicating that children have higher potential health risk than adults in the studied areas in Enugu state.

8

Cancer risk factors in Poland: the PONS study

75%

Romundstad P. , Janszky I. , Vatten L. , Hakon Biorngard J. , Langhammer A. , Manczuk M. , Zatonski W. A.

Annals of Agricultural and Environmental Medicine

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2011

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tom 18

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nr 2

9

Chemical detoxification of carcinogenic heterocyclic aromatic amines by isothiocyanates

75%

Bartoszek A. , Smiechowska A. , Przychodzen W. , Piekarska A. , Namiesnik J.

Polish Journal of Food and Nutrition Sciences

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2011

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tom 61

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nr Suppl.1

10

A single nucleotide polymorphism in the 5'untranslated region of RAD51 in breast cancer

75%

Blasiak J. , Przybylowska K. , Czechowska A. , Zadrozny M. , Rykala J. , Kolacinska A. , Morawiec Z. , Drzewoski J.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

11

Biological markers as a tool in cancer risk assessment in Upper Silesia, Poland

63%

Motykiewicz G.

Environmental Biotechnology

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2008

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tom Vol. 4, No. 1

32-39

EN

Upper Silesia is a densely populated and most polluted, industrial region of southern Poland. The major health hazard for humans comes from mining and/or processing of black coal, which generates a variety of compounds including polycyclic aromatic hydrocarbons (PAH). Ambient pollution with PAH plays an important role in risk of cancer. Between 1982 and 1997 Upper Silesia served as a study model for multi-center collaborative cancer risk assessment research, which utilized a variety of biological markers (biomarkers). This research started from testing genotoxic activity of air pollutants (using seven in vitro and in vivo tests) and was continued as the molecular epidemiology studies, which utilized eleven biomarkers of internal and biological doses of mutagen, early biologic effects as well as susceptibility markers. An ambient air genotoxicity studies were performed on benzene extracts of suspended matter collected in Upper Silesia while the molecular epidemiologic research involved human volunteers - residents of Upper Silesia and controls from a north-eastern, rural part of Poland. This review summarizes the results, presenting biomarkers as a valuable tool in the assessment of human gene damage. The preliminary results of the follow-up research on cancer incidence or mortality performed, over 10 years later, in the previously studied populations are also presented.

12

Thyroid cancer risk assesment among the population of Pomeranian and West Pomeranian voivodeship (Poland)

63%

Kasiyan O. , Tkachenko H. , Kurhaluk N. , Yurchenko S. , Jazewicz I. , Dunayevska S.

Baltic Coastal Zone. Journal of Ecology and Protection of the Coastline

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2019

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tom 23

13

Text mining approach to analyse the relation between obesity and breast cancer data

63%

Kumar A. , Thakur P. , Gupta K. , Pal A.

International Letters of Natural Sciences

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2015

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tom 44

EN

Biomedical research needs to leverage and exploit large amount of information reported in scientific publication. Literature data collected from publications has to be managed to extract information, transforms into an understandable structure using text mining approaches. Text mining refers to the process of deriving high-quality information from text by finding relationships between entities which do not show direct associations. Therefore, as an example of this approach, we present the link between two diseases i.e. breast cancer and obesity.Obesity is known to be associated with cancer mortality, but little is known about the link between lifetime changes in BMI of obese person and cancer mortality in both males and females. In this article, literature data for obesity and breast cancer was obtained using PubMed database and then methodologies which employs groups of common genes and keywords with their frequency of occurrence in the data were used, aimed to establish relation between obesity and breast cancer visualized using Pi-charts and bar graphs. From the data analysis, we obtained 1 gene which showed the link between both the diseases and validated using statistical analysis and disease-connect web server. We also proposed 8 common higher frequency keywords which could be used for indexing while searching the literature for obesity and breast cancer in combination.

14

Seasonal variations of PM2.5 and PM10 concentrations and inhalation exposure from PM-bound metals (As, Cd, Ni) : first studies in Poznań (Poland)

63%

Sówka I. , Chlebowska-Styś A. , Pachurka Ł. , Rogula-Kozłowska W.

Archives of Environmental Protection

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2018

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tom Vol. 44, no. 4

86--95

EN

Results of measurements of suspended particulate matter concentrations – PM10 and PM2..5 (ambient particles with aerodynamic diameter not greater than 10 and 2.5 μm respectively) in Poznań, Poland in years 2010–2016 alongside the results of cancer risk assessment analysis in relation to inhalation exposure to selected heavy metals: As, Cd and Ni related to PM103 in 2010 at the measurement station on Szymanowskiego street to 39 μg/m3 in 2016 at measurement stations on Polanka and Dąbrowskiego streets. Mean concentrations in the heating season were twice higher than in non-heating season at stations on Szymanowskiego street, Polanka street and Dąbrowskiego street. In the case of heavy metals, the highest average seasonal concentrations were: 3.34 ng/m3 for As in the heating season of 2016 (Chwiałkowskiego street), 0.92 ng/m3 for Cd in the heating season of 2012 (Chwiałkowskiego street), 10.82 ng/m3 for Ni in the heating season of 2016 (Szymanowskiego street). We have shown that the presence of As in PM in Poznań is connected with fossil fuel emission from home fireplaces. Road traffic and industry were a potential source of Cd and Ni. The highest risk values for residents of Poznań were acquired for average concentrations in the heating seasons from 2012–2016 of As and they were: 24.27·10-6 for children, 11.87·10-6 for women and 9.94·10-6 for men. Received risk value on an acceptable level according to US EPA is 1·10-6.

PL

Celem pracy była analiza zmienności sezonowej stężeń PM2.5 i PM10 w Poznaniu wraz z oceną wpływu inhalacyjnego wybranych metali ciężkich związanych z PM10 (As, Cd i Ni) na mieszkańców. W pracy przedstawiono wyniki pomiarów stężenia pyłu zawieszonego PM10 i PM2.5 w Poznaniu w latach 2010-2016 oraz wyniki analizy oceny ryzyka zachorowania na raka w odniesieniu do ekspozycji inhalacyjnej na wybrane wartości PM: As, Cd, Ni. Dane wykorzystane w zestawieniu pochodzą z pomiarów WIOŚ i badań własnych. Przedstawione zostały średnie roczne stężenia PM w rozpatrywanym okresie wraz z analizą jego sezonowej zmienności. W celu określenia ryzyka autorzy wykorzystali metodologię oceny ryzyka US EPA. Średnie roczne stężenia PM10 kształtowały się w przedziale od 21 g/m3 w 2010 r. (ul. Szymanowskiego) do 39 g/m3 w 2016 roku (ul. Polanka i Dąbrowskiego). W przypadku metali ciężkich najwyższą wartość stężenia As (3,34 ng/m3) określono w sezonie grzewczym 2016 r. (ul. Chwiałkowskiego), stężenia Cd (0,92 ng/m3) w sezonie grzewczym w 2012 r. (ul. Chwiałkowskiego) oraz stężenia Ni (10,82 ng/m3) w sezonie grzewczym 2016 roku (ul. Szymanowskiego) Przeprowadzone obliczenia wskazały na najwyższe wartości ryzyka dla danych zebranych w latach 2012-2016 w sezonie grzewczym i wyniosły odpowiednio dla dzieci: 24,27-10-6, kobiet: 11,87 10-6 i mężczyzn: 9,9410-6. Wartość ryzyka na poziomie akceptowalnym zgodnie z US EPA wynosi 1‧10-6.

15

Matrix metalloproteinase-2 C-1306T promoter polymorphism and breast cancer risk in the Saudi population

63%

Saeed H. M. , Alanazi M. S. , Alshahrani O. , Parine N. R. , Alabdulkarim H. A. , Shalaby M. A.

Acta Biochimica Polonica

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2013

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tom 60

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nr 3

EN

Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism (SNP) at -1306, which disrupts a Sp1-type promoter site (CCACC box), displayed a strikingly lower promoter activity with the T allele. In the present study, we investigate whether this MMP-2 SNP is associated with susceptibility to breast cancer in the Saudi population. Ninety breast cancer patients and 92 age matched controls were included in this study. TaqMan Allele Discrimination assay and DNA sequencing techniques were used for genotyping. The results showed that, the frequency of MMP-2 CC wild genotype was lower in breast cancer patients when compared with healthy controls (0.65 versus 0.79). The homozygous CC (OR=2, χ2=5.36, p=0.02) and heterozygous CT (OR=1.98, χ2=4.1, p=0.04) showing significantly high risk of breast cancer in the investigated group. In conclusion our data suggest that the MMP-2 C-1306T polymorphism may be associated with increased breast cancer risk in the Saudi population.

16

Zagrożenie chorobami nowotworowymi pracowników zakładów przemysłu gumowego w Polsce

63%

Wilczyńska U. , Szeszenia-Dąbrowska N. , Sobala W.

Elastomery

|

2003

|

tom T. 7, nr 1

17-25

PL

Przedstawiono wyniki badań epidemiologicznych dotyczących ryzyka zachorowania na raka u pracowników dwóch dużych zakładów przemysłu gumowego w Polsce. Jeden z nich produkował obuwie gumowe, drugi opony. Badania prowadzono metodą kohortową. Wyniki wieloletniej obserwacji 16 813 osób (8771 mężczyzn i 8042 kobiet) zatrudnionych co najmniej trzy miesiące w latach 1945-1985 przy produkcji obuwia gumowego wykazały istotnie zwiększone ryzyko zgonu z powodu chorób nowotworowych ogółem (mężczyźni: 678 zgonów, SMR=116, 95%CI: 107-125; kobiety: 506 zgonów, SMR=111, 95%CI: 101-121). Biorąc pod uwagę umiejscowienie nowotworu u mężczyzn odnotowano istotną nadwyżkę raka: pęcherzyka żółciowego (17 zgonów, SMR=317, 95%CI: 185-508), krtani (39 zgonów, SMR=192, 95%CI: 136-262), płuca (239 zgonów, SMR=125, 95%CI: 109-141) u kobiet: raka pęcherzyka żółciowego (42 zgony, SMR=206, 95%CI: 149-279), raka macicy (17 zgonów, SMR=220, 95%CI: 128-353) i szyjki macicy (59 zgonów, SMR=161, 95%CI: 122-207). Analiza umieralności w podkohortach wyodrębnionych wg roku zatrudnienia w zakładzie wykazała, że istotne ryzyko raka jelita grubego, pęcherzyka żółciowego, krtani i płuca dotyczy osób, które rozpoczęły pracę przed przeprowadzką zakładu do nowo wybudowanych i wyposażonych w nowoczesne urządzenia hal, tzn. pracowały w gorszych warunkach higienicznych. W grupie 16 686 pracowników zakładu oponiarskiego (10918 mężczyzn i 5768 kobiet) zatrudnionych co najmniej trzy miesiące w latach 1950 - 1995 nie odnotowano istotnego statystycznie zwiększenia ryzyka nowotworów chociaż w niektórych umiejscowieniach liczba odnotowanych zgonów przekraczała przewidywaną wartość. Jedną z prawdopodobnych przyczyn różnego obrazu umieralności w obu badanych grupach jest ich odmienna struktura wiekowa - pracownicy zakładu oponiarskiego są znacznie młodsi. Do ostatecznej oceny ryzyka raka u osób zatrudnionych w fabryce opon potrzebna jest dalsza obserwacja.

EN

Results of epidemiological research on the risk of cancer in workers of two big Polish rubber plants are reported. One manufactured rubber shoes, the other made rubber tyres. The cohort method was used in the study. The results of long-term observation of 16 813 people (8771 men and 8042 women) employed between 1945 and 1985 in the production of rubber shoes showed a significantly higher risk of death from cancer in general (men: 678 deaths, SMR=116, 95%CI: 107-125; women: 506 deaths, SMR=111, 95%CI: 101-121). Considering particular locations, increased mortalities were noted in the males for the cancer of: gallbladder (17 deaths, SMR=317, 95%CI: 185-508), larynx (39 deaths, SMR=192, 95%CI: 136-262), lung (239 deaths, SMR=125, 95%CI: 109-141) and in the females for the cancer of: gallbladder (42 deaths, SMR=206, 95%CI: 149-279), uterus (17 deaths, SMR=220, 95%CI: 128-353) and cervix (59 deaths, SMR=161, 95%CI: 122-207). Our analysis of the mortality within the sub-cohorts set up by year of employment at the plant revealed that people who had started their employment before the plant moved to the new buildings provided with modern equipment, i.e. those who experienced poorer hygienic conditions, were at a significant risk of cancer of large intestine, gallbladder, larynx and lung. In the group of 16 686 workers of the rubber tyre plant (10918 men and 5768 women), statistically significant increase in the risk of cancer was not recorded, although for some locations the number of recorded deaths was higher than expected. One of the probable causes for the differences in the pattern of mortality between the studied cohorts is that the cohort of the rubber tyre plant was much younger than that of the other plant. Further observation is necessary to obtain the final assessment of cancer risk among workers of that plant.

17

Genistein inhibits the contact-stimulated migration of prostate cancer cells

63%

Miekus K. , Madeja Z.

|

nr 3

EN

The results of several epidemiological studies have suggested that a soybean-based diet is associated with a lower risk of prostate cancer. We investigated the effect of the soy isoflavone genistein on the proliferation and contact-stimulated migration of rat prostatic carcinoma MAT-LyLu and AT-2 cell lines. Genistein almost completely inhibited the growth of both MAT-LyLu and AT-2 cells in the concentration range from 25 to 100 μM, but the addition of 1 μM genistein to the medium significantly stimulated the proliferation of both cell lines. Additionally, at concentrations above 25 μM, genistein showed a potent cytotoxic effect. However, the central finding of this study is that at physiologically relevant concentrations (1 μM and 10 μM), genistein inhibits the motility of prostate cancer cells stimulated by homo-and heterotypic contacts. These results show that at physiological concentrations, genistein exerts an inhibitory effect on the migration of prostate cancer cells and suggest that it may be one of the factors responsible for the anti-metastatic activity of plant isoflavonoids.

18

Regional distribution of heterozygous 657del5 mutation carriers of the NBS1 gene in Wielkopolska province [Poland]

63%

Ziolkowska I. , Mosor M. , Nowak J.

Journal of Applied Genetics

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2006

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tom 47

|

nr 3

EN

The homozygous 657del5 mutation, called Slavic mutation, of the NBS1 gene, causes the Nijmegen Breakage Syndrome (NBS). This syndrome is connected with a high incidence of malignancies in early childhood. A high frequency of NBS heterozygotes was found among patients with melanoma, breast, ovary and prostate cancer. The aim of our research was to determine the frequency of 657del5 mutation of the NBS1 gene in the population of Wielkopolska province. For this purpose, we analysed blood samples from anonymous Guthrie cards. In a group of 2090 newborns from the whole province, we found 16 heterozygous mutation carriers. The frequency of 1/131 is higher than 1/190 reported for populations from other regions in Poland. We observed differential regional distribution of heterozygous 657del5 mutation carriers within the province: among 464 samples from the eastern part of Wielkopolska we found 6 carriers (1/77), in contrast to the southern part without any carrier among 625 samples analysed. The high mean frequency of heterozygous 657del5 mutation (1/131) in Wielkopolska province may be associated with cancer incidence in this region.

19

Nutritional knowledge, diet quality and breast or lung cancer risk: a case-control study of adults from Warmia and Mazury region in Poland

51%

Hawrysz I. , Krusinska B. , Slowinska M. A. , Wadolowska L. , Czerwinska A. , Biernacki M.

Roczniki Państwowego Zakładu Higieny

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2016

|

tom 67

|

nr 1

EN

Background. Knowledge on proper nutrition favours the creation of pro-healthy nutritional behaviours of people. Studies related to the nutritional knowledge of adults, diet quality and incidence of breast or lung cancers are limited. Objective. Analysis of the relationship between the level of nutritional knowledge, diet quality and risk of breast cancer in women or lung cancer in men from the Warmia and Mazury region in Poland. Material and methods. The study was carried out in 202 subjects aged 23-80 years, including 107 women (17 cases of breast cancer) and 95 men (54 cases of lung cancer) from the Warmia and Mazury region in Poland. Nutritional knowledge was evaluated with the Questionnaire of Eating Behaviours (QEB), including 25 statements. Based on the frequency of the consumption of 16 food items, two diet quality indices were created: the pro-Healthy-Diet-Index-8 (pHDI-8) and the non-Healthy-Diet-Index-8 (nHDI-8). The values of pHDI-8 and nHDI-8 were calculated on the basis of the sum of the daily frequency of consumption of the selected food items and expressed as times/day. The Odds Ratio (OR) of both breast cancer or lung cancer in relation to the level of nutritional knowledge was calculated based on a logistic regression analysis. Results. The incidence of breast or lung cancer in the bottom, middle and upper tertile of nutritional knowledge was 57.6%, 32.6% and 15.8%, respectively. As nutritional knowledge grew in the subsequent tertiles, pHDI-8 was on the increase (2.63 vs. 3.78 vs. 4.22 times/day) and n-HDI-8 was on the decrease (1.32 vs. 1.21 vs. 0.94 times/day). In the upper tertile of nutritional knowledge, the Odds Ratio for the incidence of breast or lung cancers varied from 0.06 (95% CI: 0.02; 0.17; p<0.05, with adjustment for cancer type and age) to 0.17 (95% CI: 0.04; 0.69; p<0.05, with adjustment for age and sex) when compared to the bottom tertile (OR=1.00). In the middle tertile of nutritional knowledge, the Odds Ratio of both cancers varied from 0.27 (95% CI: 0.12; 0.62, p<0.05, with adjustment for cancer type and age) to 0.35 (95% CI: 0.18; 0.71, p<0.05, variables without adjustment) when compared to the bottom tertile. Conclusions. A higher level of nutritional knowledge was associated with the higher quality of a pro-healthy diet and lower risk of breast cancer in women or lung cancer in men. In contrast, a lower level of nutritional knowledge was associated with a lower diet quality and a higher risk of both types of cancers.

PL

Wprowadzenie. Wiedza na temat prawidłowego żywienia sprzyja kształtowaniu prozdrowotnych zachowań żywieniowych ludzi. Badania dotyczące wiedzy żywieniowej osób dorosłych w powiązaniu z jakością diety oraz częstością występowania raka piersi lub płuc są ograniczone. Cel. Analiza zależności między poziomem wiedzy żywieniowej, jakością diety i ryzykiem raka piersi u kobiet lub płuc u mężczyzn z regionu Warmii i Mazur w Polsce. Materiał i metody. Badania przeprowadzono wśród 202 osób w wieku 23-80 lat, w tym u 107 kobiet (17 przypadków raka piersi) i 95 mężczyzn (54 przypadki raka płuc) z regionu Warmii i Mazur. Wiedzę żywieniową respondentów oceniono za pomocą zestawu 25 stwierdzeń na temat żywności i żywienia z kwestionariusza o akronimie QEB. Na podstawie częstości spożycia 16 grup żywności utworzono dwa indeksy jakości diety: Indeks Prozdrowotnej Diety (pHDI-8) i Indeks Niezdrowej Diety (nHDI-8). Indeksy pHDI-8 i nHDI-8 obliczono przez sumowanie dziennej częstości spożycia odpowiednich grup żywności i wyrażono jako krotność/dzień. Za pomocą regresji logistycznej obliczono iloraz szans (OR) wystąpienia raka piersi lub płuc w relacji do poziomu wiedzy żywieniowej. Wyniki. Występowanie raka piersi lub płuc w dolnym, środkowym i górnym tercylu wiedzy żywieniowej wynosiło odpowiednio 57,6%, 32,6% i 15,8%. Wraz ze wzrostem wiedzy żywieniowej w kolejnych tercylach rósł wskaźnik pHDI-8 (2,63 vs 3,78 vs 4,22 krotność/dzień) oraz malał wskaźnik n-HDI-8 (1,32 vs 1,21 vs 0,94 krotność/dzień). W górnym tercylu wiedzy żywieniowej iloraz szans wystąpienia raka piersi lub płuc wynosił od 0,06 (95% CI: 0,02; 0,17; p<0,05, z adjustacją na rodzaj raka i wiek) do 0,17 (95% CI: 0,04; 0,69; p<0,05, z adjustacją na wiek i płeć) w porównaniu z dolnym tercylem (OR=1,00). W środkowym tercylu wiedzy żywieniowej ryzyko obu raków wynosiło od 0,27 (95% CI: 0,12; 0,62, p<0,05, z adjustacją na rodzaj raka i wiek) do 0,35 (95% CI: 0,18; 0,71 p<0,05, zmienne nieadjustowane) w porównaniu z dolnym tercylem. Wnioski. Większy poziom wiedzy żywieniowej był związany z lepszą jakością prozdrowotną diety i mniejszym ryzykiem wystąpienia raka piersi u kobiet lub płuc u mężczyzn. Z kolei mniejszy poziom wiedzy żywieniowej był związany z gorszą jakością diety i większym ryzykiem wystąpienia obu raków.

20

Effect of phytoestrogen intake in the diet on lipid and sex hormone metabolism in menopausal women, and increased risk of breast cancer

51%

Kostrzewa-Tarnowska A. , Czlapka-Matyasik M. , Walkowiak J. , Godlewski D.

Journal of Pre-Clinical and Clinical Research

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2015

|

tom 09

|

nr 2

EN

Introduction and objective. Phytoestrogens are one of nutritional factors exhibiting a chemoprotective action, potentially reducing vasomotor symptoms as well as cancerous lesions. The study was ocused on an association between the consumption of phytoestrogens in the diet, blood serum cholesterol concentration and urinary estrogen metabolites levels. Materials and methods. The study was conducted on 55 women in the perimenopausal period, who were characterized by an increased risk of hormone-dependent cancer. Energy and nutritive value of food rations, and especially the level of phytoestrogen consumption in the diets in the examined population, were analyzed using the Wikt Pro computer programme. Estrogen metabolites (2OHE, 16α-OHE1) were determined from 24‑urine samples by the ELISA method. The EMR index was calculated. Plasma total cholesterol concentrations was measured. Results and conclusions. The population with a higher consumption of phytoestrogens and dietary fibre in the diet, at the simultaneous slight limitation of energy value of the food ration, is characterized by an improved blood serum cholesterol concentration and an appropriate estrogen metabolism towards a significant increase in the estrogen index for the cancer lesions in the mammary glands.