Wyniki wyszukiwania - Biblioteka Nauki

1

Alternative therapies in Staphylococcus aureus diseases

100%

Kurlenda J. , Grinholc M.

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nr 2

EN

Staphylococcus aureus is a common pathogen responsible for health-care-associated infections as well as community acquired ones. It is the etiological factor of a wide spectrum of infections. Therapeutic problems are caused by resistance of S. aureus to many antibiotics, specifically to methicillin (methicillin-resistant S. aureus, MRSA). In such cases a limited spectrum of antibiotics may be used and prolonged hospitalization is costly. Hence, there is an urgent need for the development of alternative antibiotic therapeutics. This work reviews the current knowledge concerning prospective treatment of staphylococcal diseases.

2

Ocena odzialywan plazmidow na zmiane wzoru litycznego klinicznych izolatow Enterobacter cloacae

100%

Nieradko J. , Kurlenda J.

Medycyna Doświadczalna i Mikrobiologia

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2003

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tom 55

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nr 4

343-349

PL

Enterobacter s p. jest oportunistyczną patogenną bakterią mało poznaną pod względem molekularnym (7). Cechą wyróżniającą ten rodzaj od innych reprezentantów rodziny Enterobacteriacae jest wyjątkowo wysoka oporność na antybiotyki ß-laktamowe (3). Wskazuje to iż, w określonej perspektywie czasowej może w środowisku szpitalnym zostać wyselekcjonowany wielooporny szczep Enterobacter. Sądzimy, że w zaistniałej sytuacji bakteria ta może być dobrym modelem do śledzenia dróg selekcji szczepów szpitalnych opornych na bakteriofagi.

EN

The aim of this study was evaluation the plasmid influence on phage host range of clinical strains of Enterobacter cloacae. We found that strains included in restrictive pattern A, displayed reduced host range. Such reduced sensitivity make these strains excellent candidates for search restrictive-modification systems. High discriminative efficay of isolated phages (specific for strains Enterobacter cloacae) make them useful tool for phage typing in epidemiological investigations.

3

Ocena zagrozen mikrobiologicznych zwiazanych z systemem i hermetyka pakowania twarogow

100%

Steinka I. , Kurlenda J.

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nr 10

757-761

4

Determination of microbiological quality indices of vacuum-packed cottage cheese and prediction of their changes during storage

100%

Steinka I. , Kurlenda J.

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tom 11

5

Charakterystyka oporności na antybiotyki wybranych szczepów Agrobacterium rhizogenes

80%

Krolicka A. , Kurlenda J. , Lojkowska E.

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nr 2

6

Identification and antimicrobial susceptibility of fecal coliforms isolated from surface water

80%

Luczkiewicz A. , Jankowska K. , Kurlenda J. , Olanczuk-Neyman K.

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2011

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tom 20

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nr 4

EN

Of 274 fecal coliforms isolated from two watercourses influencing the costal water quality of the Gdańsk and Puck bays, 265 were identified as Escherichia coli. The remained strains belonged to: Acinetobacter spp. (n=1), Enterobacter spp. (n=3), Klebsiella spp. (n=4), and Shigella spp. (n=1). The susceptibility of 222 E. coli was tested against 19 antimicrobial agents: aminoglycosides, carbapenems, cephalosporines, folate antagonists, fluoroquinolones, monobactam, penicillins, penicillins/β-lactamase inhibitors, and tetracycline. The highest number of isolates was resistant to penicillins (ampicillin 21% and piperacillin 14%), as well as to tetracycline (16%). Up to 19% of E. coli isolates were resistant to 3 or more of the analyzed antimicrobial agents, and 9% were regarded as multiple-antibiotic-resistant (MAR) strains. Two of the analyzed isolates were regarded as extended-spectrum β-lactamase – producing strains.

7

Lack of correlation between X region spa polymorphism and virulence of methicillin resistant and methicillin sensitive Staphylococcus aureus strains

80%

Kurlenda J. , Grinholc M. , Szweda P.

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nr 1

135-138

EN

Staphylococcus aureus is an etiological factor of severe infections in both hospital and ambulatory environments. As methicillin resistant Staphylococcus aureus strains spread quickly across healthcare centers resulting in life-threatening infections with increased mortality, they are considered more virulent than MSSA strains. Protein A, encoded by the spa gene, is one of the virulence factors involved in the staphylococcal pathogenesis. It has been suggested that the number of 24-bp tandem repeat units along the X region of the spa gene correlates with the virulence level of the strains. The current work analyzed the relationships between the virulence of MRSA and MSSA strains with region X polymorphism. No obvious correlation was observed.

8

Hemolityczna aktywnosc paleczek Klebsiella pneumoniae i Klebsiella oxytoca

80%

Szramka B. , Kurlenda J. , Bielawski K.

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nr 3-4

207-213

PL

Niniejsza praca przedstawia wyniki badań nad aktywnością hemolityczną wybranych szczepów Klebsiella pneumoniae i Klebsiella oxytoca. Badane szczepy wykazywały aktywność hemolityczną specyficzną wobec erytrocytów króliczych. Hemoliza występowała tylko po inkubacji hodowli z ß-merkaptoetanolem lub chlorkiem wapnia.

EN

We demonstrated that Klebsiella pneumoniae and Klebsiella oxytoca possess a selective haemolytic activity on rabbit erythrocytes. Thirty one Klebsiella strains (18 strains of K. pneumoniae and 13 strains of K. oxytoca) were isolated from hospitalized patients. The liquid (Trypcase-soy broth - TSB) and solid (Trypcase-soy agar - TSA) medium, containing the red cells were used for the tests. All the screened strains showed a haemolytic effect on rabbit erythrocytes, provided that the supernatants of the cultures were preincubated with ß-mercaptoethanol or calcium chloride. There was no human and sheep erythrocyte lysis.

9

Hemolizyny aktywowane tiolem jako markery wirulencji bakterii

80%

Szramka B. , Kurlenda J. , Podhajska A.

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nr 3