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Wplyw kurkuminy na detoksykacyjne i antyoksydacyjne mechanizmy w watrobie szczurow podczas starzenia

100%

Gutowicz M. , Cholojczyk M. , Pyrzanowska J. , Widy-Tyszkiewicz E. , Baranczyk-Kuzma A.

Medycyna Weterynaryjna

2008

tom 64

nr 07

955-957

Curcumin (diferuloylmethane), a yellow poliphenol pigment isolated from rhizome of Curcuma longa, has been used throughout Asia for several thousands of years. Beside giving curry dishes their color, curcumin has been reported as an agent used in the treatment of various disorders. The aim of this study was to determine the effect of chronic curcumin administration on enzymatic and nonenzymatic protective mechanisms in the livers of aging rats. The liver was isolated from Wistar Albino Glaxo rats, age 6 and 22 months. All rats were fed a standard chow diet. Two groups of older animals were given a standard diet supplemented either with 10 mg/kg b.w. or with 50 mg/kg b.w. of curcumin powder for 10 weeks before their sacrifice. Malondialdehyde level, reduced glutathione, the activity of catalase, glutathione S-transferase, and arginase were determined. Increased lipid peroxidation was observed in old rat livers, elevated catalase and arginase activities, as well as the level of reduced glutathione in curcumin fed animals. No changes in glutathione S-transferase activity were found. It may be concluded that curcumin administered in a diet exerts an antioxidant effect and protects the liver against ammonia intoxication.

Zmiany statusu antyoksydacyjnego w korze mozgowej czlowieka po zatruciu heroina

86%

Gutowicz M. , Cholojczyk M. , Siwinska-Ziolkowska A. , Pokorska-Lis M. , Szymczakowski S. , Sadurska B. , Baranczyk-Kuzma A.

Bromatologia i Chemia Toksykologiczna

2004

tom 37

nr 3

277-282

W pracy przedstawiono aktywność seleno-niezależnej peroksydazy glutationowej i katalazy, poziom zredukowanego glutationu, dialdehydu malonowego i grup karbonylowych W rożnych częściach kory mózgowej człowieka. Badania prowadzono na tkankach otrzymywanych z autopsji osób zmarłych na skutek zatrucia heroiną

In the present work we examined selenium-independent glutathione peroxidase (GSHPx) and catalase (CAT) activities, as well as levels of reduced glutathione (GSH), malondialdehyde (MDA), and the amount of carbonyl groups (CO) in human brain cortex. Various parts of brain cortex (frontal, parietal, temporal, occipital ) obtained by autopsy from 9 cases intoxicated by heroin and from 7 control brains were examined. We found a significant increase in GSHPx activity in the heroin-intoxicated brains, accompanied by decreased level of GSH. No changes in CAT activity or in the amount of carbonyl groups were observed, whereas the level of MDA was almost 2 times higher in heroin-intoxicated brains vs. controls. Thus, the results indicate that heroin intoxication changes the antioxidant status in human brain cortex. The changes comprise increased lipid peroxidation and disturbed organic peroxide inactivation.