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Corrective factors of intestinal microflora disorders in the perinatal period

100%

Pisaniak P. , Huflejt M. , Gurowiec P. J. , Ozga D.

Medical Science Pulse

2019

tom 13

nr 3

Intestinal microflora is found at approximately 10⁴ bacteria per ml of intestinal fluid. Although this ecosystem is very diverse with dynamic changes taking place within it, there is a certain stability in the type and number of species, referred to as the core microbiome, found in 95% of the human population. Genetic variation of microorganisms is relatively small, and their functions are strictly defined and highly conservative. The microbiome exists symbiotically with the host, protecting it against colonization by pathogenic microorganisms, providing essential metabolites, and stimulating the immune system. Colonization begins prenatally and its development is greatly influenced by the course of pregnancy, method of delivery, food supplied to the child during the first moments of life, and post-birth environment. The appropriate intestinal microflora composition is a key determinant of health and homeostasis, and any intestinal dysbiosis can be associated later in life with the development of obesity, diabetes, allergies or cancer. Due to the increasing number of hospitalised pregnancies and deliveries, affecting the intestinal microflora of a newborn, efforts are being made to minimize this process and restore the newborn’s microbiome. The use of the Vaginal seeding procedure raises up great hopes, but also some fears concerning its safety. Some very simple and most natural factors have been recently also appreciated and promoted, such as breastfeeding or direct contact of the baby’s skin with the mother’s skin, which are allies to probiotic bacteria. The purpose of this paper is to emphasize the importance of microbial colonization of the human body and to present the latest and most effective procedures that are designed to correct the existing dysbiosis or to reduce the risk of its occurrence. The literature for the compilation of this study has been obtained from databases such as PubMed, Google Scholar, Web of Science.

The hippocampal piramidal cell synapses simulator

88%

Gorzelanczyk E. J. , Huflejt M. , Kniat J. , Murakowski J. , Wozniak P.

Acta Neurobiologiae Experimentalis

2005

tom 65

nr 3

Funkcjonalny model symulacyjny zespołu synaps zapamiętujących komórki piramidowej hipokampa

75%

Gorzelańczyk E. J. , Huflejt M. , Kniat J. , Laskowska E. , Murakowski J. , Woźniak P.

Bio-Algorithms and Med-Systems

2005

tom Vol. 1, no. 1/2

217--220

Zaproponowano model komórki piramidowej hipokampa umożliwiający przeprowadzenie obliczeń w środowisku rozproszonym. W modelu uwzględniono: aktywność elektryczną pojedynczych synaps i receptorów glutamatergicznych oraz aktywność jądra komórkowego i transport receptorów. Podstawą modelu jest koncepcja alternatywnego składania genów. Symulator umożliwia na przykład modelowanie potencjałów czynnościowych, efektu przerwy, zjawiska długotrwałego wzmocnienia synaptycznego.

The model of pyramidal cell is proposed. With this model it is possible to make calculations in diffuse environment. This model considers electrical activity of the individual synapses and glutamate receptors, and cell nucleus activity as well as the transport of receptors. The basis of this model is the alternative splicing of genes. The simulator allows for example modeling action potentials, spacing effect, and long term synaptic potentiation.

Measuring the mechanics of morphogenesis

51%

Routier-Kierzkowska A.-L. , Weber A. , Kierzkowski D. , Nakayama N. , Mosca G. , Huflejt M. , Barbierde Reuille P. , Felekis D. , Nelson B. , Kuhlemeier C. , Smith R. S.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

2013

tom 94

nr 3