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Application of RP-HPLC-ED assay to analysis of the blood of Parkinson's disease patients

Głód B. K., Stańczak K. I.

Acta Chromatographica

2005

No. 15

276-288

Results from application of reversed-phase HPLC with electroche-mical detection to analysis of catecholamines and total antioxidant poten-tial are presented. The assay was used to estimate their daily profiles in blood serum of patients treated with anti-Parkinson drugs. It was found that increases in the concentration of hydroxy radicals in blood serum, and of the total antioxidant potential related to the hydroxy radical, was inversely correlated with the concentration of catecholamines in the serum. This sug-gests that catecholamines are pro-oxidants of hydroxy radicals. The method also enabled us to study changes in the concentrations of catecholamines during their storage at room temperature. It was found that change of drug color was caused by the oxidation of benseraside.

Determination of catecholamines and the total antioxidant potential of blood plasma by use of an improved RPHPLC-ED assay

Głód B. K., Stańczak K. I., Woźniak A., Pakszys W.

Acta Chromatographica

2004

No. 14

142-148

Preliminary results are presented from application of reversed-phase HPLC with electrochemical detection to analysis of L-dopa and total antioxidant potential. It was possible to perform both analyses by using the same chromatographic conditions. The method was used to estimate their daily profiles in the blood plasma of patients treated with different types of drug.