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Genotype TNF-α(-308) and Silicosis on Factory Workers in Vietnam in 2020

Nguyen Viet, Nguyen Thi Thu Huyen, Dao Xuan Dat, Vu Xuan Quy, Pham Thi Quan, Le Thi Kim Chung, Tran Huy Thinh, Le Thi Huong, Nguyen Ngoc Anh, Nguyen Viet Nhung, Nguyen Ngoc Hong, Luong Mai Anh, Le Thi Thanh Xuan

Inżynieria Mineralna

2021

no. 2

459--466

The studFigy aims to determine the TNF-α single-nucleotide polymorphism TNF-α (-308) and assess the association of TNF-a(-308) SNP with the risk of silicosis among workers directly exposed to silica dust in Vietnam. A study was undertaken among 78 cases with silicosis and 103 controls without silicosis in Vietnam. Blood samples were collected for genomic DNA extraction from each subject. The phenotyping of TNF-α(-308) was performed using polymerase chain reaction‐based restriction fragment length polymorphism (PCR‐RFLP) and dye termination sequencing. Results: The average exposure time of the case group was slightly higher than that of the control group (12.46 ± 6.732 years vs. 12.09 ± 7.854 years). The majority of genotypes in both silicosis and non-silicosis was GG. When analyzing the concentration of TNF-α in the study participants' blood, it is shown that the average concentration of TNFα in the case group was higher than that in the control group. The genotype AG in the case group was 1.368 times higher than that in the control group. The percentage of all A alleles in the case group with silicosis was 1.342 times higher than the control group without the disease, similar to previous studies. Conclusion: The majority of genotypes in both groups was GG. The average concentration of TNF-α in blood, genotype AG, and the percentage of all A alleles in the case group was higher than that in the control group.