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Optimal feed temperature for hydrogen peroxide decomposition process occurring in a bioreactor with fixed-bed of commercial catalase: a case study on thermal deactivation of the enzyme

Grubecki I.

Chemical and Process Engineering

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2018

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Vol. 39, nr 4

491–-501

EN

On the basis of hydrogen peroxide decomposition process occurring in the bioreactor with fixed-bed of commercial catalase the optimal feed temperature was determined. This feed temperature was obtained by maximizing the time-average substrate conversion under constant feed flow rate and temperature constraints. In calculations, convection-diffusion-reaction immobilized enzyme fixed-bed bioreactor described by a coupled mass and energy balances as well as general kinetic equation for rate of enzyme deactivation was taken into consideration. This model is based on kinetic, hydrodynamic and mass-transfer parameters estimated in earlier work. The simulation showed that in the biotransformation with thermal deactivation of catalase optimal feed temperature is only affected by kinetic parameters for enzyme deactivation and decreases with increasing value of activation energy for deactivation. When catalase undergoes parallel deactivation the optimal feed temperature is strongly dependent on hydrogen peroxide feed concentration, feed flow rate and diffusional resistances expressed by biocatalyst effectiveness factor. It has been shown that the more significant diffusional resistances and the higher hydrogen peroxide conversions, the higher the optimal feed temperature is expected.

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Optimal feed temperature for an immobilized enzyme fixed-bed reactor: a case study on hydrogen peroxide decomposition by commercial catalase

Grubecki I.

Chemical and Process Engineering

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2018

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Vol. 39, nr 1

39–-57

EN

Optimal feed temperature was determined for a non-isothermal fixed-bed reactor performing hydrogen peroxide decomposition by immobilized Terminox Ultra catalase. This feed temperature was obtained by maximizing the average substrate conversion under constant feed flow rate and temperature constraints. In calculations, convection-diffusion-reaction immobilized enzyme fixed-bed reactor described by a set of partial differential equations was taken into account. It was based on kinetic, hydrodynamic and mass transfer parameters previously obtained in the process of H2O2 decomposition. The simulation showed the optimal feed temperature to be strongly dependent on hydrogen peroxide concentration, feed flow rate and diffusional resistances expressed by biocatalyst effectiveness factor.

3

Optymalna temperatura strumienia zasilającego reaktor rurowy do rozkładu H2O2 ze stałym złożem katalazy Terminox Ultra: Analiza przepływu tłokowego

Grubecki I., Zalewska A.

Inżynieria i Aparatura Chemiczna

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2017

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Nr 5

166--168

PL

Określono optymalną temperaturę strumienia przepływającego tłokowo przez izotermiczny reaktor rurowy do rozkładu nadtlenku wodoru przez immobilizowaną katalazę Terminox Ultra. Wspomnianą temperaturę wyznaczono dla stałych wartości natężenia przepływu maksymalizując przeciętny stopień przemiany H2O2 na wylocie z reaktora. Obliczenia przeprowadzono w oparciu o parametry kinetyczne i transportu masy wyznaczone dla analizowanego procesu przebiegającego w reaktorze modelowym. Wykazano, że optymalna temperatura zasilania jest zależna od stężenia roztworu zasilającego, ilości użytego enzymu, prędkości przepływu i jednocześnie oporów dyfuzyjnych wyrażonych współczynnikiem efektywności biokatalizatora.

EN

The optimal feed temperature was determined for a non-isothermal fixed-bed reactor used in hydrogen peroxide decomposition by immobilized Terminox Ultra catalase. The feed temperature was obtained by maximizing average substrate conversion under the constant feed flow rate and temperature constraints. Calculations were based on kinetic and mass transfer parameters determined for the process carried out in the model reactor. The simulation showed that the optimal feed temperature was strongly dependent on hydrogen peroxide concentration, amount of enzyme used, superficial velocity and diffusion resistance expressed by the biocatalyst effectiveness factor.