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The effect of in vitro corrosion on the mechanical properties of metallic high strength biodegradable surgical threads

Milenin Andrij, Kustra Piotr, Byrska-Wójcik Dorota, Wróbel Mirosław, Paćko Marek, Sulej‑Chojnacka Joanna, Matuszyńska Sława, Płonka Bartłomiej

Archives of Civil and Mechanical Engineering

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2020

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Vol. 20, no. 2

437--452

EN

High strength biodegradable surgical threads are in demand for surgical practice. Nowadays, such threads can be made of metallic materials such as magnesium, zinc or alloys based on these metals. In current paper, manufacturing technology of biodegradable surgical threads of Mg–Ca alloys and of pure Zn was developed and basic properties of the obtained product have been characterized. The influence of in vitro corrosion in bovine serum simulating environment in the mammal’s body on the surgical threads mechanical properties was determined. It was found that Zn and hot extruded alloys MgCa0.9 and MgCa1.2 can be recommended as a candidate for the future study in vivo. Properties of the room temperature drawn wires of the alloy MgCa0.7 are not sufficient for its application as surgical threads.

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Antybakteryjne włókna ciągłe z poli(tereftalanu etylenowego) do zastosowań medycznych

Karbownik I.

Zeszyty Naukowe. Włókiennictwo / Politechnika Łódzka

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2005

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z. 61

33-43

PL

Opracowano metodą otrzymywania antybakteryjnych nici chirurgicznych z poli(tereftalanu etylenowego) PET, na które są wrażliwe bakterie Gram+ i Gram- (gronkowiec złocisty, pałeczka okrężnicy i pałeczka ropy błękitnej). Metoda ta, to dwustopniowa modyfikacja jedwabiu skręconego lub nici chirurgicznych "plecionka", polegająca na wprowadzeniu do nich grup karboksylowych metodą szczepienia, a następnie napawanie tych wyrobów roztworami antybiotyków: z grupy cefalosporyn (Biotrakson) i linkosamidów (Dalacin). Wykonano badania fizyko - chemiczne modyfikowanego jedwabiu PET oraz stwierdzono, że modyfikowane nici chirurgiczne zawierające antybiotyk powodują gojenie się rany bez wysięków i bez stanów zapalnych.

EN

A method of obtaining antibacterial surgical PET threads that would be sensitive to Gram+ and Gram- bacteriae (S.aureus, E.coli and P.aeruginosa) was obtained. The method consists of the incorporation of carboxylic groups into fibres f poly(acrylic acid) PAA grafting copolymerization followed by fibre impregnation with Biotrakson or Dalacin solutions. A method of grafting was used, in which very slightly or not at all can side effects be observed. Infrared studies proved the chemical characted of the bond between the PET fibre and the antibiotic. Moreover, moisture sorption, swelling, elongation tenacity and tenacity in the loop of the modified threads were studied as well. The modified fibres show effective biocide liberation into NaCl solution and antibacterial activity towards Gram positive and Gram negative microorganism (S. aureus, E. coli, P. aeruginosa). Antibiotics released from surgical threads are easily incorporated into the tissue environment and in the environment infected by S. aureus, these modified surgical treads with antibiotics, make a wound heal with neither effusions nor inflammations.

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Antybakteryjne nici chirurgiczne z poli(tereftalanu etylenowego)

Bucheńska J., Słomkowski S., Tazbir J., Sobolewska E., Timler D., Karbownik I.

Zeszyty Naukowe. Chemia / Politechnika Śląska

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2001

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z. 146

211-214

EN

An effective two-stage method for obtaining poly(ethylene terphthalate) chirurgical threads with antibacterial properties has been developed. The method consist of the incorporation of carboxylic groups into surgical threads by poly(acrylic acid) grafting polymerization followed by threads impregnation with Dalacin which belongs to lincosamides. There was investigated kinetics of release of the biocid. In vitro and in vivo studies revealed that the drug loaded fibers were bioactive against Gram - positive bacteria (Staphylococcus aureus).

4

Antybakteryjny jedwab poliestrowy zawierający dalacin

Bucheńska J., Słomkowski S., Tazbir J., Sobolewska E.

Zeszyty Naukowe. Chemia / Politechnika Śląska

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1999

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z. 140

267-270

PL

Badania były skierowane na rozwój użytecznych metod modyfikacji jedwabiu poliestrowego w celu zastosowania tego materiału do implantacji. Modyfikacja, przebiegająca w procesie dwuetapowym, pozwala uzyskać jedwab zawierający antybiotyk z grupy linkozamidów. Stwierdzono, że jedwab taki ma właściwości antybakteryjne. Zbadano kinetykę uwalniania biocydu. Wyniki analizowano w oparciu o równania kinetyczne różnych modeli uwalniania. Przeprowadzone badania in vitro pokazały, że modyfikowane włókna wykazują właściwości antybakteryjne w stosunku do Staphylococcus aureus.

EN

Our studies were directed towards development of methods suitable for modification of polyester silk in a way allowing to use it as an implant material. Modification, in a two step process, gave silk loaded with antibiotic from the group of lincosamides and it was found that such silk has antibacterial properties. There was investigated kinetics of release of the biocid. Data were analyzed using kinetic equations corresponding to various models of release. Studies in vitro revealed that the modified fibers had biocidal properties against Staphylococcus aureus.