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1

Optimal docking problem of UAV at detected moving object

Nabadova Lamiya

Zeszyty Naukowe. Transport / Politechnika Śląska

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2023

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z. 120

205--214

EN

In the article, the problem of detecting a suspicious object in the control by unmanned air vehicle (UAV) and tracking it by reaching and changing its direction in the shortest period of time is explored. To solve this optimal control problem, it is considered that the flight of UAV is described with simple motion equations. In the beginning, known quantities are current coordinates and speed of UAV, equation of motion of detected suspicious object.

2

Molecular docking studies on the phytoconstituents as therapeutic leads against SARS-CoV-2

Tiwari Abhishek, Tiwari Varsha, Verma Navneet, Singh Anita, Kumar Manish, Saini Vipin, Sahoo Biswa Mohan, Kaushik Deepak, Verma Ravinder, Sagadevan Suresh

Polimery

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2022

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Vol. 67, nr 7-8

355---374

EN

Because of the present pandemic researchers are seeking for phytocandidates that can inhibit or stop SARS-CoV-2. The main protease (Mpro) of SARS-CoV-2 and spike glycoprotein (S) are both suppressed by bioactive compounds found in plants that work by docking them together. The Mpro proteins 6LU7 (complex with an inhibitor N3) and 5C3N (space group C2221) were employed in docking research. PyRx and AutoDock Vina software were used as docking engine. 22 identified phytoconstituents were selected from IMPPAT, a manually curated database, on the basis of their antiviral effects. Docking studies showed that phytoconstituents β-amyrin (-8.4 kcal/mol), withaferin A (-8.3 kcal/mol), oleanolic acid (-7.8 kcal/mol), and patentiflorin A (-8.1 kcal/mol) had the best results against 5C3N Mpro protein whereas kuwanon L (-7.1 kcal/mol), β-amyrin (-6.9 kcal/mol), oleanolic acid (-6.8 kcal/mol), cucurbitacin D (-6.5 kcal/mol), and quercetin (-6.5 kcal/mol) against 6LU7 Mpro protein. All the compounds were examined for their ADMET characteristics using SwissDock. Present research reports that the phytoconstituents along with docking score will be helpful for future drug development against Covid-19.

PL

W związku z pandemią prowadzone są badania mające na celu znalezienie fitosubstancji, które mogą hamować lub zatrzymywać rozwój SARS-CoV-2. Działanie głównych białek proteazy (Mpro) SARS-CoV-2 i glikoproteiny kolca (S) jest osłabiane przez związki bioaktywne występujące w roślinach poprzez proces dokowania. Do badań dokujących użyto białka Mpro 6LU7 (kompleks z inhibitorem N3) i 5C3N (grupa przestrzenna C2221). Jako silnik dokujący zastosowano PyRx i AutoDock Vina. Zidentyfikowano 22 fitoskładniki wybrane z bazy danych IMPPAT, z uwzględnieniem ich działania przeciwwirusowego. Najbardziej skuteczne w przypadku białka Mpro 5C3N okazały się fitoskładniki β-amyryna (-8,4 kcal/mol), witaferyna A (-8,3 kcal/mol), kwas oleanolowy (-7,8 kcal/mol) i patentifloryna A (-8,1 kcal/mol), a w przypadku białka Mpro 6LU7 kuwanon L (-7,1 kcal/mol), β-amyryna (-6,9 kcal/mol), kwas oleanolowy (-6,8 kcal/mol), kukurbitacyna D (-6,5 kcal/mol) i kwercetyna (-6,5 kcal/mol). Wszystkie substancje zbadano pod kątem ich właściwości ADMET przy użyciu SwissDock. Wykazano, że fitoskładniki mogą być pomocne w pracach nad lekami przeciwko Covid-19.

3

Generating and modeling of braking curve and the assessment of the quality of automatic stopping of the train

Anuszczyk J., Gocek A., Pacholski K., Dominikowski B.

Transport Problems

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2018

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T. 13, z. 2

13--25

EN

This paper presents the theory about generating the braking curve and the analysis of the influence of the braking controller parameters on the generation of the braking curve of the train. In this paper, computed examples of braking quality developed using generic quality factor are shown, and on the basis of the calculations, weight components of the factor and an additional criterion for assessing the quality of braking were proposed. It has been demonstrated that the developed algorithms can be used to verify the effectiveness of the braking controller and the adjustment of the terms, and the change of these algorithms affects the shape of the generated braking curve of the train. It has been shown that the analysis of a failure of the propulsion car revealed the existence of a safe braking area. The performed statistical analysis confirmed the normal distribution of the scatter of braking results, for which the regression model fitted.

4

Planowanie manewru dokowania manipulatora kosmicznego typu planarne trójwahadło metodą endogenicznej przestrzeni konfiguracyjnej

Ratajczak A., Ratajczak J.

Prace Naukowe Politechniki Warszawskiej. Elektronika

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2018

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z. 196

51--60

PL

W pracy przedstawiono propozycję algorytmu planowania ruchu manipulatora kosmicznego w obecności przeszkód. Wprowadzono matematyczny model dynamiki manipulatora kosmicznego typu planarne trójwahadło, który następnie poddano częściowo linearyzującemu sprzężeniu zwrotnemu. Algorytm planowania ruchu oparty jest na idei endogenicznej przestrzeni konfiguracyjnej. Zadanie planowania ruchu wraz z unikaniem przeszkód zostało rozwiązane przy pomocy algorytmu z priorytetowaniem zadań. Efektywność pracy algorytmu została przedstawiona przy pomocy badań symulacyjnych.

EN

In this paper we propose the motion planning with obstacle avoidance algorithm for space manipulator. The introduced dynamics of planar triple pendlum space manipulator is subjected to the partially feedback linearization. The motion planning algorithm is derived with an endogenous configuration space approach and the obstacle avoidance is included through the prioritarian approach. The efficiency of the presented method is illustrated with simulations.

5

Impact of dock tanks pumping plan on structural loads of a dock and a ship

Rajewski P.

New Trends in Production Engineering

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2018

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Vol. 1, Iss. 1

143--149

EN

Positioning of a ship on a working platform above the waterline in order to repair and modernize the underwater hull parts requires changes from continuous support to point support. And as a result of such, the load of the ship structure is subject to changes as well. In extreme cases, the loads may exceed the allowable loads and cause damage to the hull structure. The paper presents the technical aspects of the ships docking process which may have an impact on safety. It also includes a discussion on procedures that reduce the risk of malfunction and failure.