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One step 3D printing of surface functionalized composite scaffolds for tissue engineering applications

Kotlarz M., Jordan R., Wegner E., Dobrzyński P., Neunzehn J., Lederer A., Wolf-Brandstetter C., Pamula E., Scharnweber D.

Acta of Bioengineering and Biomechanics

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2018

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Vol. 20, no. 2

35--45

EN

A successful approach widely used in materials science to adapt approved materials to specific applications is to design their surface properties. A main challenge in this area is the development of processing routes enabling for a simple but efficient surface design of complex shaped geometries. Against this background, this work aimed at the implementation of self-assembly principles for surface functionalization of 3D-printed poly(lactic-co-glycolic acid) (PLGA)-based constructs with macro- and microporous geometries via precision extruding deposition. Methods: Three-component melts from PLGA, CaCO3 and amphiphilic polymers (poly(2-oxazoline) block copolymer) were printed and their bulk and surface properties were studied. Results: Melts with up to 30 mass % of CaCO3 could be successfully printed with homogeneously distributed mineral particles. PLGA degradation during the printing process was temperature and time dependent: the molecular weight reached 10 to 15% of the initial values after ca. 120 min of heat exposure. Filament surfaces from melts containing CaCO3 show an increasing microroughness along with increasing CaCO3 content. Surface roughness and amphiphilic polymer content improve scaffold wettability with both factors showing synergistic effects. The CaCO3 content of the melts affected the inner filament structure during in vitro degradation in PBS, resulting in a homogeneous mineral particle-associated microporosity for mineral contents of 20 mass % and above. Conclusions: These results provide novel insights into the behavior of three-component melts from PLGA, CaCO3 and amphiphilic polymers during precision extruding deposition and show for the first time that self-assembly processes can be used to tailor scaffolds surface properties under such processing conditions.

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Meszki i ich zwalczanie w Polsce

Wegner E.

Przegląd Komunalny

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2010

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nr 4

50-51

PL

W ostatnich latach obserwuje się coraz liczniejsze i coraz szersze występowanie gatunków meszek agresywnych w stosunku do ludzi, a okres utrzymywania się wysokich liczebności owadów dorosłych trwa od kwietnia nawet do lipca.

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Biologiczne zwalczanie komarów

Wegner E.

Przegląd Komunalny

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2010

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nr 3

85-87

PL

W wielu miastach Polski uciążliwość komarów jest poważnym problemem i coraz częściej podejmowane są akcje ich zwalczania. Regularne działania w tym zakresie prowadzone są corocznie tylko w kilku miastach - np. w Szczecinie i Wrocławiu. W doraźnych akcjach stosuje się chemiczne metody zwalczania tych owadów, choć równie skuteczna - a bezpieczniejsza dla środowiska - jest metoda biologiczna.

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Bonding with atomic rearrangement – new possibilities in material and devices technology

Hruban A., Strzelecka S., Wegner E., Pawłowska M., Gładki A., Stępniewski R., Jasiński J., Bożek R.

Optica Applicata

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2002

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Vol. 32, nr 3

355-364

EN

In this work we present the results of investigations into direct bonding of AIIIBV bulk wafers and/or epitaxial structures. A good quality junction of GaAs–GaAs, GaAs–InP, GaAs–GaP has been obtained. Bonding of GaAs/GaAlAs/GaAs epi-structures with GaAs bulk substrates enabled obtaining universal compliant substrates. On these substrates InAs epitaxial layers have been deposited. Properties of the structures have been examined by Nomarski microscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM) and X-ray diffractometry