Physical properties of materials used for infusion sets for photosensitive medicines

• Autorzy: Szafarczyk Karolina , Szewczenko Janusz , Maciak Erwin , Kałużyński Piotr , Goldsztajn Karolina

Identyfikatory

DOI

10.34821/eng.biomat.167.2022.2-9

• Języki publikacji: EN

Abstrakty

EN

Continuous infusion, as one of the most effective methods of delivering pharmaceuticals to patients, uses infusion pumps to which a syringe and infusion drains are connected. Photosensitive drugs that require UV-VIS protection are delivered to patients with special infusion sets that reduce harmful radiation. However, these drains have different transparencies, which can affect the success of therapy. This study investigated the optical properties of two types of drains used for infusion therapy of photosensitive drugs. UV-VIS spectroscopy studies were carried out, allowing the determination of the absorbance values and absorption coefficient of the two types of drains. The spectrum of their transmittance was also analyzed. The chemical composition of the samples was tested using FTIR-ATR spectroscopy. Furthermore, the roughness and wettability parameters of the drains were determined, which affect not only the kinematics of drug flow in the drains but also the way in which light is transmitted. The results of the study can be used to propose a solution to eliminate the problem of loss of properties of the photosensitive drug in drains, in contact with light. By selecting the appropriate drain thickness, it is possible to reduce the transmission of radiation in the UV-VIS range through the drain.

Słowa kluczowe

EN

infusion drains; photosensitive medicines; polyvinyl chloride; UV-VIS spectrophotometry; transmittance; absorbance

PL

spektrofotometria; biomateriały; medycyna; polichlorek winylu

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2022
• Tom: vol. 25, no. 167
• Strony: 2--9
• Opis fizyczny: Bibliogr. 13 poz., tab., wykr., zdj.

Twórcy

autor

Szafarczyk Karolina

• Silesian University of Technology, Faculty of Biomedical Engineering, Department of Biomaterials and Medical Device Engineering, 40 Roosevelta Str., 41-800 Zabrze, Poland

autor

Szewczenko Janusz

• Silesian University of Technology, Faculty of Biomedical Engineering, Department of Biomaterials and Medical Device Engineering, 40 Roosevelta Str., 41-800 Zabrze, Poland

autor

Maciak Erwin

• Silesian University of Technology, Faculty of Electrical Engineering, Department of Optoelectronics, 2B Krzywoustego Str., 44-100 Gliwice, Poland

autor

Kałużyński Piotr

• Silesian University of Technology, Faculty of Electrical Engineering, Department of Optoelectronics, 2B Krzywoustego Str., 44-100 Gliwice, Poland

autor

Goldsztajn Karolina

• Silesian University of Technology, Faculty of Biomedical Engineering, Department of Biomaterials and Medical Device Engineering, 40 Roosevelta Str., 41-800 Zabrze, Poland

Bibliografia

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• [2] Sánchez-Quiles I., Nájera-Pérez M.D., Espuny-Miró A., Titos--Arcos J.C.: Review of the Stability of Photosensitive Medications. Farmacia Hospitalaria 35(4) (2011) 204-215.
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• [8] Nowicka-Jankowska T.: Spektrofotometria UV/VIS w analizie chemicznej. Państwowe Wydawnictwo Naukowe, Warszawa 1988.
• [9] Lai H., Wang Z., Wu P., Chaudhary B.I., Sengupta S.S., Cogen J.M., Li B.: Structure and Diffusion Behavior of Trioctyl Trimellitate (TOTM) in PVC Film Studied by ATR-IR Spectroscopy. Industrial & Engineering Chemistry Research 51(27) (2012) 9365-9375.
• [10] Website: https://webbook.nist.gov/cgi/cbook.cgi?ID=C3319311&Units=SI&Mask=80#IR-Spec (access: 10.01.2023).
• [11] Website: https://webbook.nist.gov/cgi/cbook.cgi?ID=C57114&Units=SI&Type=IR-SPEC&Index=3#IR-SPEC (access: 10.01.2023).
• [12] Website: https://spectrabase.com/spectrum/DfQFrsxTH30 (access: 10.01.2023).
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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu „Społeczna odpowiedzialność nauki” - moduł: Popularyzacja nauki i promocja sportu (2022-2023)