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What is at risk? – an environmental health risk assessment related with pharmaceutical substances in drinking water

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Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Constantly increasing rate of drugs’ consumption can be related with environmental abundance of drug substances and their degradation products. Unused and used drugs are often discharged into municipal wastewaters or landfills. Wastewater treatment plants are not able to remove the entire load of drugs. Especially those which occur occasionally or at very low concentrations. Therefore, a variety of pharmaceuticals occur in surface and drinking water sources. A chronic low-level exposure to drugs occurring in a water environment can cause: antibiotic resistance, allergic reactions (eg. Penicillin), cause carcinogenesis (oxytetracycline, furazolidone), nephropathy (gentamicin) and have a negative impact on the natural human intestinal microflora. Therefore, it is not an easy task to assess a common human health effects related with chronic exposure to low doses of active pharmaceutical substances. Nonetheless, such knowledge seems essential in order to undertake preventive actions that would substantially decrease the level of health risk.
Rocznik
Strony
14--20
Opis fizyczny
Bibliogr. 38 poz., tab.
Twórcy
autor
  • Deparment of Hygiene and Epidemiology, Faculty of Medicine, Medical University of Gdansk, Dębinki 7 Str., 80-211 Gdansk, Poland
  • Deparment of Hygiene and Epidemiology, Faculty of Medicine, Medical University of Gdansk, Dębinki 7 Str., 80-211 Gdansk, Poland
  • Department of Environmental Toxicology, Faculty of Health Sciences, Medical University of Gdansk, Dębowa 23 Str., 80-204 Gdansk, Poland
autor
  • Department of Environmental Toxicology, Faculty of Health Sciences, Medical University of Gdansk, Dębowa 23 Str., 80-204 Gdansk, Poland
  • Deparment of Hygiene and Epidemiology, Faculty of Medicine, Medical University of Gdansk, Dębinki 7 Str., 80-211 Gdansk, Poland
Bibliografia
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  • [21] M. Velicu, R. Suri, “Presence of steroid hormones and antibiotics in surface water of agricultural, suburban and mixed-use areas”, Environ. Monit. Assess., vol. 154, no. 1-4, pp. 349-359, Jul 2009.
  • [22] E. Vulliet, C. Cren-Olive, M.F. Grenier- Loustalot, “Occurrence of pharmaceuticals and hormonesin drinking water treated from surface waters”, Environ Chem Lett., vol. 9, no. 1, pp. 103-114, Mar 2011.
  • [23] C.M. de Jongh, J.F. Pascal Kooij, P. de Voogt, et al., “Screening and human health risk assessment of pharmaceuticals and their transformation products in Dutch surface waters and drinking water”, Sci Total Environ., vol. 427, pp. 70–77, 2012.
  • [24] S.A. Snyder, “Occurrence, treatment, and toxicological relevance of EDCs and pharmaceuticals in water”, Ozone: Sci. Eng., vol. 30, pp. 65–69, 2008.
  • [25] Q. Zheng, R. Zhang, Y. Wang, et al., “Occurrence and distribution of antibiotics in the Beibu Gulf, China: Impacts of river discharge and aquaculture activities”, Mar Environ Res, vol. 78, pp. 26-33, Jul 2012.
  • [26] A. Wasik-Kot, J. Dębska, J. Namieśnik, „Pozostałości środków farmaceutycznych w środowisk: przemiany, stężenia, oznaczenia”, Ecol. Chem. Eng., vol. 10, no. 6, pp. 723-750, 2003.
  • [27] D. Perret, A. Gentili, S. Marchese, et al., “Sulphonamide residues in Italian surface and drinking waters: a small scale reconnaissance”, Chromatographia, vol. 63, no. 5, pp. 225–232, 2006.
  • [28] US EPA, Risk Assessment Guidance for Superfund, vol. I, Human Health Evaluation Manual. Part A (Interim Final), EPA/540/1-89/002. Office of Emergency and Remedial Response, US Environmental Protection Agency, Washington, DC, 1989.
  • [29] US EPA, Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures. EPA/630/R-00/002. Risk Assessment Forum U.S. Environmental Protection Agency Washington, DC, 2000.
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  • [31] United States Environmental Protection Agency. Human Health Risk Assessment Protocol for Hazardous Waste Combustion Facilities [Online]. Available: http://www3.epa.gov/epawaste/hazard/tsd/td/combust/riskvol.htm
  • [32] M. Cleuvers, “Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects”, Toxicol Lett, vol. 142, no. 3, pp. 185–194, May 2003.
  • [33] B. Halling-Sørensen, S. Nors Nielsen ,P.F. Lanzky, et al., “Occurrence, fate and effects of pharmaceutical substances in the environment—a review”, Chemosphere, vol. 36, no. 2, pp. 357– 393, Jan 1998.
  • [34] M.L. Farre, I. Ferrer, A. Ginebreda, et al., “Determination of drugs in surface water and wastewater samples by liquid chromatography-mass spectrometry: methods and preliminary results including toxicity studies with Vibrio fischeri”, J Chromatogr A, vol. 938, no. 1-2, pp. 187– 197, Dec 2001.
  • [35] D. Camacho-Muñoz, J. Martín, J. L. Santos, “Distribution and Risk Assessment of Pharmaceutical Compounds in River Sediments from Doñana Park (Spain)”, Water Air Soil Pollut., vol. 224, pp. 1665, 2013.
  • [36] Y. Kim, K. Choi, J. Jung, et al., “Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea”, Environ. Int., vol. 33, no. 3, pp. 275–370, Jan 2007.
  • [37] R.A. Brain, D.J. Johnson, S.M. Richards, et al., “Effects of 25 pharmaceutical compounds to Lemna gibba using a seven-day static-renewal test”, Environ Toxicol Chem, vol. 23, no. 2, pp. 371– 82, Feb 2004.
  • [38] B. Ferrari, N. Paxeus, R. Lo Giudice, et al., “Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac”, Ecotoxicol Environ Saf., vol. 55, no. 3, pp. 359– 370, Jul 2003
Uwagi
PL
Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-f08c1e87-2dc0-4bdb-b3f7-6d499f3b11a8
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