Zastosowania systemów uwalniania wankomycyny do regeneracji tkanki kostnej

• Autorzy: Träger Dominika , Niziołek Karina

Identyfikatory

DOI

10.15199/28.2023.4.2

Warianty tytułu

EN

Applications of vancomycin release systems for bone regeneration

• Języki publikacji: PL

Abstrakty

PL

Wankomycyna (VA) jest szeroko stosowanym glikopeptydowym antybiotykiem, o bardzo skutecznym działaniu bakteriobójczym/bakteriostatycznym. Jest stosowana profilaktycznie przed operacjami, po zabiegach lub w ich trakcie wraz z wszczepianym implantem celem zahamowania namnażania się bakterii i zapobiegania infekcji. Pomimo skutecznego działania bakteriobójczego, nieostrożne i niewłaściwe podanie antybiotyku może skutkować toksycznym działaniem prowadzącym do stałych uszkodzeń w ciele. W przeglądzie przedstawiono przykłady połączenia VA z implantami, które pozwalają na precyzyjne dostarczenie leku oraz kontrolę nad czasem jego uwalniania, wspomagając tym samym regenerację tkanki kostnej

EN

Vancomycin (VA) is a widely used glycopeptide antibiotic with highly effective bactericidal/bacteriostatic activity. It is used prophylactically before, after, or during surgery along with an implant to inhibit bacterial proliferation and prevent infection. Despite its effective antibacterial effect, careless and inappropriate administration of the antibiotic can result in toxicity leading to permanent damage in the body. The review provides examples of combining VA with implants that allow precise delivery of the drug and control over the timing of its release, thereby aiding bone tissue regeneration

Słowa kluczowe

PL

wankomycyna; systemy dostarczania leków; polimery; hydroksyapatyt

EN

vancomycin; drug delivery systems; polymers; hydroxyapatite

• Wydawca: Wydawnictwo SIGMA-NOT
• Czasopismo: Inżynieria Materiałowa
• Rocznik: 2023
• Tom: Vol. 44, nr 4
• Strony: 18--24
• Opis fizyczny: Bibliogr. 42 poz., rys.

Twórcy

autor

Träger Dominika

• Katedra Inżynierii Materiałowej, Wydział Inżynierii Materiałowej i Fizyki, Politechnika Krakowska

• https://orcid.org/0009-0009-8737-3515

autor

Niziołek Karina

• Katedra Inżynierii Materiałowej, Wydział Inżynierii Materiałowej i Fizyki, Politechnika Krakowska

• https://orcid.org/0000-0001-7970-3478

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