Cytotoxicity of selected antiseptics and the safety of wound treatment

• Autorzy: Pozniak Maria , Futoma-Kołoch Bożena , Szopa Monika , Siczek Marta , Ladaczek-Słyk Ewelina , Pędlowski Michał

Identyfikatory

DOI

10.5604/01.3001.0055.2292

Warianty tytułu

PL

Cytotoksyczność wybranych antyseptyków a bezpieczeństwo leczenia ran

• Języki publikacji: EN

Abstrakty

EN

Although antiseptics are commonly used in wound treatment as antimicrobial agents, their effects on human cells remains debatable. Despite their well-documented bactericidal efficacy, many antiseptics can cause adverse reactions including cytotoxicity towards fibroblasts and keratinocytes, which can negatively affect the wound healing process. The purpose of this paper is to evaluate the available data on the cytotoxicity of selected antiseptics used in wound treatment. Based on the data available in medical literature, it has been demonstrated that octenidine has a relatively high Biocompatibility Index (BI), which makes it safer to use, especially in chronic wounds. In contrast, preparations containing chlorhexidine, iodine, hydrogen peroxide, triclosan, or silver compounds may exhibit pronounced cytotoxicity, which may limit their use.

PL

Antyseptyki są powszechnie stosowane w leczeniu ran jako środki przeciwdrobnoustrojowe, jednak ich wpływ na komórki ludzkie wciąż budzi wątpliwości. Mimo dobrze udokumentowanej skuteczności bakteriobójczej wiele z nich może wywoływać działania niepożądane, w tym cytotoksyczność wobec fibroblastów i keratynocytów, co może negatywnie wpływać na proces gojenia. Celem niniejszego artykułu jest ocena dostępnych danych dotyczących cytotoksyczności wybranych antyseptyków stosowanych w leczeniu ran. Na podstawie dostępnych danych zawartych w literaturze medycznej wskazano, że oktenidyna charakteryzuje się relatywnie wysokim wskaźnikiem biokompatybilności (BI), przez co stosowanie jej jest bezpieczniejsze, zwłaszcza w przypadku ran przewlekłych. Z kolei preparaty zawierające chlorheksydynę, jod, nadtlenek wodoru, triklozan, czy związki srebra mogą wykazywać wyraźną cytotoksyczność, co może ograniczać ich zastosowanie.

Słowa kluczowe

EN

cytotoxicity of antiseptics; biocompatibility; wound treatment; safety of use

PL

cytotoksyczność antyseptyków; biokompatybilność; leczenie ran; bezpieczeństwo stosowania

• Wydawca: Wydawnictwo Akademii Wojsk Lądowych imienia generała Tadeusza Kościuszki
• Czasopismo: Scientific Journal of the Military University of Land Forces
• Rocznik: 2025
• Tom: Vol. 57, No.3(217)
• Strony: 117--140
• Opis fizyczny: Bibliogr. 48 poz., rys., tab.

Twórcy

autor

Pozniak Maria

• University of Wrocław, Poland

• https://orcid.org/0009-0002-4589-0222

autor

Futoma-Kołoch Bożena

• University of Wrocław, Poland

• https://orcid.org/0000-0003-1484-5912

autor

Szopa Monika

• Military Center of Preventive Medicine, Wrocław, Poland

• https://orcid.org/0009-0008-1487-1372

autor

Siczek Marta

• Wrocław Medical University, Poland

• https://orcid.org/0000-0002-3892-620X

autor

Ladaczek-Słyk Ewelina

• Military Center of Preventive Medicine, Wrocław, Poland

• https://orcid.org/0009-0008-4827-5413

autor

Pędlowski Michał

• Military Center of Preventive Medicine, Wrocław, Poland

• https://orcid.org/0009-0009-6868-3032

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