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  1. 4 Ginalska G.
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1
Content available Metal-organic frameworks for efficient drug adsorption and delivery
Hyjek Kornelia, Jodłowski Przemysław
Scientiae Radices
|
2023
|
Vol. 2, Iss. 2
115-189
EN
In recent years, the number of materials used as drug delivery systems (DDS) has increased dramatically. The widespread use of DDSs has improved both the safety and efficacy of therapy. The systems currently in use pose numerous drawbacks and require proper improvements. Although many modern materials are being developed, metal-organic frameworks (MOFs) deserve special attention. Thermal and chemical stability, high specific surface area, low toxicity, high biocompatibility, and great potential for modification are the main features enabling MOFs to be used as DDS. In this review, we describe MOFs, their structure, synthesis, and characterization, as well as drug loading, drug release kinetics, and bioassays. A critical approach is to outline the disadvantages as well as the limitations of MOFs and to identify areas that need to be studied more thoroughly. Nonetheless, the prospective nature of MOFs as DDS and potential adsorbents in overdose or poisoning is presented and highlighted.
2
Content available remote Zastosowania wybranych metali w przyrządach do monitorowania kultur in vitro
Zarzeczny Dawid
Przegląd Elektrotechniczny
|
2022
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R. 98, nr 2
79--82
PL
W pracy opisany został problem związany z wysokimi nakładami koniecznymi do prowadzenia badań medyczno- -biologicznych. Zaproponowano możliwość zastosowania niestandardowych rozwiązań poprawiających efektywność kosztową prowadzenia eksperymentów in vitro metodą pomiaru impedancji elektrycznej. Opisano opracowane matryce z elektrodami wykonanych z różnych materiałów do pomiaru impedancji elektrycznej komórek in vitro. Pomiary przeprowadzono wykorzystując komórki mysich fibroblastów L929 z użyciem płytek z elektrodami z Cu, Ti, NiCr i Ni. Posłużyły one do oceny wpływu danego materiału na hodowlę komórek i próbę określenia możliwości ich zastosowania w eksperymentach medyczno-biologicznych.
EN
The paper describes the problem related to the high costs necessary to conduct medical and biological research. The possibility of using non-standard solutions improving the cost-effectiveness of conducting in vitro experiments using the electrical impedance measurement method was proposed. The developed matrices with electrodes made of various materials for the in vitro measurement of cell electrical impedance are described. Measurements were performed using mouse L929 fibroblast cells using plates with Cu, Ti, NiCr and Ni electrodes. They were used to assess the effect of a given material on cell culture and to attempt to determine the possibility of their use in medical and biological experiments.
3
Content available Biopolymers as renewable polymeric materials for sustainable development : an overview
Srivastava Abhinav, Srivastava Atul Kumar, Singh Ashutosh, Singh Priti, Verma Sangeeta, Vats Monika, Sagadevan Suresh
Polimery
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2022
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Vol. 67, nr 5
185--196
EN
Based on the review of 115 literature items, the article presents biopolymers as renewable polymer materials for sustainable development. The types of biopolymers and their applications are discussed, including biopolymers based on starch, cellulose, bacteria, soy and natural polyester. It also describes the issues of biocompatibility, the principles of sustainable chemistry and sustainable development, as well as market trends and future application directions.
PL
Na podstawie przeglądu 115 pozycji literaturowych w artykule przedstawiono biopolimery jako odnawialne materiały polimerowe dla zrównoważonego rozwoju. Omówiono rodzaje biopolimerów i ich zastosowanie, w tym biopolimery na bazie skrobi, celulozy, bakterii, soi i naturalnego poliestru. Opisano również zagadnienia dotyczące biokompatybilności, zasad zrównoważonej chemii i zrównoważonego rozwoju oraz trendy rynkowe i perspektywiczne kierunki zastosowań.
4
Content available Biomimetic scaffolds based on chitosan in bone regeneration. A review
Kołakowska Anna, Gadomska-Gajadhur Agnieszka, Ruśkowski Paweł
Chemical and Process Engineering
|
2022
|
Vol. 43, nr 3
305–-330
EN
Chitosan (CS) is a polysaccharide readily used in tissue engineering due to its properties: similarity to the glycosaminoglycans present in the body, biocompatibility, non-toxicity, antibacterial character and owing to the fact that its degradation that may occur under the influence of human enzymes generates non-toxic products. Applications in tissue engineering include using CS to produce artificial scaffolds for bone regeneration that provide an attachment site for cells during regeneration processes. Chitosan can be used to prepare scaffolds exclusively from this polysaccharide, composites or polyelectrolyte complexes. A popular solution for improving the surface properties and, as a result enhancing cell-biomaterial interactions, is to coat the scaffold with layers of chitosan. The article focuses on a polysaccharide of natural origin – chitosan (CS) and its application in scaffolds in tissue engineering. The last part of the review focuses on bone tissue and interactions between cells and chitosan after implantation of a scaffold and how chitosan’s structure affects bone cell adhesion and life processes.
5
Content available remote Biological Properties of Knitted Fabrics Used in Post-Burn Scar Rehabilitation
Latańska Ilona, Kowalski Krzysztof, Kłonowska Magdalena, Jaworska Aleksandra, Doś Janusz, Karbowski Krzysztof, Sujka Witold
Autex Research Journal
|
2022
|
Vol. 22, no. 3
343--349
EN
Compression therapy along with the use of compression materials is one of the main prevention methods against scars and keloids. Compression knitted fabrics must be characterized by parameters that enabling to reaching class I compression (16–24 mmHg). When constant pressure higher than capillary vessels pressure is applied to scars, it will have a negative influence on formation of keloids and significantly prevents their hypertrophy. Long-term pressure causes tissue hypoxia, slowed-down metabolism, and reduction of the amount of fibroblasts. One of key elements of compression therapy is choosing the required knitted fabric with necessary structure and physicomechanical parameters as well as designing methodology based on Laplace law, which will ensure the application of desired value of single-unit pressure on post-burn scar. Apart from physicomechanical parameters, a medical device, such as compression garment, must be characterized by high level of biocompatibility. An added value in terms of functional parameters is the antibacterial action of the product. It was obtained from the fibers used which contain a compound in their matrix and out of which silver ions are released. Additionally, the antibacterial action was also obtained via impregnation of the knitted fabric in RUCO-BAC AGP which contains silver. In the course of the research presented in the article, compression fabric was designed with a special construction - a knitted fabric comprising two layers. The first layer, which is in direct contact with human skin, is manufactured out of a yarn with conductive-diffusive characteristics. The second layer is made of microfibers which keep the moisture out of skin surface and also diffuse it to the outside. The following article describes the final stage of developing a compression garment aiding the external treatment process; the mentioned stage is related to biological tests such as microbiological contamination, cytotoxicity, sensitization, and irritation. The article closes a series of publications presented by the Authors in bibliography. It also presents the antibacterial activity tests done on the developed double-layer knitted fabric enriched with silver. The obtained results suggest that the fabric may be used not only in compression therapy, but also in the field of cosmetics and aesthetics.
6
Content available remote Tribological and surface morphological characteristics of titanium alloys: a review
Gupta Munish Kumar, Etri Hamza El, Korkmaz Mehmet Erdi, Ross Nimel Sworna, Krolczyk Grzegorz M., Gawlik Józef, Yaşar Nafiz, Pimenov Danil Yu.
Archives of Civil and Mechanical Engineering
|
2022
|
Vol. 22, no. 2
art. no. e72, 1--23
EN
Being easily fabricated, welded, biocompatible, having a high strength-to-weight ratio, withstanding comparatively high temperatures up to 800°C and low modulus of elasticity make grade titanium and its alloys an important choice for automotive, biomedical and aerospace industries. In contempt of the different pleasant assets of Ti-6Al-4V alloy, the operation of this alloy is restricted especially when it comes to tribological and surface morphological characteristics. Enhancing these properties is important, for this purpose, a diversity of attempts and studies have been conducted. This paper mounts a review of morphological and tribological behaviors of titanium alloys including Ti-6Al-4V against different materials counting with carbide tools and other types of materials under dry and lubricated sliding conditions. The surface morphological, wear, and other properties have been discussed in this review article.
7
Content available Bioresorbable polymeric materials – current state of knowledge
Wiśniewska Kamila, Rybak Zbigniew, Wątrobiński Marcin, Struszczyk Marcin H., Filipiak Jarosław, Żywicka Bogusława, Szymonowicz Maria
Polimery
|
2021
|
T. 66, nr 1
3--10
EN
Bioresorbable materials are used in medicine for fixing, correcting or stabilizing bones in various anatomical areas, and the market for such materials is growing rapidly worldwide. The use of polymers for their production is associated with the ability to control their properties. They are prepared from bioresorbable materials with variable surface, geometry, porosity, as well as mechanical and surface properties. They support bone healing and are suitable for tissue regeneration due to their biodegradability and biocompatibility. We believe that materials from biodegradable polymers will play an increasingly important role in future medicine.
PL
Materiały bioresorbowalne są szeroko stosowane wmedycynie do uzupełniania ubytków kości w różnych stanach chorobowych i powypadkowych, a także do nadbudowy iodbudowy kostnej oraz mocowania złamań. Rynek tego typu materiałów szybko się rozwija na całym świecie. Powszechność wykorzystania polimerów jest związana z możliwością kontrolowania ich właściwości. Zaletą materia-łów polimerowych jest możliwość zmiany powierzchni, geometrii, porowatości, właściwości mechanicz-nych ipowierzchniowych, atakże ich biodegradowalność ibiokompatybilność. Materiały z polimerów biodegradowalnych będą zapewne odgrywać coraz poważniejszą rolę w medycynie przyszłości.
8
Nanocząstki magnetyczne w diagnostyce i leczeniu chorób nowotworowych
Piech Radosław, Skrzypiec Maksymilian, Drabczyk Anna
Inżynieria Materiałowa
|
2021
|
Vol. 42, nr 6
15--23
PL
W ostatnich latach intensywnie bada się nanocząstki magnetyczne (MNPs) pod względem użycia ich w medycynie, głównie w walce z chorobami nowotworowymi. Przy użyciu nanocząstek magnetycznych możliwe jest celowe, nieinwazyjne dostarczenie leku w miejsce kumulacji komórek rakowych za pomocą m.in. pola magnetycznego, co faworyzuje je w stosunku do klasycznych cytostatyków, które uszkadzają również zdrowe komórki i oddziałują na cały organizm. Nanocząstki magnetyczne mogą służyć również do wykrycia i zdiagnozowania chorób nowotworowych, jak również określania postępów terapii antynowotworowej. Różnorodność zastosowania nanocząstek magnetycznych sprawia, że są one postrzegane jako innowacyjny i przełomowy środek do zwalczania chorób nowotworowych. W artykule zebrano informacje na temat najpopularniejszych metod wytwarzania nanocząstek magnetycznych i ich wykorzystania w medycynie oraz poruszono kwestię biokompatybilności i toksyczności tychże struktur.
EN
Magnetic nanoparticles have attracted attention because of their properties that make it possible to use them to treat cancer through targeted therapy. By using a magnetic field to target nanoparticles containing drugs, it is possible to reach cancer cells directly and fight them in their place of growth without affecting healthy cells or the body as a whole. Magnetic nanoparticles can be used in diagnostics to detect and diagnose cancer as well as to determine the progress of anti-cancer therapy. In this paper, we mentioned the biocompatibility and toxicity of magnetic nanoparticles because their use also carries the risk of health damage which is a necessity for further research on this topic.
9
Content available Tailoring hydrophilicity of poly(butylene succinate) (PBS) copolymers
Zarei Moein, El Fray Miroslawa
Engineering of Biomaterials
|
2021
|
Vol. 24, no. 163
64
10
Content available Bioactive hydrocolloid-type biomaterials for potential management of highly exuding wounds
Wojcik Michał, Kazimierczak Paulina, Vivcharenko Vladyslav, Przekora Agata
Engineering of Biomaterials
|
2021
|
Vol. 24, no. 163
49
11
Content available Adhesion, microstructure and surface topography of mesoporous, Cu-doped sol-gel glass/zein coatings electrophoretically deposited on Ti-13Nb-13Zr alloy substrates
Maciąg Filip, Cholewa-Kowalska Katarzyna, Dziadek Michał, Moskalewicz Tomasz
Engineering of Biomaterials
|
2021
|
Vol. 24, no. 163
51
12
Content available Influence of the different composites (PLA/PLLA/HA/β-TCP) contents manufactured with the use of additive laser technology on the biocompatibility
Woźna Anna E., Junka Adam, Hoppe Viktoria W.
Acta of Bioengineering and Biomechanics
|
2021
|
Vol. 23, no. 2
169--180
EN
Purpose: In recent years, it has become extremely important to search for more and more natural and biocompatible materials that allow for the reconstruction of natural tissues with as few side effects as possible. The aim of the present paper is to define mechanical properties such as compressive stress and Young’s Modulus and to estimate the ability of human bone cell strains to form biofilm on bioresorbable composites manufactured of polylactide and poly-l-lactide (PLA and PLLA) and hydroxyapatite and tricalcium phosphate (HA and β-TCP) with the use of Selective Laser Sintering (SLS) method. Methods: Microbiological tests were conducted on three variants of solid specimen made with additive laser technology. Samples with different chemical compositions were made with appropriate manufacturing parameters ensuring stability of both composite ingredients. Microbiological in vitro tests helped to determine cytotoxicity of specific samples toward bone cells. Results: The results obtained indicate significantly increased ability of osteoblasts to form colonies on the surface of materials with higher content of hydroxyapatite ceramics compared to surfaces of lower hydroxyapatite content. Conclusions: The data provided can be useful for future applications of the SLS technology in production of bioresorbable PLA/PLLA/HA/β-TCP medical implants.
13
Content available Biological evaluation of selective laser melted magnesium alloy powder
Pawlak Andrzej P., Szymczyk-Ziółkowska Patrycja E., Junka Adam, Chlebus Edward
Acta of Bioengineering and Biomechanics
|
2021
|
Vol. 23, no. 1
121--133
EN
Purpose: The current study examined magnesium alloy AZ31B specimens manufactured with Additive Manufacturing method (selective laser melting – SLM) to investigate the applicability of this technology for the production of medical devices. Methods: Osteoblast cells and bacterial biofilm growth ability on specimen was examined and the effect of surface state on corrosion resistance was evaluated by electrochemical and immersion methods. Results: High survival of hFOB cells, as well as a strong tendency for Pseudomonas aeruginosa and Staphylococcus aureus biofilm proliferation on the surface of the tested specimens were shown. SLM-processed AZ31B alloy has a higher corrosion resistance in 0.9% NaCl solution and in a multi-electrolyte saline solution than the material in a conventional form of a rolled sheet. Conclusions: It has been demonstrated that the strong development of the surface of as-built processed specimens results in a significantly increased corrosion rate, which hinders the production of complex structures in tissue engineering products that support cell ingrowth.
14
Content available Struktura geometryczna powierzchni próbek ze stopu magnezu AZ31 po polerowaniu oraz modyfikacji biopolimerami wytwarzanymi metodą CVD
Gołąbczak Marcin, Maksim Przemysław, Skowron Marcin, Kyzioł Karol, Gołąbczak Andrzej, Działo Adam, Szkatulski Piotr
Obróbka Metalu
|
2020
|
nr 4
49--54
PL
W artykule przedstawiono wyniki badań dotyczące porównania parametrów struktury geometrycznej powierzchni (SGP) próbek ze stopu magnezu AZ31 po polerowaniu oraz po wytworzeniu na ich powierzchniach różnego typu biokompatybilnych powłok ochronnych. Zakres prezentowanych badań obejmował proces przygotowania próbek do ich cięcia metodą WEDM, polerowania krążkami ściernymi, chemicznego trawienia oraz modyfikację ich powierzchni poprzez wytworzenie biopolimerowych powłok ochronnych metodą chemicznego osadzania z fazy gazowej CVD.
EN
In this paper the results of investigations concerning the comparison of surface geometric structure parameters of samples made of magnesium alloy AZ31 were presented. The samples were polish and coated of various types of biocompatible protective coatings. The scope of presented studies included the process of sample preparation by WEDM cutting, abrasive disc polishing, chemical pickling and modification of their surface by producing biopolymer protective coating by chemical deposition from gas phase (CVD).
15
Titanium Grade 2 hybrid oxidation for biomedical applications
Jasiński Jarosław
Inżynieria Materiałowa
|
2020
|
Vol. 41, nr 3
18--22
EN
Results from the investigations regarding the method of manufacture and assessment of titanium substrate properties where its surface zone is Ti α (O) solid solution formed with fl uidized bed (FB) diffusion process (8 hours soaking time at 640°C) and the top layer is TiO 2 compound produced by magnetron sputtering are presented and discussed. Effects of such hybrid oxidation (HO) on titanium surface properties were investigated with scanning electron microscopy (SEM), scanning-transmission electron microscopy (STEM), confocal laser scanning microscopy (CLSM), Raman spectroscopy (RS) and nanoindentation tests (NI). Results showed that HO treatment made it possible to generate synergistic effect between FB and magnetron sputtered oxide layer interface. In turn, different share of TiO 2 phases (rutile and anatase mixture) obtained at the titanium surface allowed for a signifi cant enhancement of its biocompatibility which was confi rmed by Kokubo test.
PL
Przedstawiono wyniki badań dotyczące sposobu wytwarzania oraz oceny właściwości podłoża tytanowego, w którym strefę powierzchniową stanowi stały roztwór atomów tlenu w tytanie α (Ti α (O)) utworzony w procesie dyfuzyjnym w złożu fluidalnym (FB) (640°C, 8 h), na którą przez rozpylanie magnetronowe nanosi się warstwę ditlenku tytanu TiO 2 . Wpływ hybrydowego utleniania (HO) na właściwości powierzchni tytanu anali- zowano z zastosowaniem metod badawczych SEM, STEM, CLSM, RS oraz NI. Wykazano, że utlenianie hybrydowe umożliwia uzyskanie korzystnego synergicznego efektu w strefi e międzyfazowej Ti α (O)/TiO 2 oraz zmniejszenie naprężeń na granicy faz. Z kolei zmienny udział faz TiO 2 (mieszanina rutylu i anatazu) uzyskanych na powierzchni tytanu pozwolił na znaczącą poprawę biokompatybilności podłoży, co potwierdzono testem Kokubo.
16
Content available Modification of carbon materials surfaces by plasma: effect of the introduced functional groups on biocompatibility and adhesion of microorganisms
Duch Joanna, Pajerski Wojciech, Gołda-Cępa Monika, Ochońska Dorota, Piskorz Witold, Brzychczy-Włoch Monika, Rysz Jakub, Kotarba Andrzej
Engineering of Biomaterials
|
2020
|
Vol. 23, no. 158 spec. iss.
42
17
Content available How to stimulate polymeric surfaces biocompatibility and hydroxyapatite formation: experiments supported by MD simulations
Gołda-Cępa Monika, Chytrosz Paulina, Riedlova Kamila, Kulig Waldemar, Ćwiklik Łukasz, Kotarba Andrzej
Engineering of Biomaterials
|
2020
|
Vol. 23, no. 158 spec. iss.
40
18
Content available Functionalization of polyurethane surfaces for improved biocompatibility
Chytrosz Paulina, Gołda-Cępa Monika, Kotarba Andrzej
Engineering of Biomaterials
|
2020
|
Vol. 23, no. 158 spec. iss.
37
19
Content available Novel highly biocompatible chitosan/agarose film for potential application as skin substitute
Vivcharenko Vladyslav, Kazimierczak Paulina, Wójcik Michał, Przekora Agata
Engineering of Biomaterials
|
2019
|
Vol. 22, no. 153 spec. iss.
20
20
Content available Electrical and biological performance of oxygen and nitrogen modified CNTs
Benko Aleksandra, Popiela Tadeusz, Wilk Sabastian, Nocuń Marek, Bińczak Marta, Menaszek Elżbieta, Cruz David Medina, Webster Thomas J.
Engineering of Biomaterials
|
2019
|
Vol. 22, no. 153 spec. iss.
96
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