Comparison of durability of resorbable polymer pins in in vitro and in vivo conditions: preliminary study

• Autorzy: Stodolak-Zych E. , Pałka K. , Szponder T. , Nowicka K. , Błażewicz S.
• Konferencja: 24th Conference on Biomaterials in medicine and veterinary medicine : 9--12 October 2014, Rytro, Poland
• Języki publikacji: EN

Abstrakty

EN

The work focuses on polymeric cartilage/bone pins (pegs) that were manufactured and tested to assess their application in meniscus injuries. The bone pins measuring 1,2 and 4 mm in diameter were produced from certified resorbable PLDLA by means of hot pressing (at 126oC). In order to establish the material characteristics, tests of mechanical properties, structural testing and stability tests were performed in vitro (an immersion medium: water/PBS buffer). It was established that after three months of incubation the initial implant’s bending strength (120 MPa) decreased by 35%, whereas its tensile strength (52 Pa) weakened by 60%. The degree of degradation did not affect the pH of the immersion fluid. The observed physical changes of the implant, such as: the mass decrease, the change of shape, the increase of crystallinity (DSC/TG), the number of polymer terminal groups (-OH, -COOH), proved the advanced degradation process of PLDLA pins. Implants of particular behaviour were inoculated into the tibia of a New Zealand rabbit. In vivo tests were conducted to confirm the changes observed in vitro. Monitoring of the degradation process was performed after three months following the implantation by means of control X-ray and computed microtomography (μCT).

Słowa kluczowe

EN

meniscus; bone pins; polylactide; regeneration

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2014
• Tom: Vol. 17, no. 128-129
• Strony: 87--89
• Opis fizyczny: Bibliogr. 4 poz., tab., zdj.

Twórcy

autor

Stodolak-Zych E.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. Mickiewicza 30, 30-059 Kraków

autor

Pałka K.

• Lublin University of Technology, Department of Materials Engineering, Nadbystrzycka St. 36, 20-618 Lublin, Poland

autor

Szponder T.

• University of Life Sciences in Lublin, Faculty of Veterinary Medicine, 20-950 Lublin, 13 Akademicka Street , Poland

autor

Nowicka K.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. Mickiewicza 30, 30-059 Kraków

autor

Błażewicz S.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. Mickiewicza 30, 30-059 Kraków

Bibliografia

• [1] Ole A. Raustol, Kornelis A. Poelstra, Annikar Chhabra, David R. Diduch, The Meniscal Ossicle Revisited: Etiology and an Arthroscopic Technique for Treatment, The Journal of Arthroscopic and Related Surgery, Vol 22, 2006: pp 687
• [2] Dirk Stengel, Gerrit Matthe, Julia Seifert, Volker Tober, Sven Mutze, Grit Rademacher, Axel Ekkernkamp, Kai Bauwens, Michael Wich, Dirk Casper, Resorbable screws versus pins for optimal transplant fixation (SPOT) in anterior cruciate ligament replacement with autologous hamstring grafts: rationale and design of a randomized, controlled, patient and investigator blinded trial, BMC Surgery 2005, 5:1 doi:10.1186/1471-2482-5-1
• [3] Mirco Herbort, Sandra Zelle, Dieter Rosenbaum, Nani Osada, Michael Raschke, Wolf Petersen, and Thore Zantop, Arthroscopic Fixation of Matrix-Associated Autologous Chondrocyte Implantation: Importance of Fixation Pin Angle on Joint Compression Forces The Journal of Arthroscopic and Related Surgery, Vol 27, 2011: pp 809-816
• [4] P. J. Atkinson, R. L. Lancaster, T. S. Atkinson, S. P. Arnoczky, R. C. Haut, S. E. Weisbrode, Breaking Strength Retention and Histologic Effects Around 1.3-mm. ORTHOSORB® Polydioxanone Absorbable Pins at Various Sites in the Rabbit, The Journal of food & ankle surgery 37(1):42-47, 1998