Tytuł artykułu
Identyfikatory
Warianty tytułu
Języki publikacji
Abstrakty
Medicago Sativa (alfalfa) is used as a traditional plant treatment of diabetes mellitus. In the present study hypoglycemic effect of aqueous extract and sequential extraction by increasing polar solvents on alfalfa flower were investigated in both normal and alloxan-induced diabetic mice. It was observed that the aqueous extract of alfalfa flower possess significant blood-sugar lowering in alloxan induced diabetic mice. However, this extract did not show hypoglycemic action in healthy mice. By sequential extraction with many solvents, ethyl acetate fraction showed hypoglycemic activity. Glucose tolerance test was also improved in both normal and alloxan- induced diabetic mice. In addition, the active compounds were identified bv HPLC chromatography and their mechanism of actions as hypoglycemic agent were also studied against estimation of malonaldehyde in vivo.
Czasopismo
Rocznik
Tom
Strony
295--302
Opis fizyczny
Bibliogr. 18 poz., tab.
Twórcy
autor
autor
autor
autor
autor
- Department of Chemistry. College of Science, Salahaddin University, Erbil, Karkuk Street Runaki 235 n323, Erbil, Iraq, dlawarm@yahoo.co.uk
Bibliografia
- [1] Sauer J.D.. Historical geography of crop plants a select roster. Boca Raton. Florida. 1993.
- [2] Duke J.A.. Handbook of phytochemical constituents of GRAS herbs and other economic plants.CRS Press. 1992. 654.
- [3] Jeffrey B.. Herbert B., Chemical Dictionary of Economic Plants. 2001. 37.
- [4] Olds A.. Bot. Bull. Acad. Sin. 1996. 34. 1.
- [5] Moores M., Medicinal for Medicago Sativum. Phytochemical and Ethnobotanical Databases at the Agricultural Research Service. University of Chicago. 1996.
- [6] Swanston-Flatt S.K.. Day C.. Bailey C.J., Flatt P.R.. Diabetologia, 1990. 33(8), 462.
- [7] Gray A.M., Flatt P.R.. British J. Nutrition. 1997, 78, 325.
- [8] Gray A.M., Flatt P.R., British J. Nutrition, 1998. 80, 109.
- [9] Sqbu M.C.. Smith K., J. Ethnopharmacol.. 2002. 83. 109.
- [10] Syien D.. Synai G.. Khup P.Z.. Khongwir B.S.. Kharbuli B.. Kayang H., J. Ethanopharmacol.. 2002. 83, 55.
- [11] Shrabona C., Tuhin K., J. Ethnopharmacol.. 2003, 84, 41.
- [12] Ahmad B„ Zakir S., J. Med. Sei., 2002. 2(4), 206.
- [13] Guidet B.. Shah S.V.. Am. J. Physiol.. 1989. 257(26). 440.
- [14] Abbas A.. Raj K.. India J. Clin. Biochem.. 2003. 18(2). 8.
- [15] McCune L.M.. Timothy J.. J. Ethnopharmacol.. 2005. 82.197.
- [16] Gupta S.K.. Parkash J.. Indian J. Experimental Biol.. 2002. 40. 765.
- [17] Bartoskova L., Necas J.. Journal of the University of Veterinary and Pharmaceutical Sciences in Brno, Czech Republic. 2003. 72, 191.
- [18] McDougall G.J.. Dobson P.. Smith P.. Blake A.. Stewart D.. J. Agricul. Food Chem.. 2005. 53.2760.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BPC2-0007-0011