Bioasorbable osteofixation used devices in 165 cranial and maxillofacial cases: a multicenter report

• Autorzy: Ashammakhi N. , Renier D. , Arnaud E. , Marchac D. , Ninkovic M. , Donaway D. , Jones B. , Serlo W. , Laurikainen K. , Törmälä P. , Waris T.
• Języki publikacji: EN

Abstrakty

EN

Bioasorbable osteofixation devices were developed to avoid problems associated with metals. Bioasorbable devices are mostly made of the polymers polylactide (PLA), polyglycolide (PGA) and their copolymers (PLGA and P(L/DL)LA). Using the technique of self-reinforcement of bioabsorbable materials, it is possible to manufacture osteofixation devices with ultra high strength. Self-reinforced (SR) polyglycolide-co-polylactide (SR-PLGA) 80/20 was selected to make devices (Biosorb TM PDX) for this study because of its favorable degradation characteristics. The aim of this study was to evaluate the efficacy of using SR-PLGA (Biosorb TM) plates and screws in the fixation of osteotomies in craniomaxillofacial (CMF) surgery. In a prospective study, 165 patients (161 children and 4 adults) were operated on in four EU centers (Paris, Innsbruck, London and Oulu) from May 1st, 1998 to January 31st, 2002. Indications included correction of dyssynostotic deformities (n=159), reconstruction of bone defects following trauma (n=2), tumor removal (n=2), and treatment of encephalocoele (n=2). Plates used were 0.8, 1 or 1,2 mm thick and screws has an outer (thread) diameter of 1.5 or 2 mm and a length of 4, 6 or 8 mm. Tacks had an outer diameter of 1.5 or 2 mm and a length of 4 or 6 mm. Intraoperatively the devices were easy to handle and apply and provided stable fixation apart from two cases (7.3%), comprising infection (n=6), bone resorption (n=4), diabetes insipidus (n=1), delayed skin wound healing/skin slough (n=2), and liquorrhea (n=1). Accordingly, SR-PLGA 80/20 (Biosorb) plates and screws can be used safely and with favorable outcome in corrective cranioplasties, especially in infants and young children.

Słowa kluczowe

EN

bioasorbable osteofixation; polymers; bioabsorbable; biosorb; bones; fixation; polylactide; polyglycolide; self-reinforced

PL

polimery; bioabsorpcja; kości

• Wydawca: Polskie Stowarzyszenie Biomateriałów
• Czasopismo: Inżynieria Biomateriałów
• Rocznik: 2004
• Tom: R. 7, nr 38-42
• Strony: 13--13

Twórcy

autor

Ashammakhi N.

• Institute of Biomaterials, Tampere University of Technology, Tampere, Finland

autor

Renier D.

• Craniofacial Unit, Hopital Necker-Enfants Malades,Paris, France

autor

Arnaud E.

• Craniofacial Unit, Hopital Necker-Enfants Malades,Paris, France

autor

Marchac D.

• Craniofacial Unit, Hopital Necker-Enfants Malades,Paris, France

autor

Ninkovic M.

• Department of Plastic and Reconstructive Surgery, University of Innsbruck, Austria

autor

Donaway D.

• Craniofacial Unit, Great Ormond Street Hospital for Sick Children, London, UK

autor

Jones B.

• Craniofacial Unit, Great Ormond Street Hospital for Sick Children, London, UK

autor

Serlo W.

• Department of Pediatrics, Oulu University Hospital, Oulu, Finland

autor

Laurikainen K.

• Department of Pediatrics, Oulu University Hospital, Oulu, Finland

autor

Törmälä P.

• Institute of Biomaterials, Tampere University of Technology, Tampere, Finland

autor

Waris T.

• Department of Surgery, Oulu University Hospital, Oulu, Finland