Biomimetic scaffolds based on chitosan in bone regeneration. A review

• Autorzy: Kołakowska Anna , Gadomska-Gajadhur Agnieszka , Ruśkowski Paweł

Identyfikatory

DOI

10.24425/cpe.2022.142277

• Języki publikacji: EN

Abstrakty

EN

Chitosan (CS) is a polysaccharide readily used in tissue engineering due to its properties: similarity to the glycosaminoglycans present in the body, biocompatibility, non-toxicity, antibacterial character and owing to the fact that its degradation that may occur under the influence of human enzymes generates non-toxic products. Applications in tissue engineering include using CS to produce artificial scaffolds for bone regeneration that provide an attachment site for cells during regeneration processes. Chitosan can be used to prepare scaffolds exclusively from this polysaccharide, composites or polyelectrolyte complexes. A popular solution for improving the surface properties and, as a result enhancing cell-biomaterial interactions, is to coat the scaffold with layers of chitosan. The article focuses on a polysaccharide of natural origin – chitosan (CS) and its application in scaffolds in tissue engineering. The last part of the review focuses on bone tissue and interactions between cells and chitosan after implantation of a scaffold and how chitosan’s structure affects bone cell adhesion and life processes.

Słowa kluczowe

EN

chitosan; scaffolds; biocompatibility; bone regeneration

PL

chitozan; rusztowania; biokompatybilność; regeneracja kości

• Wydawca: Komitet Inżynierii Chemicznej i Procesowej Polskiej Akademii Nauk
• Czasopismo: Chemical and Process Engineering
• Rocznik: 2022
• Tom: Vol. 43, nr 3
• Strony: 305–--330
• Opis fizyczny: Bibliogr. 221 poz., rys., tab.

Twórcy

autor

Kołakowska Anna

• Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland

• https://orcid.org/0000-0003-3504-5332

autor

Gadomska-Gajadhur Agnieszka

• Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland

• https://orcid.org/0000-0001-7686-1745

autor

Ruśkowski Paweł

• Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland

• https://orcid.org/0000-0002-4589-0727

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