Detection of acetone as a potential non-invasive diagnosis tool for diabetes patients

• Autorzy: Jali Mohd Hafiz , Zamzuri Ahmad Nur Azeim Ahmad , Rahim Hazli Rafis Abdul , Johari Md. Ashadi Md. , Ahmad Aminah , Baharom Mohamad Faizal , Zain Huda Adnan , Harun Sulaiman Wadi

Identyfikatory

DOI

10.15199/48.2022.05.13

Warianty tytułu

PL

Wykrywanie acetonu jako potencjalnego nieinwazyjnego narzędzia diagnostycznego dla pacjentów z cukrzycą

• Języki publikacji: EN

Abstrakty

EN

This work investigated the demonstration of acetone detection device as a potential tool to diagnose diabetes patients. It offers simple and low cost approach based on glass substrate platform. The glass substrate was coated with agarose gel as a sensitive material to increase the sensing response. It has superiority in term of high porosity and capable to absorb molecule around it. The sensing mechanism is based on the change in refractive index (RI) of the agarose gel coating layer when exposed to variation acetone concentration level. This is due to the intensity of the light weakening by absorption and scattering when light propagated through the sensing material. The proposed sensor produces a significant response towards acetone concentrations with the output voltage reduced linearly from 1.6V to 1.2V. The sensitivity and resolution of the agarose coated glass substrate improves by a factor of 1.08 and 1.14 respectively as compared to uncoated glass substrate. It also performed better in term of linearity, stability, response time and hysteresis. The non-involvement of costly laser source based instruments make the proposed sensor become more practical for large production while maintaining a good sensing performances. Based on the experiment results, the proposed acetone sensor has a persuasive potential as an early biomarker for diabetes diagnosis tool.

PL

W ramach tej pracy zbadano demonstrację urządzenia do wykrywania acetonu jako potencjalnego narzędzia do diagnozowania pacjentów z cukrzycą. Oferuje proste i tanie podejście oparte na platformie z podłożem szklanym. Szklane podłoże pokryto żelem agarozowym jako wrażliwym materiałem w celu zwiększenia odpowiedzi wykrywania. Ma przewagę pod względem wysokiej porowatości i zdolności do wchłaniania otaczających ją cząsteczek. Mechanizm wykrywania opiera się na zmianie współczynnika załamania światła (RI) warstwy powłoki żelu agarozowego pod wpływem zmian poziomu stężenia acetonu. Wynika to z intensywności osłabienia światła przez absorpcję i rozpraszanie podczas propagacji światła przez materiał czujnika. Proponowany czujnik daje znaczną odpowiedź na stężenia acetonu przy napięciu wyjściowym obniżonym liniowo z 1,6V do 1,2V. Czułość i rozdzielczość podłoża szklanego pokrytego agarozą poprawia się odpowiednio o współczynnik 1,08 i 1,14 w porównaniu z podłożem szklanym niepowlekanym. Działał również lepiej pod względem liniowości, stabilności, czasu odpowiedzi i histerezy. Rezygnacja z kosztownych instrumentów opartych na źródle laserowym sprawia, że proponowany czujnik staje się bardziej praktyczny w przypadku dużych produkcji, przy jednoczesnym zachowaniu dobrych parametrów wykrywania. W oparciu o wyniki eksperymentu, proponowany czujnik acetonu ma potencjał przekonujący jako wczesny biomarker narzędzia diagnostycznego cukrzycy.

Słowa kluczowe

EN

acetone; agarose gel; glass substrate; diabetes

PL

aceton; żel agarozowy; podłoże szklane; cukrzyca

• Wydawca: Wydawnictwo SIGMA-NOT
• Czasopismo: Przegląd Elektrotechniczny
• Rocznik: 2022
• Tom: R. 98, nr 5
• Strony: 71--75
• Opis fizyczny: Bibliogr. 24 poz. rys.

Twórcy

autor

Jali Mohd Hafiz

• Faculty of Electrical Engineering. Universiti Teknikal Malaysia Melaka, Hang Tuah Jaya, 76100 Durian Tunggal, Melaka, Malaysia

• https://orcid.org/0000-0002-2894-7285

autor

Zamzuri Ahmad Nur Azeim Ahmad

• Faculty of Electrical Engineering. Universiti Teknikal Malaysia Melaka, Hang Tuah Jaya, 76100 Durian Tunggal, Melaka, Malaysia

autor

Rahim Hazli Rafis Abdul

• Faculty of Electronic and Computer Engineering, Universiti Teknikal Malaysia Melaka, Hang Tuah Jaya, 76100 Durian Tunggal, Melaka, Malaysia

• https://orcid.org/0000-0002-6001-0230

autor

Johari Md. Ashadi Md.

• Faculty of Electrical and Electronic Engineering Technology, Universiti Teknikal Malaysia Melaka, Hang Tuah Jaya, 76100 Durian Tunggal, Melaka, Malaysia

autor

Ahmad Aminah

• Faculty of Electrical and Electronic Engineering Technology, Universiti Teknikal Malaysia Melaka, Hang Tuah Jaya, 76100 Durian Tunggal, Melaka, Malaysia

• https://orcid.org/0000-0002-1393-666

autor

Baharom Mohamad Faizal

• Faculty of Electrical Engineering. Universiti Teknikal Malaysia Melaka, Hang Tuah Jaya, 76100 Durian Tunggal, Melaka, Malaysia

• https://orcid.org/0000-0003-2887-3922

autor

Zain Huda Adnan

• Department of Electrical Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia

autor

Harun Sulaiman Wadi

• Department of Electrical Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).