Możliwości zastosowania komórek macierzystych w medycynie regeneracyjnej

Galiniak, S.; Krawczyk-Merć, I.; Pedrycz, A.

doi:10.1515/phr-2016-0007

Artykuł - szczegóły

Tytuł artykułu

Możliwości zastosowania komórek macierzystych w medycynie regeneracyjnej

Autorzy

Galiniak S. , Krawczyk-Merć I. , Pedrycz A.

Treść / Zawartość

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Identyfikatory

DOI

10.1515/phr-2016-0007

Warianty tytułu

The possibilities of stem cell application in regenerative medicine

Języki publikacji

PL EN

Abstrakty

Komórki macierzyste (szczególnie embrionalne) charakteryzują się zdolnością do samopowielania i różnicowania we wszystkie typy komórek. Ta cecha daje możliwość szerokiego ich zastosowania w medycynie. Ze względów etycznych w znacznym stopniu ograniczone jednak zostały badana nad wykorzystaniem embrionalnych komórek macierzystych. Poszukuje się więc innych źródeł komórek macierzystych, m.in. izolując komórki z dorosłych organizmów czy indukując pluripotencjalność w komórkach somatycznych przez podanie czynników transkrypcyjnych. Komórki macierzyste wykorzystuje się do badań nad możliwościami leczenia chorób, które powszechnie uznaje się za nieuleczalne takich jak cukrzyca czy choroby neurodegeneracyjne. Badania z użyciem komórek macierzystych analizujące mechanizmy różnicowania się dają nadzieję na przyspieszenie regeneracji uszkodzeń skóry i komórek mięśnia sercowego. W niniejszej pracy autorzy przeanalizowali rodzaje komórek macierzystych, możliwości ich pozyskiwania oraz zastosowania w medycynie regeneracyjnej.

Stem cells are characterized by their ability to self-renew and differentiate into various cell types. They offer great potential for a wide range of applications, however, medical studies on the use of embryonal stem cells are largely limited to bioethical issues searching for alternative sources of stem cells, which include isolating cells from adult organisms or inducing pluripotentiality of somatic cells by administration of transcription factors. Nowadays, stem cells are used to study the mechanisms of cell differentiation and treat diseases that are commonly considered to be incurable, such as diabetes and neurodegenerative diseases, as well as enable regeneration of skin damage and myocardium. This review introduces the subject of stem cells, their sources and application in regenerative medicine.

Słowa kluczowe

komórki macierzyste indukowane komórki pluripotencjalne terapie komórkowe cukrzyca choroba neurodegeneracyjna

stem cells induced pluripotent cells cell therapies diabetes neurodegenerative diseases

Wydawca

Polskie Towarzystwo Medycyny i Techniki Hiperbarycznej

Czasopismo

Polish Hyperbaric Research

Rocznik

2016

Tom

nr 1(54)

Strony

49--64

Opis fizyczny

Bibliogr. 138 poz., rys.

Twórcy

autor

Galiniak S.

Zakład Histologii i Embriologii Wydział Lekarski Uniwersytet Rzeszowski

autor

Krawczyk-Merć I.

Zakład Histologii i Embriologii Wydział Lekarski Uniwersytet Rzeszowski

autor

Pedrycz A.

apw4@wp.pl

Katedra i Zakład Histologii i Embriologii z Pracownią Cytologii Doświadczalnej Uniwersytet Medyczny w Lublinie

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Uwagi

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę.

Typ dokumentu

Bibliografia

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