Production of hydroxylapatite based titania biocomposite as porous bone-like scaffold

• Autorzy: Cetiner B. N. , Erkmen Z. E.
• Języki publikacji: EN

Abstrakty

EN

Purpose: In this study titania-rutile phase- was proposed as reinforcement material with Bioglass 45S5® due to its high biomcompatibility and to bioactive glass’s induced effect on fast cell regeneration and profileration. Design/methodology/approach: Porous bioinert-bioactive composite ceramics were fabricated using HA and different composition of TiO₂ mixtures. Firstly 75 wt. % HA – 15 wt. % TiO₂ – 10 wt. % Bioglass® 45S5 composition was prepared and another batch with changing Bioglass® content was also tried for 75 wt. % HA – 10 wt. % TiO₂ – 15 wt. % Bioglass® 45S5 and H₂O₂ as pore former. Findings: The sample with 15 wt % TiO₂ has higher hardness values and the sample with 10 wt % TiO₂ have higher compressive strength values than the reference study. HA/Bioglass®/TiO₂ composites are potential biomaterials to be used in bone filling and bone regeneration techniques. Practical implications: These biocomposites can be good substitute for missing or damaged bones after supplementary in vivo testing. It is also suggested to evaluate these specimens in vitro tests in SBF (Simulated Body Fluid) solution where temperature is held constant at 37°C with continuous stirring to measure if weight gain will occur by time. Originality/value: The development of improved biocompatible materials and ultimately bonelike mechanical properties is continuous task in the bioceramics research field. The use of HA is limited due to its poor mechanical properties in load-bearing applications and porous HA structures has tendency in mechanical failure. The reinforcement of HA with several inert ceramics has beneficial effect ın its mechanical properties.

Słowa kluczowe

EN

ceramics; glass; biomaterials; bioceramic composites; mechanical properties

PL

ceramika; szkło; biomateriały; kompozyty bioceramiczne; właściwości mechaniczne

• Wydawca: International OCSCO World Press
• Czasopismo: Archives of Materials Science and Engineering
• Rocznik: 2014
• Tom: Vol. 65, nr 2
• Strony: 66--71
• Opis fizyczny: Bibliogr. 16 poz.

Twórcy

autor

Cetiner B. N.

• Department of Metallurgical and Materials Engineering, Faculty of Engineering, Marmara University, Goztepe Campus, 34722, Kadikoy, Istanbul, Turkey

autor

Erkmen Z. E.

• Department of Metallurgical and Materials Engineering, Faculty of Engineering, Marmara University, Goztepe Campus, 34722, Kadikoy, Istanbul, Turkey

Bibliografia

• [1] Z. Zyman, I. Ivanov, V. Glushko, Possibilities for strengthening hydroxyapatite ceramics, Journal of Biomedical Materials Research 46/1 (1999) 73-79.
• [2] S.P. Bruder, K.H. Kraus, V.M. Goldberg, S. Kadiyala, The effect of implants loaded with autologous mesenchymal stem cell on the healing of canine segmental bone defect, Journal of Bone and Joint Surgery. American Volume 80/7 (1998) 985-996.
• [3] G. Heimke, B.D. Hoedt, W. Schulte, Ceramics in dental implantology, in: A. Pizzoferrato (ed.), Biomaterials and Clinical Applications. European Society for Biomaterials, vol. 9, Elsevier, New York, 1987, 93.
• [4] C. Chu, X. Xue, J. Zhu, Z. Yin, Mechanical and biological properties of hydroxyapatite reinforced with 40 vol.% titanium particles for use as hard tissue replacement, Journal of Materials Science: Materials in Medicine 15 (2004) 665-670.
• [5] W. Suchanek, M. Yashima, M. Kakihana, M Yoshimura, Processing and mechanical properties of hydroxyapatite reinforced with hydroxyapatite whiskers, Biomaterials 17/17 (1996) 1715-1723.
• [6] J. Tian, Yi, S.Z. Y. Shao, H. Shan, SiC nanoparticlereinforced Hap composites, in: Abstracts of the 97th Annual Meeting of the ACerS, Cincinnati, 1995.
• [7] G. Georgiou, J.C. Knowles, J.E. Barralet, Y.M. Kong, H.E. Kim, The effect of hot pressing on the physical properties of glass reinforced hydroxyapatite, Journal of Materials Science: Materials in Medicine 15/6 (2004) 705-710.
• [8] G. Georgiou, J.C. Knowles, J.E. Barralet, Dynamic scrinkage behaviour oh hydroxyapatite and glassreinforced hydroxyapatite, Journal of Materials Science 39/6 (2004) 2205-2208.
• [9] S.H. Oh, R.R. Finõnes, C. Daraio, L.H. Chen, S. Jin, Grow of nanoscale hydroxyapatite using chemically treated titanium oxide nanotubes, Biomaterials 26/24 (2005) 4938-4943.
• [10] W. Suchanek, M. Yashima, M. Kakihana, M. Yoshimura, Hydrohyapatite ceramics with selected sintering additives, Biomaterials 18/13 (1997) 923-933.
• [11] J. Blum, K.L. Eckert, A. Schroeder, M. Petitmermet, S.W. Ha, E. Wintermantel, In vitro testing of porous titanium dioxide ceramics, in: T. Kokubo, T. Nakamura, F. Miyaji (eds.), Bioceramics, Pergamon, Otsu, Japan, 1996, 89.
• [12] M. Uchida, H.M. Kim, T. Kokubo, S. Fujibayashi, T. Nakamura, Structural dependence of apatite formation on titania gels in a simulated body fluid, Journal of Biomedical Materials Research A 64/1 (2003) 164-170.
• [13] T. Kokubo, H.M. Kim, M. Kawashita, Novel bioactive materials with different mechanical properties, Biomaterials 24/13 (2003) 2161-2175.
• [14] E. Fidancevska, G. Ruseska, J. Bossert, Y.M. Lin, A.R. Boccaccini, Fabrication and characterization of porous bioceramic composites based on hydroxyapatite and titania, Materials Chemistry and Physics 103 (2007) 95-100. 1
• [15] B.N. Cetiner, B. Ertug, Z.E. Erkmen, Production Process and Essential Characterization of Bioglass 45S5, Proceedings of the 2nd International Ceramic, Glass, Porcelain Enamel, Glaze and Pigment Congress, SERES 2011, Eskişehir, 2011.
• [16] B.N. Çetiner, Z.E. Erkmen, Production of Hydroxylapatite Based Titania Biocomposite as Porous Bone-Like Scaffold, Proceedings of the 15th International Materials Symposium IMSP’ 2014, Denizli, Turkey, 2014 (in print).