Wyniki wyszukiwania - Biblioteka Nauki

1

Spectrometric measurements of radioisotope activity in the thyroid

100%

Osko J. , Golnik N.

Polish Journal of Medical Physics And Engineering

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2008

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tom 14

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nr 3

123-134

EN

The results of measurements of iodine 131I and technetium 99mTc uptake in human thyroid, performed with scintillation or semiconductor detectors can exhibit a considerable uncertainty due to the differences in the thyroid position in the patient's neck. Basic physical laws of radiation attenuation and scattering show that the final shape of the registered spectrum should depends on the thyroid position in the neck and on the thickness of the tissue between the thyroid and the detector. The use of the spectrometric measuring method is proposed in this work for determination of the iodine gathering effective depth. The performed studies showed that the measurements results can be used for improving the accuracy of the iodine 131I activity in thyroid measurements and for selection of the group of patients for whom the anatomical position of the thyroid or the spatial distribution of the iodine gathering is much different than the standard one, assumed during the calibration of the counters. The results of the measurements were in agreement with Monte-Carlo calculations of the detector response. The method was used in routine monitoring of occupationally exposed persons, using the thyroid counter. A group of six persons with measurable internal contamination was selected and the measurements were performed on consecutive days, so the results could be registered at decreasing iodine activities in the thyroid. Larger series of measurements were performed at Brodno Regional Hospital in Warsaw, for a group of 95 patients after diagnostic administration of iodine 131I.

2

Hypocalcemia After Thyroid Surgery Single-Center Experience Based on 987 Patients Operated on for Various Thyroid Diseases Within One Year

100%

Cichoń W. , Konturek A. , Anielski R. , Barczyński M. , Gierada A. , Orlicki P. , Cichoń S.

Polish Journal of Surgery

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2007

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tom 79

|

nr 7

475-481

EN

The aim of the study was to compare the extent of surgery in removal of thyroid tissue and serum calcium values postoperatively.Material and methods. Between January 1 and December 31, 2005, 987 patients were operated on at our department due to various thyroid disorders. Patients with anaplastic, medullary and high-stage highly-differentiated (TNM>T3, N0, M0) thyroid carcinomas, as well as reoperated individuals, were excluded from the investigation. The patients were divided into three groups, depending on their serum calcium values; thus, the authors distinguished groups with mild (2.0-2.19 mmol/l), moderate (1.8-1.99 mmol/l) and severe hypocalcemia (<1.8 mmol/l). Differences between the groups were assessed by statistical methods (the t-Student's test and the X2 test - the STATISTICA software). The value of p<0.05 was accepted as statistically significant.Results. Of 987 surgical patients, 63 (6.4%) were found to have symptomatic or asymptomatic hypocalcemia. The group included 61 females and two males, their mean age being 50.1±12 years. The intensity of clinical symptoms of hypoparathyroidism was positively correlated with serum calcium values and the said symptoms were most clearly seen in patients classified as belonging to group 3 (Ca<1.8 mmol/l). The most common surgically treated thyroid disease was non-toxic nodular goiter. Hypocalcemia was the most frequent finding in patients operated on due to thyroid carcinoma. In all patients with a mild form of hypocalcemia, the onset of clinical symptoms occurred on postoperative day 2. As it follows from the analysis, there were no statistically significant differences in hypocalcemia prevalence between patients subjected to bilateral exposure of the thyroid lobes and subtotal vs. total thyroidectomy (6 (6.1%) vs 24 (7.1%) patients). On the other hand, a statistically significant difference between the lower prevalence rate of hypocalcemia in unilateral procedures (p<0.001) as compared to bilateral neck explorations (4 (1.4%) vs 59 (8.4%) patients) seems to be logical and physiologically justified. In addition, an element that was found to affect the level of calcium deficit was the number of parathyroid glands identified "in situ". Hence, the prevalence of hypocalcemia increased with a decrease in the number of identified parathyroids (p<0.05). In hypocalcemic patients, hospitalization time ranged from 3 to 11 days, with a mean time of 5.3 days as compared to 3 days in patients without complications. Six months after the surgery and pharmacotherapy, no clinical and biochemical signs of hypocalcemia were noted in the above described group.Conclusions. The risk of hypocalcemia following thyroid surgery is higher in bilateral neck explorations. There are no statistically significant differences in postoperative hypocalcemia between patients subjected to bilateral subtotal vs. total thyroidectomies.

3

Body mass analysis in patients with Hashimoto thyroiditis

100%

Popławska-Kita A. , Siewko K. , Telejko B. , Kościuszko-Zdrodowska M. , Hryniewicka J. , Szelachowska M. , Milewski R. , Górska M.

Progress in Health Sciences

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2014

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tom 4

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nr 1

18-23

EN

Introduction: Hashimoto thyroiditis (HT) is one of the most common autoimmune thyroid disorders and o the most common cause of hypothyroidism, but the relation between TSH and body mass is still unclear. Material and methods: The group studied consisted of 53 patients with HT in euthyreosis and 28 healthy individuals. All the patients underwent thyroid ultrasonography and body mass analysis with the use of a medical analyzer INBODY 200. Blood samples were also analyzed for TSH and anti-thyroid antibodies. Results: The patients with HT had higher body mass (p=0.008), body mass index (BMI) (p=0.02), Waist-Hip Ratio (WHR) (0.01) and fat mass (p=0.02) than had the controls. In HT group increased body mass was observed in 72% of the patients (overweight in 38% and obesity in 35% of them), as compared with 38% of overweight/obesity in the control group. Thyroid volume was significantly lower (p=0.01) and anti-peroxidase antibodies level was two times higher in the group with the treatment period > 2 years, but the patients with relatively short treatment period were 7 kg heavier and their fat mass was 6 kg higher than in the subjects treated longer than 2 years. Conclusions: Our results suggest that the patients with HT, even in euthyreosis, have significantly higher body mass, BMI, WHR and fat mass than healthy individuals, which is probably associated with previous disturbances that led to the increase in fat mass at the stage of hypothyroidism. The observed changes tend to normalize during L-thyroxine replacement therapy.

4

Introduction to tissue shear wave elastography

100%

Nowicki A. , Dobruch-Sobczak K.

Hydroacoustics

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2017

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tom Vol. 20

129--138

EN

Ultrasonic elastography is a technique allowing imaging of the elastic properties of tissue. There are two basic techniques of elastographic imaging; compressional - displaying the evaluation of tissue deformation under the external stress; and dynamic, tracking the propagation velocity of the shear wave generated by the acoustic radiation force. Soft tissue bulk modulus varies, from a few to several GPa, whereas the shear modulus is significantly smaller, not exceeding a few hundred Pa for adipose tissue, breast or liver, up to several hundred kPa for “hard” tissue. Forces generated in the tissue due to the external, axial piston-like stresses depend mainly on the shear modulus. In Shear Wave Elastography, long, several tens of microseconds, ultrasonic pulses successively focused at several depths are sent: generating a conical wave front moving with the supersonic velocity, depending on the tissue stiffness. Velocity of propagation of shear wave depends on the shear modulus μ and the modulus of elasticity E of the examined tissue is equal to E=3μ.

5

Temperature measurements of the rat thyroid during cryotherapy

100%

Jóźwik K. , Kurpeta G.

Mechanics and Mechanical Engineering

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2000

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tom Vol. 4, nr 1

57--62

EN

A measurement method for determining time-variable temperatures in selected areas of the rat thyroid for the locally applied source of ,,cold", measurement results and their interpretation have been presented. The knowledge of the regions of the low temperature influence on the thyroid and its adjacent tissues is of significant meaning for an application of cryotechnique methods in the thyroid cancer treatment. The measurement system discussed is used for laboratory tests. On the basis of the results obtained, the direction of further research devoted to temperature measurements of organs during cryotherapy has been outlined.

6

Effect of co-culture with thyroid follicular cells on expression of calcitonin gene in parafollicular TT cells

100%

Zabel M. , Dietel M. , Michael R.

Folia Histochemica et Cytobiologica. Supplement

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1996

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tom 34

|

nr 1

7

Usefulness of nucleolar organiser region staining [AgNORs] in the evaluation of follicular tumours of the thyroid

100%

Dzieciol J. , Musiatowicz B. , Sulkowska M. , Augustynowicz A. , Sulkowski S.

Folia Histochemica et Cytobiologica. Supplement

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1996

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tom 34

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nr 1

8

Assessment of proliferative activity of thyroid Hurthle cell tumors using PCNA, Ki-67 and AgNOR methods

100%

Augustynowicz A. , Dzieciol J. , Barwijuk-Machala M. , Dadan J. , Puchalski Z. , Sulkowski S.

Folia Histochemica et Cytobiologica

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2004

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tom 42

|

nr 3

9

IMRT versus 3D-CRT for thyroid cancer

88%

Gizynska M. , Zawadzka A.

Polish Journal of Medical Physics And Engineering

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2008

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tom 14

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nr 3

151-162

EN

A 3D-CRT involving a 4-field (5-field, 6-field, etc.) technique (photon and electron beams) and an alternative IMRT 7-field technique with 6 MV photon fields for thyroid cancer were compared. The IMRT allows reduction in the dose to the spinal cord of about 12 Gy and permits better coverage of the target volume with smaller standard deviation (average 4.65% for 3D-CRT as compared with 1.81% for IMRT). The time needed to prepare therapy (TPS, dosimetry, preparing boluses and electron aperture) and the session time are about the same for both techniques.

10

Serum tT4, fT4 and TSH concentrations in German Shepherd dogs depending on age and type of work

88%

Taszkun I. , Milczak A. , Kalisz G. , Wilkołek P. , Zwolska J. , Szczepanik M. , Taszkun I. , Milczak A. , Kalisz G. , Wilkołek P. , Zwolska J. , Szczepanik M.

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11

Evaluation of the Harmonic Scalpel Use in the Surgical Treatment of Thyroid Diseases

88%

Gniłka W. , Dąbrowiecki S.

Polish Journal of Surgery

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2010

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tom 82

|

nr 2

53-58

EN

There are different methods to reach hemostasis in the operative field. Recently the harmonic scalpel in surgery has been analyzed.The aim of the study was to compare the advantages in terms of operative time of thyroidectomies performed using the harmonic scalpel versus conventional suture ligation technique. Another aim of the study was to evaluate complications in both groups.Material and methods. From January 1, 2005, to December 31, 2006, 43 patients underwent subtotal thyroid resection using the harmonic scalpel for hemostasis (group 1). They were compared with a group of 46 patients who underwent conventional thyroidectomy with hemostasis achieved by following electrocoagulation and ligation (group 2). The study analyzed the duration of the procedure, considering the volume of the operated thyroid gland and extent of the thyroidectomy in both groups.Results. The duration of the thyroidectomies ranged between 30 and 160 minutes. The comparison in the mentioned groups showed that the harmonic scalpel shortened the duration of the procedure. An iterative procedure was applied with the step of 1 ml of the goiter volume, to check if this effect was present in whole volume range of the operated thyroid.Analysis in subgroups demonstrated that only in case of goiter size <50 ml the use of the harmonic scalpel clinically significant shortened the time of operation.Conclusions. The use of the harmonic scalpel shortened the time of thyroidectomy, as only in patients with the smaller goiter volume.

12

Total Thyroidectomy for Multinodular Goiter. Possibility of Implementation in a District Hospital

88%

Cichoń W. , Walencik G. , Gierczak W. , Aksędowski K. , Bucki J. , Cichoń S.

Polish Journal of Surgery

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2013

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tom 85

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nr 2

53-57

EN

Increasing number of surgical subspecialities causes general surgeons have little experience with more complex procedures as total thyroidectomy. The aim of the study was to present the outcome of total thyroidectomy following its implementation in a district hospital where such procedure has not been performed previously. Material and methods. 293 patients were operated on for goiter between 01.10.2008 and 30.09.2011 in the District Hospital in Proszowice by one contracted endocrine surgeon. Hemithyroidectomy was performed in 75 (23.7%) patients and total thyroidectomy in 191 (76.3%) patients for multinodular goiter and only the latter group was subjected for further analysis. Results. There were no bilateral recurrent laryngeal nerve palsy. A unilateral transient recurrent laryngeal nerve palsy occured in 6 patients (3.1%; 1.5% per risk) and postoperative hypocalcemia in 29 (15.7%) patients. 2 (1%) patients required wound revision due to a postoperative bleeding. Postoperative pathology revealed in 12 (6.2%) patients differentiated thyroid cancer. Conclusions. 1. Total thyroidectomy in a district hospital is still a safe way to operate on thyroid for nonmalignant disorders with low number of complications. 2. Total thyroidectomy is a definite surgical treatment in patients diagnosed by postoperative pathology with differentiated thyroid cancer.

13

A preliminary evaluation of thyroid and respiratory tract neuroendocrine cells in the rat after experimental hypercalcaemia

88%

Sawicki B. , Nowosielski C. , Arciszewska E. , Borowska H.

Folia Morphologica

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2004

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tom 63

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nr 1

EN

The goal of this study was to investigate the influence of experimentally induced hypercalcaemia (after 100000 UI Vigantol and CaCl₂) on neuroendocrine cells (NECs) in the thyroid and airways in the rat. After 24 h, 7 days and 14 days the thyroid and lungs were collected. Paraffin sections were immunocytochemically stained with specific antibodies against CGRP, calcitonin (CT) and synaptophysin (SY) in the airway NECs and thyroid C cells. The largest hypercalcaemia were observed in experimental rats after 7 days. More significant changes in the number and size of neuroendocrine cells were observed in the thyroid gland as well as in the airways. In the airways only a slight increase in the number of neuroepithelial bodies (NEBs) was observed, some of which gave evidence of hypertrophy symptoms.

14

Proliferative activity of the thyroid oxyphilic tumors cells estimated by means of morphometric analysis of silver stained proteins of the nucleolar organizer regions [AgNORs]

88%

Augustynowicz A. , Dzieciol J. , Dadan J. , Puchalski Z. , Sulkowski S.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

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nr 1

15

The role of ingredients contained in fish and fish products in hashimoto disease®

75%

Lachowicz K. , Stachoń M. , Kołota A.

Postępy Techniki Przetwórstwa Spożywczego

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2020

|

tom nr 1

90--102

EN

Hashimoto disease is one of the most commonly recognized autoimmune and endocrine diseases. The development and the course of the ailment depends on a variety of factors, nutritional among other things. Fish and fish-based products contain nutrients regulating the homeostasis of thyroid hormones and the immune system functions. The paper provides up-to-date knowledge on the mechanisms of effects exerted by nutrients contained in fish on the thyroid functions and thyroid-released hormones, and on the course of inflammation in this gland. Familiarity with these issues is necessary for a proper planning of nutrition in Hashimoto-affected patients.

PL

Choroba Hashimoto jest jedną z najczęściej rozpoznawanych chorób autoimmunologicznych i endokrynnych. Rozwój i przebieg schorzenia zależy od wielu czynników, w tym żywieniowych. Ryby i ich przetwory są produktami zawierającymi składniki regulujące homeostazę hormonów tarczycy i funkcjonowanie układu odpornościowego. W artykule scharakteryzowano aktualną wiedzę na temat mechanizmów wpływu składników zawartych w rybach na działanie tarczycy i wydzielanych przez nią hormonów oraz przebieg procesu zapalnego w gruczole. Ich znajomość jest niezbędna do prawidłowego planowania żywienia dla osób z chorobą Hashimoto.

16

The thyroid structure in ontogenetic development of Bufo calamita Laur.

75%

Francois-Krassowska A.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1989

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tom 37

|

nr 4-6

17

Metoda klasyfikacji obrazów USG tarczycy z wykorzystaniem indukcji drzew decyzji

75%

Omiotek Z. , Burda A. , Wójcik W.

Prace Instytutu Elektrotechniki

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2012

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tom Z. 260

57-68

PL

W artykule przedstawiono metodę klasyfikacji zdjęć USG tarczycy. Metoda ta pozwala zaklasyfikować analizowane przypadki do jednej z dwóch kategorii: chory lub zdrowy. Wyselekcjonowana w trakcie badania grupa przypadków błędnie klasyfikowanych zdaniem autorów może zawierać cechy charakterystyczne dla wczesnego stadium rozwoju choroby Hashimoto. Do budowy modelu klasyfikacji wykorzystano indukcję drzew decyzji. Wyniki testów pokazały, iż zaproponowana metoda może stanowić punkt wyjścia do budowy systemu wspomagającego lekarza w procesie diagnozy.

EN

The article presents a method for classification of ultrasound thyroid images. This method allows to classify the analyzed cases as sick and healthy. It also allows to separate fairly large group of incorrectly classified cases. According to the authors, this group may include characteristics of the early stage of Hashimoto's disease. Decision tree induction has been used to build a classification model. Test results showed that the proposed method can provide a starting point to build a support system in the process of medical diagnosis.

18

Comparative studies of nuclear DNA content in benign and malignant thyroid lesions.

75%

Konarska L. , Skierski J. , Ellert A. , Steinbrich J. , Woźniak A. , Kałczak M.

Acta Biochimica Polonica

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2001

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tom 48

|

nr 3

783-793

EN

Currently available data suggest that DNA aneuploidy is associated with aggressive behavior of and unfavorable prognosis in several malignant human tumors as compared with diploid malignancies. However, the diagnostic and prognostic importance of flow cytometric DNA measurements in the case of thyroid neoplasms remains controversial. Therefore, the aim of our study was to evaluate utility of DNA index (DI) and proliferative index (PI) in distinguishing benign from malignant thyroid lesions taking into account the possible influence of intra-tumor heterogeneity and tissue preparation mode on DNA flow-cytometry measurements. A retrospective study was performed on 71 paraffin-embedded specimens from 57 patients with benign and malignant thyroid pathologies: 13 colloid goitres, 12 parenchymatous goitres, 19 adenomas and 13 carcinomas. In 14 of 57 cases two separate specimens taken from different areas of the same lesion were analysed and DNA parameters were compared. Additionally, flow cytometry DNA analysis was parallelly performed on 3 adjacent but differently processed tissue sections (fresh, formalin-fixed and paraffin-embedded) taken from each of 26 surgically excised thyroid lesions. DNA content was also analysed in both fresh and formalin-fixed twin specimens of normal pig thyroid glands (N = 6). We demonstrated that all tumors diagnosed as thyroid carcinomas were associated with abnormal nuclear DNA content although aneuploidy was not found specific to malignant thyroid tumors. Aneuploid samples of benign thyroid lesions exhibited higher proliferative activity, expressed as mean PI values, than diploid ones. In carcinomas the mean PI values were significantly higher than in benign lesions, independently whether they concerned aneuploid or diploid tissues. Considering intra-tumor heterogeneity, the flow cytometric DNA parameters can be assumed as reproducible despite differences in the mode of tissue fixation and preparation for analysis.

19

Estimation of I131 doses absorbed by the thyroid in the period from May to June 1986

75%

Chas J. , Baltrukiewicz Z.

Acta Physiologica Polonica

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1987

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tom 38

|

nr 4

20

The influence of the vascularisation of the follicular thyroid nodules on the proliferative activity of the follicular cells

75%

Lebkowska U. M. , Dzieciol J. , Lemancewicz D. , Boguslowicz W. , Lewszuk A.

Folia Morphologica

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2004

|

tom 63

|

nr 1

EN

The enlargement of the thyroid is, in general, benign in origin and due to nodular goitre. Follicular cellular proliferation of thyroid nodules has been increasingly observed recently. With fine needle aspiration biopsy (FNAB) this is classified as a follicular tumour. These lesions present various patterns of vascularisation in ultrasound examination. The aim of the study was to establish the relation between follicular nodule vascularisation and the proliferative activity of various types of follicular cell. According to the manner of proliferation, patients were divided into groups as follows: (I) patients with hyperplastic nodules (46 cases), (II) patients with follicular adenoma (42 cases), and (III) patients with follicular cancer (9 cases). In each case B-mode sonography, Power Doppler, sonographically guided FNAB (S-FNAB), morphological examination and morphometry were performed. The proliferative activity was detected with immunohistochemical methods (PCNA, Ki 67 and MPM2) to determine the so-called “proliferative index”. The study revealed increased proliferative activity in tumours of malignant origin and increased vascularisation in coexistence with increased proliferation of the follicular cells. As assessed by Power Doppler, an increased flow pattern in the centre of the nodules correlates with increased proliferative activity. The results suggest that Power Doppler examination could be helpful in selecting nodules for FNAB, especially in multinodular goitre.