Wyniki wyszukiwania - Biblioteka Nauki

1

Prevalence of Polyomaviruses in Polish patients

100%

Badura M. , Dworzanski J. , Polz A. , Polz-Dacewicz M.

Current Issues in Pharmacy and Medical Sciences

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2014

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tom 27

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nr 4

250-252

EN

The aim of our study was to investigate the prevalence of new polyomaviruses KIPyV and WUPyV in the Polish population in the Lublin region. In it, we demonstrated that the prevalence of this viruses is low - 1.1% WU and 3.4% KI. The viruses are most commonly detected in materials from the respiratory tract, both in children and the elderly. Polyomaviruses KI and WU in co-infection, often occur with other respiratory viruses (influenza, enterovirus).

2

Identification of the human respiratory system during experiment with negative pressure impulse excitation

88%

Gajda J. , Piwowar P.

Metrology and Measurement Systems

|

2009

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tom Vol. 16, nr 4

569-582

EN

This article describes an innovative measurement method enabling one to identify mechanical parameters of the respiratory tract. The method is compared with traditional techniques such as the forced oscillation technique (FOT), forced expiration technique, and the interrupter technique (IT). The developed characteristics of the method were examined by simulation and experiments. The results confirmed its specificity and sensitivity.

3

Choroby układu oddechowego – jak poprawić dostępność i wyniki leczenia?

88%

Wasilewski P.

Kontrola Państwowa

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2017

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tom 62

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nr 2 (373)

72-81

EN

According to epidemiological forecasts, the incidence and mortality related to chronic diseases of the respiratory tract will be increasing systematically due to, among others, the growing number of persons above the age of 65, the pollution of the natural environment and smoking. In the opinion of the World Health Organisation, smoking is the main reason for diseases associated with the progress of civilisation, closely related to the respiratory tract. The Supreme Audit Office, taking the above factors into account, conducted the first coordinated audit in this area.

4

History of respiratory tract endoscopy

88%

Sapikowski G. , Nicpon J. , Popiel J. , Kurosad A. , Czerw P.

Acta Scientiarum Polonorum. Medicina Veterinaria

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2007

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tom 06

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nr 2

5

A preliminary evaluation of thyroid and respiratory tract neuroendocrine cells in the rat after experimental hypercalcaemia

88%

Sawicki B. , Nowosielski C. , Arciszewska E. , Borowska H.

Folia Morphologica

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2004

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tom 63

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nr 1

EN

The goal of this study was to investigate the influence of experimentally induced hypercalcaemia (after 100000 UI Vigantol and CaCl₂) on neuroendocrine cells (NECs) in the thyroid and airways in the rat. After 24 h, 7 days and 14 days the thyroid and lungs were collected. Paraffin sections were immunocytochemically stained with specific antibodies against CGRP, calcitonin (CT) and synaptophysin (SY) in the airway NECs and thyroid C cells. The largest hypercalcaemia were observed in experimental rats after 7 days. More significant changes in the number and size of neuroendocrine cells were observed in the thyroid gland as well as in the airways. In the airways only a slight increase in the number of neuroepithelial bodies (NEBs) was observed, some of which gave evidence of hypertrophy symptoms.

6

Ditlenek azotu. Dokumentacja proponowanych wartości dopuszczalnych wielkości narażenia zawodowego

75%

Starek A.

Podstawy i Metody Oceny Środowiska Pracy

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2005

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tom Nr 3 (45)

49--64

PL

Ditlenek azotu (NO2) jest gazem, który dosyć często występuje w środowisku pracy i środowisku komunalnym. Związek ten powstaje podczas: spalania substancji organicznych zawierających azot, detonacji materiałów wybuchowych, obróbki elektrochemicznej metali oraz pracy silników dieslowskich. W 2001 r. w Polsce było 736 osób narażonych zawodowo na ditlenek azotu o stężeniu większym od obowiązującej wartości NDS. Zarówno u ludzi, jak i u zwierząt laboratoryjnych narządem krytycznym dla ditlenku azotu jest układ oddechowy. Ostre zatrucie tym związkiem manifestuje się obrzękiem płuc prowadzącym nawet do zejścia śmiertelnego; związek jest klasyfikowany jako substancja toksyczna. Ditlenek azotu może działać klastogennie (czynnik powodujący załamania chromosomów i ich następstwa w postaci pozyskania, utraty lub przemieszczenia części chromosomów) oraz może sprzyjać rozwojowi nowotworów. Związek ten może również negatywnie wpływać na ontogenetyczny rozwój organizmu. Podstawą wartości najwyższego dopuszczalnego stężenia (NDS) ditlenku azotu są wyniki dobrze udokumentowanych badań przeprowadzonych w przemyśle, których wyniki posłużyły do wykazania pneumotoksycznego działania związku. Wartość NDS ditlenku azotu obliczono na podstawie wartości LOAEL (2,95 mg/m3) i dwóch współczynników niepewności. Na podstawie wartości NDS obliczono również wartość najwyższego dopuszczalnego stężenia chwilowego (NDSCh) ditlenku azotu. Po analizie wyliczeń zaproponowano przyjęcie wartości NDS ditlenku azotu wynoszącej 0,7 mg/m3 oraz wartości NDSCh wynoszącej 1,5 mg/m3.

EN

Nitrogen dioxide (NO2) is a gas commonly present in both occupational and general environments. It is a product of fired materials containing nitrogen. In 2001 in Poland 736 workers were exposed to NO2 at a level above the MAC value. Respiratory tract is a critical organ for toxic action of NO2 in both humans and animals. This chemical is a clastogen. In the industry pneumotoxic effects in workers exposed to NO2 at level of 0.8 – 5.1 mg/m3 were observed. The MAC (TWA) value of 0.7 mg/m3 was calculated on the basis of the LOAEL value (2.95 mg/m3) and relevant uncertainty factors. The MAC (STEL) value was established by calculation at level of 1.5 mg/m3.

7

Airway remodeling in chronic obstructive pulmonary disease and asthma: the role of matrix metalloproteinase-9

75%

Grzela K. , Litwiniuk M. , Zagorska W. , Grzela T.

Archivum Immunologiae et Therapiae Experimentalis

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2016

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tom 64

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nr 1

8

Role of bronchoalveolar lavage in the initial diagnosis of smoking-related interstitial lung diseases

75%

Domagala-Kulawik J. , Maskey-Warzechowska M. , Krenke R. , Chazan R.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

243-251

9

Role of the host genetic variability in the influenza A virus susceptibility

75%

Arcanjo A. C. , Mazzocco G. , de Oliveira S. F. , Plewczynski D. , Radomski J. P.

Acta Biochimica Polonica

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2014

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tom 61

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nr 3

10

Badanie depozycji pyłów w modelu górnych dróg oddechowych człowieka

75%

Sosnowski T. R. , Moskal A. , Gradoń L.

Inżynieria i Aparatura Chemiczna

|

2006

|

tom Nr 5s

126-129

11

Comorbidities and clinical outcomes of a lung cancer screening trial participants with chronic obstructive pulmonary disease in three-year follow-up

75%

Undrunas A. , Bąk A. , Kasprzyk P. , Dziedzic R. , Dziurda D. , Rzyman W. , Gierlotka M. , Kuziemski K.

European Journal of Translational and Clinical Medicine

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2022

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tom 5

|

nr 2

24-30

EN

Background To improve the effectiveness of lung cancer screening using low-dose computed tomography (LDCT), the presence of smoking-related comorbidities that may significantly affect mortality in this group should be taken into account. Material and methods A questionnaire survey and spirometry tests were conducted in a group of 730 respondents as part of a lung cancer screening study between 2016 and 2018. People diagnosed with COPD underwent a three-year follow-up to assess the incidence of medical events. Results Our study confirmed that cardiovascular diseases (CVDs) were the most common comorbidities in patients who were diagnosed with COPD and participated in LDCT lung cancer screening. Among the CVDs, the most common were arterial hypertension (45.8%) and coronary artery disease (12.5%). Tobacco-related diseases (e.g. CVD, lung cancer, and exacerbations of COPD) were the leading causes of emergency department visits and hospitalizations. The number of visits due to COPD in specialized clinics more than doubled in the observed period. Conclusions Properly planned screening tests allow not only for the detection of the disease for which they were designed but also for the assessment of comorbidities. In patients undergoing lung cancer screening, it is justified to extend the diagnostics to include spirometry.

12

Evaluation of the immunogenicity of the vaccine against Pasteurella multocida infections in calves

75%

Borkowska-Opacka B. , Kedrak A. , Truszczynski M.

Bulletin of the Veterinary Institute in Puławy

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1999

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tom 43

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nr 2

EN

Evaluation of the immunogenicity of the vaccine against respiratory tract infections in calves caused by Pasteurella multocida, and prepared from antigen of a local strain of serotype 3 with oil adjuvant addition, was the object of the prescnt studies. Two experiments were carried out using calves. Vaccine was given them at a dose of 2 ml i.m., twice every 14 days. In experiment 1, sera were obtained before vaccination, 2 and 5 weeks after the first vaccination, in experiment 2 - before vaccination, 2 weeks, 1 and 2 months after the first vaccination. lmmunogenicity of the vaccine was evaluated by means of an agar gel immunodiffusion (AGID) test and an ELISA test. The carrier-state of Pasteurella multocida on mucous membrane of nasal cavity was examined. lt was found that immunisation stimulated the production of the specific precipitins for serotype 3 and it caused the increase of IgG level found using ELISA test with microplate coated with whole-bacterium antigen or LPS of that serotype. The investigation confirms the good immunogenicity of the vaccine.

13

Preliminary evaluation of neuroendocrine cells in the respiratory tract in rats with experimental uremia

75%

Azzadin A. , Kasacka I. , Sawicki B. , Malla H. , Dadan J. , Buczko W.

Folia Histochemica et Cytobiologica

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2001

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tom 39

|

nr 2

14

Neuroendocrine cells in the nasal mucosa - preliminary report

75%

Sieskiewicz A. , Olszewska M. , Olszewska E. , Garbowicz M. , Trojan S. , Chyczewski L. , Rogowski M.

Folia Histochemica et Cytobiologica

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2007

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tom 45

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nr 2

15

Comparative phenotypic characteristics of Staphylococcus aureus isolated from cystic fibrosis patients versus blood and skin-mucosal infections isolates

75%

Sadowska B. , Bonar A. , Rzezniczak M. , Solarska I. , Rudnicka W. , Rozalska B.

Bulletin of the Polish Academy of Sciences. Biological Sciences

|

2000

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tom 48

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nr 2

16

The effect of selected essential oils on anaerobic bacteria isolated from respiratory tract

75%

Kedzia A. , Ostrowski-Meissner H.

Herba Polonica

|

2003

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tom 49

|

nr 1-2

EN

A total of 111 strains (77 strains were Gram-negative and 34 were Gram-positive) of anaerobic bacteria isolated from respiratory tract, were tested. The following essential oils were used for these determinations: Tea Tree Oil, Manuka Oil, Australian Lemon Myrtle Oil and Australian Sandalwood Oil. The susceptibility bacterial strains was determined by means of plate dilution techniques in Brucella agar with 5% sheep blood. Incubation was performed in anaerobic conditions. The MIC was interpreted as the lowest concentrations of the essential oils inhibiting the growth of bacteria. The results indicated, that strains of Prevotella (40-81%), Porphyromonas (40-60%) and Fusobacterium (53-65%) were the most sensitive to the lowest concentrations of the 4 essential oils (MIC <0.03-0.12 mg/ml). From among Gram-positive anaerobic bacteria, the strains of the Peptostreptococcus were the most susceptible to Manuka Oil and Tea Tree Oil (82-95% strains respectively were susceptible with values of MIC from <0.03 to 0.12 mg/ml). The most active against all examined anaerobic bacteria were the Manuka Oil and the Tea Tree Oil. The tested essential oils were more active against Gram-positive anaerobic bacteria.

PL

Zbadano wrażliwość 111 szczepów bakterii beztlenowych (77 Gram-ujemnych i 34 Gram-dodatnich), wyizolowanych od pacjentów z zakażeniami dróg oddechowych, na olejki z drzewa herbacianego, manuka, mirtowego i sandałowego. Wrażliwość bakterii beztlenowych oznaczono metodą seryjnych rozcieńczeń olejków w agarze Brucella z dodatkiem 5% krwi baraniej. Inkubację prowadzono w warunkach beztlenowych. MIC określano jako najmniejsze rozcieńczenie olejku, które hamowało wzrost bakterii. Wyniki wskazują, że szczepy z rodzaju Prevotella (40-81%), Porphyromonas (40-60%) i Fusobacterium (53-65%) byly najbardziej wrażliwe na najniższe stężnia 4 badanych olejków (MIC <0,03-0,12 mg/ml). Spośród Gram-dodatnich beztlenowych bakterii szczepy z rodzaju Peptostreptococcus byly najbardziej wrażliwe na olejek manuka i z drzewa herbacianego (82-95% szczepów wrażliwych). Najskuteczniejsze działanie wobec wszystkich badanych bakterii beztlenowych wykazały olejki manuka i z drzewa herbacianego. Oceniane olejki byty bardziej aktywne wobec Gram-dodatnich drobnoustrojów beztlenowych.

17

Preliminary evaluation of endocrine cells in the rat respiratory tract after thyroid and parathyroid gland removal

75%

Sawicki B. , Kasacka I. , Azzadin A. , Dadan J. , Malla H. , Nowosielski C. , Buczko W. , Niklinska W.

Folia Histochemica et Cytobiologica

|

2001

|

tom 39

|

nr 2

18

PM10 and the respiratory tract: what do we know?

75%

Zielinski H. , Mudway I. S. , Kelly F. J.

Polish Journal of Environmental Studies

|

1998

|

tom 07

|

nr 5

EN

The present review deals mainly with recent developments in research on the impact of PM10 (particulate matter below 10 mm) air pollution on the respiratory system and the possibly oxidant reactions that occur as a result of breathing these particles.

19

Kinetics of calcium ion concentration accompanying signal transduction in neutrophils from children with increased susceptibility to infections

63%

Jakubczak B. , Wasik M. , Popko K. , Demkow U.

Journal of Physiology and Pharmacology. Supplement

|

2006

|

tom 57

|

nr 4

131-137

EN

Increased susceptibility to infections can be a consequence of altered function of immune cells including neutrophils. The goal of the study was to evaluate the process of neutrophil activation via Ca2+-mediated signal. The study was performed on isolated peripheral blood neutrophils obtained from 41 children with recurrent infections (21 girls, 20 boys) 3-10 years old with more than five episodes of respiratory tract infection (RI) per year and from a control group of 30 healthy children age and sex matched, free from allergic, immune and hematological disorders. Neutrophils were activated by bacterial peptide fMLP, opsonized zymosan (OZ), and phorbol myristat acetate (PMA). The kinetics of the intracellular Ca2+ concentration i[Ca2+] was assessed by flow cytometry (Coulter Epics XL) with the use of Fluo3 and Fura Red fluorescent dyes. Data were collected in histograms displaying Fluo3 fluorescence vs. time and Fura Red fluorescence vs. time and the mean channels of fluorescence intensity were used for calculations. fMLP and OZ-induced Ca2+ mobilization lasted shorter in the RI group (P<0.05). The peak influx of free Ca2+ and i[Ca2+] in the resting state after stimulation with fMLP were lower in the patients (P<0.05). In the RI group stimulation with OZ was delayed compared with that in the control group (P<0.01). In response to PMA, i[Ca2+] decreased faster. The kinetic slopes of i[Ca2+] in both groups examined differed statistically at all points measured. A decrease in i[Ca2+] after PMA stimulation was greater (P<0.01) and lasted longer in the RI group. We conclude that increased sensitivity to infections in RI children may be related to the disturbance in neutrophil activation that is mediated by changes in i[Ca2+] with the subsequent production of free oxygen radicals. Such a disturbance may be inheritable or secondary to infection and antibiotic therapy.

20

Association between clinical activity and high-resolution tomography findings in pulmonary Wegener,s granulomatosis

63%

Zycinska K. , Wardyn K. A. , Zycinski Z. , Zielonka T. M.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

|

nr 6

833-838