Wyniki wyszukiwania - Biblioteka Nauki

1

Simultaneous quantitation of nicotinamide riboside and nicotinamide in dietary supplements via HPTLC–UV with confirmation by online HPTLC–ESI–MS

100%

Neamţu A. S. , Biţă A. , Scorei I. R. , Rău G. , Bejenaru L. E. , Bejenaru C. , Rogoveanu O.-C. , Oancea C. N. , Radu A. , Pisoschi C. G. , Neamţu J. , Mogoşanu G. D.

Acta Chromatographica

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2020

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tom Vol. 32, no. 2

128--133

EN

The identification and quantitation of nicotinamide riboside (NAR) and its main related compound (nicotinamide) were achieved using high-performance thin-layer chromatography (HPTLC)–ultraviolet (UV) densitometry with confirmation by online electrospray ionization (ESI)–mass spectrometry (MS). As the stationary phase, HPTLC Si 60 F 254 glass plates were employed; the mobile phase was ethanol–1 M ammonium acetate–formic acid (7:1:0.1, v/v/v). No derivatization was applied, and UV densitometry was performed in the absorbance mode (270 nm). The method was validated by specificity, linearity, accuracy, precision, and robustness.

2

Synthesis, Spectroscopic Interpretations, and Antioxidant Efficiency of Two Vital Selenium Complexes

86%

Al-Khodir F.

Acta Physica Polonica A

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2017

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tom 132

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nr 4

1265-1271

EN

This paper aimed to synthesis, spectroscopic characterizations, and antioxidant assessment of two new selenium complexes with nicotinamide (Nic) and riboflavin (RF) as drug chelates. The speculated structures of the synthetic selenium complexes have been discussed by using different tools of spectroscopic analyses like infrared, the Raman, electronic, ¹H-NMR, and mass. Accordingly, the Fourier transform infrared and ¹H-NMR spectra, the mode of complexation is supported, as four molecules of nicotinamide drug act as a monodentate chelate through the N-atom of the pyridine ring with [Se(Nic)₄]·H₂O formula. The two riboflavin drug molecules coordinated to selenium metal as a bidentate chelate through azomethine nitrogen of pyrazine ring and O-atom of C=O pyrimidine-2,4-dione group with general formula [Se(RF)₂]. Both of Nic and RF chelates act as neutral charge ligands. The conductivity measurements indicated that the selenium complexes are non-electrolytes behaviors. Thermal analyses (thermal gravimetric-differential thermal analysis) of the studied complexes show that the decomposition process takes place in one broadening step with a wide temperature range. The surface morphology of the mentioned complexes was studied by scanning electron microscope and the particle size is calculated using X-ray powder diffraction. Thermodynamic kinetic parameters are calculated by using the Coats and Redfern equation. Screening of antioxidant activities of selenium complexes in vitro are assessed. The antioxidant activity is studied by three methods (DPPH assay, β-carotene/linoleic acid bleaching assay, and ferric reducing power assay), the studied complexes have a significant antioxidant activity compared to synthetic antioxidants like trolox and BHT.

3

Zastosowanie mezoporowatych krzemionek MCF oraz SBA-16 w procesie adsorpcji nikotynamidu

86%

Kaszyński Ł. , Geszke-Moritz M. , Moritz M. , Dadej A. , Jelińska A.

Przemysł Chemiczny

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2018

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tom T. 97, nr 8

1387--1391

PL

Przedstawiono wyniki badań dotyczących oceny właściwości adsorpcyjnych wobec nikotynamidu niemodyfikowanych mezoporowatych krzemionek MCF oraz SBA-16. Przeprowadzono modelowanie procesu adsorpcji z zastosowaniem izoterm Freundlicha, Jovanovicia, Langmuira oraz Dubinina i Astachowa. Parametry równań oszacowano metodą dopasowania nieliniowego, zaś optymalne parametry równań wyznaczono stosując metodę sumy znormalizowanych błędów. Krzemionka SBA-16 odznacza się nieznacznie lepszą pojemnością adsorpcyjną wobec nikotynamidu niż materiał MCF.

EN

Two types of SiO2 were used in a proportion of 0.100 g per 0.01 L nicotinamide solns. in acetonitrile (concns. 250-7150 mg/L) to det. nicotinamide adsorption isotherms at 25°C by using the Freundlich, Jovanovic, Langmuir and Dubinin-Astakhov models. Non-linear matching anal. and the sum of normalized errors were used to est. isotherm parameters and det. their optimal values, resp. Adsorption of nicotinamide on silicas was best described by the Jovanovic and Dubinin-Astakhov models

4

Low placental visfatin expression is related to impaired glycaemic control and fetal macrosomia in pregnancies complicated by type 1 diabetes

72%

Iciek R. , Brazert M. , Wender-Ozegowska E. , Pietryga M. , Brazert J.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 1

5

Inhibition of phosphodiesterase 3B in insulin-secreting cells of normal and streptozotocin-nicotinamide-induced diabetic rats: implications for insulin secretion

72%

Zywert A. , Szkudelska K. , Szkudelski T.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 3

6

Pancreatitis-associated protein-1 suppresses apoptosis in cerulein-stimulated pancreatic acinar cells in response to nuclear factor-kappaB activation

72%

Yu J. H. , Lim J. W. , Kim H.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 6

7

1-methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages

72%

Biedron R. , Ciszek M. , Tokarczyk M. , Bobek M. , Kurnyta M. , Slominska E. M. , Smolenski R. T. , Marcinkiewicz J.

Archivum Immunologiae et Therapiae Experimentalis

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2008

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tom 56

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nr 2

8

Variations of niacin content in saltwater fish and their relation with dietary RDA in Polish subjects grouped by age

58%

Majewski M. , Lebiedzinska A.

Roczniki Państwowego Zakładu Higieny

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2014

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tom 65

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nr 2

EN

Introduction. A rich and natural source of readily assimilated dietary protein together with invaluable vitamins and minerals are fish, particularly the saltwater species. The quality of any given foodstuff is determined by its nutritional value, which in turn depends on the food type and methods used for manufacture, processing and storage. Many fish products contain fewer water soluble vitamins than the source foodstuff as a result of using various technologies during food processing, such as smoking or deep freezing, where vitamins are often either degraded or leached out. In the case of niacin it is relatively easy to make good such losses by eating niacin-rich foods or by taking dietary supplements e.g. the essential amino acid L-tryptophan. Objectives. To determine niacin content in sea fish that are commonly available on the Polish market and to assess whether this dietary source is sufficient to satisfy the RDA requirements for various age groups of selected subjects living in Poland. Material and methods. Niacin levels were measured firstly in 10 saltwater fish species together with butterfish and Norwegian salmon that formed a separate group. Altogether, 15 types of fish products were analysed in all. They consisted of smoked fish: whitefish, butterfish, sprat, trout, herring (kippers) and mackerel, and frozen fish: butterfish, Norwegian salmon, sole, grenadier and panga. Each product was measured as ten replicates, thus in total 150 analyses were performed. A microbiologically-based method was used for the niacin determination, with enzyme hydrolysis by 40 mg papain and diastase on a 2 g sample (according to the AOAC procedure) to release the free form from the bioavailable form that is bound to NAD and NADP. Results. The most plentiful sources of niacin were found in smoked fish with the highest amounts in butterfish, after warm temperature smoking, and in mackerel; respectively 9.03 and 8.90 mg/100 g. Such 100 g portions of smoked fish are a good dietary source of niacin, in that for men and women above 19 years of age, they constitute respectively 22% - 56% and 25% - 64% of the RDA (Recommended Daily Allowance). The highest levels of niacin in frozen fish were found in butterfish and Norwegian salmon; respectively 8.05 and 5.75 mg/100 g which in turn represent respectively 10% - 50% and 11% - 56% of the RDA in men and women aged above 19 years. Conclusions. Niacin concentrations varied according to fish species. The richest dietary sources were smoked fish consisting of butterfish, after warm temperature smoking, and mackerel. In frozen fish, butterfish and Norwegian salmon had the highest niacin amounts. A 100 g serving of such sea fish can, to quite a large extent, satisfy the adult RDA.

PL

Wprowadzenie. Ryby zwłaszcza morskie stanowią naturalne źródło łatwo przyswajalnego białka oraz wielu cennych witamin i minerałów. Witamina B3 to grupa związków w skład których wchodzą kwas nikotynowy (niacyna) oraz amid kwasu nikotynowego (nikotynamid). Stosunkowo łatwo uzupełniać niedobory niacyny spożywając regularnie produkty bogate w tą witaminę, jak i białko lub szeroko dostępne na rynku suplementy diety. Cel badań. Celem pracy było oznaczenie zawartości niacyny w łatwo dostępnych na rynku rybach morskich, a także ocena analizowanych ryb jako potencjalnego dobrego źródła niacyny w diecie człowieka (RDA) w różnych grupach wiekowych. Materiał i metody. Oznaczono zawartość niacyny w piętnastu rodzajach ryb słonowodnych. w rybach wędzonych (sieja, ryba maślana, szprot, pstrąg, śledź oraz makrela) i mrożonych (ryba maślana, łosoś norweski, sola, grenadier, panga). Łącznie przebadano 150 produktów rybnych. Niacynę oznaczono metodą mikrobiologiczną według AOAC stosując hydrolizę enzymatyczną za pomocą papainy i diastazy w celu wyodrębnienia witaminy z analizowanych próbek. Metoda enzymatyczna pozwala na wyodrębnienie tylko biologicznie dostępnych form niacyny związanych w NAD i NADP. Wyniki. Najlepszym źródłem niacyny były ryby wędzone, a najwięcej witaminy stwierdzono w wędzonych na ciepło rybie maślanej (9,03 mg/100 g) i makreli (8,90 mg/100 g). Porcja ryby wędzonej (100 g) może być bardzo dobrym źródłem niacyny realizując normy dziennego zapotrzebowania dla kobiet i mężczyzn w wieku powyżej 19 lat, odpowiednio w zakresie wartości od 24% do 64% i od 21% do 56%. W grupie badanych ryb mrożonych najwyższą zawartość niacyny zawierała ryba maślana (7,89 mg/100 g) i łosoś norweski (5,75 mg/100 g). Porcja ryby mrożonej (100 g) pokrywała dzienne zapotrzebowanie na niacynę normy dla kobiet i mężczyzn w wieku powyżej 19 lat, odpowiednio w zakresach od 11% do 56% i od 10% do 49%. Wnioski. Przeprowadzone analizy zawartości niacyny wykazały zróżnicowanie pomiędzy poszczególnymi gatunkami ryb. Wykazano, iż najlepszym źródłem niacyny są ryby wędzone, spośród których najwięcej analizowanej witaminy posiadają ryba maślana wędzona na ciepło oraz makrela. W grupie ryb mrożonych najwyższą zawartość niacyny oznaczono w rybie maślanej oraz w łososiu norweskim. Porcja ryby morskiej (100 g) może być bardzo dobrym źródłem niacyny.

9

Embryogenic callus formation by cotyledon and leaf explants of Crambe abyssinica seedlings

58%

Furmanek T. , Banas W.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2011

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tom 92

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nr 2

10

Effects of 1-methylnicotinamide and its metabolite N-methyl-2-pyridone-5-carboxamide on streptozotocin-induced toxicity in murine insulinoma MIN6 cell line

58%

Przygodzki T. , Slominska E. , Polakowska E. , Mlynarski W. , Watala C.

Acta Biochimica Polonica

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2011

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tom 58

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nr 1

EN

1-methylnicotinamide (MNA) is a primary metabolite of nicotinamide. In recent years several activities of MNA have been described, such as anti-inflammatory activity in skin diseases, induction of prostacyclin synthesis via COX-2, aortal endothelium protection in diabetes and hypertriglyceridaemia and increased survival rate of diabetic rats. 1-methylnicotinamide was also suggested to protect pancreatic cells from streptozotocin in vivo. Streptozotocin toxicity is known to be mediated by poly-ADP-ribose polymerase. Nicotinamide and its derivatives have been shown to ameliorate poly-ADP-ribose polymerase-dependent nucleotide pool reduction. We aimed to verify if 1-methylnicotinamide and its metabolite, N-methyl-2-pyridone-5-carboxamide, can protect insulinoma cells from streptozotocin-induced toxicity. We found that N-methyl-2-pyridone-5-carboxamide, but not 1-methylnicotinamide, restores the pool of ATP and NAD+ in streptozotocin-treated cells, but neither compound improved the cell viability. We conclude that inhibition of poly-ADP-ribose polymerase-dependent nucleotide pool reduction may not be sufficient to protect cells from streptozotocin toxicity.

11

Idiopatyczne ropno-ziarniniakowe zapalenie skóry u psa - opis przypadku

44%

Pryszcz M. , Likus M. , Albu K.

Weterynaria w Praktyce

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2020

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tom 17

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nr 03

12

Przezywalnosc a spozycie wybranych skladnikow pokarmowych przez mezczyzn w wieku podeszlym

36%

Kaluza J. , Dolowa J. , Roszkowski W. , Brzozowska A.

Roczniki Państwowego Zakładu Higieny

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2005

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tom 56

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nr 4

361-370

PL

Wykorzystując analizą przeżycia stwierdzono istotnie wyższe ryzyko zgonu wśród mężczyzn, którzy w mniejszym zakresie realizowali normy /lub zalecenia żywieniowe/ na węglowodany ogółem, błonnik pokarmowy, witaminy В1 , В6, PP oraz potas, fosfor, magnez, cynk i miedź, a także na tłuszcz ogółem, nasycone i jednonienasycone kwasy tłuszczowe.

EN

The aim of this paper was to determinate whether the intake of energy and nutrients was associated with all-cause mortality in the elderly men of the Warsaw region. Data on the intake of energy and nutrients were collected using a 3-day record method, in spring 1999. The mortality follow-up period lasted until December 31, 2003. During this period 43 men (29.5 % subjects) died. The all- cause mortality was higher among subgroup of elderly men with lower intake of carbohydrates, dietary fiber, vitamin B1, vitamin B6, vitamin PP, potassium, phosphorus, magnesium, zinc, copper and among subgroup of men with lower intake of total fat, saturated and monounsaturated fatty acids.