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  1. 12 Journal of Physiology and Pharmacology
  2. 5 Archivum Immunologiae et Therapiae Experimentalis
  3. 4 Acta Biochimica Polonica
  4. 4 Folia Histochemica et Cytobiologica
  5. 3 Polish Journal of Veterinary Sciences
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  1. 1 2020
  2. 1 2019
  3. 1 2017
  4. 3 2016
  5. 1 2015
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  1. 3 Takeuchi K.
  2. 3 Wessely-Szponder J.
  3. 2 Deptula W.
  4. 2 Marcinkiewicz J.
  5. 2 Tanaka A.
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1
Content available Interindividual variability of atorvastatin treatment influence on the MPO gene expression in patients after acute myocardial infarction
100%
Sygitowicz G. , Maciejak A. , Piniewska-Juraszek J. , Pawlak M. , Góra M. , Burzyńska B. , Dłużniewski M. , Opolski G. , Sitkiewicz D.
Acta Biochimica Polonica
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2016
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tom 63
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nr 1
89-95
EN
Myeloperoxidase (MPO) and C-reactive protein (CRP) may play critical roles in generation of oxidative stress and the development of the systemic inflammatory response. The aim of the study was to determine the effect of atorvastatin therapy on the MPO gene expression and its plasma level in relation to lipids level lowering and an anti-inflammatory response in patients after acute myocardial infarction. The research material was represented by 112 samples. Thirty-eight patients with first AMI receiving atorvastatin therapy (40 mg/day) and followed up for one month were involved in the study. The relative MPO gene expression in peripheral blood mononuclear cells (PBMCs) was examined using RT-qPCR in 38 patients before-, 38 patients after-therapy and in 36 patients as the control group. The plasma concentrations of MPO and serum concentrations of biochemical parameters were determined using commercially available diagnostic tests. After one month of atorvastatin therapy, in 60.5% patients a decrease of MPO gene expression, whereas in 39.5% patients an increase, was observed. The plasma MPO levels behaved in the same way as the MPO gene expression. However, the serum lipids and CRP concentrations were significantly lower after one month of atorvastatin therapy in both groups of patients - with decreased and increased MPO gene expression. Atorvastatin exhibited a different effect on MPO gene expression and its plasma level. Short-term atorvastatin therapy resulted in lipid lowering and anti-inflammatory activity in patients after AMI, independently of its effect on MPO gene expression. The molecular mechanisms of this phenomenon are not yet defined and require further research.
2
The biosynthesis of neutrophil and eosinophil granule proteins
86%
Olsson I. , Egesten A. , Gullberg U. , Lantz M. , Stromberg K. , Winqvist I.
Folia Histochemica et Cytobiologica
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1986
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tom 24
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nr 2
3
Content available remote The antioxidant quercetin protects HL-60 cells with high myeloperoxidase activity against pro-oxidative and apoptotic effects of etoposide
86%
Papież M. , Krzyściak W.
Acta Biochimica Polonica
|
2014
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tom 61
|
nr 4
795-799
EN
The protective action of quercetin against the pro-oxidant and apoptotic effect of etoposide was investigated in HL-60 cells with a high level of myeloperoxidase (MPO) activity and in cells treated with MPO inhibitor, 4-aminobenzoic acid hydrazide (ABAH). Quercetin significantly protected MPO-rich cells against the pro-oxidative (p<0.05) and apoptotic (p<0.05) effects of etoposide. Pre-treatment with ABAH abolished this protective influence of quercetin on apoptosis induced by etoposide but actually enhanced the action effect of quercetin against etoposide-generated reactive oxygen species (ROS) level by this cytostatic drug. Thus quercetin can protect HL-60 cells against the pro-oxidative activity of etoposide regardless of MPO activity.
4
Oxidative modification of type II collagen differentially affects its arthritogenic and tolerogenic capacity in experimental arthritis
86%
Marcinkiewicz J. , Biedron R. , Maresz K. , Kwasny-Krochin B. , Bobek M. , Kontny E. , Maslinski W. , Chain B.
Archivum Immunologiae et Therapiae Experimentalis
|
2004
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tom 52
|
nr 4
5
Content available Experimental inflammatory bowel disease - role of T cells
86%
Szczepanik M. , Gryglewski A. , Bryniarski K. , Stachura J. , Ptak W.
Journal of Physiology and Pharmacology
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2000
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tom 51
|
nr 2
6
Myenteric plexuses atrophy in the vicinity of colorectal cancer tissue is not caused by apoptosis or necrosis
72%
Kozlowska A. , Kwiatkowski P. , Oponowicz A. , Majewski M. , Kmiec Z. , Godlewski J.
Folia Histochemica et Cytobiologica
|
2016
|
tom 54
|
nr 2
7
Content available remote Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis
72%
Krajewska J. B. , Pietruszka P. , Tomczyk D. , Chen C. , Owczarek A. , Karolewicz B. , Czapor-Irzabek H. , Gorniak A. , Fichna J.
Journal of Physiology and Pharmacology
|
2019
|
tom 70
|
nr 2
8
Content available remote Role of COX inhibition in pathogenesis of NSAID-induced small intestinal damage
72%
Takeuchi K. , Tanaka A. , Ohno R. , Yokota A.
Journal of Physiology and Pharmacology. Supplement
|
2003
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tom 54
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nr 4
165-182
EN
Nonsteroidal antiinflammatory drugs (NSAIDs) such as indomethacin decrease mucosal PGE2 production by inhibiting cyclooxygenase (COX) activity and produce damage in the small intestine. The development of intestinal lesions as induced by indomethacin was accompanied by increases in intestinal motility, enterobacterial invasion, and myeloperoxidase (MPO) as well as inducible nitric oxide synthase (iNOS) activity, together with the up-regulation of COX-2 and iNOS mRNA expression. Neither the selective COX-1 inhibitor, SC-560, nor the selective COX-2 inhibitor, rofecoxib, alone caused intestinal damage, but their combined administration produced lesions. SC-560, but not rofecoxib, caused intestinal hypermotility, bacterial invasion and the expression of COX-2 as well as iNOS mRNAs, yet the iNOS and MPO activity was increased only when rofecoxib was administered together with SC-560. Although SC-560 inhibited the PG production, the level of PGE2 was recovered, in a rofecoxib-dependent manner. The intestinal hypermotility response to indomethacin was prevented by both 16,16-dimethyl PGE2 and atropine but not ampicillin, yet all these agents inhibited not only the bacterial invasion but also the expression of COX-2 as well as the iNOS activity in the intestinal mucosa following indomethacin treatment, resulting in preventing the intestinal lesions. These results suggest that inhibition of COX-1, despite causing intestinal hypermotility, bacterial invasion and iNOS expression, up-regulates the expression of COX-2, and the PGE2 derived from COX-2 counteracts deleterious events caused by COX-1 inhibition and maintains the mucosal integrity. These sequences of events explain why intestinal damage occurs when both COX-1 and COX-2 are inhibited.
9
Non-specific humoral immunity in rabbits immunised with Chlamydia psittaci - Gocaltovo strain
72%
Pawlikowska M. , Deptula W.
Polish Journal of Veterinary Sciences
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2003
|
tom 06
|
nr 3 Suppl.
10
The influence of isoprivet on neutrophil secretory action in the course of BRD in calves
72%
Wessely-Szponder J. , Kloc K.
Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine
|
2010
|
tom 13
|
nr 4
11
Content available remote The role of local and systemic cytokines in patients infected with Clostridium difficile
72%
Czepiel J. , Biesiada G. , Brzozowski T. , Ptak-Belowska A. , Perucki W. , Birczynska M. , Jurczyszyn A. , Strzalka M. , Targosz A. , Garlicki A.
Journal of Physiology and Pharmacology
|
2014
|
tom 65
|
nr 5
12
The NADPH oxidase family and its inhibitors
72%
Kleniewska P. , Piechota A. , Skibska B. , Goraca A.
Archivum Immunologiae et Therapiae Experimentalis
|
2012
|
tom 60
|
nr 4
13
The effect of shepherd's purse extract (Capsella bursa pastoris (L.) Medik.) on the activity of some enzymatic systems essential for defensive function of granulocytes
72%
Rzadkowska-Bodalska H. , Olechnowicz-Stepien W. , Gasiorowski K.
Bulletin of the Polish Academy of Sciences. Biological Sciences
|
1987
|
tom 35
|
nr 10-12
14
Content available remote Cinacalcet, a calcimimetic, prevents nonsteroidal antiinflammatory drug-induced small intestinal damage in rats
72%
Hayashi S. , Kurata N. , Kitahirachi E. , Nishimura Y. , Amagase K. , Yano T. , Takeuchi K.
Journal of Physiology and Pharmacology
|
2013
|
tom 64
|
nr 4
15
Content available remote Anti-inflammatory effects of nesfatin-1 in rats with acetic acid - induced colitis and underlying mechanisms
72%
Ozturk C. C. , Oktay S. , Yuksel M. , Akakin D. , Yarat A. , Kasimay Cakir O.
Journal of Physiology and Pharmacology
|
2015
|
tom 66
|
nr 5
16
Phagocyte NADPH oxidase: a multicomponent enzyme essential for host defenses
72%
El-Benna J. , My-Chan Dang P. , Gougerot-Pocidalo M. A. , Elbim C.
Archivum Immunologiae et Therapiae Experimentalis
|
2005
|
tom 53
|
nr 3
17
Assessment of neutrophil components as markers of lung injury in the course of bovine respiratory tract infections
72%
Wessely-Szponder J. , Bobowiec R. , Martelli F. , Wojcik M. , Kosior-Korzecka U.
Polish Journal of Veterinary Sciences
|
2004
|
tom 07
|
nr 3
EN
To define the role of activated neutrophils in lung injury during bovine respiratory tract infections (BRTI) their in vitro function was investigated. As a means to achieve this goal the comparison of secretory action between neutrophils from the BRTI group and control was made on the basis of elastase, myeloperoxidase (MPO), alkaline phosphatase (ALK-P) release, and nitric oxide production. We noted that there is an interdependence between secretory response of neutrophils and clinical severity of BRTI. The release of elastase was greater in the BRTI group than in the control group (49.17 ±4.41 versus 46.43 ±4.95% of the total content). Neutrophils from infected heifers exhibited a significantly (p<0.05) higher value of MPO release than from healthy heifers and reached 39.23 ± 10.18 versus 25.54 ± 8.41% of the total content. ALK-P containing granules released significantly (p<0.001) more enzyme in the group with BRTI than in the control group (22.42 ± 6.27 versus 13.74 ± 2.01% of the total enzyme content). The level of nitrite accumulation rose in the culture of cells isolated from heifers with BRTI from 4 ± 0.53 μM after 0.5h to 6.9 ± 0.52 μM after 72 h. Our data suggest that during BRTI the increase of neutrophil secretory action results in augmentation of enzyme release including elastase, MPO and ALK-P, and the nitrite production. During an excessive secretory response of neutrophils all these factors contribute to lung injury and worsen the course of a disease and might be recognised as markers of lung injury. Moreover, such a destructive action of neutrophils must be taken into account during the introduction of new methods of BRTI treatment.
18
Inactivation and denaturation of some proteins by enzyme system: myeloperoxidase, chloride and hydrogen peroxide
72%
Drozdz R. , Naskalski J. W.
Folia Histochemica et Cytobiologica
|
1993
|
tom 31
|
nr 2
19
Content available remote Pro-resolution, protective and anti-nociceptive effects of a Cannabis extract in the rat gastrointestinal tract
58%
Wallace J. L. , Flannigan K. L. , McKnight W. , Wang L. , Ferraz J. G. P. , Tuitt D.
Journal of Physiology and Pharmacology
|
2013
|
tom 64
|
nr 2
20
The effect of TNFalpha on the production of nitric oxide by neutrophils isolated from heifers in the course of bovine respiratory disease
58%
Wessely-Szponder J.
Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine
|
2007
|
tom 10
|
nr 4
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