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Content available remote Sprzężony kwas linolowy cis-9, trans-11 CLA a zmiany miażdżycowe
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PL
Choroby układu sercowo-naczyniowego ze względu na rozpowszechnienie i powikłania stanowią jeden z najpoważniejszych problemów zdrowotnych w naszym kraju. W 2. połowie XX wieku intensywnie wzrosła liczba badań, których zadaniem było wskazanie przyczyn i mechanizmów powstawania oraz zapobiegania miażdżycy. Celem pracy była ocena wpływu diety z dodatkiem izomeru cis-9, trans-11 sprzężonego kwasu linolowego (CLA) na redukcję masy ciała, cholesterolu ogółem i triacylogliceroli oraz na rozwój zmian miażdżycowych u różnych modeli zwierzęcych.
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Cardiovascular disease is a major cause of death in developed countries and most cardiovascular events are secondary to artherosclerosis. In the last 10 years increased the research groups, which have looked for a possible mechanism and the effect of the CLA isomers on artherosclerotic lesions levels, tested in animal models. The objective of this review was to evaluate the effect of supplementation of cis-9, trans-11 conjugated linoleic acid (CLA) on body mass, total cholesterol, triacyloglycerols and development of atherosclerosis in animal models.
EN
The term “functional food” refers to modified food products that claim to provide an additional function besides basic nutrition needs. The consumption of functional food is known to exert a positive impact on health and to prevent the occurrence of pathological conditions, such as cardiovascular diseases, some types of cancer, and obesity. Functional food products should resemble conventional food in terms of appearance and taste. The goal is usually achieved by adding active ingredients to the traditional food products (e.g., phytosterols/stanols are added to margarine, dairy, and cereal products), removing or limiting the concentration of potentially harmful agents, or by agricultural and genetic modifications of already existing edible plants and animals (e.g., feeding hens on algae or fish in order to obtain n-3 PUFAs-enriched eggs, and inducing genetic and/or nutritional changes during animal production to obtain meat with lower cholesterol levels). Well-designed intervention trials are scarce in this field, and more effort should be directed toward conclusively proving the role of functional food in disease prevention and health improvement among the population. These associated benefits and the advances in food processing industry should stimulate the development of products that would match the requirements of a healthy diet, simultaneously reducing the risk of chronic diseases. The aim of the present review was to present the examples of functional foods that are essential for the prevention of obesity and cardiovascular disease, and thereby report on their putative mechanisms of action, health-promoting effects, and limitations by conducting various intervention studies.
EN
Environmental factors affect human organism in many ways. They can stabilize, modify or be the cause of many diseases, particularly of circulation system. Diseases of circulation system at the end of the last millennium in USA were the cause of 38% of all deaths. Such high degree of mortality causes necessity of undertaking prophylactic actions in order to reduce the negative influence of risk factors, particularly those environment factors which influence on pathogenesis of some diseases can be modified. Environment might be the factor which causes heart disease by: oxidation stress, inflammatory process, induction of coagulation system, dysfunction of autonomic system. Schetler (70) divided the factors favoring diseases of circulation system into two groups: risk factors (which have admitted participations in pathogenesis of heart and vascular diseases) and environmental factors which significance in pathogenesis of heart diseases still increases. It is commonly acknowledged that environmental factors which favor development of many diseases of circulation system belong to: physical factors polluting the air, water, soil and food, noise, electromagnetic field, ionizing radiation and electric energy. Most of them are industrial pollution – organic and non-organic. They include also six basic air pollution compounds (ozone, CO2, SO2, CO, PbO4, dust); chemical elements (Pb, Hg, Cd, CO, As, lack of Se); medicaments; alcohol and drug inducing stupor; smoking and passive smoking. Also malnutrition and low physical activity increase the risk of occurrence of many circulation system diseases. The described situation is magnified by the fact, that present civilization still increases the number of environmental factors negatively influencing heart-vascular system.
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Content available Żywienie a prewencja chorób układu krążenia
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EN
Atherosclerotic cardiovascular disease has been recognized as the leading cause of death for both men and women in developed countries. During the past century epidemiological and observational studies established that inappropriate nutrition together with reduced physical activity and increased tobacco consumption are key factors for cardiovascular disease development. Recent epidemiological and clinical trial data provide evidence of the great effectiveness of dietary interventions in cardiovascular disease prevention and treatment. Therefore, the efforts to improve diet play an important role in shifting population disease risk. In this paper, the scientific background and current recommendations for dietary prevention of cardiovascular disease are summarized.
EN
Coronary Artery Disease is the type of cardiovascular disease (CVD) that happens when the blood vessels which stream the blood toward the heart, either become tapered or blocked. Of this, the heart is incapable to push sufficient blood to encounter its requirements. This would lead to angina (chest pain). CVDs are the leading cause of mortality worldwide. According to WHO, in the year 2019 17.9 million people deceased from CVD. Machine Learning is a type of artificial intelligence that uses algorithms to help analyse large datasets more efficiently. It can be used in medical research to help process large amounts of data quickly, such as patient records or medical images. By using Machine Learning techniques and methods, scientists can automate the analysis of complex and large datasets to gain deeper insights into the data. Machine Learning is a type of technology that helps with gathering data and understanding patterns. Recently, researchers in the healthcare industry have been using Machine Learning techniques to assist with diagnosing heart-related diseases. This means that the professionals involved in the diagnosis process can use Machine Learning to help them figure out what is wrong with a patient and provide appropriate treatment. This paper evaluates different machine learning models performances. The Supervised Learning algorithms are used commonly in Machine Learning which means that the training is done using labelled data, belonging to a particular classification. Such classification methods like Random Forest, Decision Tree, K-Nearest Neighbour, XGBoost algorithm, Naïve Bayes, and Support Vector Machine will be used to assess the cardiovascular disease by Machine Learning.
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Objectives: In the general population, cadmium seems to be responsible for hypertension, atherosclerosis and an increase in acute coronary events. Therefore, the purpose of this meta-analysis was to analyze controlled studies conducted on cadmium and arterial pressure in occupationally-exposed workers. Materials and Methods: After analyzing all the relevant articles found in the literature, 6 publications were selected. Results: A higher prevalence of hypertension and higher values of systolic and diastolic blood pressure were recorded in the exposed subjects. Conclusions: Cadmium in occupationallyexposed individuals appears to induce an increase in systolic and diastolic blood pressure and an increase in the prevalence of hypertension.
EN
Objective: The aim of this study was to establish the prevalence of cardiovascular disease (CVD) risk factors amongst South African colliery executives presenting normal blood pressure (normotensive), pre-hypertension and hypertension. Materials and Methods: Selected CVD risk factors of a non-randomized, available population of 143 Caucasian male executives from fi ve South African collieries situated in Mpumalanga and Gauteng Provinces were recorded. Results: Executives with pre-hypertension and hypertension exhibited a higher prevalence of CVD risk factors, compared to the persons with normal blood pressure levels. The percentage of executives with CVD risk factors, with the exception of BMI, was greater amongst those with pre-hypertension than those with hypertension. Conclusion: The current study showed that a workplace CVD risk screening process was effective in identifying the relatively high prevalence of CVD risk factors amongst SA colliery executives. In addition, out of all the studied risk factors, undesirable body composition (BMI, WHR and fat %) exhibited the highest prevalence amongst pre-hypertensive and hypertensive SA colliery executives.
EN
Purpose: To determine effect of working in the night shift system on nutritional status, anthropometric measurements, and risk of cardiovascular disease of health staff. Materials and Methods: This cross-sectional study was conducted between August-November 2017 at Samsun Ondokuz Mayıs University among 111 health staff. Data was collected with a questionnaire form including questions about demographic characteristics, nutritional status and anthropometric measurements. SPSS 21.0 statistical package program was used for statistical analysis and p<0.05 was considered statistically significant. Results: Based on waist circumference, 14.3% of men and 31.1% of women were at high risk, and based on waist/hip ratio, 4.8% of men and 33.3% of women were at risk of cardiovascular diseases. It has been shown that eating patterns are disrupted during shifts (89.2%), and 73.9% of participants cannot eat because their meals cool down during shifts. The difference in the numbers of main and snack meals consumed by health staff during the night shift was statistically significant (p<0.05). Body mass index, waist circumference, and hip circumference measurements decreased with increasing shift time. However, body mass index, waist circumference, and hip circumference increased as time spent in the profession increased. Conclusion: It was seen that night shift health staff are at risk of cardiovascular disease due to insufficient and unhealthy nutrition. It is clear that nutrition education programs are required for health staff working night shifts to reduce excess weight and obesity in this population.
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The most effective and the cheapest method of cardiovascular disease prevention is changing lifestyle. Cardiovascular disease is caused by many factors. They include: a diet rich in saturated fat and cholesterol, smoking, a sedentary lifestyle, physical inactivity, overweight and obesity. The aim of the research was to assess the level of knowledge of the students of the Medical University about cardiovascular disease prevention. Material and methods: Research was conducted on 200 students of the Medical University of Lublin, residing in the Student House No. 4 in Lublin. Self-authorship questionnaires were used to assess the level of knowledge of the students of the Medical University about cardiovascular disease prevention. Research results: The students of the Medical University have broad knowledge about the influence of physical activity, diet, cigarettes and alcohol use on cardiovascular disease prevention. 90.5 percent of the respondents know that smoking greatly increases the risk of cardiovascular disease. More than a half of the students are aware that excessive alcohol consumption has a negative impact on the cardiovascular system. 38.67 percent of the respondents recognize moderate alcohol consumption as protective for cardiovascular disease. The remaining 3.13 percent of the students have no knowledge about this issue. Almost half of the respondents (45 percent) is aware that psychosocial factors have an impact on the cardiovascular system. 86.5 percent of the students believe that there is a correlation between cardiovascular disease and factors such as: low socioeconomic status, social isolation, stress, negative emotions, depression. The remaining 13.5 percent of the respondents have incomplete knowledge about this issue. Almost the half of the respondents knows that type A personality increases the risk of cardiovascular disease, whereas the remaining 52 percent of the students have incomplete knowledge about this issue.
EN
Objectives To investigate a hypothesized positive association between employment in occupations where heavy lifting is likely to occur, and the risk of ischaemic heart disease (IHD). Material and Methods Male blue-collar workers from Denmark (N = 516 180) were monitored with respect to hospital treatment or death due to IHD, through national registers over the years 2001–2010. Poisson regression was used to estimate relative rates of IHD between “workers in occupations which, according to an expert opinion, are likely to involve heavy lifting” and “other blue-collar workers.” Prevalent cases were excluded from the analysis. Results The rate ratio was estimated at 0.97 (95% confidence interval (CI): 0.94–1.00) for deaths or hospitalizations due to IHD and 1.07 (95% CI: 0.94–1.21) for deaths due to IHD. Conclusions The results do not support the hypothesis that occupational heavy lifting is an important risk factor for IHD.
EN
Objectives The role of leisure-time physical activity in reducing all-cause and cardiovascular mortality is well explored. The knowledge on occupational and commuting physical activity continues to be ambiguous and misleading. The aim of the study is to assess the influence of different kinds of physical activity on cardiovascular mortality risk in men. Material and Methods Data analysis on physical activity level and other selected cardiovascular risk factors acquired from 3577 men in the age between 50–80 years who participated in the National Multicenter Health Survey WOBASZ (Wieloośrodkowe Ogólnopolskie Badanie Stanu Zdrowia), Poland (2003–2005) was linked with male mortality in 2004–2009. Data about causes of deaths were obtained from the Central Statistical Office and the Population Electronic Register. Results Among males aged 50–59 years, the strongest risk factor was living in large settlements and provincial capitals as a place of residence and the most protective factor was occupational physical activity. In the age group 60–69 years and 70–80 years, the strongest protective effect was observed for leisure-time physical activity. In men aged between 70–80 years (unlike in the 50–59 years age group), the protective effect of large settlements and provincial capitals as a place of residence was noted. Conclusions Occupational physical activity significantly reduced cardiovascular mortality in men aged 50–69 years, while for leisure-time activity the positive effect was observed in age group 60–69 years and 70–80 years. On the other hand, for the inhabitants of large settlements and provincial capitals, significantly higher risk of cardiovascular mortality in the age group 50–69 years and lower risk in the age group ≥ 70 years was noted, both in comparison with smaller places of residence.
EN
Background. Insulin-like growth factor 1 (IGF-1) is known as somatomedin C. This polypeptide hormone is functionally and structurally similar to insulin. IGF-1 effects on tissue by the IGF-1R and the insulin-like growth factor-binding protein also known as IGFBP. Abnormal IGF-1 and IGFBP signaling are positively correlated with a high risk of selected civilization diseases development. Physical inactivity is a one of the main causes of majority of chronic diseases and it is associated with eg. IGF-1 and IGFBPs level. Objective. The aim of the study was to explanation the effect of physical activity on IGF-1 and its binding protein – IGFBPs concentration in the context of selected civilization diseases prevention. The review of clinical trial. Material and Methods. The review of articles had published in databases: MEDLINE, EMBASE, Scopus and Web of Science until December 2015. The selected prospective studies about the effect of exercise on IGF-1 level and its binding protein IGFBP in the context of selected civilization diseases prevention were collected. Results. The majority of the included studies indicate that mechanical loading is a key mechanism linking IGF-1/IGFBPs concentration and selected chronic diseases development. The duration and intensity of physical activity have a significant impact on IGF-1 and IGFBP serum. The highest concentration of IGF-1 in serum was after eccentric training. “Overtraining” increases unfavorable and unbound IGF-1 levels and contributes to the increased incidence of hormone-cancer and osteoarthritis. Conclusions. Irregularity of the GH/IGF-1 axis may affect on the development of rheumatic diseases, cardiovascular diseases (regulate cardiac growth and metabolism) and metabolic syndrome.
PL
Wprowadzenie. Insulinopodobny czynnik wzrostu 1 (IGF-1, insulin-like growth factor 1), zwany inaczej somatomedyną C. IGF-1 to hormon polipeptydowy, który funkcjonalnie i strukturalnie jest podobny do insuliny. IGF-1 oddziałuje na tkanki za pomocą receptora IGF-1R i białek wiążących IGFBP. Nieprawidłowości w produkcji IGF-1 i IGFBP są związane z wysokim ryzykiem rozwoju wielu chorób cywilizacyjnych. Brak aktywności fizycznej i związany z tym nieprawidłowy poziom krążącego IGF-1 przyczyniają się do rozwoju wielu przewlekłych chorób. Cel. Celem badania była próba wyjaśnienia wpływu zmian stężenia IGF-1 i jego białka wiążącego IGFBP pod wpływem aktywności fizycznej na profilaktykę chorób cywilizacyjnych na podstawie analizy badań klinicznych. Materiał i metody. Dokonano przeglądu artykułów opublikowanych do grudnia 2015 i zamieszczonych w bazach: MEDLINE, EMBASE, Scopus i Web of Science. Zebrano najnowsze badania prospektywne dotyczące znaczenia wysiłku fizycznego dla utrzymania prawidłowego poziomu IGF-1 i jego białka wiążącego IGFBP w kontekście profilaktyki wybranych chorób cywilizacyjnych. Wyniki. Większość analizowanych badań wskazuje, że aktywność fizyczna regulując stężenie IGF-1 i IGFBPs wpływa na rozwój wybranych chorób cywilizacyjnych. Długość trwania i intensywność wysiłku fizycznego ma istotne znaczenie dla stężenia IGF-1 i IGFBPs. Największy wzrost IGF-1 obserwuje się w wyniku escentrycznej pracy mięśni. Stan „przetrenowania” powoduje wzrost niekorzystnego, niezwiązanego IGF-1 w surowicy. Wzrost poziomu IGF-1 niezwiązanego przyczynia się do zwiększonej zachorowalności na nowotwory hormonozależne i chorobę zwyrodnieniową stawów. Wnioski. Nieprawidłowości osi GH/IGF-1 mogą wpływać na rozwój chorób reumatycznych, chorób układu krążenia i zespołu metabolicznego.
EN
Background. The appropriate nutrition is an important component of the secondary prevention of cardiovascular diseases (CVD). Objectives. The aim of the study was to investigate if the patients with cardiovascular disease were informed of the role of appropriate nutrition in prevention or received nutrition guidelines and to assess the dietary intake compared to recommendations for patients with cardiovascular disease who received or not nutrition guidelines. Material and Methods. The study was conducted among patients with cardiovascular disease (n = 127) of cardiological hospital clinic, aged 62 ± 11. The questionnaire was used to obtain personal and anthropometric details, information if patients had received nutrition guidelines. The method of 3-day food records was used for dietary assessment. Results. 20% of subjects had not received nutrition guidelines and almost 40% of subjects did not recognize the nutrition effect on cardiovascular disease development. Compared to the diets of the subjects who had not received nutrition guidelines, the diets of those who had received them were of significantly lower intake of: energy from saturated fatty acids (15%, p = 0.006), cholesterol (21%, p = 0.012) and higher intake (14-26%) of potassium (p = 0,003), sodium (p = 0.013), phosphorus (p = 0.044), magnesium (p = 0.003), iron (p = 0.005), copper (p = 0.001), zinc (p = 0.046). Among the patients who had received nutrition guidelines, percentage of the subjects whose intake of nutrients was consistent with recommendations was higher. Conclusions. Not all subjects had received nutrition guidelines. Diets of those who had received them were more balanced, but in neither group nutrition guidelines were complied with.
PL
Wprowadzenie. Prawidłowe żywienie jest ważnym elementem w ochronie wtórnej u pacjentów z chorobami układu sercowo-naczyniowego (CVD). Cel. Celem badania była ocena czy pacjenci ze zdiagnozowanymi chorobami układu sercowo-naczyniowego zostali poinformowani o roli odżywiania podczas leczenia oraz czy otrzymali zalecenia żywieniowe w ramach profilaktyki wtórnej, jak też ocena porównawcza sposobu żywienia osób, które otrzymały lub nie zalecenia żywieniowe. Materiał i metody. Badanie przeprowadzono wśród 127 pacjentów kliniki kardiologicznej jednego z warszawskich szpitali, pacjenci byli w wieku 62 ± 11 lat. Informacje nt. danych socjo-demograficznych i antropometrycznych oraz otrzymania zaleceń żywieniowych zostały zebrane za pomocą autorskiego kwestionariusza. Badane osoby wypełniły również kwestionariusz 3-dniowego bieżącego notowania spożycia żywności w celu oceny sposobu żywienia. Wyniki. Dwadzieścia procent osób nie otrzymało zaleceń żywieniowych, a prawie 40% osób nie dostrzegło wpływu żywienia na rozwój choroby. Odnotowano statystycznie istotne różnice w sposobie żywienia pomiędzy osobami, które uzyskały zalecenia żywieniowe a osobami, które takich zaleceń nie otrzymały, tj. niższy udział energii z nasyconych kwasów tłuszczowych (SFA) o 15%, niższe o 21% średnie spożycie cholesterolu oraz wyższe o 14-26% spożycie składników mineralnych, tj. potasu, sodu, fosforu, magnezu, żelaza, miedzi i cynku. Ponadto grupa osób, która otrzymała zalecenia żywieniowe charakteryzowała się lepszą realizacją norm na składniki żywieniowe i większą prawidłowością sposobu żywienia. Wnioski. Pomimo kluczowej roli, jaką odgrywa żywienie w profilaktyce i leczeniu chorób układu sercowo-naczyniowego, nie wszystkie badane osoby otrzymały wskazówki jak powinny się odżywiać. Osoby, które otrzymały zalecenia żywieniowe odżywiały się lepiej od tych, którym takich zaleceń nie przekazano, jednak ich sposób żywienia również odbiegał od norm i zaleceń.
EN
Introduction: Repetitive or long-lasting activity of stressors can cause cardiovascular disease. The purpose of this paper was to assess dependence between the level of intensity of stress at work and in everyday life and the occurrence of cardiovascular disease. Material and methods: One hundred people (50 with cardiovascular disease and 50 healthy ones) were answering the questions from the HSE survey to assess stress at work, SRRS survey to assess stressful events and Mini-COPE survey to assess coping with stress. Results: It was stated that healthy people as well as treated people suffering from cardiovascular disease experience stress at work. However, the people from the comparison group were under less strain than the people from the test group (p = 0,0044). It was also indicated that the people from the test group more often resigned from undertaking efforts to cope with a difficult situation (p = 0,0459). Conclusions: People suffering from cardiovascular disease are significantly more often under strain at work and slightly more under strain in everyday life than healthy people. Simultaneously, healthy people were coping better with stress than people with cardiovascular disease.
PL
Wstęp: Powtarzające się lub długotrwałe działanie stresorów może powodować choroby układu krążenia. Celem pracy była ocena zależności pomiędzy poziomem natężenia stresu w pracy i w życiu codziennym a występowaniem chorób układu krążenia. Materiał i metody: Sto osób (50 z chorobami układu krążenia i 50 zdrowych) odpowiadało na pytania kwestionariusza HSE do oceny stresu w pracy, kwestionariusza SRRS do oceny wydarzeń stresujących, kwestionariusza Mini-COPE do oceny radzenia sobie ze stresem. Wyniki: Stwierdzono, że osoby zdrowe jak i osoby badane, u których występują choroby układu krążenia doświadczają stresu w pracy, jednak mniejsze narażenie na stres wykazały osoby z grupy porównawczej niż osoby z grupy zasadniczej (p = 0,0044). Wykazano również, iż osoby z grupy zasadniczej znacznie częściej rezygnowały z prób poradzenia sobie z trudną sytuacją (p = 0,0459). Wnioski: Osoby u których występują choroby układu krążenia były istotnie częściej narażone na stres w pracy oraz nieznacznie częściej narażone były na stres w życiu codziennym aniżeli osoby zdrowe. Jednocześnie, osoby zdrowe lepiej radziły sobie ze stresem niż osoby z chorobami układu krążenia.
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