Wyniki wyszukiwania - Biblioteka Nauki

1

Stomach metastasis from breast cancer-mimicking linitis plastica

100%

Czerko K. , Ostrowski M. , Bodnar L.

OncoReview

|

2022

|

tom 12

|

nr 3

65-67

EN

We report a rare case of metastatic gastric cancer from invasive carcinoma of the breast (BC) as the first symptom of disease-mimicking primary gastric linitis plastica.

2

Biomarkers in breast cancer

100%

Laguens G. , Coronato S. , Girolamo W.

Open Medicine

|

2006

|

tom 1

|

nr 4

330-347

EN

Breast cancer is one of the most frequently diagnosed cancers among women in the western world. Due to the aggressive behaviour of some specific types and the possibility of an early diagnosis, breast cancer has been constantly studied. Tumour size, histological type, cellular and nuclear characteristics, mitotic index, vascular invasion, hormonal receptors and axillary lymph node status are biomarkers routinely used. However, these parameters are not enough to predict the course of this disease. Molecular biology advances have made it possible to find new markers, which have already been incorporated to the clinical practice. Their ultimate goal is to reduce mortality by identifying women at risk for the development of this disease, help diagnosis, determine prognosis, detect recurrences, monitor and guide treatment, and in particular cancers they are suited for general screening. Tumour markers in breast cancer were ranked in categories reflecting their clinical utility, according to the American College of Pathologists. This article focuses on traditional and new molecular markers stratifying them into categories and emphasizing their relevance in the routine evaluation of patients with breast cancer.

3

Retrospective analysis of local recurrence rate in breast cancer patients treated at the department of surgical oncology in Łódź between 2009 and 2013

100%

Morawiec J. , Dziki A. , Morawiec Z. , Kołacińska A.

Polish Journal of Surgery

|

2015

|

tom 86

|

nr 2

77-81

EN

The aim of the study was to analyze clinicopathological features in breast cancer patients with local recurrence (LR). Material and methods. A retrospective analysis of database of breast cancer patients operated on in the Department of Surgical Oncology in Łódź from 2 January 2009 to 30 June 2013, identified 1080 women with primary breast cancer and 11 patients with LR. Results. LR rate was 0.23% per year. True recurrence (TR) occurred more frequently in patients with luminal B molecular subtype, in HER-2 positive and in triple-negative subgroups. In one patient with luminal -A subtype new primary (triple negative) occurred. TR were noted predominantly in patients with axillary lymph nodes metastases and with luminal B subtype who did not receive adjuvant chemotherapy but were given only endocrine therapy. LR were observed more frequently in patients who did not receive adjuvant radiotherapy or this treatment was delayed. Minimal surgical margins in postoperative specimens measured by pathologist were 4-25 mm, mean 9.5 mm. Conclusions. The LR rate in patients operated on breast cancer in the Department of Surgical Oncology between 2009 and 2013 was low. TR was diagnosed in patients with non- luminal A breast cancer despite wide surgical margins, especially if the patients did not receive optimal adjuvant systemic treatment or radiotherapy was delayed or omitted. Complete cancer excision followed by an immediate implementation of optimal adjuvant treatment seems to be crucial especially in patients with poor tumor biology.

4

Results of a multi-centre survey concerning the treatment of hormone-dependent breast cancer in Poland in 2009–2013

100%

Jagiełło-Gruszfeld A.

OncoReview

|

2015

|

tom 5

|

nr 1

A21-A26

EN

In order to present a reliable picture of hormone-dependent breast cancer treatment in Poland, an on-line survey has been conducted in 19 oncology centres. As a result, data on the treatment of 486 patients have been obtained (405 of them initially presenting with stage I–III of disease advancement, and 81 representing stage IV). It has been concluded that in the majority of cases the treatment in question involves combined therapy, including chemotherapy, hormonal therapy, targeted molecular therapy, radiotherapy, and surgical methods with reference to the group of patients subjected to radical treatment.

5

Depression and Anxiety Before and After Breast Amputation in Women

85%

Nowicki A. , Szwed A. , Laskowski R.

Polish Journal of Surgery

|

2008

|

tom 80

|

nr 7

377-384

EN

Breast cancer is the most frequent malignancy in women. The diagnosis of neoplastic disease produces or deepens anxiety and depression in a patient.The aim of the study was to assess the influence of surgery and socio-demographic factors on the level of anxiety and depression in women suffering from breast cancer.Material and methods. 50 women (30-71 years old, mean age 54.7 years) with breast cancer were enrolled into the study. They were assessed two times - before and after surgery. To evaluate the level of depression BECK scale was used. It consists of 21 points that determine the level of depression. HAD scale containing seven descriptions of a patient's status was used to assess the level of anxiety.Results. Most of patients (17(34%) women had vocational education. More than half of the analyzed women were free of depression both before and after surgery, 50 % and 60% respectively. 2% of all women had extremely deep depression preoperatively. A normal and high level of anxiety before surgery was felt by 21 (42%) and 21 (42%) women respectively.A high level of anxiety was found in 15 patients (30%) postoperatively. The level of depression after surgery decreased in 32 women and psychological status was deteriorated in 9 patients according to BECK scale. The level of anxiety after surgery decreased in 30 patients and deteriorated in 8 cases according to HAD scale. The intensity of anxiety decreased after surgical treatment. The most intensive increase in depression was observed in women with secondary education (51 points) before surgery and 35 points in women with vocational education after surgery. The highest level of anxiety before surgical treatment was found in women with secondary as well as vocational education (21 points). Whereas the highest level of anxiety after surgery was observed in patients with secondary education. (21 points). The hardest depression was observed in working patients (51 points) preoperatively and they still had the hardest depression (35 points) postoperatively, too. The level of anxiety was highest in working women both preoperatively and postoperatively (21 points). The most intensive depression before surgery was observed in women at middle social status (35 points) and this tendency was observed also after surgery. The level of anxiety before surgery was the highest in women with good and middle social status (21 points). After surgery it was the highest in patients with middle social status (21 points). The most intensive depression before surgical treatment was found in patients between 51 and 60 years old (51 points). The hardest depression after surgery was observed in women between 41 and 50 years old (35 points). The highest level of anxiety was felt by patients between 41 and 50 and between 51 and 60 years old (21 points) preoperatively and in women between 51 and 60 years old (21 points) postoperatively.Conclusions. The intensity of depression and anxiety in women with breast cancer decreased significantly after mastectomy. Patients with university education had lower levels of anxiety and depression both before and after surgery. Working women with average social status had the highest levels of anxiety and depression both before and after surgical treatment. The age of a patient did not influence significantly on the levels of anxiety and depression both before and after surgery.

6

Detection of circulating breast cancer cells in peripheral blood by a two-marker reverse transcriptase-polymerase chain reaction assay.

80%

Fabisiewicz A. , Kulik J. , Kober P. , Brewczyńska E. , Pieńkowski T. , Siedlecki J. A.

Acta Biochimica Polonica

|

2004

|

tom 51

|

nr 3

747-755

EN

The aim of this study was to use a two-marker assay for the detection of breast cancer cells circulating in patients' blood. We have applied a PCR-based methodology to follow up the possibility of the development of metastatic disease in stage I and II patients who had undergone curative surgery. Since the number of circulating cancer cells in peripheral blood is very low, the technique for their detection needs to be not only highly sensitive, but also very specific. The reverse transcriptase-polymerase chain reaction (RT-PCR) technique may improve the sensitivity of breast cancer cell detection up to only a few cells per one million. The principle of the RT-PCR assay is to amplify a messenger RNA characteristic for breast epithelial cells in a blood sample. Since we do not expect such cells to be circulating in peripheral blood of healthy subjects, detection of the characteristic mRNA should indicate the presence of circulating breast cancer cells. We analyzed the usefulness of three mRNA markers: cytokeratin 19 (CK19), mammaglobin (hMAM) and β subunit of human chorionic gonadotropin (β-hCG) for this test. Blood samples (112) were obtained from 55 patients, in stages I and II, with or without metastasis to regional lymph nodes (N0 or N1). We found that a two-marker assay increases the sensitivity of detection of breast cancer cells in comparison with a single-marker one. Combination of two tumor-specific mRNA markers, hMAM/CK19 or β-hCG/CK19, allowed the detection of circulating breast cancer cells in 65% of N1 patients and 38% of N0 patients. By comparison, the combination hMAM/β-hCG allowed the detection of circulating breast cancer cells in the blood of 68% of N1 patients and 46% of N0 patients. Addition of the third marker did not significantly increase the detection sensitivity.

7

Acceptance of the illness and the quality of life of patients with breast cancer

80%

Kamińska M. , Ciszewski T. , Bronikowska A. , Ferańska M. , Pawlak-Warszawska A. , Paśnik E.

Polish Journal of Public Health

|

2015

|

tom 124

|

nr 1

5-9

EN

Introduction. Breast cancer is the most frequent cancer diagnosed in women. Its treatment is a combined therapy and the sequence and time are established according to the accepted standards in Poland. Consequences posed by this disease include disorder in the physical, mental and social spheres in women. Adapting to cancer is very important for the process of treatment, and the acceptance of the disease is the determinant. Aim. The aim of the study was to determine and compare the degree of acceptance of the illness and the assessment of quality of life among breast cancer patients during cancer treatment. Material and methods. The survey included 85 ill people treated in a conserving way and 94 ill people treated by breast amputation. Patients after the surgical procedure were subjected to adjuvant treatment involving chemotherapy (90 women) and/or endocrine therapy (87 women). The study used standardized questionnaires EORTC (European Organisation for Research and Treatment of Cancer): QLQC-30 and the scale (AIS Approval IIIness Scale). Results. The highest level of acceptance of the disease, so the best ability to adapt to cancer have those women who have undergone radical mastectomy and adjuvant hormone therapy during the treatment. The lowest level of acceptance of the illness, expressed as a negative assessment was observed in women after BCT and during chemotherapy treatment. The use of the EORTC QLQC-30 to assess the overall health and quality of life of patients allowed us to capture statistically significant differences in the percentages stating good health, with the relatively highest negative response rates which were observed in the subgroups treated with chemotherapy and hormone therapy. With regard to the highest quality of life, the percentage of negative responses was observed in subgroups treated with the use of hormone therapy and after mastectomy. Conclusions. Good acceptance of the disease was obtained by women treated for breast cancer who have undergone mastectomy in the course of adjuvant endocrine therapy. The assessment of general health and quality of life was influenced by oncological treatment. Patients during chemotherapy and hormone therapy showed a negative impact of this form of treatment on overall well-being and functioning.Patients after mastectomy and during hormone therapy treatment showed a comparatively lower quality of life compared to a group of patients after BCT and during treatment with chemotherapy

8

ANALIZA SPECYFICZNYCH OBJAWÓW U PACJENTEK PO USUNIĘCIU PIERSI Z POWODU RAKA Z WYKORZYSTANIEM KWESTIONARIUSZA QLQ-BR23

80%

Benirowska S.

Long-Term Care Nursing

|

2019

|

tom 3

|

nr 3

EN

Introduction The World Health Organization as the main task, set himself to care about the good quality of life in patients after anti¬cancer treatment. Aim The aim of the study is the analysis of specific symptoms in patients after removal of breast cancer with the use of questionnaire QLQ-BR23. Material and methods The study was conducted among 100 patients. The study uses a questionnaire QLQ-C23. Results The discomfort of the patient concerned to taste the food, feel sick/bad, feels pain in the arm or shoulder, swelling of shoulder or arm, difficulty lifting up the arm, swelling of the affected mammary gland responses remained at the average level. Conclusions These problems clearly decreased in the patients satisfaction from life.

PL

Wstęp Światowa Organizacja Zdrowia jako naczelne zadanie stawia sobie dbałość o dobrą jakość życia chorych po leczeniu przeciwnowotworowym . Cel Celem pracy jest analiza specyficznych objawów u pacjentek po usunięciu piersi z powodu raka z wykorzystaniem kwestionariusza QLQ-BR23. Materiał i metody Badania zostały przeprowadzone pośród 100 chorych. W badaniach wykorzystano kwestionariusz QLQ-C23. Wyniki Dyskomfort u pacjentek dotyczył odczuwania smaku potraw, czucia się chorym/niedobrze, odczuwania bólu w ramieniu lub barku, obrzęku ramienia lub ręki, trudności z podnoszeniem ramienia, obrzęku chorej piersi -odpowiedzi utrzymywały się na poziomie średnim. Wnioski Wskazane problemy, niewątpliwie pogarszały u pacjentek satysfakcję z życia.

9

Results of sentinel lymph node biopsy in patients with breast cancer in 10-year own material of the 4th Military Teaching Hospital with Polyclinic in Wrocław

80%

Kabziński P. , Rac J. , Dorobisz T. , Pawłowski W. , Ziomek A. , Chabowski M. , Janczak D. , Leśniak M. , Janczak D.

Polish Journal of Surgery

|

2016

|

tom 88(3)

130-135

EN

At present, sentinel lymph node biopsy is a standard procedure to assess the advancement of breast cancer and cutaneous melanoma. The aim of the study was to assess the role of the sentinel lymph node biopsy in the treatment of patients with breast cancer in our own material. Material and methods. Analyzed was medical documentation of 258 patients with initially operable breast cancer, qualified for operation with sentinel lymph node biopsy in 2004-2014 in the Department of Surgery of the 4th Military Teaching Hospital. A few hours prior to the planned surgery, radioisotope (technitium-99 sulfur colloid) was applied in the area of tumor or under the areola. 1-2 hours after administering the tracer, the lymphoscintigraphy with the labelling of the sentinel lymph node on the skin was performed. Results. On the basis of the gathered material, obtained were the following parameters: sensitivity – 100%, and specificity – 94.6%. Four cases were false negative (5.5%). Conclusions. 1. Marking the sentinel lymph node in breast cancer, based on the single visualisation method with the use of radioisotope, is a useful and effective technique. 2. The factor influencing the results of the sentinel lymph node biopsy (true positive and negative results and false negative result) was the number of the excised lymph nodes except for the sentinel lymph node. 3. Patients with estrogen receptor expression had often metastases to sentinel lymph node (145 cases – 56%). 4. The false negative rate, i.e. 5.5% in our material, is within the limits of acceptability given in the literature. 5. The sentinel lymph node biopsy performed by the experienced surgical team is a reliable diagnostic tool with a low complication rate.

10

Tumor Size and Pathologic Characteristics of Breast Cancer Analysis of 639 Early Breast Cancers

80%

Sęk P. , Piekarski J. , Kubiak R. , Szymczak W. , Nejc D. , Pluta P. , Bilski A. , Jeziorski A.

Polish Journal of Surgery

|

2007

|

tom 79

|

nr 2

78-84

EN

Primary tumor size, an essential clinical parameter, is assessed by oncologist during the physical examination of a patient with breast cancer. The results of such assessment constitutes a basis for classification of breast cancer staging, selection of proper primary treatment, selection of type of surgical treatment and initial evaluation of patient prognosis.The aim of the study was to describe changes in biological characteristics of breast cancers relative to increases in primary tumor size.Material and methods. All women treated surgically for breast cancer in the Department of Surgical Oncology, Medical University in Łódź, from 1999 to 2004, were included in our study. We confined our analysis to primary operable, invasive, primary tumors less than 3 cm. 639 cases comprised the study group. We analyzed the associations between primary tumor size and other routinely assessed clinical and pathological parameters.Results. We found statistical associations between primary tumor size and the presence of metastases in axillary lymph nodes (p<0.0001), presence of extracapsular extension of lymph nodes metastases (p<0.0001), presence of tumor cells emboli (p<0.0001), absence of expression of estrogen receptor (p=0043) and absence of progesterone receptor (p=0.0196) in cancer cells. No association was found between tumor size and histologic tumor type (p=0.205). In a subgroup of ductal carcinomas, tumor size was associated with the grade of cancer (p=0.0002).Conclusions. Increases in tumor size are accompanied by increasing incidence of unfavorable prognostic factors and decreasing incidence of favorable prognostic factors. Tumor size constitutes the source of direct and indirect prognostic information.

11

The influence of socio-demographic factors on making a decision related to the disease and treatment in women with breast cancer

80%

Nowicki A. , Wiśniewska K. , Rhone P.

OncoReview

|

2015

|

tom 5

|

nr 3

A125-132

EN

Introduction. Socio-demographic factors may affect the decision making associated with the disease and the long-term results of treatment. Objective. Exploring the relationship between socio-demographic factors of women treated for breast cancer and decision- making associated with the disease and treatment. Material and methods. The study involved 100 women aged 30 to 72 (mean: 57 years) who were treated at the Oncology Center in Bydgoszcz in 2013–2014 due to breast cancer. A survey questionnaire on socio-demographic factors and data on knowledge about prevention and disease was used in the study. Results. The number of women performing breast self-examination decreased with age; 83% of patients over 50 years old and 76% (p = 0.0001) over 69 years old underwent mainly mammography (p = 0.03). Self-detection of breast tumor also decreased with age and was detected more frequently by the medical personnel (p = 0.0001). More educated women (85%) examined themselves more often than those with primary and vocational education (p = 0.001). According to our assessment, the number of women with knowledge about cancer decreased with age (p = 0.004). The same was true for women in a very good and good financial situation, with 94% of them declaring a higher knowledge level (p = 0.001). Conclusions. Women’s knowledge about breast cancer is not satisfactory, especially in older and less educated women. They obtain knowledge from the Internet mainly and from the medical staff in the smallest degree. Young women up to 49 years of age perform self-examination to detect breast cancer most often, while older women use mammography. Almost all women immediately report to the doctor and are admitted to clinics after detecting lesions with mammography or self-examination.

12

Ocena kardiotoksyczności u pacjentek z rakiem piersi leczonych trastuzumabem*

80%

Sidło-Stawowy A. , Sawicka M. , Kubeczko M. , Sikoń E. , Piszko J. , Maruszczyk W. , Stando R. , Bracik J.

Annales Academiae Medicae Silesiensis

|

2013

|

tom 67

|

nr 2

123-127

EN

INTRODUCTION Breast cancer is the most frequent malignancy in women in Poland. Overexpression of the HER2 receptor positively correlates with the aggressiveness of the disease. Trastuzumab, a humanized monoclonal antibody against HER2, radically improves the prognosis in such patients. However, its main side effect is cardiotoxicity. The aim of this study is to evaluate the cardiotoxicity in trastuzumab-treated patients. MATERIALS AND METHODS The cases of 19 women treated in the Department of Internal Medicine and Oncologic Chemotherapy Medical University of Silesia in Katowice in the period of 2010–2011 were retrospectively analyzed. RESULTS The median age at the time of diagnosis – 57 years, pathology: invasive ductal carcinoma in 17, invasive lobular carcinoma in 2 patients. Overexpression of HER2 was observed in all the cases. Trastuzumab was administered to 16 of them after previous therapy with antracyclines and/or taxan; the median total antracycline dose was 680 mg. Moreover, 13 patients were subjected to radiotherapy; the median total dose was 50 Gy. In 3 patients, trastuzumab and chemotherapy was used in the management of metastasized disease. The median time between the administration of trastuzumab and anthracyclines was 3 months. The median number of cycles was 10. Before administration of the drug, ECG and echocardiography were performed along with ejection fraction (EF) assessment. Before and after therapy the median EF was 65% and 61%, respectively. The therapy was withheld in 1 patient because of a decrease in EF to 40%. CONCLUSIONS The treatment with trastuzumab was well tolerated. In most patients, we did not observe a significant decrease in EF. However, the cases should be followed up to detect delayed cardiotoxicity.

PL

WSTĘP Rak piersi to najczęstszy nowotwór złośliwy u kobiet w Polsce. W praktyce klinicznej ważne jest określenie ekspresji receptorów, w tym dla naskórkowego czynnika wzrostu typu 2 (HER2) na komórkach nowotworowych. Gdy komórki te wykazują wzmożoną ekspresję HER2, przebieg choroby jest agresywniejszy. Trastuzumab, humanizowane przeciwciało monoklonalne przeciw HER2, znacząco poprawia rokowanie. Jednak terapia taka nie jest pozbawiona działań niepożądanych, w tym kardiotoksyczności. Celem pracy była ocena kardiotoksyczności leczenia trastuzumabem u pacjentek z rakiem piersi. MATERIAŁ I METODY Dokonano retrospektywnej analizy historii chorób 19 kobiet leczonych w Klinice Chorób Wewnętrznych i Chemioterapii Onkologicznej Śląskiego Uniwersytetu Medycznego w Katowicach w latach 2010–2011. WYNIKI Mediana wieku w chwili rozpoznania – 57 lat, typ histologiczny: rak przewodowy naciekający u 17, rak zrazikowy naciekający u 2 pacjentek. Nadekspresję HER2 stwierdzono u wszystkich 19 kobiet, u 16 z nich zastosowano trastuzumab po wcześniejszym leczeniu upełniającym antracyklinami i/lub taksanami – mediana sumarycznej dawki antracyklin 680 mg. U 13 pacjentek dodatkowo przeprowadzono radioterapię – mediana dawki sumarycznej 50 Gy. U 3 pacjentek podano trastuzumab oraz chemioterapię w leczeniu rozsianej choroby nowotworowej. Mediana czasu włączenia trastuzumabu po antracyklinach wyniosła 3 miesiące. Liczba cykli: mediana 10. Przed włączeniem leku wykonano badanie EKG i czynnościowe serca z oceną frakcji wyrzutowej (EF). Mediana EF przed rozpoczęciem leczenia: 65%, po leczeniu: EF 61%. U jednej pacjentki przerwano leczenie z powodu obniżenia EF do 40%. WNIOSKI Leczenie trastuzumabem było dobrze tolerowane. U większości pacjentek nie obserwowano znamiennego obniżenia EF wymagającego odstawienia leku. Badana grupa wymaga jednak badań czynnościowych serca również po odstawienia trastuzumabu w celu wykrycia późnych powikłań kardiotoksycznych.

13

Connecting the dots: understanding the relationship between religiosity, psychological resilience and depression in breast cancer patients

80%

Fradelos E.

Progress in Health Sciences

|

2019

|

tom 1

98-104

EN

Introduction: Death anxiety, fear of abundance, isolation, stigma of the disease and medication side effects are among the most common sources of anxiety and depression in patients with breast cancer. Purpose: To examine the possible relationship between religiosity, psychological resilience and depression on breast cancer patients. Materials and methods: A cross-sectional design was employed in this study which 152 breast cancer patients participated. Data were collected with the following instruments: Patient Health Questionnaire-2-item scale, Connor-Davidson Resilience Scale 25 and Centrality of Religiosity Scale and a special designed sheet reporting social, demographic and clinical characteristics. Statistical analyses were conducted with the Statistical Package for the Social Science V25. Descriptive statistics such means, and frequencies were calculated and inferential statistics such correlation test, simple and multiple regression analysis were applied. Results: Approximately 1 in 3 patients suffered symptoms of depression while they were reporting moderate religiosity and resilience values. Based on the four-step mediation analysis religiosity was strongly associated with psychological resilience but it was not found to affect directly either depression, but psychological resilience can be a mediator between religiosity and depression. Conclusion: This study supports the notion thatreligiosity and spirituality can have a beneficial influence on health outcomes.

14

The use of fulvestrant in patients with advanced breast cancer

80%

Kufel-Grabowska J.

OncoReview

|

2018

|

tom 8

|

nr 1

15-18

EN

Breast cancer is the most common malignancy in women in Poland and the entire world, but thanks to early diagnostics and efficacious therapeutic methods, its prognosis is good. In some patients with advanced breast cancer, long-term survival is observed, which is why it is essential to select the most appropriate therapy, and to follow up on the course of disease and possible adverse events related to the treatment applied. The slow development of hormone-receptor-positive cancer, and a multitude of therapeutic options constitute a real challenge in palliative treatment. The use of fulvestrant resulted in a good response in both of the presented cases, and did not in any way comprise the daily lives of the patients over a long period of time.

15

Health behaviors of patients after breast cancer surgery in the Podkarpackie voivodeship

80%

Aleksandra Pusz-Sapa A. , Greta Gaweł G. , Joanna Sobczyk J. , Aneta Wojtasik A. , Małgorzata Król M. , Emilia Misiewicz E. , Barbara Lidwin B.

European Journal of Clinical and Experimental Medicine

|

2017

|

nr 4

310-314

EN

Aim. An evaluation of lifestyle changes (physical activity, diet) in patients after breast cancer surgery. Materials and method. 200 women after breast cancer surgery were surveyed. The respondents were asked whether the surgery caused a change in their diet and physical activity. An analysis was performed concerning the education, place of residence and age of the respondents. Results. Prior to being diagnosed with breast cancer, about one third of the respondents were concerned about their diet and physical activity. After the surgery more than a half of the respondents were concerned about a healthy lifestyle. Women below 50 years old with higher education, who live in a city, were concerned about their diet and physical activity both before and after surgery. Conclusions. As a result of the breast cancer surgery, lifestyle changes were most often found in women aged 50-69 years old with higher education who lived in a city. Statistical relevance of the results was noted.

16

Malignant mixed mullerian tumor in two patients receiving tamoxifen therapy

80%

Koukouliata A.

Progress in Health Sciences

|

2011

|

tom 1

|

nr 1

167-170

EN

Patients with breast cancer exhibit an increased risk in developing neoplasms of other organs. In the case of the endometrium, the increased risk might be due to tamoxifen adjuvant therapy. We present two cases of homologous malignant mixed mullerian tumor (MMMT) of the uterine in two women, 77-year-old and 76-year-old, respectively, after tamoxifen treatment for postmenopausal breast cancer with positive estrogen receptors. The findings for two patients were studied and compared with similar ones discussed in the relevant literature.

17

Cardiotoxicity in breast cancer patients after radiotherapy – modern methods of minimizing the dose to the heart and dilemmas of choosing critical cardiac structures for monitoring dose distribution

80%

Pudełek K. , Pudełek J. , Nawrocki S.

OncoReview

|

2016

|

tom 6

|

nr 3

A113-117

EN

Radiotherapy in breast cancer patients is an important component of multidisciplinary treatment. It reduces the risk of local recurrence and mortality from breast cancer. However, it can lead to secondary effects due to the presence of the heart within the irradiation field. Adjuvant radiation therapy for breast cancer increases the risk of coronary artery disease, myocardial infarction and cardiovascular death. It is important to determine the optimal treatment to minimize cardiotoxicity. Modern radiotherapy techniques may reduce radiation-induced cardiac toxicity, but it is necessary to determine the most sensitive structures within the heart, tolerance doses, and methods for early detection and monitoring of adverse effects.

18

Same quality of life for polish breast cancer patients treated with mastectomy and breast reconstruction or breast-conserving therapy

80%

Szutowicz-Wydra B. , Wydra J. , Ciesielski M. , Kruszewski W. J. , Szajewski M. , Walczak J. , Hansdorfer-Korzon R.

Polish Journal of Surgery

|

2016

|

tom 88(5)

464-474

EN

Breast cancer often requires combined oncologic treatments, the base of which is surgery. Quality of life (QoL) after each surgical procedure may influence the process of decision making among women, who qualify for multiple oncological strategies. Our knowledge about QoL in breast cancer patients is derived from comparative studies. Results may differ, depending on country, culture, and societal relations. The aim of the study was to investigate the quality of life of Polish patients treated with breastconserving therapy (BCT) or mastectomy with breast reconstruction. Material and methods. The study involved women who underwent surgery for breast cancer in the Department of Surgical Oncology of the Gdynia Oncology Center from September 2010 to November 2013. Eighty-two breast reconstructions (in 79 patients) and 226 BCT procedures were performed. QoL was measured with the use of EORTC QLQ-C30 and QLQ-BR23 questionnaires. Results. Global QoL was high in both groups and did not differ significantly. Body image was slightly better after BCT than after mastectomy with breast reconstruction, but sexual QoL was lower. Future perspective was quite low in both groups. Disease symptoms were not bothering. Conclusions. The global QoL among Polish breast cancer patients treated with BCT or mastectomy with breast reconstruction is high and does not differ between groups. There is a need for anxiety and disease-related fear prophylaxis and for the improvement of sex life of breast cancer survivors.

19

Physiotherapy in women after breast cancer treatment – review

80%

Skutnik K. , Ustymowicz W. , Zubrewicz K. , Zińczuk J. , Kamińska D. , Pryczynicz A.

Progress in Health Sciences

|

2019

|

tom 1

162-168

EN

Introduction: Breast cancer is the most common malignant tumor in women in the Polish region. Surgery is a basic method of breast cancer treatment. Surgery often carries a lot of unwanted changes as follows: limitation of mobility in the shoulder joint on the operated side, secondary lymphoedema, post mastectomy pain syndrome (PMPS), reduction of muscle strength or disorders in body posture. Therefore, the implementation of physiotherapeutic activities that are designed to prevent and eliminate postoperative complications seems very important. The main aim of this work was to present physiotherapeutic management in women after mastectomy based on the analysis of available literature. The physiotherapeutic process can be divided into three periods: early hospital, early ambulatory and the late ambulatory period. In the first period, active slow exercises, self-support of the upper limb on the operated side and breathing exercises on the thoracic track are used to prevent circulatory disorders, pulmonary complications, and edema. The early ambulatory period includes corrective exercises, general improvement exercises, stretching and learning of automatic massage of the upper limb of the operated side. The last period should be enriched by recreational methods of physical activity such as swimming, cycling or Nordic walking to maintain physical fitness, proper mobility of the shoulder girdle and improve the patient's psychophysical state. It is very important the patient regular continues the rehabilitation program after curing of breast cancer as well. In the case of secondary lymphoedema of the upper limb, comprehensive rehabilitation physiotherapy is used, consisting of manual lymphatic drainage, healing exercises, compression therapy, and skin care. Conclusions: Physiotherapy in women after breast cancer surgery is a complex and long-term process. Physiotherapeutic methods are effective in treating complications after surgery of breast cancer surgery. It is necessary to constantly update the physio-therapy knowledge in women after breast cancer surgery.

20

Acceptance of illness after surgery in patients with breast cancer in the early postoperative period

80%

Nowicki A. , Krzemkowska E. , Rhone P.

Polish Journal of Surgery

|

2015

|

tom 87(11)

539-550

EN

The breast cancer is the most common cancer in women, both in Poland and in the world. Consequences entail a disruption in the physical, psychological and social functioning. The aim of the study was to assess the acceptance of illness by patients treated for breast cancer in the early postoperative period. Material and methods. The research was conducted on the group of 100 consecutive patients aged 32‑80 years (median 56 years) who underwent surgery for breast cancer in the Centre of Oncology in Bydgoszcz w 2014 roku. 68 of women had mastectomy, 32 of women had conservative surgery. Polling was conducted in the early period after surgery. The original questionnaire containing closed questions the scale of acceptance of the disease (AIS) as well as mental adaptation to cancer (Mini-Mac) was used in the study. Results. 38% of patients had high acceptance of the disease, 48% averageand 14% had low acceptance. Patients after conservative surgery had a higher average values for the mental strategies to cope with the disease, for the fighting spirit (23.1), helplessness and hopelessness (13.5), positive revaluation (23), the patients had a lower average (16.5) in the strategy to absorb anxiety. Patients after conservative surgery had a higher average for constructive style (2.6) but lower for destructive style (1.5). High level of mental coping with the disease was observed in 53%of patients with constructive style and 4% of patients with destructive style. While, a low level of mental coping with the dosease was observed in 5% of patients with constructive style and 46% of patients with destructive style. Conclusions. Almost half of women after mastectomy or conservative surgery had an average acceptance of the disease. The disease was accepted best by educated women living in the cities, whitecollar workers with a good economic situation. The following factors were affected the better management of the disease, in order: age, education, current occupation and economic situation, while the type of surgery did not affect better management. More than half of women, regardless of the type of surgery reflected the high level of constructive style.