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Synthesis, characterization and controlled toxicity of a novel hybrid material based on cisplatin and docetaxel

100%

Prodana M. , Voiculet A. , Garea S. , Radu M. , Iovu H. , Demetrescu I. , Dinischiotu A.

Open Chemistry

2014

tom 12

nr 10

1008-1015

This paper is focused on the synthesis and characterization of a novel hybrid material based on cisplatin and docetaxel-loaded functionalized simultanously carbon nanotubes able to be used in cancer therapy as drug delivery system with controlled toxicity. This material was physico-chemically investigated by determining the structure, as evidenced by Fourier transform infrared (FTIR) spectroscopy, transmission electronmicroscopy (TEM) and its stability was studied with the aid of thermogravimetric analysis (TGA). The amount of platinum ions released into the solution of simulated body fluid (SBF) was highlighted by coupled plasma mass spectrometry (ICP-MS). Toxicology experiments were performed with MDA-MB 231 breast cancer epithelial cells. The performance of the new drug delivery hybrid material was compared with functionalised carbon nanotubes with therapeutic agents functionalized with a single therapeutic agent.

Depletion of intracellular glutathione and increased lipid peroxidation mediate cytotoxicity of hematite nanoparticles in MRC-5 cells

84%

Radu M. , Munteanu M. C. , Petrache S. , Serban A. I. , Dinu D. , Hermenean A. , Sima C. , Dinischiotu A.

Acta Biochimica Polonica

2010

tom 57

nr 3

355-360

Particles generated from numerous anthropogenic and/or natural sources, such as crystalline α-Fe2O3 nanoparticles, have the potential to damage lung cells. In our study we investigated the effects of these nanoparticles (12.5 µg/ml) on lipid peroxidation and the antioxidative system in MRC-5 lung fibroblast cells following exposure for 24, 48 or 72h. Exposure to α-Fe2O3 nanoparticles increased lipid peroxidation by 81%, 189% and 110% after 24, 48 and 72h, respectively. Conversely, the reduced glutathione concentration decreased by 23.2% and 51.4% after 48 and 72h of treatment, respectively. In addition, an augmentation of the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione transferase and glutathione reductase within the interval between 48-72h was noticed. Taking into account that the reduced glutathione level decreased and the malondialdehyde level, a lipid peroxidation product, remained highly increased up to 72h of exposure, it would appear that the MRC-5 antioxidant defense mechanisms did not efficiently counteract the oxidative stress induced by exposure to hematite nanoparticles.