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Signal transduction in human pancreatic cancer: roles of transforming growth factor beta, somatostatin receptors, and other signal intermediates

100%

Li M. , Becnel L. S. , Li W. , Fisher W. E. , Chen C. , Yao Q.

Archivum Immunologiae et Therapiae Experimentalis

2005

tom 53

nr 5

381-387

Pancreatic cancer is a devastating disease because of the lack of early detection markers and effective treatments. It is the fourth leading cause of cancer-related death in western countries, including the United States. The mechanisms of pancreatic cancer progression remain unknown. Transforming growth factor beta (TGF-beta), a multifunctional cytokine, regulates cell growth and differentiation in healthy tissues, yet fails to do so in pancreatic cancer. Alterations of the TGF-beta and TGF-beta receptor/Smad signal transduction pathway have been implicated in pancreatic cancer. Furthermore, both the TGF-beta receptor and Smad proteins interact with a variety of cellular signal pathways, such as the somatostatin receptors (SSTRs), ERK1/2, and Wnt signal transduction cascades. This suggests that pancreatic cancer is a multi-gene-controlled malignancy and that effective treatments for pancreatic cancer should be aimed at multiple targets. In this review, we summarized the major signal intermediates involved in pancreatic cancer signal transduction pathways and specifically discussed how alterations in the regulatory functions of TGF-beta and Smad proteins allow for pancreatic carcinogenesis.

Theoretical Analysis of the TE Mode Cerenkov Type Second Harmonic Generation in Ion-Implanted X-Cut Lithium Niobate Planar Waveguides

84%

Du G. , Li G. , Zhao S. , Qiao W. , Yang K. , An J. , Li M. , Wang J. , Wang W.

Acta Physica Polonica A

2009

tom 115

nr 3

685-689

We present a study of the Cerenkov configuration second harmonic generation in X-cut ion-implanted lithium niobate waveguides. An approximate solution of conversion efficiency is given and plotted which shows that it is very sensitive to the waveguide depth and pump wavelength. The results can be used in the design of waveguides for the efficient second harmonic generation in the Cerenkov configuration.